Digital Commons Network^™

Moderate Coffee And Tea Consumption Is Associated With Slower Cognitive Decline, Stephanie R. Rainey-Smith, Kelsey R. Sewell, Belinda M. Brown, Hamid R. Sohrabi, Ralph N. Martins, Samantha L. Gardener

Research outputs 2022 to 2026

Background: Globally, coffee and tea are consumed extensively, potentially providing neuroprotection through anti-inflammatory and antioxidative stress effects. Objective: This study aimed to investigate associations between coffee and tea intake and cognitive function. Methods: In a longitudinal prospective cohort study, dementia-free (n = 8715; age range 60.0–85.2 years) older adults from the UK Biobank self-reported coffee and tea intake over the previous year; ‘never’, ‘moderate’ (1–3 cups/day), or ‘high’ (≥4 cups/day). Participants completed cognitive assessments at ≥2 timepoints (mean of 9.11 years). Results: Those ‘never’ consuming coffee and ‘moderate’ coffee consumers (β = 0.06, p = 0.005; β = 0.07, p <  0.001, respectively), as well as ‘moderate’ tea consumers and ‘high’ tea consumers (β = 0.06, p = 0.009; β = 0.06, p = 0.003, respectively) had slower fluid intelligence decline. Additionally, those ‘never’ consuming coffee and ‘moderate’ coffee consumers had a slower increase in pairs matching errors (β = −0.05, p = 0.022; β = 0.05, p = 0.013) compared to ‘high’ consumers. Conclusions: ‘Moderate’ coffee, and ‘moderate’ and ‘high’ tea intake may be a protective factor against cognitive decline. Randomized controlled trials are required to establish causal relationships leading to evidence-based recommendations regarding benefits of coffee and tea intake.

Combining Lumipulse P-Tau217 And Aβ42/40 As Confirmatory Tests For Aβ Positivity Prior To Disease-Modifying Therapy, James D. Doecke, Ahmed Chenna, Mintzu Lo, Youssouf Badal, Brandon Yee, Robert Martone, Christos Petropoulos, Christopher J. Fowler, Simon Laws, Stephanie R. Rainey-Smith, Ralph N. Martins, Christopher C. Rowe, Colin L. Masters, John Winslow

Research outputs 2022 to 2026

Introduction: For a blood-based biomarker to be considered a confirmatory test for the detection of abnormal amyloid beta (Aβ) levels, the sensitivity and specificity must be equivalent to that of current cerebrospinal fluid tests. Methods: In the current study we assessed the ability of phosphorylated tau (p-tau)217 and Aβ42/40 from the Lumipulse G p-tau217 and β-amyloid ratio (1-42/1-40) tests, individually and combined, to predict Aβ positron emission tomography status in two sub-cohorts from the Australian Imaging, Biomarkers, and Lifestyle Study of Ageing. Results: Testing an Alzheimer's disease continuum cohort, the area under the curve (AUC), sensitivity, specificity, and accuracy for …

Evaluation Of A Theoretical And Experiential Training Programme For Allied Healthcare Providers To Prescribe Exercise Among Persons With Multiple Sclerosis: A Co-Designed Effectiveness-Implementation Study, Yvonne C. Learmonth, Georgios Mavropalias, Kym Wansbrough

Research outputs 2022 to 2026

Background: Multiple sclerosis (MS) is the most prevalent neurological disorder in young adults, characterised by physical, psychological and cognitive dysfunction. Exercise training is a safe management strategy. Healthcare providers (HCPs) acknowledge deficiencies in awareness, counselling strategies, and resources that prevent them from promoting and prescribing this effective treatment. We implemented an online evidence-based educational programme and evaluated the effect, acceptability, appropriateness, and feasibility of the programme in improving HCP confidence, knowledge, and attitudes towards remote exercise prescription to persons with MS. Methods: Physiotherapists and exercise physiologists were recruited and received the educational programme (online theory and 16-week experience of prescribing …

Lower Limb Muscle Strength Matters: Effect Of Relative Isometric Strength On Countermovement And Rebound Jump Performance In Elite Youth Female Soccer Players, Jack Fahey, Paul Comfort, Nicholas Joel Ripley

Research outputs 2022 to 2026

Background: Expression of maximal and rapid force in the hip, knee, and plantar flexors is important for athletic performance in female soccer. This study was designed to determine the effect of relative isometric strength in the isometric mid-thigh pull (IMTP) on countermovement jump (CMJ) and rebound jump (CMJ-R) performance in female youth soccer players. Methods: Ninety-six female soccer players (age: 14.1 ± 2.3 years, height: 160.5 ± 9.7 cm, mass: 55.0 ± 10.3 kg) completed three trials of the IMTP, CMJ, and CMJ-R using force plates. Players were categorized as stronger (top quartile, n = 19) and weaker players (bottom …

Prevalence Of Oral Mucosal Lesions Among Geriatric Dental Patients In Egypt: A Cross-Sectional Study, Dalia Ghalwash, Ahmed Hamdy, Sara Abd El-Wahed

Dentistry

Background. The oral health needs of older adults must be prioritized due to the shifting demographics of the population and rising life expectancy. This study investigated the prevalence of oral mucosal lesions (OMLs) among geriatric dental patients in a sample of the Egyptian population and explored the association with age, gender, smoking habit, as well as the impact on the quality of life. Methods. This cross-sectional study screened 300 geriatric dental patients aged 65 years or older, from several dental hospitals and mobile clinics in various regions in Egypt. Demographic data and information regarding denture use, systemic diseases, and smoking …

A Novel Neutrosophic Multi-Layered Complex Refined Hyperstructure: Theoretical Advancement With Illustrative Examples From Employee Mental Health Education Effectiveness In Enterprises, Min Zhang, Yaozu Wang, Rui Huang, Qiao Wu, Bingqing Bingqing Li

Neutrosophic Sets and Systems

No abstract provided.

Linguistic Pythagorean Hypersoft Set With Application: Decision Making In Medical Diagnosis And Treatment, B. Sathiyapriya, Dr. V.Pankajam

Neutrosophic Sets and Systems

No abstract provided.

A Multineutrosophic Offset Model For Clustering And Optimizing College Students' Mental Health Literacy In Interdisciplinary Contexts, Yan Li

Neutrosophic Sets and Systems

No abstract provided.

Offset-Neutrosophic Upside-Down Assessment Model (On-Uam): A New Way To Measure The Performance Of Basic Education Informatization, Yanna Deng

Neutrosophic Sets and Systems

No abstract provided.

Complex Neutrosophic Vague Soft Graphs, Suriyakumar G., V. J. Sudhakar, Syed Tahir Hussainy, Mana Donganont

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophy-Driven Deep Learning For Predicting Student Performance, Nguyen Thi Kimson, Nguyen Thothong, Nguyen Huuquynh

Neutrosophic Sets and Systems

No abstract provided.

Intuitionistic Quadri-Partitioned Neutrosophic N-Soft Set To Evaluate The Emotional Resilience Of Students In A Dynamic Learning Environment, Sai Anu P, Arulselvam A

Neutrosophic Sets and Systems

No abstract provided.

Heightened Risk: Childhood Trauma And Anticipatory Grief Exacerbate The Impact Of Loneliness On Depressive Symptoms And Lps-Stimulated Cytokines In Dementia Caregivers, Kelly N Brice, Jensine Paoletti-Hatcher, E Lydia Wu-Chung, Vincent D Lai, Daniel L Argueta, Michelle A Chen, Itee Mahant, Bryan T Denny, Charles Green, Luis D Medina, Paul Schulz, Jennifer Stinson, Samantha K Henry, Cobi Heijnen, Christopher P Fagundes

Faculty, Staff and Student Publications

Dementia spousal caregivers are at a disproportionate risk for adverse mental and physical health outcomes. Loneliness is associated with depressive symptoms and proinflammatory cytokine production among caregivers. Additionally, childhood trauma, anticipatory grief, and poor sleep quality are all associated with enhanced stress reactivity. This study used a cross-sectional design to investigate whether loneliness is associated with proinflammatory cytokine production and depressive symptoms in caregivers, and whether these relationships are strongest among caregivers who report high levels of childhood trauma, high amounts of anticipatory grief, or poor sleep quality. A sample of 111 dementia spousal caregivers provided blood samples and completed …

Peripartum Depression Pharmacotherapies Targeting Gaba-Glutamate Neurotransmission, Alan C Courtes, Louisa Smitherman, Lokesh Shahani, Jair C Soares, Laura Goetzl, Rodrigo Machado-Vieira

Faculty, Staff and Student Publications

Peripartum depression (PPD) represents a significant public health concern, affecting 10-17% of women globally. Traditional monoaminergic treatments demonstrate limited efficacy and delayed onset of action. The glutamate-GABA imbalance hypothesis provides a novel theoretical framework for understanding depression pathophysiology and developing targeted therapeutic interventions. This review examines emerging pharmacotherapeutic approaches targeting glutamatergic and GABAergic neurotransmitter systems for PPD treatment. Search criteria targeted randomized clinical trials investigating GABA-A-positive allosteric modulators (brexanolone, zuranolone, and ganaxolone) and NMDA receptor antagonists (ketamine and esketamine) in PPD patients. Brexanolone was the first neurosteroid to receive FDA approval for PPD, while zuranolone also shows promise. Ketamine and …

The Late Positive Potential Predicts Contingency Management Outcomes For Cocaine Use Disorder, Heather E Webber, Douglas J Calvillo, Francesco Versace, Constanza De Dios, Robert Suchting, Charles E Green, Scott D Lane, Joy M Schmitz

Faculty, Staff and Student Publications

Contingency management (CM) relies on motivation and reward processing and is among the most effective treatments available for cocaine use disorder (CUD), yet success rates do not meet desired clinical efficacy. To improve treatment-individual fit, we investigated the late positive potential (LPP), a measure of incentive salience to cues, as a predictor of treatment response. Treatment-seeking adults with CUD (N = 58) completed an EEG task where they viewed pleasant, unpleasant, cocaine, and neutral images. Participants received CM and counseling for four weeks. Urine was collected thrice weekly. We defined incentive salience to cues by A) cluster analyses on LPP …

Which Score For What? Operationalizing Standardized Cognitive Test Performance For The Assessment Of Change, Cristan Farmer, Audrey Thurm, Tanvi Das, E Martina Bebin, Jonathan A Bernstein, Elizabeth Berry-Kravis, Joseph D Buxbaum, Charis Eng, Thomas Frazier, Antonio Y Hardan, Alexander Kolevzon, Darcy A Krueger, Julian A Martinez-Agosto, Hope Northrup, Craig M Powell, Latha Valluripalli Soorya, Joyce Y Wu, Mustafa Sahin, Developmental Synaptopathies Consortium

Faculty, Staff and Student Publications

Developmental domains, such as cognitive, language, and motor, are key concepts of interest in longitudinal studies of intellectual and developmental disabilities (IDD). Normative scores (e.g., IQ) are often used to operationalize performance on standardized tests of these concepts, but it is the interval-distributed person-ability scores that are intended for the assessment of within-individual change. Here we illustrate the use and interpretation of several Stanford Binet, 5th Edition score types (IQ, extended IQ, Z-normalized raw score, developmental quotient, raw sum score, age equivalent, and ability score) using data from two longitudinal studies of rare genetic conditions associated with IDD. We found …

Habit And The Potential For Actor Training With Immersive And Virtual Production Technology, John Matthews

School of Art, Design and Architecture

The advance of immersive and virtual technologies draws into starker contrast the analogue modalities of dominant approaches to actor training and makes more visible certain of their dynamics, which are analysed here using a philosophical framework of habit and habitus as propositionally causative. This technology is disruptive to habit and habitus in actor training and signifies potential to experiment with these dynamics to address extant problems in actor training. Problems in training habitus discussed here derive from trainers’ habits but arise primarily for trainees, and especially so for certain groups. I use Lazlo Pearlman and Deirdre McLaughlin’s critique of the …

The Significance Of Blockchain Technology In Preserving Digital Evidence Integrity In Forensic Investigations, Marwa Popal, Ashfaq Ahmad, Muhammad Arshad

Research Outputs: 2025-Present

Digital forensics is the application of technology to the investigation and accounting of digital crime and the extraction and analysis of digital evidence from systems and networks. As the number of IoT [Internet of Things] devices has proliferated, the complexity inherent in forensic investigations has skyrocketed. While IoT forensics addresses the challenges of a lack of standardized security protocol and ensuring the integrity as well as security of evidence data, it brings to bear all the difficulties existing in classic forensics. Unfortunately, traditional digital forensic tools are generally inadequate in shielding that evidence from tampering or unauthorized access. Digital evidence …

Dental Shame: A Call For Understanding And Addressing The Role Of Shame In Oral Health, Louise Folker, Luna Dolezal, Astrid Pernille Jespersen, Martha Paisi, Lyndsey Withers, Christina Worle, Esben Boeskov Øzhayat

Peninsula Medical School

This commentary highlights dental shame as a pervasive but underexplored phenomenon with significant implications for oral health and systemic inequities. It proposes dental shame as a critical lens for understanding and addressing the complex interplay between personal, social, economic, cultural and systemic factors contributing to oral health challenges. Drawing on interdisciplinary expertise, the authors collectively propose that dental shame is both a consequence and determinant of oral health issues, leading to a self-reinforcing dynamic of avoidance, withdrawal and exacerbated inequities. They identify five key aspects of oral health where dental shame warrants deeper investigation: clinical encounters, care and social services, …

Students' Purchase Intention Of Street Food In Front Of De La Salle University - Dasmariñas Cavite, Patricia Jana J. Abeabe, Shanin S. Albios, Brent Louis C. Aure, Jimford U. Tabuyo

ICHRIE Research Reports

This study examined the factors that influence students' buying intentions for street food. A quantitative descriptive research design was employed to assess students' purchasing intentions toward street food in front of De La Salle University - Dasmariñas Gate 1. The study utilized convenience sampling, with 371 respondents consisting of undergraduate, masters, and doctoral students. Data were collected through an online survey using a Four-Point Likert Scale questionnaire. Statistical tools are weighted mean and Analysis of Variance (ANOVA) T-test. The findings revealed that perceived food quality and convenience significantly influenced students' buying intentions, while perceived food value also played a crucial …

Robust Ai Solutions For Financial Markets Through Generative Modeling, Dynamic Graph Learning, And Reinforcement-Based Portfolio Optimization, Jingyi Gu

Dissertations

Financial markets are inherently uncertain and dynamic, driven by complex factors such as macroeconomic signals, investor sentiment, and evolving inter-asset relationships. While machine learning has advanced financial modeling, existing approaches often fall short in addressing the real-world intricacies of finance. This dissertation confronts two critical challenges, human-driven stochasticity and risk-intensive decision-making under real-world trading constraints, while seizing a pivotal opportunity, the structural dynamics of evolving financial systems. These elements are foundational to advancing robust and practical financial intelligence.

To this end, this dissertation develops a unified framework for robust financial modeling and decision-making. The framework is architected as a progressive, …

Optimizing Hip And Knee Assistance For Walking And Sit-To-Stand Transitions: An Intrinsic Muscle Mechanics Based Predictive Approach, Neethan Ratnakumar

Dissertations

As the global population ages, the demand for wearable assistive technologies continues to rise, driven by their potential to enhance mobility and independence in older adults. Effectively designed controllers for lower-limb exoskeletons to assist sit-to-stand (STS) and walking are crucial for delivering efficient, safe, and comfortable assistance during daily activities. Traditionally, controller optimization involves biomechanical modeling and user-specific customization. Musculoskeletal simulations play a central role in this process by providing insights into human-exoskeleton interaction dynamics, thereby informing and refining control strategies.

This work presents a simulation-driven approach for developing exoskeleton controllers for walking and STS using two distinct methods: optimal …

Reasons For Cheating In Online Assessments And Strategies For Mitigating It: A Specific Study From The Perspectives Of English Language Teachers In Jeddah Governorate, Abdulelah M. Alqarni

Journal of King Abdulaziz University: Arts and Humanities

Assessment is one of the challenges facing online education, as academic integrity can be compromised due to students' cheating behavior. The current qualitative research sought to examine English language teachers' perceptions of the reasons why students cheat on online assessments. It also sought to find strategies to reduce cheating in these assessments. Thirteen teachers (seven males and six females) with at least five years of teaching experience in various secondary schools in the Jeddah Education Governorate participated in the study. Data were collected through semi-structured interviews and analyzed using MAXQDA software, version 2024. Data analysis revealed several reasons for cheating …

Open Science Is Coming To Theory Construction: The Case Of Document Analysis, Sarah R. Bostrom, Gina L. Levalley, Katrina Cooley, Richard E. Niemeyer

The Qualitative Report

Growing concerns about the reproducibility of scientific findings have led to efforts to enhance the transparency and rigor of social science research. Improving the accuracy and precision of theory development and adopting Open Science practices, such as open data, are widely considered effective means to achieve these ends. However, current Open Science practices primarily target quantitative methodologies and tend to ignore qualitative methods, like document analysis, due to perceived insurmountable obstacles. Since document analysis is often crucial for constructing accurate and precise theories, the inability to integrate Open Science practices with qualitative research methods undermines the effectiveness of these solutions …

Exploring Technology-Enhanced Learning: A Comparative Study Of Online And Offline Interactive Practices In The Iranian Higher Education System, Naser Rashidi, Mohamad Reza Farangi, Ali Hosseini

The Qualitative Report

This study explored how interactive teaching and learning are enacted through technology-enhanced methods in Iran’s higher education system. Using an exploratory qualitative design, it investigated the pedagogical strategies employed by instructors and examined whether these practices align with the principles of Technology-Enhanced Learning (TEL) across online and in-person contexts. Data were collected through the analysis of 263 class reports and 37 semi-structured interviews with university instructors. Thematic analysis using MAXQDA revealed six cohesive and interpretive themes: fostering human connection, empowering student voices, learning as dialogue, adaptive teaching, multimodal engagement, and feedback as dialogue. These themes reflect a holistic view of …

The Association Between Irregular Sleep Patterns And Learning Outcomes: Implications For Students’ Health In Iraq, Hazhmat Ali, Dildar Haji Musa, Ary Habeeb Mohammed, Hiwa Abdulraheem, Sherzad Salahadeen, Alind Mustafa

Makara Journal of Health Research

Background: Students often exhibit irregular sleep patterns due to rigorous academic workloads, which exert a considerable negative impact on their mental health. The present study aims to investigate the influence of irregular sleep on academic performance.

Methods: This study recruited a cohort of 409 medical students of both genders. Upon their consent, participants filled out a closed-ended questionnaire on various sleep parameters, including sleep habits, duration, and environment.

Results: Students with irregular sleep patterns reported higher rates of sleep deprivation, late sleep onset, and troubled sleep. Moreover, they spent a longer duration using smart devices before bedtime …

Nursing Students’ Sociodemographic Characteristics And Consumer Preferences’ Prediction Level Of Perceived Food Literacy, Sinan Duru

Makara Journal of Health Research

Background: Food literacy, which is a critical competency for nursing students, plays a pivotal role in promoting evidence-based nutrition behaviors and contributes effectively to public health. This study aimed to determine the level of perceived food literacy among nursing students.

Methods: This cross-sectional study involved 488 nursing students from two universities in the south of Turkey. The research data were collected face to face via the Personal Information Form, the Consumer Preferences Form, and Self Perceived Food Literacy. The data was analyzed using the Independent Sample t Test, One Way ANOVA, and multiple linear regression.

Results: The …

The Association Between Pain Catastrophizing, Somatization, Psychological Distress And Low Back Pain Severity Among Academics In Malaysia, Noordiyana Izyanti Mohamad Saufi, Eva Nabiha Zamri

Makara Journal of Health Research

Background: Psychological factors may influence the severity of low back pain (LBP), especially in high-stress professions such as academia. This study aimed to identify the relationship between psychological factors and LBP severity among Malaysian public university academics.

Methods: This cross-sectional study aimed to assess the relationship between psychological factors and LBP among academics at four public universities located in the northern region of West Malaysia. A self-administered questionnaire was used to collect information on sociodemographic characteristics, work information, lifestyle factors, LBP presence and intensity, and psychological factors. Data were analyzed using ordinal logistic regression and reported in terms …

Academic Burnout And Its Association With Sleep Quality, Physical Activity, And Social Media Addiction Among University Students In Perak, Malaysia: A Cross-Sectional Study, Kai Eng Joanne Lim, Khang Jin Cheah, Farzana Athirah Abdul Latif, Fatin Izzaty Mohd Shahrin

Makara Journal of Health Research

Background: Academic burnout among Malaysian undergraduates is a rising concern, driven by academic pressure and compounded by lifestyle and behavioural factors. This study aimed to examine the associations between academic burnout, sleep quality, physical activity, and social media addiction.

Methods: A cross-sectional study involving 382 undergraduate students was conducted using an online survey to collect the data. The chi-square test was used to assess bivariate associations, and multivariable logistic regression was employed to identify independent predictors of academic burnout.

Results: The majority of respondents were aged 21 to 23 years (59.7%) and female (60.7%). Overall, 56.0% of …

Psychometric Properties Of The Turkish Version Of The Palliative Care Attitude Scale (T-Pcas-9) In Cancer Patients, Sevgi Demir Çam, Neşe İşcan Ayyildiz, Hasan Evcimen, Timüçin Çil, Berna Bozkurt Duman

Makara Journal of Health Research

Background: A reliable, validated Turkish measurement tool will allow researchers to measure the impact of attitudes towards palliative care on other health outcomes in individuals with chronic and critical illness. This study aimed to examine the Turkish psychometric properties of the Palliative Care Attitude Scale (PCAS-9) for individuals with cancer.

Methods: The Turkish adaptation of the PCAS-9 (T-PCAS-9) included 505 cancer patients, who were aged >18 years, had a diagnosis of cancer, and no mental problems. The factor structure of the T-PCAS-9 was examined using exploratory factor analysis, confirmatory factor analysis, convergent-divergent validity, and measurement invariance analysis.

Results: The three-factor …