Digital Commons Network^™

Development Of Small-Molecule Inhibitors For Bacteroides, Naegleria, And Toxoplasma Microorganisms And Synthesis Of N-Heterocycles From Thiolated Ene-Ynes And Azodicarboxylates, Samuel Kwain

All Dissertations

Humans and microorganisms are intricately interconnected, with microbes constituting an essential component of human biology and ecology. This interdependence necessitates a delicate balance between leveraging beneficial microbes and mitigating the impact of harmful ones. The human gut microbiome, home to trillions of microorganisms, predominantly comprises commensal species that support health. However, dysbiosis within this ecosystem has been linked to serious diseases. For instance, an overrepresentation of Bacteroides species is associated with Type I diabetes mellitus (T1D) and various chronic gut disorders, including ulcerative colitis, inflammatory bowel disease, celiac disease, and colorectal cancer. Similarly, Naegleria fowleri, a free-living amoeba, causes …

The New Road Chosen: An Examination Of Why Black Educators Are Choosing Alternative Certification Pathways, Devin Aucoin

All Dissertations

This narrative study explores the experiences of eight Black educators who entered the teaching profession through alternative certification programs. Alternative certification programs were originally designed to address teacher shortages by providing individuals with a college degree a fast-track route to teacher licensure; however, research reveals an extreme shortage of Black educators and a growing number of Black educators completing alternative certification pathways. Grounded in Black Critical Theory (BlackCrit) and Social Cognitive Career Theory (SCCT), this study examines how anti-Blackness impacts the Black educator pipeline and how self-efficacy beliefs, perceived outcomes, personal goals, and contextual variables influence career decisions. Findings reveal …

Upstate South Carolina Mental Health And Sport Initiative: Contributing Solutions To The Mental Health Crisis Via Improvement Of Mental Health Literacy Among Adults In Youth Sport Communities, Margaret Domka

All Dissertations

This study contributed solutions to the youth mental health crisis by providing effective options for mental health awareness training (MHAT) that can be utilized in youth sport for increasing mental health literacy (MHL) among adults. Widely implementing MHAT has the potential to improve youth mental health status through increased help-seeking behaviors by adults. This study first evaluated whether mental health status and MHL are correlated in a youth sport setting with significant results indicating that investing time and resources into MHAT is worthwhile. Next, two MHAT modules were evaluated to determine their effectiveness for increasing MHL among this audience, i.e., …

The Spectral Asymptotics Of Toeplitz Operators On Hilbert Spaces Of Analytic Functions, Trevor Camper

All Dissertations

Many physical systems, whether they are ocean waves or particles moving through space, can be described using the mathematical language of “partial differ- ential equations.” In many circumstances, it is useful to study how these equations amplify an input to the equation, in which case the amplification factor is called an “eigenvalue.” The usefulness of these amplification factors is that they can be used to describe properties of the physical system. In this dissertation, I have studied this amplification factor for a related set of equations called “Toeplitz operators.” In par- ticular, I have studied eigenvalues using statistical techniques. The …

Ex Vivo Multiplex Knockdown Of Angptl3 And Cypor In Hepatocytes As A Novel Cell Therapy For Familial Hypercholesterolemia, Callie D. Clark

All Dissertations

Inherited metabolic diseases (IMDs) affect approximately 1 in 800 individuals. The only curative treatment for IMDs is liver transplantation. However, transplantation carries significant risks, including organ rejection and a lifelong need for immunosuppression. Therefore, gene editing has emerged as a promising alternative to liver transplantation for treating IMDs.

Familial hypercholesterolemia (FH) is and IMD characterized by elevated LDL-C levels resulting in premature cardiovascular disease. CRISPR-Cas9-mediated gene editing to disrupt the gene encoding angiopoietin-like 3 (ANGPTL3) in the liver represents a novel therapeutic approach for FH. Nonviral delivery performed ex vivo is safer than systemic delivery because gene editing is in …

A System And Method For Measuring Spatially Varying Surface Appearances With A Study Of Feathers, Jessica Baron-Lis

All Dissertations

Real-world materials, particularly biological structures such as feathers exhibit complex appearances that vary spatially across their surfaces. The field of computer graphics provides a means of understanding such surfaces through material modeling which uses both analytical models and data acquired from light-surface interactions. There are many efforts within the past decade in measuring materials for graphics, but common limitations in these works include not accounting for spatially varying properties and reliance on neural networks and synthetic datasets.

Feathers from modern birds present diverse appearances due to how light interacts with their unique hierarchical microstructures. Variations in those structures lead to …

The Administrators’ Role In Teacher Retention And Their Role On Teachers’ Perceptions Of School Climate At An Exemplar Title I School: A Qualitative Study, Stephen W. Brown Iii

All Dissertations

This study looks at how principals affect teacher perception of school climate and teacher retention at Title I schools. While teacher retention and school climate have historically been issues at Title I schools, the issue has been exacerbated by the COVID-19 pandemic. This qualitative study explored an elementary school in South Carolina through the lens of Critical Systems Theory. According to publicly available data, this school was an anomaly among Title I schools regarding the climate and teacher retention, with both measures being extremely high. To explore these phenomena, semi-structured interviews were conducted with both the teachers and administrators at …

A Systemic Approach To Maximize Heterogeneous System Performance, Thomas L. Randall

All Dissertations

Continuous increases in high performance computing (HPC) throughput have served as catalysts for industry and scientific advancement in countless manners that have fundamentally shaped our modern world. Our demands on compute resources continue to scale, but the limitations of Ahmdal’s law and Dennard scaling have proven increasingly difficult to overcome when approached solely through hardware or software design. Furthermore, many HPC applications fail to utilize the collective system’s performance, even on the most advanced supercomputers.

However, the resurgence of AI in the industry has promoted an explosion of hardware and software codesign that have fueled massive improvements in GPU design …

An Examination Of The Role Of Recreational Therapy In Forensic And Correctional Settings, Sarah R. Fischer

All Dissertations

The estimated prevalence of adults, age 18 and older, with serious mental illness (SMI) in the United States is approximately 6% (NIMH, 2022a). Having a mental illness places individuals at higher risk for arrest and incarceration (NAMI, n.d.b) where they receive treatment, including recreational therapy (RT) in state hospitals, jails or prisons. The purpose of this multi-method study was to gain a better understanding of the role of RT in treating adults with SMI in forensic and correctional settings. A non-standardized 122-item cross-sectional survey (n=49) was used to identify what interventions recreational therapists are using, for what intended outcomes; and …

Domain Decomposition For Coupled Systems Of Fluid-Structure Interaction And Numerical Modeling For Thin Film Polymers, Amy De Castro

All Dissertations

We consider two primary areas of physical application in this work: fluid interaction systems with either linear elastic structures or with poroelastic structures, and thin film polymers, where the majority of the work focuses on the fluid-structure interaction systems.

In the first chapter, we present a strongly coupled partitioned method for fluid structure interaction (FSI) problems based on a monolithic formulation of the system which employs a Lagrange multiplier (LM). We prove that both the semi-discrete and fully discrete formulations are well-posed. To derive the partitioned scheme, a Schur complement equation, which implicitly expresses the Lagrange multiplier and the fluid …

Investigate The Use Of Nucleic Acids As Pesticides To Manage Major Pests And Pathogens Of Crops In South Carolina, Prasanna Valavanur Shekar

All Dissertations

The sugarcane aphid (SCA, Melanaphis sorghi), first discovered on grain sorghum in late 2013, has gradually become a major insect pest of sorghum. It inflicts significant damage to the crop year after year, causing millions of dollars in losses throughout the sorghum-producing regions of the United States. Similarly, Armillaria root rot—also referred to as oak root rot—is a major cause of decline in peach (Prunus persica) production in the southeastern United States. This disease is caused by Armillaria mellea and Armillaria tabescens. Current management practices for controlling M. sorghi include the use of synthetic pesticides, resistant varieties, and regular scouting. …

Enhancing Photovoltaic Inverter Reliability Through Advanced Hardware Protection And Simulation Techniques, Buck Brown

All Dissertations

Power electronics converter reliability is an issue in today’s grid, and it is an issue that will only become more prevalent as the nation and world move toward greater renewable energy penetration. While a significant amount of research has been conducted pertaining to power electronics converter reliability, (1) there lacks a universal way to protect the most critical component in a power electronics converter—the power device—from the two most common failure modes—short- and open-circuit faults; and (2) there does not exist a tool that considers both the component- and system-levels of a photovoltaic (PV) inverter for the purposes of lifetime …

Design And Characterization Of Lignin-Based, Thermoresponsive Soft Composites With Improved Mechanical And Transport Properties, Missoury D. Wolff

All Dissertations

In an attempt to reduce reliance on petroleum-based polymers, lignin – an abundant biopolymer – has gained popularity as a sustainable alternative. However, research on lignin-containing soft composites – i.e., hydrogel (bio)composites – has largely been heuristic, providing limited insight into the fundamental structure-processing-property relationships that govern performance improvements in this emerging class of ‘green’ soft composites. As such, this dissertation presents a systematic investigation of how lignin molecular weight (MW), composite composition, and the concentrations of crosslinker and accelerator impact the mechanical and transport characteristics of soft composites composed of lignin, poly(N-isopropylacrylamide) (PNIPAm), and poly(vinyl alcohol) (PVA).

In the …

Understanding Conversion Of Long Chain Fatty Acids In Anaerobic Digestion Systems, Julia Ann Funk

All Dissertations

Anaerobic co-digestion with fats, oils, and grease (FOG) waste can increase energy production due to the high methane potential of lipids. However, adding FOG can lead to operational issues caused by accumulating saturated long-chain fatty acids (LCFA). My research explored why saturated LCFAs are often the primary intermediate that accumulates and the microbial sensitives of the populations responsible for their degradation. In each batch or semi-continuous experiment, all intermediates of FOG degradation, including LCFAs, volatile fatty acids (VFAs), Hydrogen gas (H₂), and endpoint methane production, were paired with temporal quantitative polymerase chain reaction (qPCR) of the Syntrophomonas genus …

Step To Freedom : A Lament And Grieving Redemption Experience, Anitta K. Tilly

ATS Dissertations

No abstract provided.

Demographic Groups’ Use Of Agency Intimate Partner Violence (Ipv) Services: A Quality Improvement Project To Identify And Engage Local Underserved Populations, Mia Parker

Capstone Experience: Master of Public Health

This quality improvement project intended to identify populations of adult intimate partner violence (IPV) survivors in Spokane County, Washington, by race/ethnicity and sex who are underserved by a local victim service agency and provide action-oriented, evidence-informed recommendations that the agency may utilize to increase engagement with these local underserved populations. Methods used include secondary data analysis, timeline creation, literature review, and interpretation of quantitative and qualitative data analysis. This was a capstone project designed to demonstrate multiple public health competencies.

Is Diabetes A Predictor Of A Diagnosis Of Hypertension In The Population Of 32- To 70-Year-Olds In A Cohort Study? A Multivariate Logistic Regression Analysis Of A Subset Of Data Obtained From The Framingham Study, Walter Marquez-Lavenant

Capstone Experience: Master of Public Health

Objective: Assess the independent role of diabetes on hypertension using logistic regression, while adjusting for covariates such as age, sex, BMI

Methods: A subset of data from the Framingham Cohort study, with 5,209 participants and collected across three periods from 1956 to 1968, was analyzed. The dataset includes laboratory, clinic, questionnaire, and event data from 4,434 individuals and was analyzed using SAS software for logistic regression.

Results:In the adjusted model, diabetes was not associated with hypertension (aOR:1.1, 95% CI:0.67-1.81, p=0.7). Females had 26% higher odds of hypertension than males (aOR=1.26, 95%CI:1.09-1.25, p=0.00). Participants aged 51 or older (aOR=2.86, 95%CI:2.37-2.47, …

The Role Of Responsive Feeding In Childhood Development And Clinical Implications: A Comprehensive Literature Review, Alexander Burbach

Capstone Experience: Master of Public Health

Responsive feeding refers to caregiver-infant feeding interactions that encourage healthy eating behaviors and support the child’s autonomy by responding to their hunger and satiety cues. Responsive feeding supports healthy early childhood development, influencing self-regulation in eating behaviors and long-term health outcomes, particularly in obesity prevention. A comprehensive literature review was conducted to examine the impact of responsive feeding practices on childhood development in the United States and its clinical implications. The objectives were to explore the role of parental feeding practices in shaping childhood eating behaviors, understand the relationship between responsive feeding and obesity, and determine literature daps. Articles for …

Evaluating Surge Capacity In The Emergency Department: A Comprehensive Literature Review On Preparedness And Response Frameworks, Tanner J. Riscoe

Capstone Experience: Master of Public Health

Medical surge capacity in emergency departments is influenced by four critical factors: staff, stuff, space, and systems. Understanding these factors and the interplay between them is critical. Emergency departments are increasingly encountering issues with overcrowding, patient boarding, and medical surge events causing interruptions in care and depleting critical resources. Coordination of medical surge is challenging during normal operations but is intensified during times of crisis. This comprehensive literature review seeks to better understand the current state of the literature surrounding surge preparedness and response in emergency departments across the United States, identify gaps in the current literature, and ultimately recommend …

Feasibility Study Of Service Expansion To Non-American Indians At The Santee Health & Wellness Center, Phil D. Jaquith

Capstone Experience: Master of Public Health

Challenges with obtaining access to healthcare in rural communities continue to be a clear issue. There are both structural and economic issues that limit patient access to care. With geographic issues also affecting access, many patients in Nebraska must travel further and wait longer throughout most rural communities to receive needed care. Care services seem to be retracting vs expanding, and patients continue to seek options that are closer to home and more comprehensive in scope. It is vital for communities and health services organizations to assess all care options and services they can expand or currently have to attract …

A Comprehensive Literature Review Of Barriers And Facilitators To Alcohol Use Disorder Screening And Treatment, Lizette M. Orihuela

Capstone Experience: Master of Public Health

Background: Alcohol Use Disorder (AUD) remains a significant public health issue with extensive personal, societal, and economic impacts. Recent studies indicate that no amount of alcohol consumption is entirely safe, linking it directly to increased chronic disease risks, including cancer. Despite well-documented negative health outcomes, clear guidance on what constitutes AUD through diagnostic criteria provided by the DSM-5, AUD continues to be underdiagnosed and undertreated.

Objectives: This comprehensive literature review explores the key barriers and facilitators influencing AUD screening and treatment engagement.

Methods: A comprehensive literature review was conducted, gathering from various databases including, PubMed, PsycINFO, Scopus, Google Scholar, and …

Optimizing Case Management Manuals: A Ryan White Quality Improvement Project For Northwest Missouri, Megan Mcbane

Capstone Experience: Master of Public Health

The Ryan White HIV/AIDS Act, established in 1990, has played a critical role in providing essential services for individuals living with HIV, including medication access, adherence support, health coverage, housing, and transportation. In rural Missouri, particularly in the northwest region, HIV case management under the Ryan White program is guided by four separate manuals, creating inefficiencies and burdens for case managers. This paper presents a process evaluation plan utilizing the Plan-Do-Study-Act (PDSA) framework to address these challenges and improve service delivery. The aim of this quality improvement project is to enhance the efficiency and effectiveness of HIV case management in …

Cardiac Patient Care Coordination: A Comprehensive Literature Review On Outcomes, Payton Allen

Capstone Experience: Master of Public Health

Care coordination is a vital aspect of the U.S. primary care landscape. Care Coordination is the deliberate process of managing a patient across different provider settings and services and is a vital part of chronic patient care. Most primary care providers (PCPs) today have moved to adopt some form of patient-centered care that serves as the central hub for coordinating and managing a patient's complete healthcare journey. PCPs' access to specialist records and their familiarity with their patients' long-term disease courses uniquely position them as the prime coordinators of patient care. Care coordination is becoming increasingly important in cardiac care …

A Comparative Analysis Of Preventable Deaths And Healthcare Accessibility: The U.S. Healthcare System Vs. Canada, The United Kingdom, And Australia, Aleya K. Byrd

Capstone Experience: Master of Public Health

The United States continues to struggle to improve healthcare performance and patient outcomes in comparison with other developed nations. This study examines access to primary care services and preventable deaths by comparing the performance of the United States, Australia, Canada, and the United Kingdom. (Blumenthal et al., 2024). A comprehensive scoping literature review method was applied to examine the health systems of three countries' public health structures to better understand the factors that may influence the US health system performance in accessing primary care services and decreasing preventable deaths. Understanding the structures that lead to the outcomes can help provide …

Barriers To Medication-Assisted Treatment For Opioid Use Disorder In Prisons And Jails In The United States: A Comprehensive Literature Review, Amy C. Smith

Capstone Experience: Master of Public Health

Background: The American Society for Addiction Medicine guidelines state that all FDA-approved medication for opioid use disorder should be available for all patients (CDC, 2024). Medication-assisted treatments for opioid use disorders, also known as medication for opioid use disorder (MOUD), are treatments that help diminish the physical symptoms of addiction to opioids. Currently, there are three FDA-approved medications to treat opioid use disorder: buprenorphine, methadone, and naltrexone (FDA, 2024). Despite being at an increased risk for opioid misuse and overdose, incarcerated individuals in the U.S. often do not have access to MOUD. This comprehensive literature review aimed to determine the …

Investing In Embedded Practitioners: Lessons From The Region Vii Public Health Expansion Program, Julia Quigley

Capstone Experience: Master of Public Health

Public health systems in the United States face mounting challenges, including workforce shortages, skill gaps, and increasing demands on practitioners. These issues are particularly acute in rural and Tribal communities, where systemic barriers and health disparities persist. The Region VII Public Health Expansion Program (PHES) addresses these challenges by investing in practitioners already embedded in their communities. Through fully funded public health degree programs, the PHES aims to enhance workforce retention, strengthen skills, and support the delivery of essential public health services in Missouri, Iowa, Nebraska, and Kansas. This study evaluates the program's innovative approach, which departs from traditional recruitment …

Enhancing Safety In Healthcare Construction: A Comprehensive Training Program On Managing Construction Dust, Melissa Nalath

Capstone Experience: Master of Public Health

In healthcare settings, construction activity poses significant risks due to the formation and release of construction dust containing allergens, pathogens, and toxic substances. This culminating project will develop a comprehensive training course for contractors to mitigate these risks while ensuring the safety of patients, employees, and construction workers. The training programs will raise awareness of the health risks associated with construction dust and educate contractors on proper dust handling techniques and ensure compliance with relevant regulations. Key elements such as containment, ventilation, and proper personal protective equipment (PPE) use will be emphasized. The program will also underscore the potential for …

Evaluating The Nebraska Medical Center's Repatriation Of Inter-Hospital Transfers, Natalie Crump

Capstone Experience: Master of Public Health

Background: Bed capacity challenges at large academic medical centers delay the transfer of rural patients, negatively impacting their safety and quality of care. Repatriating inter-hospital transfer (IHT) patients to referral facilities upon completing specialized care can improve tertiary hospital bed capacity and community hospital financial sustainability.

Objectives: This project aims to identify the barriers and facilitators to successful IHT repatriation and the process and outcome variables influenced by the Nebraska Medical Center’s reverse transfer program.

Study Design: A retrospective observational cohort study was conducted to identify barriers and facilitators of NM’s IHT repatriation program.

Methods: Descriptive and comparative analyses of …

A Research Report: What Are The Challenges That Refugee Women Experience When Seeking Healthcare Related To Pregnancy In The United States?, Manuela Krieger-Adi

Capstone Experience: Master of Public Health

Background

Refugees in the United States, including African refugee women, face many challenges in seeking healthcare after moving to the United States to resettle. It is urgent and essential to look into some of the health challenges the refugee community faces here in Omaha, Nebraska, that prevent them from seeking healthcare, especially when pregnant. This Capstone research project aims to focus on African refugee women, specifically in Omaha, Nebraska, and the challenges they face seeking healthcare related to pregnancy.

Methods

This research report involved five in-depth interviews conducted over Zoom. The target population was refugee mothers who had given …

Winning The Battle, Losing The War: Rahimi, Women, And The Supreme Court, Dana Raigrodski

Articles

Domestic violence and DV-related firearm use are a grave and persistent issue in the United States and have an extensive harmful and deadly impact in the lives of many women. In its 2024 Rahimi decision, the United States Supreme Court held that, as applied to the facts of the case, 18 U.S.C. § 922(g)(8), which bans firearms possession by those subject to a DV protective order, is facially constitutional under the Second Amendment. The Court upheld § 922(g)(8) under Bruen’s “Nation’s historical tradition of firearm regulations” test, finding that founding era laws included provisions preventing individuals who threaten physical harm …