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The Effects Of Obesity And Surgically-Induced Weight Loss On Exercise Ventilation: Influence Of Central Adiposity And Serum Leptin, Jeffrey Herrick
The Effects Of Obesity And Surgically-Induced Weight Loss On Exercise Ventilation: Influence Of Central Adiposity And Serum Leptin, Jeffrey Herrick
Theses and Dissertations
Truncal adiposity impairs ventilation in obese adults by altering normal ventilatory mechanics. Leptin, an inflammatory adipocytokine, is elevated in obesity and has been shown to alter ventilatory responses to exercise. Leptin’s bioavailability appears to be regulated by its soluble receptor (LRe), which is reduced in obesity. Roux-en-Y gastric bypass surgery (RYGBS) is a weight loss intervention that reduces total fat mass and improves several obesity related co-morbidities including pulmonary dysfunction. The purpose of this study was to first evaluate the differences between ventilatory responses to carbon dioxide (VE/VCO2 slope) during progressive treadmill walking in morbidly obese and normal weight females. …
Time Course Of Vascular Function Changes Following An Acute Maximal Exercise Bout In Obese And Normal Weight Males, R. Lee Franco
Time Course Of Vascular Function Changes Following An Acute Maximal Exercise Bout In Obese And Normal Weight Males, R. Lee Franco
Theses and Dissertations
One of the earliest sub-clinical stages associated with atherosclerosis is endothelial dysfunction (ED), which has been shown to predict future cardiovascular events. Chronic exercise is thought to improve endothelium-dependent vasodilation; however, few studies have evaluated the effects of acute exercise on vascular function (VF). Moreover, studies evaluating ED following an exercise training program lack a standardized time frame in which to measure VF. Although most studies require subjects to abstain from exercise for 24 hours prior to any VF measure, no study to date has assessed VF longer than 24 hours after the cessation of exercise. Additionally, no studies have …
The Impact Of Mental Challenge On Indicators Of Endothelial Function In Obese Individuals, Chun-Jung Huang
The Impact Of Mental Challenge On Indicators Of Endothelial Function In Obese Individuals, Chun-Jung Huang
Theses and Dissertations
A number of investigators have examined psychological stress-induced endothelial dysfunction, however, the underlying mechanisms for these responses have not been clearly elucidated. The purpose of this study was to compare the effects of mental challenge on forearm blood flow, total antioxidant capacity (a measure of oxidative stress), the release of norepinephrine (NE; stress induced neurotransmitter), and pro-inflammatory cytokine responses [both lipopolysaccharide (LPS)-stimulated TNF-α and IL-6 cytokine and mRNA] in lean and obese individuals. Twelve subjects who had a BMI above 30 kg/m2 and were above 30% body fat were categorized as obese and twelve subjects with a BMI below 25 …