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Key Genetic Drivers Of Volitional Physical Activity In The Central Nervous System, Brayden K. Leyva, Timothy M. Moore, Alexander R. Strumwasser, Xia Yang, Aldons J. Lusis, Andrea L. Hevener
Key Genetic Drivers Of Volitional Physical Activity In The Central Nervous System, Brayden K. Leyva, Timothy M. Moore, Alexander R. Strumwasser, Xia Yang, Aldons J. Lusis, Andrea L. Hevener
International Journal of Exercise Science: Conference Proceedings
Previous studies suggest that physical activity is driven by the Central Nervous System (CNS). PURPOSE: We determined the central genetic drivers of volitional activity in the CNS and identified several molecular mechanisms promoting improvements in metabolism as a consequence of daily exercise. METHODS: Leveraging genetic diversity, we studied 100 strains of sedentary (SED) and exercise-trained (TRN; in cage running wheels) animals of the UCLA hybrid mouse diversity panel (HMDP). Candidate gene identification analysis and single-cell RNA sequencing in three brain regions (hypothalamus, hippocampus, and striatum) were performed. Differential gene analysis was conducted between a cohort of exercise-trained and …
Medical Schools Ignore The Nature Of Consciousness At Great Cost, Anoop Kumar
Medical Schools Ignore The Nature Of Consciousness At Great Cost, Anoop Kumar
Journal of Wellness
The essential question of the relationship between consciousness and matter is ignored in medical school curricula, leading to a machine-like view of the human being that contributes to physician burnout and intellectual dissatisfaction. The evidence suggesting that the brain may not be the seat of consciousness is generally ignored to preserve the worldview of the primacy of matter. By investigating new frameworks detailing the nature of consciousness at different levels of hierarchy, we can bring intellectual rigor to a once opaque subject that supports a fundamental reality about our experience: We are human beings, not only human bodies.