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Synthesis And Characterization Of Biodegradable Elastomeric Polyurethane Scaffolds Fabricated By The Inkjet Technique.”, Changhong Zhang, Xuejun Wen, Narendra Vyavahare, Thomas Boland
Synthesis And Characterization Of Biodegradable Elastomeric Polyurethane Scaffolds Fabricated By The Inkjet Technique.”, Changhong Zhang, Xuejun Wen, Narendra Vyavahare, Thomas Boland
Thomas Boland
Biodegradable polyurethanes (PUs) were synthesized from methylene di-p-phenyl-diisocyanate (MDI), polycaprolactone diol (PCL-diol) and N,N-bis (2-hydorxyethyl)-2-aminoethane-sulfonic acid (BES), serving as a hard segment, soft segment and chain extender, respectively. MDI was chosen due to its reactivity and wide application in synthesis of biomedical polyurethanes due to its reactivity; PCL-diol was chosen because of its biodegradability; and BES was chosen because it allowed the introduction sulfonic acid groups onto the polymer chains. We evaluated the polyurethanes' degradation rate, mechanical properties, hydrophilicity, antithrombogenecity, and ability to support fibroblast cell attachment and growth by comparing with polymers having a 2,2-(methylimino)diethanol (MIDE) chain extender. Mechanical …
Loading Dependent Swelling And Release Properties Of Novel Biodegradable, Elastic And Environmental Stimuli-Sensitive Polyurethanes, Changhong Zhang, Kejia Zhao, Tj Hu, Xiaofeng Cui, Nathan Brown, Thomas Boland
Loading Dependent Swelling And Release Properties Of Novel Biodegradable, Elastic And Environmental Stimuli-Sensitive Polyurethanes, Changhong Zhang, Kejia Zhao, Tj Hu, Xiaofeng Cui, Nathan Brown, Thomas Boland
Thomas Boland
A novel degradable, elastic, anionic, and linear polyurethane was synthesized from hexamethylene diisocyanate, polycaprolactone diol, and a bicine chain extender. The chemical structure, mechanical properties, degradation rate, and swelling ratio were characterized by comparing the polymer with a polyurethane containing a 2,2-(methylimino) diethanol chain extender. Due to the incorporation of negatively charged carboxyl side groups, the bicine extended polymers exhibited higher micro-phase separation, better mechanical properties in dry condition, and better sensitivity to environmental stimuli than controls, as demonstrated by its high swelling ratio at elevated pH, lower ionic strength, or higher temperature. The swelling ratio of membranes showed reversible …