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تخليق وتقييم إمكانات مضادات الليباز والالتحام الجزيئي لـلمركب الجديد N '- (2-Hydroxy-5-Nitrobenzylidene) Naphthalene-2-Sulfonohydrazide, Sameer Amereih, Abd Daraghmeh, Ismail Warad, Mohammed Al-Nuri
تخليق وتقييم إمكانات مضادات الليباز والالتحام الجزيئي لـلمركب الجديد N '- (2-Hydroxy-5-Nitrobenzylidene) Naphthalene-2-Sulfonohydrazide, Sameer Amereih, Abd Daraghmeh, Ismail Warad, Mohammed Al-Nuri
Palestine Technical University Research Journal
N’-(2-Hydroxy-5-nitrobenzylidene) naphthalene-2-sulfonohydrazide (SB) was prepared by condensation reaction, of naphthalene-2-sulfonylchloride with 2-Hydroxy-5-nitrobenzaldehyde. The Schiff base product (SB) was isolated, purified and then spectrally characterized via UV-Vis, FT-IR, 1H and 13C NMR analysis, where strong evidences confirmed the formation of the desired product. Pancreatic porcine lipase inhibition of the Schiff base product was evaluated and compared with the reference “Orlistat”. The product was an active as a lipase enzyme inhibitor with IC50 42.65±0.97 mcg/ml. The molecular docking of the compound with porcine pancreatic lipase was investigating, the results of theoretical docking explained the experimental one since several hydrogen bonds between the …
تحضير وتوصيف وتقييم النشاط البيولوجي للمركب "(E)- N’-(2,5-Dimethoxybenzalidene) Naphthalene-2-Sulfonohydrazide", Ismail Warad
تحضير وتوصيف وتقييم النشاط البيولوجي للمركب "(E)- N’-(2,5-Dimethoxybenzalidene) Naphthalene-2-Sulfonohydrazide", Ismail Warad
Palestine Technical University Research Journal
Condensation reaction of naphthalene -2-Sulfonylhydrazide, as starting material with 2,5-dimethoxy benzaldehydewas used to produce (E)-N’-(2,5-dimethoxybenzalidene) naphthalene-2-sulfonohydrazide. The Schiff base product was isolated, purified and then spectrally characterized via UV-Vis, GC/MS, FT-IR, 1H and 13C NMR analysis, where strong evidences confirmed the formation of the desired product. Antimicrobial activity of Schiff base product was evaluated in vitro against several types of bacteria such as: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae and MRSA by Minimum Inhibitory Concentration (MIC) test using tetracycline (TE) as a standard antibiotic. The tests showed a promising bacteriostatic effect of this compound against gram negative bacteria …