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Creating A Type I Diabetic Rat With Streptozotocin, Kai Ybarbo, Ann-Katrin Grotle, Audrey J. Stone

International Journal of Exercise Science: Conference Proceedings

ABSTRACT

The American Heart Association (AHA) recognizes diabetes as a risk factor for developing cardiovascular disease. Type 1 diabetes (T1D) is characterized by absolute insulin deficiency due to the destruction of the insulin-producing pancreatic beta cells. A common model for studying T1D is the streptozotocin (STZ) induced rat. STZ targets and destroys beta cells of the pancreas and therefore causes the rats to develop T1D. PURPOSE: The purpose of this project was to describe the procedure for inducing T1D in a in vivo rat model, to study the cardiovascular responses to exercise. METHODS: Male and female Sprague Dawley rats were …

Augmented Mechanoreflex In Type 2 Diabetic Rats: Piezo Channels, An Important Part Of The Puzzle?, Ann-Katrin Grotle, Yu Huo, Audrey J. Stone

International Journal of Exercise Science: Conference Proceedings

Type 2 diabetics (T2DM) have an abnormal cardiovascular response to exercise. The exercise pressor reflex, which is evoked by metabolic and mechanical stimuli arising from the contracting muscle, is a critical cardiovascular regulatory mechanism during exercise and is exaggerated in hypertension, heart failure, and peripheral artery disease. A recent study found that T2DM patients have an augmented metaboreflex. However, whether the mechanoreflex is also augmented in T2DM is not known. PURPOSE: The purpose of the study was to test whether the mechanoreflex is exaggerated in T2DM. Furthermore, we tested the contribution of mechano-gated Piezo 1 and 2 channels to …