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Full-Text Articles in Engineering
Detection Of Nucleotides In Hydrated Ssdna Via 2-D H-Bn Nanopore With Ionic-Liquid/Salt-Water Interface, Jungsoo Lee
Detection Of Nucleotides In Hydrated Ssdna Via 2-D H-Bn Nanopore With Ionic-Liquid/Salt-Water Interface, Jungsoo Lee
Multidisciplinary Studies Theses and Dissertations
Accomplishing slow translocation speed with high sensitivity has been the greatest mission for solid-state nanopore (SSN) to electrically detect nucleobases in single-stranded DNA (ssDNA). In this study, a method to detect nucleobases in ssDNA using a SSN is introduced by considerably slowing down the translocation speed and effectively increasing its sensitivity. The ultra-thin titanium dioxide (TiO2) coated hexagonal boron nitride (h-BN) nanopore was fabricated, along with an ionic-liquid [bmim][PF6]/2.0 M KCl aqueous (cis/trans) interfacial system, to increase both the spatial and the temporal resolutions. As the ssDNA molecules entered the nanopore, a …
A Versatile Microparticle-Based Immunoaggregation Assay For Macromolecular Biomarker Detection And Quantification, Haiyan Wu, Yu Han, George G. Chase, Qiong Tang, Chen-Jung Lee, Bin Cao, Jiang Zhe, Gang Cheng
A Versatile Microparticle-Based Immunoaggregation Assay For Macromolecular Biomarker Detection And Quantification, Haiyan Wu, Yu Han, George G. Chase, Qiong Tang, Chen-Jung Lee, Bin Cao, Jiang Zhe, Gang Cheng
Dr. Jiang Zhe
The rapid, sensitive and low-cost detection of macromolecular biomarkers is critical in clinical diagnostics, environmental monitoring, research, etc. Conventional assay methods usually require bulky, expensive and designated instruments and relative long assay time. For hospitals and laboratories that lack immediate access to analytical instruments, fast and low-cost assay methods for the detection of macromolecular biomarkers are urgently needed. In this work, we developed a versatile microparticle (MP)-based immunoaggregation method for the detection and quantification of macromolecular biomarkers. Antibodies (Abs) were firstly conjugated to MP through streptavidin-biotin interaction; the addition of macromolecular biomarkers caused the aggregation of Ab-MPs, which were subsequently …
Zwitteration Of Dextran: A Facile Route To Integrate Antifouling, Switchability And Optical Transparency Into Natural Polymers, Bin Cao, Linlin Li, Haiyan Wu, Qiong Tang, Bingbing Sun, He Dong, Jiang Zhe, Gang Cheng
Zwitteration Of Dextran: A Facile Route To Integrate Antifouling, Switchability And Optical Transparency Into Natural Polymers, Bin Cao, Linlin Li, Haiyan Wu, Qiong Tang, Bingbing Sun, He Dong, Jiang Zhe, Gang Cheng
Dr. Jiang Zhe
This communication reports a facile method for zwitteration of dextran with carboxybetaine (CB), which integrates superior antifouling properties, switchability between zwitterionic and cationic forms, as well as enhanced optical transparency into one polysaccharide material. This study provides a new avenue for generating multifunctional zwitterionic CB materials in situ.