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Articles 1 - 2 of 2
Full-Text Articles in Philosophy of Science
Tumor Suppressor Mir-489 Regulates Proliferation, Autophagy And Overcomes Drug-Resistance In Breast Cancer, Mithil Soni
Tumor Suppressor Mir-489 Regulates Proliferation, Autophagy And Overcomes Drug-Resistance In Breast Cancer, Mithil Soni
Theses and Dissertations
Despite decades of extensive research, breast cancer remains an untamable disease due to complexity and heterogeneity of disease. It is for this very reason, most efforts targeting a single pathway did not yield satisfactory results. Discovery of a novel therapeutic agents targeting multiple pathways, such as miRNAs, holds promise for future cancer therapy. This study was aimed to explore therapeutic potential of one such microRNA, miR-489. In the first study, we identified autophagy as a novel pathway targeted by miR-489 and reported ULK1 and LAPTM4B to be a direct of miR-489 target. We showed that miR-489 mediated autophagy inhibition and …
Ideology In Physics: Ontological Naturalism And Theism Confront Big Bang, Cosmic Fine Tuning, And The Multiverse Of M-Theory, Anthony Walsh, Marc Ruffinengo
Ideology In Physics: Ontological Naturalism And Theism Confront Big Bang, Cosmic Fine Tuning, And The Multiverse Of M-Theory, Anthony Walsh, Marc Ruffinengo
Journal of Ideology
The most profound questions that philosophers and scientists have asked across the centuries have been metaphysical and existential, such as “What is the meaning and purpose of life, why are we here, and why is there something rather than nothing?” There can be no definitive answers to these questions, so those who pose and propose answers to them necessarily engage ideology. Some physicists have become philosophers in that they are attempting to answer these profound questions with highly speculative theories as, for instance, Hawking and Mlodonow’s book The Grand Design (2010) which they tout as providing new answers to age-old …