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Glycosaminoglycan Stabilization In Bovine Pericardium, Lauren Browne
Glycosaminoglycan Stabilization In Bovine Pericardium, Lauren Browne
All Theses
Glutaraldehyde crosslinked bovine pericardium has been used for fabrication of bioprosthetic heart valves as well as cardiac patches for soft tissue repair. However, calcification and limited mechanical stability result in shortened life for the prostheses. Previous research has shown that glutaraldehyde crosslinking does not stabilize glycosaminoglycans (GAGs) and that GAGs are lost from porcine bioprosthetic heart valves[1]. Bovine pericardial tissue is composed of an amorphous network of collagen and elastin fibers, proteoglycans, and GAGs. The GAGs of bovine pericardium include dermatan sulfate, chondroitin sulfate, and hyaluronan [2].
It is hypothesized that Glut does not stabilize GAGs in pericardium and loss …