Open Access. Powered by Scholars. Published by Universities.®
Health and Physical Education Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Health and Physical Education
High Altitude Exposures And Intestinal Barrier Dysfunction, Zachary J. Mckenna
High Altitude Exposures And Intestinal Barrier Dysfunction, Zachary J. Mckenna
Health, Exercise, and Sports Sciences ETDs
Gastrointestinal complaints are often reported during high altitude ascent (>2500m), though their etiology is unknown. One explanation is hypoxia-mediated intestinal barrier dysfunction. High altitude exposures can result in splanchnic hypoperfusion and hypoxemia causing hypoxic and oxidative stress. Exertion may worsen hypoxia-induced intestinal injury via greater splanchnic hypoperfusion and hypoxemia. We propose that these stressors injure the intestinal barrier leading to increased permeability, bacterial translocation, and local/systemic inflammation which may contribute to gastrointestinal complications or Acute Mountain Sickness (AMS). To test this, we investigated the effects of hypoxia on exercise-induced gastrointestinal symptoms and markers of intestinal injury. Next, we determined …
Relationship Between Orthostatic Stress Response And Acute Mountain Sickness Susceptibility At High Altitude: A Pilot Study, Bryanne Bellovary, Jack Loeppky, Andrew Wells, Zac Fennel, Jeremy Ducharme, Jonathan Houck, Trevor Mayschak, Kelsey Bourbeau, Ann Gibson, Scott Drum, Christine Mermier
Relationship Between Orthostatic Stress Response And Acute Mountain Sickness Susceptibility At High Altitude: A Pilot Study, Bryanne Bellovary, Jack Loeppky, Andrew Wells, Zac Fennel, Jeremy Ducharme, Jonathan Houck, Trevor Mayschak, Kelsey Bourbeau, Ann Gibson, Scott Drum, Christine Mermier
Health, Exercise, and Sports Sciences ETDs
The purpose of this study was to determine whether there is a difference in hemodynamic responses to head-up tilt (HUT) in subjects who do, and do not, experience acute mountain sickness (AMS) during exposure to hypobaric hypoxia. Secondarily, we aimed to determine if those hemodynamic variables altered during HUT correlated with AMS severity. Fifteen participants completed three testing sessions: 1) VO2max test to determine workload at 50% VO2max for hypoxia exposure; 2) HUT test consisting of supine rest for 20 min followed by 70° upright tilting for ≤ 40 min; and 3) six hours of hypobaric …