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- Cardiomyocytes; competitive-inhibition model; matrix synthesis; mesenchymal stem cells; Michaelis-Menten kinetics; protein degradation; secretome release (1)
- Developmental neurotoxicity; Neural stem cells; Insecticides; AEA; Chlorpyrifos; Multi-variable logistic regression; Mechanotoxicology (1)
- Low modulus beta titanium alloys; Mechanical alloying; Spark plasma sintering; Corrosion; Biomedical applications (1)
Articles 1 - 3 of 3
Full-Text Articles in Engineering
Spark Plasma Sintering Of Low Modulus Titanium-Niobium-Tantalum-Zirconium (Tntz) Alloy For Biomedical Applications, Nicholas Mavros, Taban Larimian, Javier Esqivel, Rajeev Kumar Gupta, Rodrigo Contieri, Tushar Borkar
Spark Plasma Sintering Of Low Modulus Titanium-Niobium-Tantalum-Zirconium (Tntz) Alloy For Biomedical Applications, Nicholas Mavros, Taban Larimian, Javier Esqivel, Rajeev Kumar Gupta, Rodrigo Contieri, Tushar Borkar
Mechanical Engineering Faculty Publications
In metallurgy, titanium has been a staple for biomedical purposes. Its slow toxicity and alloying versatility make it an attractive choice for medical applications. However, studies have shown the difference in elastic modulus between titanium alloys (116 GPa) and human bone (10–40 GPa), which contributes to long term issues with loose hardware fixation. Additionally, long term studies have shown elements such as vanadium and aluminum, which are commonly used in Ti-6Al-4V biomedical alloys, have been linked to neurodegenerative diseases like Alzheimer and Parkinson. Alternative metals known to be less toxic are being explored as replacements for alloying elements in titanium …
Synthesis And Secretome Release By Human Bone Marrow Mesenchymal Stem Cell Spheroids Within Three-Dimensional Collagen Hydrogels: Integrating Experiments And Modelling, Jyotsna Joshi, Mohammadreza Dehghan Abnavi, Chandrasekhar R. Kothapalli
Synthesis And Secretome Release By Human Bone Marrow Mesenchymal Stem Cell Spheroids Within Three-Dimensional Collagen Hydrogels: Integrating Experiments And Modelling, Jyotsna Joshi, Mohammadreza Dehghan Abnavi, Chandrasekhar R. Kothapalli
Chemical & Biomedical Engineering Faculty Publications
Myocardial infarction results in loss of cardiac cell types, inflammation, extracellular matrix (ECM) degradation, and fibrotic scar. Transplantation of bone marrow-derived mesenchymal stem cells (BM-MSCs) is being explored as they could differentiate into cardiomyocyte-like cells, integrate into host tissue, and enhance resident cell activity. The ability of these cells to restore lost ECM, remodel the inflammatory scar tissue, and repair the injured myocardium remains unexplored. We here elucidated the synthesis and deposition of ECM (e.g., elastin, sulfated glycosaminoglycans, hyaluronan, collagen type III, laminin, fibrillin, lysyl oxidase, and nitric oxide synthases), matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), and other secretome …
Biophysical And Biomechanical Properties Of Neural Progenitor Cells As Indicators Of Developmental Neurotoxicity, Gautam Mahajan, Moo-Yeal Lee, Chandrasekhar R. Kothapalli
Biophysical And Biomechanical Properties Of Neural Progenitor Cells As Indicators Of Developmental Neurotoxicity, Gautam Mahajan, Moo-Yeal Lee, Chandrasekhar R. Kothapalli
Chemical & Biomedical Engineering Faculty Publications
Conventional in vitro toxicity studies have focused on identifying IC50 and the underlying mechanisms, but how toxicants influence biophysical and biomechanical changes in human cells, especially during developmental stages, remain understudied. Here, using an atomic force microscope, we characterized changes in biophysical (cell area, actin organization) and biomechanical (Young's modulus, force of adhesion, tether force, membrane tension, tether radius) aspects of human fetal brain-derived neural progenitor cells (NPCs) induced by four classes of widely used toxic compounds, including rotenone, digoxin, N-arachidonoylethanolamide (AEA), and chlorpyrifos, under exposure up to 36 h. The sub-cellular mechanisms (apoptosis, mitochondria membrane potential, DNA damage, glutathione …