Engineering Commons^™

Device, Method, And Algorithm To Assess Changes In Cardiac Output Via Intracardiac Impedance Monitoring, Geoffrey Fredrick Schau

Dissertations and Theses

Cardiac output, the volume of blood pumped by the heart over time, is a powerful clinical metric used by physicians to assess overall cardiac health and patient well-being. However, current cardiac output estimation methods are typically invasive, time-consuming, expensive, or some combination of all three. Patients that receive artificial cardiac pacemaker devices are particularly susceptible to cardiac dysfunction and often require long-term cardiac monitoring support.

This thesis proposes a novel cardiac output monitoring solution which leverages an implantable intracardiac medical device. The principles of traditional impedance cardiography, an established cardiac output monitoring technique in practice for over fifty years, have …

Chemical Reaction Network Control Systems For Agent-Based Foraging Tasks, Joshua Stephen Moles

Dissertations and Theses

Chemical reaction networks are an unconventional computing medium that could benefit from the ability to form basic control systems. In this work, we demonstrate the functionality of a chemical control system by evaluating classic genetic algorithm problems: Koza's Santa Fe trail, Jefferson's John Muir trail, and three Santa Fe trail segments. Both Jefferson and Koza found that memory, such as a recurrent neural network or memories in a genetic program, are required to solve the task. Our approach presents the first instance of a chemical system acting as a control system. We propose a delay line connected with an artificial …