Philosophy of Science Commons^™

Tumor Suppressor Mir-489 Regulates Proliferation, Autophagy And Overcomes Drug-Resistance In Breast Cancer, Mithil Soni

Theses and Dissertations

Despite decades of extensive research, breast cancer remains an untamable disease due to complexity and heterogeneity of disease. It is for this very reason, most efforts targeting a single pathway did not yield satisfactory results. Discovery of a novel therapeutic agents targeting multiple pathways, such as miRNAs, holds promise for future cancer therapy. This study was aimed to explore therapeutic potential of one such microRNA, miR-489. In the first study, we identified autophagy as a novel pathway targeted by miR-489 and reported ULK1 and LAPTM4B to be a direct of miR-489 target. We showed that miR-489 mediated autophagy inhibition and …