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Characterization Of The Discriminative Stimulus Properties Of The Atypical Antipsychotic Amisulpride In C57bl/6 Mice, Timothy J. Donahue

Theses and Dissertations

Amisulpride, a benzamide derivative, is an atypical antipsychotic drug used to treat both schizophrenia and depression. Amisulpride is a selective antagonist at dopamine D₂ and D₃ receptors and at serotonin 5-HT_2B and 5-HT₇ receptors and displays an atypical clinical profile with reduced extrapyramidal motor effects. The drug has a chiral center and is a mixture of two optical isomers: (S)-amisulpride and (R)-amisulpride. The present study used a two-lever drug discrimination assay to allow a direct comparison between amisulpride and its two isomers. Additionally, substitution testing was conducted with the typical antipsychotics, atypical antipsychotics, antidepressants, …