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- Publications (3)
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- Imine (1)
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- Protein arginine methyltransferases (1)
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Articles 1 - 4 of 4
Full-Text Articles in Entire DC Network
Triflic Acid Controlled Successive Annelation Of Aromatic Sulfonamides: An Efficient One-Pot Synthesis Of N-Sulfonyl Pyrroles, Indoles And Carbazoles, Abid Shaikh, Liliana Teixeira, Béla Török
Triflic Acid Controlled Successive Annelation Of Aromatic Sulfonamides: An Efficient One-Pot Synthesis Of N-Sulfonyl Pyrroles, Indoles And Carbazoles, Abid Shaikh, Liliana Teixeira, Béla Török
Abid Shaikh
A novel one-pot synthesis of N-substituted heterocycles via successive cyclization/annelation starting from primary sulfonamides is described. This process directly leads to N-sulfonyl pyrroles, indoles and carbazoles. The selection of an appropriate reactant/triflic acid ratio successfully controls the formation of the desired product.
Protein Arginine Methyltransferase 1: Positively Charged Residues In Substrate Peptides Distal To The Site Of Methylation Are Important For Substrate Binding And Catalysis, Tanesha C. Osborne, Obiamaka Obianyo, Xing Zhang, Xiadong Cheng, Paul R. Thompson
Protein Arginine Methyltransferase 1: Positively Charged Residues In Substrate Peptides Distal To The Site Of Methylation Are Important For Substrate Binding And Catalysis, Tanesha C. Osborne, Obiamaka Obianyo, Xing Zhang, Xiadong Cheng, Paul R. Thompson
Tanesha C. Osborne
Protein arginine methyltransferases (PRMTs) are a group of eukaryotic enzymes that catalyze the methylation of Arg residues in a variety of proteins (e.g., histones H3 and H4), and their activities influence a wide range of cellular processes, including cell growth, RNA splicing, differentiation, and transcriptional regulation. Dysregulation of these enzymes has been linked to heart disease and cancer, suggesting this enzyme family as a novel therapeutic target. To aid the development of PRMT inhibitors, we characterized the substrate specificity of both the rat and human PRMT1 orthologues using histone based peptide substrates. N- and C-terminal truncations to identify a minimal …
Using Gold Nanorods To Probe Cell-Induced Collagen Deformation, John W. Stone, Patrick N. Sisco, Edie C. Goldsmith, Sarah C. Baxter, Catherine J. Murphy
Using Gold Nanorods To Probe Cell-Induced Collagen Deformation, John W. Stone, Patrick N. Sisco, Edie C. Goldsmith, Sarah C. Baxter, Catherine J. Murphy
John W. Stone
In biological tissue, complex mechanisms of cellular response are closely linked to the mechanical environment that cells experience. The key to understanding these mechanisms may lie in measurement of local mechanical fields near living cells and between cells. We have developed a novel optical measurement technique which combines the light elastically scattered from gold nanorods with digital image analysis to track local deformations that occur in vitro between cells, in real time, under darkfield optical microscopy. We find that measurable tension and compression exist in the intercellular matrix at the length scale of micrometers, as the cells assess, adapt, and …
Synthesis Of Trifluoromethyl-Imines By Solid Acid/Superacid Catalyzed Microwave-Assisted Approach, Abid Shaikh, Markku Savolainen, Shainaz M. Landge, Jinbo Hu, G. K. S. Prakash, George A. Olah, Béla Török
Synthesis Of Trifluoromethyl-Imines By Solid Acid/Superacid Catalyzed Microwave-Assisted Approach, Abid Shaikh, Markku Savolainen, Shainaz M. Landge, Jinbo Hu, G. K. S. Prakash, George A. Olah, Béla Török
Abid Shaikh
Trifluoromethyl, Imine, Clay, Solid acids, Solid superacid, Catalysis, Microwave irradiation Abstract: A new solid acid/superacid catalyzed microwave assisted synthesis of trifluoromethyl-imines is described. Various α,α,α-trifluoromethylketones react readily with primary amines to produce the corresponding imines. Two different strategies have been employed; one is the application of microwave irradiation coupled with solvent-free solid acid catalysis. The other method, for highly deactivated substrates includes the use of a pressure vessel at 175 °C temperature, with solid superacid catalysis. Using the solid acid K-10 montmorillonite or the superacidic perfluorinated resinsulfonic acid Nafion-H, a wide variety of trifluoromethylated imines have been synthesized using the …