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Full-Text Articles in Engineering
The Relationship Between Basic Multicellular Unit Activation And Origination In Cancellous Bone, C. J. Hernandez, S. J. Hazelwood, R. B. Martin
The Relationship Between Basic Multicellular Unit Activation And Origination In Cancellous Bone, C. J. Hernandez, S. J. Hazelwood, R. B. Martin
Biomedical Engineering
Activation frequency is often used as a measure of basic multicellular unit (BMU) activity in cancellous bone. However, activation frequency expresses the rate of BMU appearance in a histologic slide and not the rate of origination, which is a more physiologic indicator of remodeling activity and is necessary for the development of BMU-level bone remodeling simulations. Using identical assumptions to those for calculating the activation frequency, it is shown that the origination frequency in cancellous bone is equal to the activation frequency divided by the total distance traveled by the BMU and its width.
The Effect Of Stimulus Current Pulse Width On Nerve Fiber Size Recruitment Patterns, Robert B. Szlavik, Hubert De Bruin
The Effect Of Stimulus Current Pulse Width On Nerve Fiber Size Recruitment Patterns, Robert B. Szlavik, Hubert De Bruin
Biomedical Engineering
There have been theoretical studies presented that postulate a change in the stimulus current amplitude required to recruit nerve fibers with different stimulus current pulse widths. Based on these theoretical predictions, it has been suggested that the stimulus pulse width parameter may be used to selectively recruit fibers of different sizes and that this selectivity should increase with increasing distance from the stimulus electrode. In this paper, a simulation study of the recruitment patterns of a population of motor nerve fibers with a histologically accurate fiber diameter distribution is presented. Nerve fiber excitation simulations coupled with a time varying field …
In Vivo Electrical Stimulation Of Motor Nerves, Robert B. Szlavik
In Vivo Electrical Stimulation Of Motor Nerves, Robert B. Szlavik
Biomedical Engineering
Stimulus waveform parameters and stimulation protocols are fundamental to the use of electrical stimulation in medical applications. This thesis presents new simulation and experimental procedures that for the first time can quantify the effects on nerve fiber recruitment patterns of variable stimulus waveform parameters, such as pulse width and changes in the stimulation protocol with respect to electrode orientation. The study of the effect of variable electrical stimulus waveform parameters and stimulation protocols is important from the perspective of therapeutic and diagnostic medicine. Variations in the stimulus waveform such as stimulus pulse width have been shown to offer some promise …
Optimal Stimulus Electrode Dipole Orientation, Robert B. Szlavik, Hubert De Bruin
Optimal Stimulus Electrode Dipole Orientation, Robert B. Szlavik, Hubert De Bruin
Biomedical Engineering
The elicited M-Wave that results from the surface stimulation of the median nerve is highly dependent upon the geometric orientation of the stimulus electrode dipole. This phenomenon could make standardization of M-Wave measurements between tests performed on a single subject problematic. We present an experimental paradigm that illustrates this variability in terms of an estimate of the slope of the M-Wave peak potential versus stimulus current amplitude and the minimum stimulus current required to consistently elicit a minimal response. The design of an automated instrument for selecting the optimal stimulus electrode dipole orientation based on the electrode orientation experiment is …
The Effects Of Testing Methods On The Flexural Fatigue Life Of Human Cortical Bone, L. V. Griffin, J. C. Gibeling, R. B. Martin, V. A. Gibson, S. M. Stover
The Effects Of Testing Methods On The Flexural Fatigue Life Of Human Cortical Bone, L. V. Griffin, J. C. Gibeling, R. B. Martin, V. A. Gibson, S. M. Stover
Biomedical Engineering
A flexural model of four-point bending fatigue that has been experimentally validated for human cortical bone under load control was used to determine how load and displacement control testing affects the fatigue behavior of human cortical bone in three-point and symmetric four-point bending. Under load control, it was predicted that three-point bending produced no significant differences in fatigue life when compared to four-point bending. However, three-point bending produced less stiffness loss with increasing cycles than four-point bending. In four-point bending, displacement control was predicted to produce about one and a half orders of magnitude greater fatigue life when compared to …