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Heterogeneous Baroreflex Control Of Sympathetic Action Potential Subpopulations In Humans, Stephen A. Klassen, M. Erin Moir, Charlotte W. Usselman, J. Kevin Shoemaker
Heterogeneous Baroreflex Control Of Sympathetic Action Potential Subpopulations In Humans, Stephen A. Klassen, M. Erin Moir, Charlotte W. Usselman, J. Kevin Shoemaker
Bone and Joint Institute
© 2020 The Authors. The Journal of Physiology © 2020 The Physiological Society Key points: Emission patterns in muscle sympathetic nerve activity stem from differently sized action potential (AP) subpopulations that express varying discharge probabilities. The mechanisms governing these firing behaviours are unclear. This study investigated the hypothesis that the arterial baroreflex exerts varying control over the different AP subpopulations. During baseline, medium APs expressed the greatest baroreflex slopes, while small and large APs exhibited weaker slopes. On going from baseline to lower body negative pressure (LBNP; simulated orthostatic stress), baroreflex slopes for some clusters of medium APs expressed the …
Ventilation Inhibits Sympathetic Action Potential Recruitment Even During Severe Chemoreflex Stress, Mark B. Badrov, Otto F. Barak, Tanja Mijacika, Leena N. Shoemaker, Lindsay J. Borrell, Mihajlo Lojpur, Ivan Drvis, Zeljko Dujic, J. Kevin Shoemaker
Ventilation Inhibits Sympathetic Action Potential Recruitment Even During Severe Chemoreflex Stress, Mark B. Badrov, Otto F. Barak, Tanja Mijacika, Leena N. Shoemaker, Lindsay J. Borrell, Mihajlo Lojpur, Ivan Drvis, Zeljko Dujic, J. Kevin Shoemaker
Bone and Joint Institute
© 2017 the American Physiological Society. This study investigated the influence of ventilation on sympathetic action potential (AP) discharge patterns during varying levels of high chemoreflex stress. In seven trained breath-hold divers (age 33 ± 12 yr), we measured muscle sympathetic nerve activity (MSNA) at baseline, during preparatory rebreathing (RBR), and during 1) functional residual capacity apnea (FRCApnea) and 2) continued RBR. Data from RBR were analyzed at matched (i.e., to FRCApnea) hemoglobin saturation (HbSat) levels (RBRMatched) or more severe levels (RBREnd). A third protocol compared alternating periods (30 s) of FRC and RBR (FRC-RBRALT). Subjects continued each protocol until …
Methods And Considerations For The Analysis And Standardization Of Assessing Muscle Sympathetic Nerve Activity In Humans, Daniel W. White, J. Kevin Shoemaker, Peter B. Raven
Methods And Considerations For The Analysis And Standardization Of Assessing Muscle Sympathetic Nerve Activity In Humans, Daniel W. White, J. Kevin Shoemaker, Peter B. Raven
Bone and Joint Institute
© 2015 Elsevier B.V.. The technique of microneurography and the assessment of muscle sympathetic nerve activity (MSNA) are used in laboratories throughout the world. The variables used to describe MSNA, and the criteria by which these variables are quantified from the integrated neurogram, vary among studies and laboratories and, therefore, can become confusing to those starting to learn the technique. Therefore, the purpose of this educational review is to discuss guidelines and standards for the assessment of sympathetic nervous activity through the collection and analysis of MSNA. This review will reiterate common practices in the collection of MSNA, but will …