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Western Kentucky University

Health and Physical Education

Muscle damage

Publication Year

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Full-Text Articles in Education

The Effects Of Cannabidiol Supplementation On Measures Of Performance And Fatigue Following Eccentric Exercise, Brett Crossland, Nicholas A. Levine, Cayla Clark, Kyndall Ramirez, Nicole Varone, Julio Sanchez, Anthony A. Duplanty, Brandon R. Rigby Feb 2022

The Effects Of Cannabidiol Supplementation On Measures Of Performance And Fatigue Following Eccentric Exercise, Brett Crossland, Nicholas A. Levine, Cayla Clark, Kyndall Ramirez, Nicole Varone, Julio Sanchez, Anthony A. Duplanty, Brandon R. Rigby

International Journal of Exercise Science: Conference Proceedings

Following intense exercise, there is a period of time where performance is decreased. This period of reduced performance is characterized by several factors including myofibrillar disruption, reduced range-of-motion, inflammation, and an influx of enzymes and proteins. Cannabidiol (CBD) has been marketed as a recovery supplement capable of reducing markers of fatigue and inflammation following exercise, yet this claim has not been investigated. PURPOSE: The purpose of this study was to determine if CBD supplementation limits fatigue and expedites a return to performance following intense eccentric exercise. METHODS: A double-blind, crossover design with repeated measures was used. Twenty-four NCAA …


Ubiquitin Proteasome System Activity Is Suppressed By Curcumin Following Exercise-Induced Muscle Damage In Human Skeletal Muscle, Thomas D. Cardaci, Steven B. Machek, Dylan T. Wilburn, Paul S. Hwang, Darryn Willoughby Phd Feb 2020

Ubiquitin Proteasome System Activity Is Suppressed By Curcumin Following Exercise-Induced Muscle Damage In Human Skeletal Muscle, Thomas D. Cardaci, Steven B. Machek, Dylan T. Wilburn, Paul S. Hwang, Darryn Willoughby Phd

International Journal of Exercise Science: Conference Proceedings

PURPOSE: Curcumin is a natural polyphenolic compound with antioxidant and anti-inflammatory properties. In vitro and in vivo animal studies have demonstrated that exposure to curcumin leads to dysregulation of the ubiquitin-proteasome system (UPS). However, to date, no study has investigated curcumin’s ability to influence UPS activity in a human model. Therefore, the purpose of this study was to investigate the effects of curcumin supplementation on markers of UPS activity in the presence of elevations in UPS activity due to exercise-induced muscle damage. METHODS: Twenty-three recreationally active male and female participants between the ages of 18-30 were randomized into …


Curcumin And Boswellia Serrata Supplementation Result In Reduced Inflammation Following Eccentric Leg Press Exercise, Asheal A. Davis, Elizabeth A. Tanner, Melody A. Gary, Brian K. Mcfarlin Feb 2019

Curcumin And Boswellia Serrata Supplementation Result In Reduced Inflammation Following Eccentric Leg Press Exercise, Asheal A. Davis, Elizabeth A. Tanner, Melody A. Gary, Brian K. Mcfarlin

International Journal of Exercise Science: Conference Proceedings

Repetitive exercise on consecutive days is a key component of many long-term training plans. This type of exercise results in muscle inflammation and soreness that limits the capacity to sustain exercise at a high effort. Several dietary polyphenols have the capacity to manage inflammation and thus supplementation may be an effective component of a long-term training plan. PURPOSE:The purpose of this study was to investigate the effect of combined oral supplementation with curcumin and boswellia serrata prior to and following three consecutive days of intense interval exercise. METHODS:All protocols were approved by the University IRB committee and participants …


Inflammation-Associated Rna Signaling Is Reduced Following A Half-Marathon Race When Supplemented With Curcumin And A Pomegranate Extract, Elizabeth A. Tanner, Melody A. Gary, Asheal A. Davis, Brian K. Mcfarlin Feb 2019

Inflammation-Associated Rna Signaling Is Reduced Following A Half-Marathon Race When Supplemented With Curcumin And A Pomegranate Extract, Elizabeth A. Tanner, Melody A. Gary, Asheal A. Davis, Brian K. Mcfarlin

International Journal of Exercise Science: Conference Proceedings

Prolonged endurance exercise performances provide a unique model for investigating the combined effects of oxidative stress and eccentric muscle contraction on differential gene expression with nutritional interventions known to blunt inflammation. Dietary polyphenols (i.e. curcumin, pomegranate, etc.) have been shown to reduce exercise-induced inflammation associated mRNA and protein expression with fewer side effects than NSAIDs. PURPOSE: To investigate the effect of combined curcumin (500-1000 mg/d; Longvida®) and pomegranate extract (500-1000 mg/d; Pomella®) supplement for 30-days on mRNA expression following a half marathon race. METHODS: All protocols were approved by the University IRB committee and participants gave written informed consent. Participants …


Using Dietary Polyphenols To Manage Post Exercise Inflammation, Melody A. Gary, Elizabeth A. Tanner, Brian K. Mcfarlin, Asheal A. Davis Feb 2019

Using Dietary Polyphenols To Manage Post Exercise Inflammation, Melody A. Gary, Elizabeth A. Tanner, Brian K. Mcfarlin, Asheal A. Davis

International Journal of Exercise Science: Conference Proceedings

Individuals participating in prolonged exercise sessions and associated training experience regular inflammation and muscle soreness. Natural products with known anti-inflammatory and/or oxidative stress blocking effects represent attractive options to traditional NSAID treatments. PURPOSE: To investigate the effect of combined curcumin (500-1000 mg/d; Longvida®), pomegranate extract (500-1000 mg/d; Pomella®), and Methylsulfonylmethane (500-1000 mg/d; OptiMSM®) supplement for 30-days on protein inflammatory biomarkers, inflammation-associated RNA, and oxidative. METHODS: All protocols were approved by the University IRB committee and participants gave written informed consent. Subjects were supplemented for 30-d prior to the half marathon race. Venous blood samples were collected for serum or RNA …