Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Engineering
Computer Simulation Of Cerebrovascular Circulation : Assessment Of Intracranial Hemodynamics During Induction Of Anesthesia, Steven D. Wolk
Computer Simulation Of Cerebrovascular Circulation : Assessment Of Intracranial Hemodynamics During Induction Of Anesthesia, Steven D. Wolk
Theses
The purpose of this project was to develop a computer model of cerebrovascular hemodynamics interacting with a pharmacokinetic drug model to examine the effects of various stimuli during anesthesia on cerebral blood flow and intracranial pressure.
The mathematical model of intracranial hemodynamics is a seven compartment constant volume system. A series of resistances relate blood and cerebrospinal fluid fluxes to pressure gradients between compartments. Arterial, venous, and tissue compliance are also included. Autoregulation is modeled by transmural pressure dependent arterial-arteriolar resistance. The effect of a drug (thiopental) on cerebrovascular circulation was simulated by a variable arteriolar-capillary resistance. Thiopental concentration, in …