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The Neuromodulatory And Hormonal Effects Of Transcutaneous Vagus Nerve Stimulation As Evidenced By Salivary Alpha Amylase, Salivary Cortisol, Pupil Diameter, And The P3 Event-Related Potential, Christopher M. Warren, Klodiana D. Tona, L. Ouwerkerk, Jeroen Van Paridon, Fenna Poletiek, Henk Van Steenbergen, Jos A. Bosch, Sander Nieuwenhuis
The Neuromodulatory And Hormonal Effects Of Transcutaneous Vagus Nerve Stimulation As Evidenced By Salivary Alpha Amylase, Salivary Cortisol, Pupil Diameter, And The P3 Event-Related Potential, Christopher M. Warren, Klodiana D. Tona, L. Ouwerkerk, Jeroen Van Paridon, Fenna Poletiek, Henk Van Steenbergen, Jos A. Bosch, Sander Nieuwenhuis
Psychology Faculty Publications
Background
Transcutaneous vagus nerve stimulation (tVNS) is a new, non-invasive technique being investigated as an intervention for a variety of clinical disorders, including epilepsy and depression. It is thought to exert its therapeutic effect by increasing central norepinephrine (NE) activity, but the evidence supporting this notion is limited.
Objective
In order to test for an impact of tVNS on psychophysiological and hormonal indices of noradrenergic function, we applied tVNS in concert with assessment of salivary alpha amylase (SAA) and cortisol, pupil size, and electroencephalograph (EEG) recordings.
Methods
Across three experiments, we applied real and sham tVNS to 61 healthy participants …
Dissociation Of The Role Of The Prelimbic Cortex In Interval Timing And Resource Allocation: Beneficial Effect Of Norepinephrine And Dopamine Reuptake Inhibitor Nomifensine On Anxiety-Inducing Distraction, Alexander R. Matthews, Olivia H. He, Mona Buhusi, Catalin V. Buhusi
Dissociation Of The Role Of The Prelimbic Cortex In Interval Timing And Resource Allocation: Beneficial Effect Of Norepinephrine And Dopamine Reuptake Inhibitor Nomifensine On Anxiety-Inducing Distraction, Alexander R. Matthews, Olivia H. He, Mona Buhusi, Catalin V. Buhusi
Psychology Faculty Publications
Emotional distracters impair cognitive function. Emotional processing is dysregulated in affective disorders such as depression, phobias, schizophrenia, and PTSD. Among the processes impaired by emotional distracters, and whose dysregulation is documented in affective disorders, is the ability to time in the seconds-to-minutes range, i.e. interval timing. Presentation of task-irrelevant distracters during a timing task results in a delay in responding suggesting a failure to maintain subjective time in working memory, possibly due to attentional and working memory resources being diverted away from timing, as proposed by the Relative Time-Sharing model. We investigated the role of the prelimbic cortex in the …