Engineering Commons^™

A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb

Masters Theses

One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …

Peer-To-Peer Energy Trading In Smart Residential Environment With User Behavioral Modeling, Ashutosh Timilsina

Theses and Dissertations--Computer Science

Electric power systems are transforming from a centralized unidirectional market to a decentralized open market. With this shift, the end-users have the possibility to actively participate in local energy exchanges, with or without the involvement of the main grid. Rapidly reducing prices for Renewable Energy Technologies (RETs), supported by their ease of installation and operation, with the facilitation of Electric Vehicles (EV) and Smart Grid (SG) technologies to make bidirectional flow of energy possible, has contributed to this changing landscape in the distribution side of the traditional power grid.

Trading energy among users in a decentralized fashion has been referred …

Energy Planning Model Design For Forecasting The Final Energy Consumption Using Artificial Neural Networks, Haidy Eissa

Theses and Dissertations

“Energy Trilemma” has recently received an increasing concern among policy makers. The trilemma conceptual framework is based on three main dimensions: environmental sustainability, energy equity, and energy security. Energy security reflects a nation’s capability to meet current and future energy demand. Rational energy planning is thus a fundamental aspect to articulate energy policies. The energy system is huge and complex, accordingly in order to guarantee the availability of energy supply, it is necessary to implement strategies on the consumption side. Energy modeling is a tool that helps policy makers and researchers understand the fluctuations in the energy system. Over the …

Scheduling Allocation And Inventory Replenishment Problems Under Uncertainty: Applications In Managing Electric Vehicle And Drone Battery Swap Stations, Amin Asadi

Graduate Theses and Dissertations

In this dissertation, motivated by electric vehicle (EV) and drone application growth, we propose novel optimization problems and solution techniques for managing the operations at EV and drone battery swap stations. In Chapter 2, we introduce a novel class of stochastic scheduling allocation and inventory replenishment problems (SAIRP), which determines the recharging, discharging, and replacement decisions at a swap station over time to maximize the expected total profit. We use Markov Decision Process (MDP) to model SAIRPs facing uncertain demands, varying costs, and battery degradation. Considering battery degradation is crucial as it relaxes the assumption that charging/discharging batteries do not …

Computational Model For Neural Architecture Search, Ram Deepak Gottapu

Doctoral Dissertations

"A long-standing goal in Deep Learning (DL) research is to design efficient architectures for a given dataset that are both accurate and computationally inexpensive. At present, designing deep learning architectures for a real-world application requires both human expertise and considerable effort as they are either handcrafted by careful experimentation or modified from a handful of existing models. This method is inefficient as the process of architecture design is highly time-consuming and computationally expensive.

The research presents an approach to automate the process of deep learning architecture design through a modeling procedure. In particular, it first introduces a framework that treats …

Optimal Sampling Paths For Autonomous Vehicles In Uncertain Ocean Flows, Andrew J. De Stefan

Dissertations

Despite an extensive history of oceanic observation, researchers have only begun to build a complete picture of oceanic currents. Sparsity of instrumentation has created the need to maximize the information extracted from every source of data in building this picture. Within the last few decades, autonomous vehicles, or AVs, have been employed as tools to aid in this research initiative. Unmanned and self-propelled, AVs are capable of spending weeks, if not months, exploring and monitoring the oceans. However, the quality of data acquired by these vehicles is highly dependent on the paths along which they collect their observational data. The …