Arts and Humanities Commons^™

The Search For A Coherent Language: The Science And Politics Of Drug Testing And Approval, Jason Karlawish

Jason Karlawish

No abstract provided.

Brief Motivational Interviewing Training For Allied Health Professionals: Targeting Eating Behaviour Change, Elizabeth Edwards, Peta Stapleton

Dr Elizabeth Edwards

No abstract provided.

Barriers And Facilitators For Colorectal Cancer Screening Practices In The Latino Community: Perspectives From Community Leaders, Ana Natale-Pereira, Jonnie Marks, Marielos Vega, Dawne Mouzon, Shawna Hudson, Debbie Salas-Lopez

Debbie Salas-Lopez MD, MPH

BACKGROUND: Colorectal cancer (CRC) is the second-leading cause of cancer-related death in the United States and the third most commonly diagnosed cancer among Latinos. While Latinos represent one of the fastest-growing ethnic groups in the United States, their participation in cancer prevention and treatment trials is low. METHODS: Thirty-six Latino community leaders participated in five focus groups that examined factors affecting CRC screening practices among Latinos. RESULTS: The top four barriers identified were low knowledge and awareness of CRC, language barriers, lack of insurance, and undocumented legal status. Additional barriers included seeking health care only when sick, fatalism, fear, denial …

Perspectives On Cancer Screening Among Latino Community Members And Internal Medicine Residents, Debbie Salas-Lopez, Dawne Mouzon, Jonnie Marks, Neil Kothari, Ana Natale-Pereira

Debbie Salas-Lopez MD, MPH

BACKGROUND: Latinos have lower rates of cancer screening, partially because of cultural beliefs that conflict with those of health care professionals. Moreover, established programs for training physicians in cultural competency often fail to incorporate input from the community.

METHODS: To explore beliefs about cancer and cancer screening among Latino community members and internal medicine residents. Three focus groups of Latino community members (n = 31) and one focus group of internal medicine residents (n = 9) were conducted to compare ideas regarding cancer and cancer screening.

RESULTS: We identified clear disconnects between residents and Latino community members regarding their understandings …

Cultural Competency In New Jersey: Evolution From Planning To Law, Debbie Salas-Lopez, Linda Holmes, Dawne Mouzon, Maria Soto-Greene

Debbie Salas-Lopez MD, MPH

No abstract provided.

The Importance Of Play In Organisation, Irina M. Verenikina, Helen M. Hasan

I. Verenikina

The role of play as a `social innovation' is attracting emerging research attention since it can affect the emotional climate and complex collaborative performance of the modern workplace. The psychology of play recognises the benefits of incorporating play and `playing games' at work. The increasing use of computer games throughout our society motivates the use of games and game technology for serious purposes including education, training and research. While managers are often reluctant to publicly state that play is good for work, they are willing to use the term `Serious Games'. These are games that engage users in their pursuit, …

Hsisp Annotated Bibliography: Attitudes Toward Animals (1998-2013), Erich Yahner

Erich Yahner, MSLIS

No abstract provided.

Repetition Failure Is Not Required For Maximal Strength Adaptation, John Sampson, Herbert Groeller, Darryl Mcandrew, Alison Britton, Nigel Taylor

Darryl J McAndrew

No abstract provided.

Inline Control Period: An Important Methodological Design Consideration For Assessing Adaptation To A Resistance Training Intervention, John Sampson, Herbert Groeller, Darryl Mcandrew, Alison Britton

Darryl J McAndrew

No abstract provided.

Endurance Training History Influences Individual Responsiveness To Resistance Training, John Sampson, Herbert Groeller, Darryl Mcandrew, Alison Britton, Nigel Taylor

Darryl J McAndrew

No abstract provided.

Mechanomyographic Measures Of Muscle Contractile Properties Are Influenced By The Duration Of The Stimulatory Pulse, Darryl Mcandrew, John Brown, Nicholas Rosser

Darryl J McAndrew

No abstract provided.

Mechanomyography; Lasers For Non-Invasive Quantification Of Muscle Recovery From Exercise Induced Fatigue, Nicholas Rosser, Darryl Mcandrew, Donald Iverson

Darryl J McAndrew

Muscle fatigue is a common clinical sign and possible precursor to musculoskeletal injury. Existing methods of detecting muscle fatigue qualify changes within muscle or across joints, but are expensive, invasive or difficult to use. A technique of mechanomyography utilising maximal percutaneous stimulation (known as the Muscle Displacement Laser {MDL}) is an easy non-invasive assessment tool, which may have considerable application in measuring muscle fatigue and determining recovery. Specifically, this study attempted to validate the MDL as a tool to measure muscle fatigue and determine the time-course of recovery from Delayed Onset of Muscle Soreness in human biceps brachii muscle. Methods: …

Muscles Within Muscles: Coordination Of 19 Muscle Segments Within Three Shoulder Muscles During Isometric Motor Tasks, Darryl Mcandrew, Xu-Feng Huang, James Wickham, Mark Brown

Darryl J McAndrew

No abstract provided.

The Effect Of Elbow Flexion Speed And Partial Limb Occlusion On Emg Activity, John Sampson, Herbert Groeller, Darryl Mcandrew, R Achttien, J Stege

Darryl J McAndrew

This investigation aimed to determine the neuromuscular response of the bicep brachii during heavy (6RM) dynamic resistance exercise performed to volitional exhaustion. Electromyographic (EMG) activity was compared in twelve male subjects performing dominant-limb elbow flexion exercise during four conditions: i) Explosive concentric and eccentric (SSC); ii) Explosive concentric, control eccentric (EC); iii) control (C); and iv) control with limb occlusion (CO) (110mmHg). CO and SSC are reported to increase motor unit activity when compared to control exercise (2 second flexion, 2 second extension). It was hypothesised that EMG activity will be higher in conditions of explosive exercise. Surface EMG activity …

Emg Activity And Total Work Reduction In Occluded And Non-Occluded Resistance Exercise Conditions, John Sampson, Herbert Groeller, Darryl Mcandrew, Heath Kilah

Darryl J McAndrew

No abstract provided.

Muscles Within Muscles: A Mechanomyographic Analysis Of Muscle Segment Contractile Properties Within Human Gluteus Maximus, Darryl Mcandrew, John Brown, Mark Gorelick

Darryl J McAndrew

No abstract provided.

Mechanomyographic Changes To The Biceps Brachii Following High Intensity Resistance Training, Herbert Groeller, John Sampson, Darryl Mcandrew

Darryl J McAndrew

No abstract provided.

Development Of Antigen-Specific Memory Cd8+ T Cells Following Live-Attenuated Chimeric West Nile Virus Vaccination, Heidi Smith, Thomas Monath, Pamela Pazoles, Alan Rothman, Diane Casey, Masanori Terajima, Francis Ennis, Farshad Guirakhoo, Sharone Green

Alan Rothman

ChimeriVax-WN02 is a novel live-attenuated West Nile virus (WNV) vaccine containing modified WNV premembrane (prM) and envelope (E) sequences inserted into the yellow fever 17D vaccine genome. We investigated the induction and evolution of CD8(+) T cell responses to a WNV envelope epitope, which is a dominant target in naturally infected HLA-A*02-positive individuals. WNV epitope-specific CD8(+) T cells were detected by HLA tetramer staining in 22 of 23 donors tested, with peak frequencies occurring between days 14 and 28. WNV epitope-specific T cells evolved from an effector phenotype to a long-lived memory phenotype. In the majority of donors, CD8(+) T …

Intracellular Cytokine Production By Dengue Virus-Specific T Cells Correlates With Subclinical Secondary Infection, Steven Hatch, Timothy Endy, Stephen Thomas, Anuja Mathew, James Potts, Pamela Pazoles, Daniel Libraty, Robert Gibbons, Alan Rothman

Alan Rothman

The pathophysiology of dengue virus infection remains poorly understood, although secondary infection is strongly associated with more severe disease. In the present study, we performed a nested, case-control study comparing the responses of pre-illness peripheral blood mononuclear cells between children who would subsequently develop either subclinical or symptomatic secondary infection 6-11 months after the baseline blood samples were obtained and frozen. We analyzed intracellular cytokine production by CD4(+) and CD8(+) cells in response to stimulation with dengue antigen. We found higher frequencies of dengue virus-specific TNFalpha, IFNgamma-, and IL-2-producing T cells among schoolchildren who subsequently developed subclinical infection, compared with …

Determinants Of Inapparent And Symptomatic Dengue Infection In A Prospective Study Of Primary School Children In Kamphaeng Phet, Thailand, Timothy Endy, Kathryn Anderson, Ananda Nisalak, In-Kyu Yoon, Sharone Green, Alan Rothman, Stephen Thomas, Richard Jarman, Daniel Libraty, Robert Gibbons

Alan Rothman

BACKGROUND: Dengue viruses are a major cause of morbidity in tropical and subtropical regions of the world. Inapparent dengue is an important component of the overall burden of dengue infection. It provides a source of infection for mosquito transmission during the course of an epidemic, yet by definition is undetected by health care providers. Previous studies of inapparent or subclinical infection have reported varying ratios of symptomatic to inapparent dengue infection.

METHODOLOGY/PRINCIPAL FINDINGS: In a prospective study of school children in Northern Thailand, we describe the spatial and temporal variation of the symptomatic to inapparent (S:I) dengue illness ratio. Our …

T-Cell Responses To Dengue Virus In Humans, Ichiro Kurane, Takaji Matsutani, Ryuji Suzuki, Tomohiko Takasaki, Siripen Kalayanarooj, Sharone Green, Alan Rothman, Francis Ennis

Alan Rothman

Dengue virus (DENV) is a leading cause of morbidity and mortality in most tropical and subtropical areas of the world. Dengue virus infection induces specific CD4+CD8- and CD8+CD4- T cells in humans. In primary infection, T-cell responses to DENV are serotype cross-reactive, but the highest response is to the serotype that caused the infection. The epitopes recognized by DENV-specific T cells are located in most of the structural and non-structural proteins, but NS3 is the protein that is most dominantly recognized. In patients with dengue hemorrhagic fever (DHF) caused by secondary DENV infection, T cells are highly activated in vivo. …

Cross-Reactivity And Expansion Of Dengue-Specific T Cells During Acute Primary And Secondary Infections In Humans, Heather L. Friberg-Robertson, Hema Sundara Bashyam, Tomoko Toyosaki-Maeda, James A. Potts, Thomas C. Greenough, Siripen Kalayanarooj, Robert V. Gibbons, Ananda Nisalak, Anon Srikiatkhachorn, Sharone Green, Henry A. F. Stephens, Alan L. Rothman, Anuja Mathew

Alan Rothman

Serotype-cross-reactive memory T cells responding to secondary dengue virus (DENV) infection are thought to contribute to disease. However, epitope-specific T cell responses have not been thoroughly compared between subjects with primary versus secondary DENV infection. We studied CD8(+) T cells specific for the HLA-A*1101-restricted NS3(133) epitope in a cohort of A11(+) DENV-infected patients throughout acute illness and convalescence. We compared the expansion, serotype-cross-reactivity, and activation of these cells in PBMC from patients experiencing primary or secondary infection and mild or severe disease by flow cytometry. Our results show expansion and activation of DENV-specific CD8(+) T cells during acute infection, which …

B-Cell Responses During Primary And Secondary Dengue Virus Infections In Humans, Anuja Mathew, Kim West, Siripen Kalayanarooj, Robert Gibbons, Anon Srikiatkhachorn, Sharone Green, Daniel Libraty, Smita Jaiswal, Alan Rothman

Alan Rothman

Low-avidity serotype-cross-reactive antibodies are hypothesized to play a key role in triggering severe disease in patients with secondary dengue virus (DENV) infection. However, there is little systematic information about the frequency, avidity, and cross-reactivity of DENV-specific B cells in individuals experiencing primary instead of secondary infection. We compared DENV-specific B-cell responses in a cohort of Thai children with primary or secondary DENV infection. B cells specific for DENV precursor membrane protein, envelope (E) protein, and nonstructural protein 1 were detectable in immune peripheral blood mononuclear cells with the highest frequencies of DENV E-specific B cells detected in patients experiencing primary …

Health Behaviour Change Counselling For Healthy Eating And Physical Activity: An Examination Of Brief Motivational Interviewing Training, Elizabeth Edwards(Nee Scott), Peta Stapleton

Dr Elizabeth Edwards

No abstract provided.

European Society For The History Of The Human Sciences (Eshhs), Conference 2014, Oulu (Finland), Paper: “Dangerous Passions. The Construction And Cultural And Social Impact Of The ‘Psychiatric’ Framework Of The Passions In France (1790-1830)”, July 22-25 (23th), 2014., Marco Solinas

Marco Solinas

Numerous excellent works have been written on the formation process of ‘psychiatry’ and its concomitant impact on society and culture at the end of the eighteenth century and in the first three decades of the nineteenth century, in particular with regard to France. From Gladys Swain to Dora Weiner, from Jacques Postel to Jan Goldstein, from Jackie Pigeaud to Juan Rigoli, the issue has been analysed in depth and from a variety of different perspectives. However, despite constantly and inevitably resurfacing in these studies, no particular attention has been paid to the passions and emotions drawn up by nascent psychiatry. …

Newcastle And Northumbria Universities, Conference “Fashionable Diseases. Medicine, Literature And Culture, Ca. 1660-1832", Paper: “On The End Of Fashionable Melancholy”, July 3-5 (4th), 2014., Marco Solinas

Marco Solinas

The paper analyze the crucial moment of rupture in the history of the definitions, descriptions and classifications of melancholy within the ambit of medicine that occurred between the end of the Eighteenth- and beginning of the Nineteenth-century, in particular in France. That is the point at which Philippe Pinel, absorbing the contributions of Seventeenth-century British psychiatry, proceeded to abandon both the humoral doctrine and the old Renaissance conception of the dual character – melancholy as a psycho-physiological illness and as a literary and philosophical mood. Pinel now locates melancholy only among forms of mental alienation. I will proceed with the …

Scientists And Animal Research: Dr. Jekyll Or Mr. Hyde?, Andrew N. Rowan

Andrew N. Rowan, DPhil

Why is the public so sensitive about the use of a few tens of millions of animals in research when they do not object to killing hundreds of millions of pigs and cows and billions of chickens for our meat diet? Why is animal research considered so bad despite the public's high opinion of science (and scientists)? Perhaps it is the image of the scientist as an objective and cold individual who deliberately inflicts harm (pain, distress, or death) on his (the public image is usually male) innocent animal victims that arouses so much horror and concern. This paper does …

Caritas In Communion: Theological Foundations Of Catholic Health Care, M. Lysaught

M. Therese Lysaught

No abstract provided.

Graduate School Of Nursing Papers, 1982 – 2010: A Finding Aid, Kristine M. Reinhard

Kristine M. Sjostedt

The Graduate School of Nursing Papers documents the establishment of the Graduate School of Nursing at the University of Massachusetts Medical School, and chronicles its early history and development.

Robert E. Tranquada Papers, 1979-2009: A Finding Aid, Kristine M. Reinhard

Kristine M. Sjostedt

The Robert E. Tranquada Papers chronicle Tranquada’s role as Chancellor and Dean of the University of Massachusetts Medical School.