Philosophy Commons^™

What Do We Owe The Other Animals In Health-Related Research?, Jessica A. Du Toit

Electronic Thesis and Dissertation Repository

In this dissertation, I provide an account of the protections to which most captive non-human animals are morally entitled when they participate in health-related research. At least in the animal ethics literature, it is uncontroversial that the protections currently afforded to captive research animals are inadequate. This has much to do with the fact that most animals who serve as research participants are 1) sentient and, thus, have important morally considerable interests; 2) unable to provide informed consent to their research participation; and 3) seriously harmed as a result of their participation.

Unsurprisingly, then, a number of authors have proposed …

A Critical Examination Of Informed Consent Approaches In Pragmatic Cluster-Randomized Trials, Cory E. Goldstein

Electronic Thesis and Dissertation Repository

This thesis addresses the tension in pragmatic cluster-randomized trials between their social value and the requirement to respect the autonomy of research participants. Pragmatic trials are designed to evaluate the effectiveness of treatments in real-world settings to inform clinical decision-making and promote cost-efficient care. These trials are often embedded into clinical settings and ideally include all patients who would receive the treatments under investigation as a part of routine care. Trialists increasingly adopt cluster-randomized designs—in which intact groups, such as hospitals or clinics, are allocated randomly to study interventions—to simplify the inclusion of all patients. But including all-comers conflicts with …