Engineering Commons^™

Micro Pipes – A Portable Integrated Platform For Electrochemical Sensing Using Essence Architecture, Hansin Kim

Theses

The field of microfluidics and lab-on-chip (LOC) technology has the potential to have a truly transformative effect in biological engineering. This includes areas such as single-cell analysis, environmental monitoring, regenerative medicine, and point-of-care diagnostics. Yet despite being the subject of intense research over the past two decades, LOC devices have not been widely adopted. It is increasingly evident that there is a need for an effective and adaptable integration strategy to realize the potential of this technology.

Presented in this thesis is a design for a chip-to-world interface that aims to improve integration while maintaining cost-efficiency and ease of fabrication. …

Lithium As A Possible Therapeutic Drug In Posttraumatic Brain Injury, Tulika Das

Theses

Lithium, a popular drug for treating mental health disorder has shown promising effect in recent research on traumatic brain injury (TBI). The mechanism of lithium for treating bipolar mood disorder is still not properly understood, but recent studies showed that lithium is neuroprotective in TBI. In my thesis, the neuroprotective effects of lithium were examined in primary neuronal culture and mild blunt injury using rodent model of Lateral Fluid Percussion Injury (LFPI). At first determination of the neuroprotective/toxicity effects of lithium in neuronal culture was done and observed that 0.5 - 1.0 mM concentrations were found to be neuroprotective as …

Vergence Eye Movement Parameters For Pre/Post-Obvat And Sham Therapy On Binocularly Normal Controls, Joel V. Rajah

Theses

Vergence is the disjunctive movement of the eyes to maintain single binocular vision. Vergence eye movements are necessary to maintain the object of interest on the fovea of each eye as an individual looks from one object to another. Recent studies show that office based vergence/accommodative therapy (OBVAT) is an effective treatment for the binocular dysfunction known as convergence insufficiency. This study was performed to investigate the changes in oculomotor parameters parameter data for pre- and post-therapy subjects who are binocularly normal controls. A haploscope was used to collect eye movement data pre- and post-therapy. The analysis of the eye …

Longitudinal Investigation Of Disparity Vergence In Young Adult Convergence Insufficiency Patients, Patrick C. Crincoli

Theses

Vergence is a form of eye movement in which the eyes move in opposite directions to minimize retinal disparity. It allows an object at different distances from a viewer to appear single during binocular vision by centering the image on the fovea of each retina. Convergence insufficiency (CI) is a binocular disfunction in which blurry and double vision is a symptom. Office-based Vergence/Accommodative Therapy (OBVAT) has been shown to be effective in treating CI. A randomized clinical trial was designed to study fifty participants with CI before and after therapy using randomized therapy treatment (active and placebo), standardized clinical definitions, …

Experimentally Linking Head Kinematics To Brain Deformation, Imouline Algharbi

Theses

Traumatic brain injury (TBI) research is used to study the effects of brain injuries and the rehabilitations for them. TBI contributes to major cause of disability and deaths quantifying up to 30% of all the head injuries. To mimic real world impact to understand the mechanism of injury head-surrogate models are used. This thesis describes a method to record head kinematics from acceleration and angular rate sensors of head-brain surrogate model for blast and blunt injury. This methodology is validated through experimental testing. To get a better insight of the head kinematics experienced by a real skull a drop tower …