Digital Commons Network^™

Agent-Based Modeling Of Cellular Dynamics In Adoptive Cell Therapies, Yujia Wang

Dissertations and Theses (Open Access)

Adoptive cell therapies (ACT) have shown promising progress in combating cancer, but clinical responses remain heterogeneous. Key determinants, including the functional states of infused cells, tumor–immune interactions, and dosing strategies, are difficult to resolve experimentally in the dynamic and heterogeneous tumor microenvironment, limiting optimization of ACT products and treatment regimens. To address the gap, we developed ABMACT (Agent-Based Model for Adoptive Cell Therapies), a computational framework that reconstruct key cellular functions, interactions, and molecular signatures to recapitulate cell population dynamics associated with differential treatment responses. ABMACT encodes autonomous “virtual cells” using literature-informed rules calibrated with experimental data, enabling simulation of …

Ai-Driven Segmentation And Volumetric Response Modeling Of Liver Regions To Radiotherapy, Aashish Chandra Gupta

Dissertations and Theses (Open Access)

In liver-directed radiotherapy (RT), liver regions receiving higher doses typically undergo atrophy while contralateral/adjacent lower-dose regions may exhibit compensatory hypertrophy through regeneration of healthy tissue. Optimizing the RT plan to promote regional hypertrophy while minimizing the risk of developing atrophy has the potential to enhance post-RT liver function and long-term survivorship. However, current clinical practice largely relies on global liver dose-volume metrics during RT-planning, which may obscure favorable dose-response correlation and limit actionable guidance for clinicians. Therefore, we hypothesized that post-RT regional liver response is governed by a combination of region-specific dose-volume and patient clinical features, and that these responses …

Oxidative Stress Mediated Glutamate Release And Nmda Receptor-Dependent Synaptic Remodeling In Radiation-Induced Cognitive Dysfunction, Thanh Lam

Dissertations and Theses (Open Access)

In children younger than 14 years old, the brain and other parts of the central nervous system are the most common sites for solid tumors. Radiotherapy is an effective treatment for central nervous system (CNS) tumors. However, it often causes a progressive decline in cognitive functions, which is especially devastating for pediatric patients. Although post-mitotic neurons are generally considered resistant to radiation-induced immediate cell death, ionizing radiation causes complex neurochemical and structural changes that damage synaptic integrity. In this study, we examined the molecular cascades following a 10 Gy radiation dose applied to mouse cortical neurons. We found that radiation-induced …

From Geometry To Recognition: A Quantitative Framework For Tcr-Pmhc Structural Analysis In The Age Of Predicted Structures, Kun Hee Kim

Dissertations and Theses (Open Access)

Recognition of antigen by a T cell begins with a single physical event, the engagement of the T cell receptor (TCR) with a peptide-major histocompatibility complex (pMHC), and this interaction is encoded in the geometry with which the receptor docks onto the composite pMHC surface. Whether that docking geometry is biologically organized, and whether the structures now produced at scale by prediction preserve recognition or only reproduce that organization, are the two questions this thesis addresses. Two gaps stand in the way. The first is a gap of measurement, because docking geometry has never been made quantitatively comparable across many …

Antigen Discovery In Multiple Myeloma Using Integrated Long-Read Transcriptomics And Immunopeptidomics, Aya Albittar

Dissertations and Theses (Open Access)

Multiple myeloma (MM) remains an incurable plasma cell malignancy, with relapse driven by persistent chemotherapy-resistant cells and residual disease following treatment. Although immunotherapies have transformed MM care, their success depends on identifying tumor-specific antigens that can be safely targeted. While aberrant genomic structural variation and transcriptional dysregulation are increasingly recognized as sources of novel antigens in MM, the HLA-presented antigenic landscape of MM remains incompletely characterized, particularly for non-canonical, structurally-derived peptides, and long-read transcriptome-informed immunopeptidomic data specific to MM remain scarce.

We established an integrated antigen discovery platform combining long-read RNA sequencing (Iso-Seq) with mass spectrometry-based HLA immunoprecipitation and immunopeptidomics …

“We’Re Just Always There For Each Other”: Examining Social Support For African American Caregivers Of Oncology Patients, Madeleine Lee, Keisha White Makinde

Posters

No abstract provided.

Operationalizing Frailty: A Comparison Of Measurement Frameworks, Audrey P. Doege, Madeline Donnelli, Daniel Forsha, Thomas Cochran, William R. Black, David A. White

Posters

No abstract provided.

Low-Cost Modular Transradial Prosthetic System, Caleb E. Barajas

Master's Theses

Upper-limb loss can significantly impact overall quality of life by limiting  a person's ability to perform activities of daily living (ADLs). Although prosthetic devices can help bridge the gap, many upper-limb prostheses are limited by high costs, discomfort, limited repairability, and accessibility barriers. Current commercial myoelectric prosthetic hands can provide high levels of functionality, but are often expensive and require specialized clinical access. In contrast, many current low-cost and open source prosthetic devices improve affordability but are limited in function or designed for partial hand applications rather than full transradial limb loss.

The purpose of this thesis was to design, …

Development And Initial Testing Of Novel Microfabricated Soap Film Frames For Use In Studying Instability Mechanisms In Liquid Sheet Edges, Sam Hastings, Sam Hastings

Master's Theses

The breakup of retracting liquid sheet edges into droplets is governed by instability mechanisms that, in some ways, are not yet fully understood. Previous and limited experimental soap film retraction experiments using straight edges have produced results that differ from the behavior predicted by Rayleigh-Plateau and Rayleigh-Taylor instability models, suggesting that uncontrolled imperfections in traditional wire frames (used to form and detach the soap films) may influence film detachment and the subsequent edge instability observed. This thesis presents the development of a new experimental approach using microfabricated silicon wafer-based soap film frames to provide improved control over the initial conditions …

2025-2026 Internal Funding Bulleting, Uno Office Of Research And Creative Activity

Internal Funding Newsletters

The University of Nebraska at Omaha is committed to exceptional education, groundbreaking research, and the life-long success of our students, alumni, and faculty. The 2025-2026 Academic Year brought many exciting opportunities for us to invest in a multitude of funding programs that promote research and creative activity. This year’s internal funding programs provided over $850,000 in awards for students and faculty. Projects from a wide variety of disciplines reflect the UNO community’s scholarly interests, including utilizing a virtual reality headset to reimagine scenic painting for theater productions, exploring the factors influencing the adoption of generative AI tools in U.S. local …

A Critical-Constructivist Grounded Theory Exploration Of The Mental Health Experiences Of Individuals With Intellectual Disabilities In Post-Secondary Settings, Alyssa L. Decker

Dissertations, 2020-current

Individuals with intellectual disabilities (ID) now have access to higher education, often through inclusive post-secondary education programs (IPSE), to increase employability and quality of life. IPSE programs, historically, have provided academic and life skill support and not mental health support within programs’ curricula. A recent review of IPSE programs reveals that if mental health services are included, they are often accessed through university health services. Transitioning from high school to college induces high levels of stress, which can exacerbate underlying mental health conditions. Mental health care is defaulted to an already overburdened college counseling center without the knowledge and skills …

Climate-Driven Degradation And Lifecycle Reliability Of Building-Integrated Photovoltaic Systems: Integration Challenges And Deployment Pathways, Mohammad Nur-E-Alam, Mohammad Khairul Basher, Mohammad Tariqul Islam, Mongi Amami, Rajesh Haldhar, M. Khalid Hossain

Research outputs 2022 to 2026

Building-integrated photovoltaics (BIPV) are becoming a more popular source of renewable energy. It is an on-site renewable energy source within buildings but has limited growth due mainly to lifespan issues throughout the entire life cycle from manufacturing to design, installation, electrical integration, operation, and end of life. This paper reviews the climate-driven deterioration mechanisms of BIPV, including thermal cycling, moisture ingress, atmospheric pollutants, wind loads, etc. They relate these climate-driven deterioration mechanisms to BIPV performance deterioration, energy yield reductions, safety concerns related to energy loss, and long-term reliability of BIPV systems across all parts of the BIPV life cycle. Through …

The Ambivalent Wisdom Of Moral Disgust, Brandon Yip

Research Collection School of Social Sciences

This paper has two aims. First, to provide a positive account of moral disgust. I suggest that moral disgust is a response to acts that are socially corrosive, namely, acts that undermine the normative structure to which an agent is attuned. I support this analysis with two lines of evidence: (1) moral disgust serves the important function of guarding normative structures from socially corrosive actions and (2) the analysis provides an illuminating explanation of moral disgust in a wide variety of cases. The secondary aim of this paper is to probe the normative implications of my positive account. I suggest …

Wevit: Weight-Entangled Vision Transformers With Class-Specific Attention For Weakly Supervised Semantic Segmentation, Narges Saeedizadeh, Seyed Mohammad Jafar Jalali, Burhan Khan, Shady Mohamed

Research outputs 2022 to 2026

Weakly Supervised Semantic Segmentation (WSSS) is a challenging task in computer vision, as it relies on limited supervision to generate precise object localization maps, often using Class Activation Maps (CAMs). Traditional methods struggle with balancing localization accuracy and scalability due to their reliance on fixed network architectures and handcrafted strategies. Neural Architecture Search (NAS), despite its proven success in optimizing network designs across tasks, has not yet been explored in WSSS due to the need for efficient weight sharing. To address these limitations, we propose WEViT, a novel framework that integrates NAS with transformers to optimize network architectures and generate …

Remote Assessment And Management Of Physical Function In Older Adults (Ramp): An International Expert Delphi Process, Jack Dalla Via, Hurst, Elsa Dent, Jackson J. Fyfe, Paul Jansons, Eleanor J. Hayes, Marc Sim, Mylene Aubertin-Leheudre, Alex Barreto De Lima, Lucimere Bohn, Sabine Britting, Fanny Buckinx, Gavin Connolly, Lora Giangregorio, Duarte Henriques-Neto, Jennifer R.A. Jones, Robert Kob, Suzanne N. Morin, Girish N, Lucas B.R. Orssatto, Maria Pearson, Daniel Pinto, Esmee M. Reijnierse, Catherine M. Said, Mohamed Salem, Gary Skinner

Research outputs 2022 to 2026

Background: Remote methods may help older adults improve their physical function, but understanding the perspectives of experts who deliver this care is critical. This modified Delphi process aimed to develop expert consensus on effectiveness, feasibility and implementation of remote assessment and management of physical function in older adults. Methods: This online Delphi process included experts involved in supporting older adults to maintain or improve their health. The Round 1 survey presented 33 Delphi statements assessed using an 11-point Likert scale (0–10; ≥7 indicated agreement). Statements with strong (≥80 %), moderate (50–<80 %) and low (<50 %) agreement were accepted, revised, or rejected, respectively. Revised statements were presented in Round 2, and accepted statements were consolidated into key messages. Results: In total, 108 respondents (67 % female; mean [SD] age 41.4 [10.9] years) from 16 countries (five continents) completed Round 1. Fourteen statements were accepted (88–100 % agreement) and 10 were rejected (8–39 % agreement). The remaining nine statements (52–69 % agreement) were revised, and two new statements were developed for Round 2, which was completed by 89 (82 %) respondents. Five Round 2 statements were accepted (82–93 % agreement). Seven key messages were developed from 19 accepted statements, highlighting that remote care should be accessible to older adults with requisite capabilities, is feasible for older adults and health professionals with adequate support and training, and requires guidelines, policies, and further research to support wider adoption. Conclusions: The findings of this Delphi process can inform the implementation of remote care approaches for assessing and managing physical function in older adults.

Global Prevalence Of Depression Among University Students: A Comprehensive Umbrella Review, Gilda Yun Kai Sam, Xun Ci Soh, Harshitha Balaji, Gabriel X. D. Tan, Shu Fen Diong, Meilan Hu, Andree Hartanto, Nadyanna M. Majeed

Research Collection School of Social Sciences

Depression has become a major concern for educational institutes due to its increasing incidence and detrimental impacts on students’ well-being. However, its global prevalence in the context of tertiary education remains unclear. This umbrella review summarised existing meta-analyses and systematic reviews to examine the worldwide prevalence of depression among university students. Several sociodemographic and methodological factors, including differences in depression prevalence before, during, and after COVID-19, were examined as moderators. Structured and exhaustive searches were conducted in five bibliographic databases and five journals, alongside two sources of grey literature. A total of 61 meta-analyses and systematic reviews were included in …

When The Best-Fit Model Is Not Best: The Glass Slipper Fallacy And Latent Growth Mixture Modelling, Jonathan L. Chia, Markus Wettstein, Andree Hartanto

Research Collection School of Social Sciences

Despite the use of latent growth mixture modelling (LGMM) to study longitudinal changes, existing practices may inadvertently impede this very investigation. Although subgroup trajectories may theoretically differ in their structure (e.g., some subgroups being linear, some curvilinear), the current convention advocates overreliance on the baseline model to derive subsequent profile trajectories, which may obscure these structural differences. In this article, we provide a brief description of extant LGMM practices, after which we explicate the pitfalls of the current approach. Finally, we provide a principled approach for LGMM research moving forward. Specifically, we recommend specifying a set of theoretically plausible models …

Caring With Ai: The Efficacy Of A Customised Chatgpt-Delivered Self-Compassion Intervention On College Students' Well-Being And Academic Functioning, Tracy Xi Chen, Chi-Ying Cheng, Andree Hartanto

Research Collection School of Social Sciences

College students face various challenges, including academic pressure, social stress, and the transition into adulthood, which can lead to increased anxiety and other mental health issues. By recognizing personal struggles as part of a shared human experience and responding with kindness, self-compassion serves as a powerful strategy for enhancing resilience, facilitating better well-being and performance outcomes. Although effective, Compassion-Focused Therapy often requires substantial resources and time, limiting its applicability to college students. To overcome these barriers, the current study designed and evaluated Your Self-Compassion Companion, a ChatGPT-powered AI chatbot intervention grounded in self-compassion theory and delivered over three weekly 20-min …

A Mixed Methods Study: Exploring The Concept Of Rematriation Through The Work Of Indigenous Doulas In New Mexico, Michelle Gutiérrez

Theses and Dissertations

Both the United States and New Mexico are facing a maternal health crisis. Despite significant resources and medical advances, Indigenous mothers continue to be impacted by health disparities. This research study explored the concept of Rematriation, most simply defined, as a return to a traditional and spiritual way of life with respect to Mother Earth or the Land, through the work of certified Indigenous birth doulas in New Mexico. Using a mixed methods approach that integrated a survey, body mapping, and interviews with 10 self-identified Indigenous doulas, this research sought insights and knowledge on their experiences and practices in birthwork, …

Inline Spectroscopy Of Foley Drainage Urine Under Free-Flow And Chaotic Flow Conditions To Detect Optical Signatures Of Urinary Constituents And Measure Urine Quality, Kordell Mitchell Bernaldez Tan

Theses and Dissertations

Foley catheter drainage systems remain largely passive, and assessment of urine passage, drainage interruption, and changes in urine appearance continues to depend on intermittent visual inspection, nursing documentation, caregiver observation, or delayed laboratory testing. Optical monitoring through the drainage-tube wall could provide objective information without opening the closed drainage pathway or placing sensors in direct contact with urine. This dissertation investigated the feasibility of a clamp-on multispectral optical platform for detecting urine passage and measuring wavelength-dependent optical changes under static and free-flowing drainage conditions.The investigation followed a staged medical-device development approach. Literature reviews characterized monitoring needs in acute, chronic, community, …

Differential Effects Of Physical Activity Interventions On Gross And Fine Motor Difficulties In Children With Autism Spectrum Disorder: Insights From A Multilevel Meta-Analysis With Moderator Analyses, Changhui Peng, Jinrong He, Kai Xu, Xueping Wu, Dandan Wang, Lei Zhang

Research outputs 2022 to 2026

Background Difficulties in gross and fine motor skills negatively affect the healthy development of children with autism spectrum disorder (ASD), yet evidence for physical activity interventions (PAIs) remains limited and inconsistent. Therefore, this study aimed to investigate the differential effects of PAIs on gross and fine motor difficulties in children with ASD and to explore potential moderators. Methods Following PRISMA guidelines, empirical studies published from inception to April 21, 2026 were systematically searched across PubMed, Web of Science, Embase, the Cochrane Library, and SPORTDiscus. Effect sizes were synthesized using a three-level random-effects model and were expressed as Hedges’ g (g). …

Gut Microbiome Changes In Preclinical Alzheimer’S Disease, D. M. Sithara Dissanayaka, Stephanie R. Rainey-Smith, Hamid R. Sohrabi, Thilini N. Jayasinghe, Vincent Ho, Vijay Jayasena, Kevin Taddei, Colin L. Masters, Ralph N. Martins, W. M.A.D.Binosha Fernando

Research outputs 2022 to 2026

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that develops many years before clinical symptoms appear. The biological changes involved in the earliest stages remain poorly understood, particularly during the preclinical stage. Our previous work has identified gradual gut microbial and metabolic changes during this stage, suggesting these may represent early biological shifts that precede disease progression. Recent studies suggest that the gut microbiome may contribute to early AD processes through its effects on immune regulation, metabolism, and gut–brain communication. Changes in gut microbial composition, including reduced levels of short-chain fatty acid (SCFA)-producing bacteria, such as Faecalibacterium, Roseburia, and Eubacterium, …

Reinforcement Learning For Cathode Material Design Through Sequential Decision-Making Frameworks, Taimoor Muzaffar Gondal, Muhammad Qasim, Yasir Arafat

Research outputs 2022 to 2026

The cathode material design is a persistent challenge in the development of next-generation rechargeable batteries. The cathode performance is critically influenced by certain key parameters, i.e., composition, crystal structures, ion transport, and degradation behaviour. Moreover, techno-economic and sustainable considerations also play a pivotal role in the viable cathode material design. In recent years, the integration of static machine learning models with conventional experimental techniques has significantly enhanced the cathode material design. However, the sequential nature of cathode discovery has not been fully captured by these techniques as they do not update their decision strategy based on prior outcomes. In this …

Validated Near-Infrared Spectroscopy And Chemometric Modelling For Rapid Quantification Of Essential Oil Yield And Α/Β-Santalol In Santalum Album L., Muhammad Hassnain, Muhammad Rizwan Azhar

Research outputs 2022 to 2026

The sandalwood industry remains constrained by destructive, time-intensive assays for essential oil (EO) yield, composition, moisture content, and wood fraction, which limit real-time decision-making. We report a unified near-infrared spectroscopy-artificial intelligence (NIRS-AI) platform for non-destructive analytics across the Santalum album L. value chain. Reflectance and transmittance spectra from solid matrices (disks, logs, chips, and powders), oils, ethanol extracts, and CID-derived emulsions were acquired using benchtop (400–2500 nm) and portable (900–1700 nm) spectrometers and calibrated against hydrodistillation, gas chromatography, extraction, and moisture assays. Advanced chemometric modelling using AI-based machine learning techniques, including regularised regression, ensemble learning, boosting algorithms, and neural networks, …

What Is Left After Memory: Love, The Body, And The Unconscious In Little Fish, Paul Longley Arthur, Isabel Smith

Research outputs 2022 to 2026

Chad Hartigan’s science fiction romantic drama Little Fish was released in 2020, soon after the start of the COVID-19 pandemic. However, the disease plaguing communities in Little Fish is not affecting people’s bodies but their minds—those who have contracted Neuroinflammatory Affliction (NIA) are losing their memories. The story centres upon the experiences of one young couple as they anxiously witness the disease take hold of their community, loved ones, and eventually one another. The film explores relationships between memory and identity, and poses questions about the ways these processes interact with those of love and loss. Who are we once …

Right-Sized Glycolysis In Growing Children: A Muscle Mass-Based Scaling Perspective, Sébastien Ratel, Joffrey Bardin, Anthony J. Blazevich

Research outputs 2022 to 2026

No abstract provided.

Attenuation Of Redox Interference In Ruo2 Ph Sensor Using A Ta2o5/Nafion Multilayer Architecture, Wade Lonsdale, Magdalena Wajrak, Md Mahamudul Hassan, James Jin Kang

Research outputs 2022 to 2026

Despite the growing preference for solid-state pH sensors due to their advantages over glass pH electrodes, their practical application is still limited by challenges, particularly in metal-oxide based systems. The main issue is their susceptibility to redox-active species such as dissolved oxygen, ascorbic acid, sulfides, and transition-metal ions. In this work, the effects of representative redox interferents, with particular emphasis on ascorbic acid, together with dissolved oxygen and potassium permanganate, were investigated and mitigated through the application of Ta2O5/Nafion overlayers. The solid-state metal-oxide pH-sensitive electrodes were fabricated with laser micro-etching of radio-frequency (RF) sputtered RuO2 thin films deposited on ceramic …

Cartel Del Noreste And Human Smuggling: Understanding Modern Tactics: A React Case Study, Anjun Dhillon, Isaac J. Moelter

Reports, Projects, and Research

On August 23, 2026, three members of Cartel Del Noreste (CDN) attempted to smuggle three people across the U.S. southern border in Laredo, Texas. Francisco Suarez, age 20, along with Luis Daniel Segura Guzman, age 26, prepared to transport the group from Mexico to the United States. The cartel members used Facebook to advertise their transportation services and to recruit aliens who needed help. A third CDN member, Bernardo Aniceto Garza, age 27, was placed in charge of driving the vehicle.

Perceptions Of Situational Leadership Styles On The Behavioral Intervention Skills Of General Educators, Kendall Jordan Baethge

Electronic Theses and Dissertations

The researcher conducted the following study to describe the lived experiences and perceptions of general educators employed in a rural, central Texas school district. The study specifically inquired about the perceptions of leadership styles and strategies to successful behavior intervention strategies for inclusive general education classrooms. The problem addressed within the study was the growing diversity in general education classrooms ensuring inclusive opportunities to students with disabilities who exhibit challenging behaviors. The purpose of the study was to better understand those leadership styles currently being used and styles that are most appropriate to develop perceived self-efficacy and proficiency in behavior …

On The Operation Of A Proteomics Core Facility: Selected Mass Spectrometric Studies And Methods, Rachel E. Muriph

Graduate Doctoral Dissertations

Mass spectrometry has become an indispensable analytical platform for investigating complex biological systems owing to its sensitivity, selectivity, and molecular specificity. This Dissertation demonstrates the versatility of liquid chromatography-tandem mass spectrometry (LC-MS/MS) through three studies focused on nanoparticle characterization, protein structural analysis, and plasma proteomics. In Chapter 2, LC-MS methods were developed to characterize novel lipidoid incorporated into lipid nanoparticles (LNPs) and to evaluate their in vivo biodistribution following systematic administration. Comparative proteomic analysis of the resulting protein coronas revealed distinct differences between liver and lung targeting LNP formulations, providing insight into the potential role of adsorbed blood proteins in …