Digital Commons Network^™

Use Of Parthenolide Derivatives As Antileukemic And Cytotoxic Agents, Peter A. Crooks, Craig T. Jordan, Xiaochen Wei

Pharmaceutical Sciences Faculty Patents

Compounds of the formula having anti-tumor activity, wherein R₁ and R₂ are as described herein

Merged Ionization/Dissociation Fronts In Planetary Nebulae, William J. Henney, R. J. R. Williams, Gary J. Ferland, Gargi Shaw, C. R. O'Dell

Physics and Astronomy Faculty Publications

The hydrogen ionization and dissociation front around an ultraviolet radiation source should merge when the ratio of ionizing photon flux to gas density is sufficiently low and the spectrum is sufficiently hard. This regime is particularly relevant to the molecular knots that are commonly found in evolved planetary nebulae, such as the Helix Nebula, where traditional models of photodissociation regions have proved unable to explain the high observed luminosity in H₂ lines. In this paper we present results for the structure and steady state dynamics of such advection-dominated merged fronts, calculated using the Cloudy plasma/molecular physics code. We find …

Spitzer Irs Observations Of Seyfert 1.8 And 1.9 Galaxies: A Comparison With Seyfert 1 And Seyfert 2, R. P. Deo, D. M. Crenshaw, S. B. Kraemer, M. Dietrich, Moshe Elitzur, H. Teplitz, T. J. Turner

Physics and Astronomy Faculty Publications

We present Spitzer mid-infrared spectra of 12 Seyfert 1.8 and 1.9 galaxies over the 5-38 μm region. We compare the spectral characteristics of this sample to those of 58 Seyfert 1 and 2 galaxies from the Spitzer archives. An analysis of the spectral shapes, the silicate 10 μm feature and the emission-line fluxes have enabled us to characterize the mid-IR properties of Seyfert 1.8/1.9s. We find that the EWs of the 10 μm silicate feature are generally weak in all Seyfert galaxies, as previously reported by several studies. The few Seyfert galaxies in this sample that show …

Forage News [2007-12], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Heart of America Grazing Conference to Be Held in Missouri
• Forage Producers to Be Featured at KCA
• SRM/AFGC in Louisville
• Panoramic 2SL Registered for Weed Control in Pastures
• Hay – 2007
• Energy Savings with New Light Bulbs
• Corn Stalks and a Protein Block…That All You Got?
• Reflections at My 80^th Birthday - Carl S. Hoveland, October 25, 2007
• Upcoming Events

Methods Of Delaying Development Of Cea-Associated Tumors Using Anti-Idiotype Antibody 3h1, Malaya Chatterjee, Kenneth A. Foon, Sunil K. Chatterjee

Pharmaceutical Sciences Faculty Patents

The present invention provides methods of delaying development of CEA-associated tumors using the anti-idiotype antibody 3H1, particularly in high-risk individuals.

Nonsexual Transmission Of Anogenital Warts In Children: A Retrospective Analysis, Valerie Jones, Shawn J. Smith, Hatim A. Omar

Pediatrics Faculty Publications

The purpose was to evaluate the prevalence of sexual abuse in patients who were referred to a pediatric gynecologist for evaluation based on the clinical findings of anogenital warts. A retrospective analysis was performed on 131 patients between the ages 6 month and 9 years referred to a pediatric gynecologist after the finding of anogenital warts by a clinical provider, parent or caregiver. A complete physical examination under colposcopy by a the same, trained pediatric gynecologist was completed, and a complete medical and family history including maternal and sibling history for evidence of Human Papillomavirus (HPV) and anogenital warts. The …

Membranous Dysmenorrhea: A Case Series, Hatim A. Omar, Shawn J. Smith

Pediatrics Faculty Publications

The purpose was to illustrate the variability of hormonal contraception of patients that presented with membranous dysmenorrheal. A case analysis chart review was completed on six patients referred to a Pediatric Gynecologist in an academic setting. In each case the patient underwent a thorough pelvic and bimanual exam. Following the initial presentation, each patient continued to be followed on a regular visits. Cases: Two were using the transdermal contraceptive patch and oral contraceptive, but following the expulsion of decidual cast, they were both placed on depot medroxyprogesterone acetate (DMPA) without further complications. Three of the six cases were on DMPA …

Pre-Mrna Secondary Structures Influence Exon Recognition, Michael Hiller, Zhaiyi Zhang, Rolf Backofen, Stefan Stamm

Molecular and Cellular Biochemistry Faculty Publications

The secondary structure of a pre-mRNA influences a number of processing steps including alternative splicing. Since most splicing regulatory proteins bind to single-stranded RNA, the sequestration of RNA into double strands could prevent their binding. Here, we analyzed the secondary structure context of experimentally determined splicing enhancer and silencer motifs in their natural pre-mRNA context. We found that these splicing motifs are significantly more single-stranded than controls. These findings were validated by transfection experiments, where the effect of enhancer or silencer motifs on exon skipping was much more pronounced in single-stranded conformation. We also found that the structural context of …

Leptospira Interrogans Endostatin-Like Outer Membrane Proteins Bind Host Fibronectin, Laminin And Regulators Of Complement, Brian Stevenson, Henry A. Choy, Marija Pinne, Matthew L. Rotondi, M. Clarke Miller, Edward Demoll, Peter Kraiczy, Anne E. Cooley, Trevor P. Creamer, Marc A. Suchard, Catherine A. Brissette, Ashutosh Verma, David A. Haake

Microbiology, Immunology, and Molecular Genetics Faculty Publications

The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues. Infectious leptospires are resistant to killing by their hosts' alternative pathway of complement-mediated killing, and interact with various host extracellular matrix (ECM) components. The LenA outer surface protein (formerly called LfhA and Lsa24) was previously shown to bind the host ECM component laminin and the complement regulators factor H and factor H-related protein-1. We now demonstrate that infectious L. interrogans contain five additional paralogs of lenA, which we designated lenB, lenC, lenD, lenE and lenF …

Allelic Heterogeneity At The Equine Kit Locus In Dominant White (W) Horses, Bianca Haase, Samantha A. Brooks, Angela Schlumbaum, Pedro J. Azor, Ernest Bailey, Ferial Alaeddine, Meike Mevissen, Dominik Burger, Pierre-André Poncet, Stefan Rieder, Tosso Leeb

Veterinary Science Faculty Publications

White coat color has been a highly valued trait in horses for at least 2,000 years. Dominant white (W) is one of several known depigmentation phenotypes in horses. It shows considerable phenotypic variation, ranging from approximately 50% depigmented areas up to a completely white coat. In the horse, the four depigmentation phenotypes roan, sabino, tobiano, and dominant white were independently mapped to a chromosomal region on ECA 3 harboring the KIT gene. KIT plays an important role in melanoblast survival during embryonic development. We determined the sequence and genomic organization of the approximately 82 kb equine KIT gene. A mutation …

Democracy’S Archive: The Importance Of Government Documents To The Historical Record, Tracy Campbell

History Presentations

No abstract provided.

Transcriptional Control Of Vascular Smooth Muscle Cell Proliferation By Peroxisome Proliferator-Activated Receptor-Γ: Therapeutic Implications For Cardiovascular Diseases, Florence Gizard, Dennis Bruemmer

Internal Medicine Faculty Publications

Proliferation of vascular smooth muscle cells (SMCs) is a critical process for the development of atherosclerosis and complications of procedures used to treat atherosclerotic diseases, including postangioplasty restenosis, vein graft failure, and transplant vasculopathy. Peroxisome proliferator-activated receptor (PPAR) gamma is a member of the nuclear hormone receptor superfamily and the molecular target for the thiazolidinediones (TZD), used clinically to treat insulin resistance in patients with type 2 diabetes. In addition to their efficacy to improve insulin sensitivity, TZD exert a broad spectrum of pleiotropic beneficial effects on vascular gene expression programs. In SMCs, PPARgamma is prominently upregulated during neointima formation …

Understanding Barriers For Adherence To Follow-Up Care For Abnormal Pap Tests, Katherine S. Eggleston, Ann L. Coker, Irene Prabhu Das, Suzanne T. Cordray, Kathryn J. Luchok

CRVAW Faculty Journal Articles

Objective: Approximately 4000 women annually will die from preventable and treatable cervical cancer. Failure to adhere to follow-up recommendations after an abnormal Pap test can lead to development of cervical cancer. This paper summarizes the body of literature on adherence to follow-up after an abnormal Pap test in order to facilitate development of interventions

to decrease morbidity and mortality due to cervical cancer.

Methods: We conducted a comprehensive search of published literature addressing risk factors for adherence or interventions to improve adherence following an abnormal Pap test as the outcome. We included peer-reviewed original research conducted in the …

The Battle Over Implied Preemption: Products Liability And The Fda, Mary J. Davis

Law Faculty Scholarly Articles

A mere five years ago, the Food and Drug Administration (the "FDA") began, for the first time in its 100-year history, to take the position that its prescription drug labeling regulations defeated the ability of injured plaintiffs to pursue common law tort claims based on the adequacy of the labeling. This position, radical to many and rational to others, places federal preemption of prescription drug labeling actions directly in the center of the debate over the proper roles of federal regulation and state tort laws in promoting product safety. The U.S. Supreme Court has contributed to this debate with several …

[Review Of] Hit Songs, 1900-1955: American Popular Music Of The Pre-Rock Era, Robert A. Aken

Library Faculty and Staff Publications

No abstract provided.

Forage News [2007-11], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky Grazing Conference
• Forage Spokesman Featured at Grazing Conference
• KFGC Presents Forage Awards
• Sources for Hay
• If You Procrastinate, It May Be Too Late
• Buffalo Trace Hay Auction
• Volunteer Corn
• Winter Feeding Will Be a Challenge
• State Summary Of 2007
• Environmental Effects of Increased Atmospheric Carbon Dioxide
• Upcoming Events

Does Welfare Reform Work In Rural America? A 7-Year Follow-Up, Ann Tickamyer, Debra Henderson, Barry Tadlock

University of Kentucky Center for Poverty Research Discussion Paper Series

Even before the advent of welfare reform, studies of low income working and welfare dependent groups showed that low wage working women are worse off than those who combine welfare with other income sources and that most used a wide variety of livelihood strategies. This is especially the case in poor rural settings where work is scarce and additional obstacles to employment such as lack of transportation and childcare are endemic. Data from a selfadministered survey of users of human service agency programs in four counties in a distressed region of Appalachian Ohio in 1999, 2001, and 2005, provide a …

Forage Spokesman Information, Lowell J. Clifford, Barry Drury, John Mcglone, Mac Stone

Kentucky Grazing Conference

No abstract provided.

Techniques For Reducing Mud Problems And Improving Pasture Abused Areas, Ken Johnson

Kentucky Grazing Conference

I would like to approach this topic from two directions, mud control and then problem areas. Mud control in concentrated areas almost impossible with forages alone. Using a mud control product is usually advised. I will talk about several.

My Experiences With Summer Lovegrass, Tim Phillips

Kentucky Grazing Conference

I first heard about teff (Eragrostis tef) being used as a hay crop in early 2006 at a meeting near the Shenandoah Valley area of Virginia. The meeting was about orchardgrass production, so I was speaking about new varieties that are available for producers to grow. Several farmers had experienced massive stand losses of their established orchardgrass hay fields, so they had tried this ‘new’ summer annual grass. Some of the farmers were surprised that I knew about this grass, but I didn’t know about its use as a hay or pasture grass. Teff is the Ethiopian name for a …

Experiences With "Teff" (Summer Love Grass) In Kentucky, Bob Jaynes

Kentucky Grazing Conference

Following publicity about the Klamath Experiment Station evaluation of Teff as an annual forage in 2003 and 2004, requests for more information and seed sources kept KES staff busy for weeks last spring. We received over 300 contacts from 41 states. Local seed salesman Laverne Hankins processed over 150 orders for more than 5 tons of seed. Those who received seed were sent a questionnaire this fall in hopes that we would get feedback on growers experience with this new forage species. To date we have received responses from about 15 growers.

Options For Summer Grazing, David C. Ditsch

Kentucky Grazing Conference

Summer is the time during the growing season when shortages of forage most often occur in Kentucky. The summer of 2007 will long be remembered as one the warmest and driest in recent years and cause many livestock producers to evaluate their current forage systems. Most Kentucky pastures are predominately cool-season grasses such as tall fescue, orchardgrass and bluegrass. During the historically hot, dry periods in July and August, these species produce very little growth and can quickly become overgrazed. At this point, some producers have no alternative except to buy feed or begin feeding stored forage intended for winter …

Does Grazing Method Matter?, Garry D. Lacefield

Kentucky Grazing Conference

Interest in and opportunities for grazing continues to increase not only in Kentucky, but throughout the U.S. In Wisconsin, 12% or approximately 5000 dairymen are now using grazing. In Michigan, over 40% of the dairymen are using grazing for a significant part of their feed requirements. Over 15% of these dairymen are using intensive grazing. Similar numbers exist for Pennsylvania.

Surviving The 2007 Drought, Roy Burris

Kentucky Grazing Conference

Kentucky beef producers could feel the effects of the ’07 drought for a long time. Decisions made now will impact the ’08 and ’09 calf crops. The current hay/feed shortage has stimulated a lot of “panic buying”. Feedstuffs with very low nutritive values are being purchased at an alarming rate. These “feeds” are being purchased at much higher costs than we normally pay for good quality hay. If properly supplemented, they can be used successfully. However, their use to replace the normal hay supply could have disastrous results.

Recovering From The "Freeze" And "Drought" Of 2007, S. Ray Smith

Kentucky Grazing Conference

As all of you know, 2007 has been a devastating year for forage agriculture in Kentucky. The season started with an abnormally warm 7 weeks during late winter and early spring, which promoted lush vegetative growth. Normally this would have been a “good thing”, but it actually made forage plants more vulnerable to below freezing temperatures. Then the severe freeze occurred, with April 7, 8, and 9 the coldest 3 day period in April in KY history. Pastures were stunted for weeks and first cut hay yields were reduced by 35 to 100%. At this point we were still hopeful …

Foreword And Kfgc Award Winners [2007], Garry D. Lacefield, Christi L. Forsythe

Kentucky Grazing Conference

No abstract provided.

A Non-Circadian Role For Clock-Genes In Sleep Homeostasis: A Strain Comparison, Paul Franken, Ryan Thomason, H. Craig Heller, Bruce F. O'Hara

Biology Faculty Publications

BACKGROUND: We have previously reported that the expression of circadian clock-genes increases in the cerebral cortex after sleep deprivation (SD) and that the sleep rebound following SD is attenuated in mice deficient for one or more clock-genes. We hypothesized that besides generating circadian rhythms, clock-genes also play a role in the homeostatic regulation of sleep. Here we follow the time course of the forebrain changes in the expression of the clock-genes period (per)-1, per2, and of the clock-controlled gene albumin D-binding protein (dbp) during a 6 h SD and subsequent recovery sleep in three inbred strains of mice for which …

Induction Of Insulin Secretion In Engineered Liver Cells By Nitric Oxide, Latha Muniappan, Sabire Özcan

Molecular and Cellular Biochemistry Faculty Publications

BACKGROUND: Type 1 Diabetes Mellitus results from an autoimmune destruction of the pancreatic beta cells, which produce insulin. The lack of insulin leads to chronic hyperglycemia and secondary complications, such as cardiovascular disease. The currently approved clinical treatments for diabetes mellitus often fail to achieve sustained and optimal glycemic control. Therefore, there is a great interest in the development of surrogate beta cells as a treatment for type 1 diabetes. Normally, pancreatic beta cells produce and secrete insulin only in response to increased blood glucose levels. However in many cases, insulin secretion from non-beta cells engineered to produce insulin occurs …

Chemotherapy And Survival For Patients With Multiple Myeloma: Findings From A Large Nationwide And Population-Based Cohort, Nidhi Rohatgi, Xianglin L. Du, Ann L. Coker, Lemuel L. Moye, Michael Wang, Shenying Fang

CRVAW Faculty Journal Articles

Objective: To assess the patterns of chemotherapy use for patients with multiple myeloma and to determine if chemotherapy is effective in prolonging survival outside the clinical trial settings.

Methods: We studied a nationwide and population-based retrospective cohort of 4902 patients ≥65 years of age with stage II or III multiple myeloma from 1992 to 1999, identified from the Surveillance, Epidemiology, and End-Results-Medicare data. Multivariate logistic regression was used to estimate the odds ratio of receiving chemotherapy and Cox proportional hazard model was used to estimate the hazard ratio of mortality associated with chemotherapy.

Results: Of 4902 patients with stage II …

A Simple Array Platform For Microrna Analysis And Its Application In Mouse Tissues, Xiaoqing Tang, Jozsef Gal, Xun Zhuang, Wang-Xia Wang, Haining Zhu, Guiliang Tang

Plant and Soil Sciences Faculty Publications

MicroRNAs (miRNAs) are a novel class of small noncoding RNAs that regulate gene expression at the post-transcriptional level and play a critical role in many important biological processes. Most miRNAs are conserved between humans and mice, which makes it possible to analyze their expressions with a set of selected array probes. Here, we report a simple array platform that can detect 553 nonredundant miRNAs encompassing the entire set of miRNAs for humans and mice. The platform features carefully selected and designed probes with optimized hybridization parameters. Potential cross-reaction between mature miRNAs and their precursors was investigated. The array platform was …