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Methods For Detecting High-Frequency Oscillations In Ongoing Brain Signals: Application To The Determination Of Epileptic Seizure Onset Zones, Chiran Dilip Doshi
Methods For Detecting High-Frequency Oscillations In Ongoing Brain Signals: Application To The Determination Of Epileptic Seizure Onset Zones, Chiran Dilip Doshi
Master's Theses (2009 -)
Epilepsy is a neurological disorder with varied expression. Patients with focal onset seizures that are resistant to medications can benefit from ablative surgery. However, localization of the seizure onset zone (SOZ) and characterization of propagation to secondary areas can be challenging. The present study aimed at developing the appropriate signal processing methodology to detect bursts of interictal high-frequency oscillations (HFOs), as a possible signature of the SOZ, in patients with drug-resistant partial epilepsy. Additionally, invasive interictal and ictal intracranial electroencephalography (iEEG) data and non-invasive electromagnetic source imaging with magnetoencephalography (MEG) data from three subjects were analyzed. We developed a novel …