Engineering Commons^™

Carboxymethylcellulose Hydrogels Support Central Nervous System-Derived Tumor-Cell Chemotactic Migration: Comparison With Conventional Extracellular Matrix Macromolecules, Tanya Singh, Chandrasekhar Kothapalli, Devika Varma, Steven B. Nicoll, Maribel Vazquez

Publications and Research

The local microenvironment plays an important role in maintaining the dynamics of the extracellular matrix and the cell-extracellular matrix relationship. The extracellular matrix is a complex network of macromolecules with distinct mechanical and biochemical characteristics. Disruptions in extracellular matrix homeostasis are associated with the onset of cancer. The extracellular matrix becomes highly disorganized, and the cell-matrix relationship changes, resulting in altered cell-signaling processes and metastasis. Medulloblastoma is one of the most common malignant pediatric brain tumors in the United States. In order to gain a better understanding of the interplay between cell-extracellular matrix interactions and cell-migratory responses in tumors, eight …

Utilizing Fast Spin Echo Mri To Reduce Image Artifacts And Improve Implant/Tissue Interface Detection In Refractory Parkinson’S Patients With Deep Brain Stimulators, Subhendra N. Sarkar, Pooja R. Sarkar, Efstathios Papavassiliou, Rafael Rojas

Publications and Research

Introduction. In medically refractory Parkinson’s disease (PD) deep-brain stimulation (DBS) is an effective therapeutic tool. Postimplantation MRI is important in assessing tissue damage and DBS lead placement accuracy. We wanted to identify which MRI sequence can detectDBS leads with smallest artifactual signal void, allowing better tissue/electrode edge conspicuity.

Methods. Using an IRB approved protocol 8 advanced PDpatientswere imagedwithinMRconditional safety guidelines at lowRF power (SAR ≤ 0.1 W/kg) in coronal plane at 1.5T by various sequences.The image slices were subjectively evaluated for diagnostic quality and the lead contact diameters were compared to identify a sequence least affected by metallic leads.

Results …

Pre-Saccadic Modulation Of The Visually Evoked Potential, Leslie Guadron

Dissertations and Theses

Saccades are rapid eye movements that allow us to focus the fovea on different parts of our visual environment. Many psychophysical studies have shown that subjects can discriminate stimuli presented at the saccadic target better than at any other location before an eye movement is made. It is believed that covert attention allotted to the intended destination of a saccade, called pre-saccadic attention, accounts for the improved discrimination of stimuli. Covert top-down attention, which consists of orienting your attention, and not your gaze, to an object in your visual periphery, is known to facilitate behavioral performance in a manner similar …

A Comprehensive View Of Electrosleep: The History, Finite Element Models And Future Directions, Berkan Guleyupoglu

Dissertations and Theses

Transcranial Electrical Stimulation (tES) encompasses all methods of non-invasive current application to the brain used in research and clinical practice. We present the first comprehensive and technical review, explaining the evolution of tES in both terminology and dosage over the past 100 years of research to present day. Current transcranial Pulsed Current Stimulation (tPCS) approaches such as Cranial Electrotherapy Stimulation (CES) descended from Electrosleep (ES) through Cranial Electro-stimulation Therapy (CET), Transcerebral Electrotherapy (TCET), and NeuroElectric Therapy (NET) while others like Transcutaneous Cranial Electrical Stimulation (TCES) descended from Electroanesthesia (EA) through Limoge, and Interferential Stimulation. Prior …