Digital Commons Network^™

The Role Of Microbiome In Cancer, R. B. Nerli, Shridhar C. Ghagane

Indian Journal of Health Sciences and Biomedical Research KLEU

No abstract provided.

Design, Formulation, And Evaluation Of, Fatima Sanjeri Dasankoppa, Pooja Solankiy, Hasanpasha N. Sholapur, Vilas G. Jamakandi, Vinuta M. Sajjanar, Pooja M. Walveka

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

The significant problem in the ocular drug delivery is the attainment of optimal drug concentration at the site of action. Development of therapeutic agents that require repeated long-term administration is a driver for the sustained release drug delivery systems, to result in less frequent dosing, and less invasive techniques. Therefore, to overcome the anatomical barriers and ocular bioavailability constrains, a novel drug delivery system

in situ

gels have been developed.

Materials and Methods:

The

in situ

gelling system comprises gellan gum, an anionic polymer responsible for the ionic gelation. Methylcellulose a nonionic polymer contributes for the viscosity and gels …

Influence Of Strength And Proprioception Training On Functional Ankle Stability Among Young Skaters, Priyanka Mudaliar, Snehal Dharmayat

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Stability of the ankle joint during functional activities depends on the presence of intact neural input from proprioceptors in the joint capsules, ligaments, muscles, tendons, and skin. Roller skaters are prone for more ankle injuries due to the nature of the sport. Repetitive falls and sprains lead to deficits that account for decreased performance and increased risk of falls.

Purpose:

The purpose of this study is to determine the effect of strength and proprioceptive training on functional ankle stability among young skaters.

Design:

This was a single arm pre- and post-experimental study.

Settings:

The study was conducted at two …

Formulation And Characterization Of Oxiconazole-Loaded Emulgel For Topical Application, A. P. Gadad, Amol Prakash Magdum, P. M. Dandagi, U. B. Bolmal, Shriraj Kamat

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Oxiconazole nitrate is a new topical broad spectrum antifungal agent used to treat superficial fungal infections. It has a low aqueous solubility due to which different techniques are employed to enhance its bioavailability. Emulgel has emerged as one of the most interesting topical drug delivery system for hydrophobic drugs like Oxiconazole as it has dual release control systems i.e. emulsion and gel.

Objective:

In the present work an attempt was made to prepare Emulgel of Oxiconazole nitrate for enhancing its topical delivery.

Materials and Methods:

Emulgel formulations were characterized by various parameters like pH, viscosity, spreadability, extrudability,

in vitro …

Influence Of Occupation On Median Nerve Cross-Sectional Area In Apparently Healthy Volunteers, Anthony Chukwuka Ugwu, Benjamin Efiong Udoh, Alhaji Modu Ali, Mohammed Abba, Emmanuel Buba, Mohammed Yusuf Mohammed

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Sonographic measurement of the median nerve has been proposed as a useful alternative to the electrodiagnostic test in the diagnosis of the carpal tunnel syndrome because of its ability to reveal morphological changes.

Objective:

The objective of this study was to investigate the influence of occupation, gender, and hand dominance on the median nerve cross-sectional area (MNCSA).

Methodology:

One hundred and eighty apparently healthy volunteers were recruited for the study. Hand dominance was ascertained in all volunteers. The device used was Voluson P8 ultrasound system with a 12-MHz transducer, using custom preset for musculoskeletal ultrasound. The Anteroposterior (D

1 …

Effect Of Scapular Proprioceptive Neuromuscular Facilitation On Shoulder Pain, Range Of Motion, And Upper Extremity Function In Hemiplegic Patients A Randomized Controlled Trial, Deepak Joshi, Jeba Chitra

Indian Journal of Health Sciences and Biomedical Research KLEU

Background and Purpose:

Poststroke shoulder pain is one of the most prevalent impairments (34%–86%) and it hinders the performance of daily activities and also interferes with stroke rehabilitation. The purpose of this study was to examine the effect of scapular proprioceptive neuromuscular facilitation (PNF) on shoulder pain, range of motion (ROM), and upper extremity (UE) function in hemiplegic patients.

Methods:

Thirty hemiplegic patients were recruited and randomly allocated to Group A (

n

= 15) and Group B (

n

= 15). Experimental group received conventional treatment plus scapular PNF-hold relax technique while control group received only conventional treatment comprised …

“Comparison Of Preincisional Port Site Infiltration Of 0.5% Levobupivacaine Versus 0.5% Ropivacaine For Postoperative Pain Relief In Patients Undergoing Laparoscopic Appendicectomy A One Year Hospital-Based Double-Blind Randomized Controlled Trial”, Santosh Subarao Patil, Vandana A. Gogate

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Administration of local anesthetic into the wound before incision has been found to reduce postoperative pain following laparoscopic surgery. Levobupivacaine and ropivacaine which are less cardiotoxic and neurotoxic than bupivacaine are being used for local infiltration.

Objective:

To compare the efficacy of preincisional port site infiltration of 0.5% levobupivacaine versus 0.5% ropivacaine for postoperative pain relief in patients undergoing laparoscopic appendicectomy.

Methodology:

By computer-generated randomization table, sixty adult patients undergoing elective laparoscopic appendicectomy under general anesthesia were divided into two groups. Group 1 patients received 14 mL of 0.5% levobupivacaine preincisional port site infiltration and Group 2 patients received …

A Study Of Knowledge, Attitude, And Practices Of Menstrual Health Among Adolescent School Girls In Urban Field Practice Area Of Medical College, Tumkur, Purva Shoor

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Menstruation is a phenomenon unique to females. In India, limited access to products of sanitary hygiene and lack of safe sanitary facilities could increase the likelihood of resorting to unhygienic practices to manage menstruation.

Materials and Methods:

A cross-sectional study was conducted from April 2013 to April 2014 by interviewing 452 adolescent school girls using a semi-structured, pretested questionnaire. There were 6 schools and 1 PUC college in the study area. Data were analyzed using Epi Info 3.5.3.

Objectives:

The objectives of this study were (1) to study the knowledge and attitude toward menstruation among adolescent school girls, (2) …

One Year Cross-Sectional Study Of Association Between Androgenetic Alopecia And Benign Prostatic Hyperplasia In A Tertiary Care Hospital, Prarthana B. Desai, B. S. Manjunath Swamy, R. B. Nerli

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Androgenetic alopecia (AGA) and benign prostatic hyperplasia (BPH) are both androgen-dependent disorders in which the enzyme 5-alpha reductase plays a key role in conversion of testosterone to dihydrotestosterone. The purpose of this study is to analyze the association between AGA and BPH.

Materials and Methods:

Male patients between the age group of 25–45 years attending dermatology outpatient department at a tertiary care hospital with AGA during the period January 2015–December 2015 were included in the study. Ethical clearance was obtained from the Institutional Ethics Committee of Human Subjects Research. A short questionnaire recording their particulars and a detailed dermatological …

Knowledge Of Anganwadi Workers Regarding Different Components Provided By Integrated Child Development Scheme A Cross-Sectional Study, Prithutam Bhattarai, Padmaja R. Walvekar, Ashwini Narasannavar

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Integrated child development service (ICDS) program was launched on October 02, 1975 and is the world's largest and unique program for early childhood care and development. It is working in urban and rural areas through Anganwadi centers. The beneficiaries that come under ICDS are 0–6 year's children, pregnant and lactating women, and adolescent girls. There are six core services provided by ICDS through Anganwadis. It is very essential to assess the knowledge of Anganwadi workers (AWWs) about different components of ICDS.

Objective:

The objective of the study was to assess the knowledge status of AWW regarding different ICDS components …

Review Of Research Works Done On Generalized Anxiety Disorder At Institute For Postgraduate Teaching And Research In Ayurveda, Jamnagar, Divya S. Zala, Anup B. Thakar, Nilesh N. Bhatt

Indian Journal of Health Sciences and Biomedical Research KLEU

Generalized anxiety disorder (GAD) is one of the most common anxiety disorders characterized by persistent worrying, anxiety symptoms, and tension. It is most frequent anxiety disorder in primary care and associated with a significant economic burden owing to decreased work productivity and increased use of health-care services. GAD is a highly disabling illness, often complicated by multiple comorbidities, most commonly depression and other anxiety disorders. Being an alarming disease, it requires effective management. Ayurveda, with its holistic approach, can be helpful in such situation. In this direction, to assess the actual efficacy of different Ayurveda treatment modalities; few works have …

Characteristics And Anesthetic Management Of Patients Presenting For Cleft Surgery, Babatunde B. Osinaike, Stella A. Ogunmuyiwa, Olalere O. Gbolahan, A. A. Odewabi

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Anesthetic management during surgery for cleft repair can be challenging due to abnormal airway anatomy and preoperative medical conditions. We sought to determine the characteristics, type, and incidence of associated medical problems, airway and other intraoperative complications in patients who presented to our facility for cleft lip and palate repair.

Methodology:

Fifty-six consecutive patients aged 16 years and below who had surgical repair of cleft lip or palate under general anesthesia during the study period were involved in this prospective, observational study. Routine preoperative review and anesthetic management were not altered. Preoperative medical and airway problems, associated congenital anomalies, …

Bibliometric Evaluation Of Published Indian Research On “Knowledge, Attitude, And Practices”, Sandeep Sachdeva, T. R. Sachdev, Ruchi Sachdeva

Indian Journal of Health Sciences and Biomedical Research KLEU

Objective:

Evaluation of knowledge, attitude, and practices (KAPs) based published Indian research on selected parameters.

Methodology:

A bibliometric analysis of Indian KAP research manuscript published in journals indexed in PubMed for the last 2 years and/or published in Indian Journal of Community Medicine (IJCM) and Indian Journal of Public Health (IJPH) for the last 15 years (year 2000–2014) was undertaken under certain criteria.

Results:

PubMed (

n

= 196) revealed maximum KAP research undertaken from the states of Karnataka (16.8%) followed by Delhi (9.6%), Maharashtra (9.1%), and more than two states (11.7%). There was poor reflection with no publication of …

A Comparative Evaluation Of Different Compensating Curves And Power Arm Length During Retraction Of Maxillary Anterior Teeth A Finite Element Study, Dhvani Sumatichandra Doshi, Tejashri Mirji Pradhan

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

The strategic design of an appliance for anterior retraction by using orthodontic mini-implant anchorage and sliding mechanics must take into account the height of the power arm and compensating curve in archwire. This study was conducted to analyze the change in maxillary anterior teeth displacement and stress distribution using different compensating curves in the arch wire and varying power arm length in first premolar extraction case during sliding mechanics.

Materials and Methods:

6 geometric models were created using ANSYS software. This geometric model was converted into a finite element model with the help of software HYPERMESH 11.0. Bilaterally mini-implants …

Correlation Of Serum Ferritin Levels, In Female Patients With Chronic Diffuse Hair Loss A Cross Sectional Study, Sridevi Ramachandra Raichur, A. M. Pandit, Anil Malleshappa

Indian Journal of Health Sciences and Biomedical Research KLEU

Context:

Iron is involved in critical physiological processes within the hair follicle, suggesting that iron deficiency (ID) could disrupt hair synthesis. The relationship between body iron status and hair loss has been investigated in a number of studies, however, with relatively discrepant findings.

Aim:

The aim of this study is to evaluate whether chronic telogen effluvium (CTE) and female pattern hair loss (FPHL) in patients were associated with decreased tissue iron stores, as measured by serum ferritin levels.

Setting and Design:

This was a cross-sectional study, conducted in a teaching hospital.

Materials and Methods:

Forty female patients aged between 15 …

Assessment Of Static And Dynamic Balance In Overweight And Obese Children With And Without Flatfoot A Cross-Sectional Study, Pallavi Sharma, Deepa Metgud

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Childhood obesity and overweight have been referred by health organization as serious epidemic and global problems that are on the rise. The consequence of being overweight in children is the greater impairment of mobility which may result in several orthopedic conditions. The foot dimensions of overweight children and obese children will be larger than those of normal weight children. Balance is defined as an ability to maintain the center of mass over base of support. Balance as a sensorimotor ability helps in maintaining static and dynamic equilibrium. The presence of abnormalities in the foot structures may affect the displacement …

“Evaluation Of Wound Healing And Bone Regeneration Using Autologous Platelet-Rich Plasma And Platelet-Rich Fibrin Postextractions” A Comparative Study, Niyati Satish Balse, Shridhar Baliga

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

It has already been established in the past that platelets play a major role in wound healing. Platelet- rich plasma (PRP) and Platelet- rich fibrin (PRF) are autologous concentrates of platelets in a relatively small volume of plasma and they enable delivery of growth factors in increased amounts to surgical sites to promote wound healing.

Aims and Objectives:

This study focuses on comparing the two platelet concentrates – platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) as graft materials in extraction sockets and their efficacy in wound healing and bone regeneration.

Materials and Methods:

Sixty patients requiring extraction of unilateral …

“Comparative Evaluation Of Intranasal Dexmedetomidine And Intranasal Midazolam For Premedication In Children Undergoing Anesthesia” A 1-Year Double-Blind Randomized Controlled Trial, Narendra Malineni, Manjunath C. Patil

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Children undergoing surgical procedures can experience significant anxiety and distress during perioperative period. Use of sedative premedication helps to reduce anxiety and facilitate a smooth induction of anesthesia. Midazolam is the most commonly used premedication agent with adverse effects such as behavioral changes, hiccups, and paradoxical hyperactive reactions. Dexmedetomidine, a highly selective α-2 agonist, has sedative properties.

Aims and Objectives:

The aim and objective of this study was to compare the efficacy of intranasal dexmedetomidine and intranasal midazolam for premedication in pediatric age group for parental separation anxiety and acceptance of anesthesia mask.

Materials and Methods:

This study included …

Effect Of Denture Adhesive And Its Forms On Microbial Colonization In Diabetic And Nondiabetic Complete Denture Wearers An, Ruta Jadhav, Sounyala Rayannavar, Raghunath Patil, Vinuta Hiremath, Sumati A. Hogade

Indian Journal of Health Sciences and Biomedical Research KLEU

Problem:

Denture adhesives are known to enhance the retention and stability in denture wearers, especially in patients with resorbed ridges. However, dentists hesitate to prescribe them fearing denture adhesive-induced oral microbial infections or hyperplasia in the oral cavity.

Aim:

The aim of this was to evaluate and compare the effect of denture adhesives and its forms on the microbial colonization of diabetic and nondiabetic edentulous patients using complete dentures.

Methodology:

Forty subjects were included in the study (Group A: 20 diabetics and Group B: 20 nondiabetics). After 2 weeks of complete denture insertion, samples were collected from the hard palate …

Utilization Of Janani Suraksha Yojana By Eligible Pregnant Women In Rural South India A Qualitative Study, Biswamitra Sahu, Anita Nath, R. Anil Kumar

Indian Journal of Health Sciences and Biomedical Research KLEU

Context:

In India, the Janani Suraksha Yojana (JSY) scheme, translated as “safe motherhood scheme,” has been implemented to tackle this financial insecurity by giving cash incentives to women who give birth in public health facilities and accredited private health facilities. Although there is a reported increase in the number of institutional deliveries, there has not been much improvement in maternal or neonatal mortality rates.

Objective:

To explore the utilization of and barriers toward the use of JSY scheme by eligible rural pregnant women.

Design:

Qualitative research method in the form of in-depth interview was used for data collection and analysis. …

Risk Of Depression In Patients With Chronic Obstructive Pulmonary Disease And Its Determinants, Sujeer Khan, Bhagyashri B. Patil

Indian Journal of Health Sciences and Biomedical Research KLEU

Background and Objectives:

Depression is an important comorbid condition of chronic obstructive pulmonary disease (COPD). There is a risk of undertreatment for depression in patients with COPD as depressive symptoms, including suicidal tendencies, can erroneously be conceptualized as an understandable reaction to COPD and not as signs of an independent depressive disorder. The exact prevalence of depression in COPD patients among the Indian population is unknown.

Aim:

This study aims to know the prevalence of depression in COPD patients attending tertiary care hospital.

Materials and Methods:

A total of 120 COPD patients were enrolled in the study according to Global …

Comparison Of The Glottic View During Intubation Using Airtraq And Macintosh Laryngoscopes In Adult Patients Undergoing Surgeries Under General Anesthesia With A Simulated Cervical Spine Immobilization A 1-Year Hospital-Based Randomized Controlled Trial, Avinash Rayavarapu, M. G. Dhorigol

Indian Journal of Health Sciences and Biomedical Research KLEU

Background and Objectives:

The present study was undertaken to compare the glottic view during intubation using Airtraq and Macintosh laryngoscopes in adult patients undergoing surgeries under general anesthesia with a simulated cervical spine immobilization.

Methods:

This 1-year randomized clinical study was conducted between January 2015 and December 2015 on 60 American Society of Anesthesiologists Grade I and II patients of either gender, aged between 18 and 60 years. The study population was randomly divided into two groups. Group A (

n

= 30): intubation performed using Airtraq laryngoscope. Group L (

n

= 30): intubation performed using Macintosh laryngoscope.

Results: …

Accuracy Of Measurements Of Foramen Magnum And Occipital Condyle As An Indicator For Sex Determination Using Computed Tomography, Harshita Rai, Vaishali Keluskar, Santosh Patil, Anjana Bagewadi

Indian Journal of Health Sciences and Biomedical Research KLEU

Background and Objectives:

The determination of sex in forensic investigation is an important and crucial step. Unidentifiable crania are very common due to warfare, mass disasters, intentional attempt to obscure facial identity in criminal attacks, or physical injury caused by weapons, explosives, or fire. In such a situation, the determination of sex becomes extremely complicated and challenging.

Aim:

The present study was undertaken to provide data on foramen magnum and occipital condyle (OC) for the purpose of sex determination for establishing the identity in cases of unknown fragmentary skulls.

Settings and Design:

Retrospective.

Subjects and Methods:

The study group included …

A Comparison Of Standard And Rotational Techniques For Ease Of Insertion Of Proseal Laryngeal Mask Airway In Adult Patients A 1-Year Hospital-Based Randomized Clinical Trial, Sachinkumar H. Shet, K. S. Kedareshvara, R. Mane, M. G. Dhorigol

Indian Journal of Health Sciences and Biomedical Research KLEU

Title:

A prospective randomised clinical trial for comparison of two techniques of insertion of proseal laryngeal mask airway in adults - index finger insertion technique versus 90 degree rotational technique.

Introduction:

ProSeal laryngeal mask airway is not easy to be inserted due to its larger cuff especially in Indian population. The 90 degrees rotation technique for inserting the PLMA is reported to be better than the standard index finger insertion technique to improve the insertion success rate. The objective of this study was to evaluate and compare the ease of insertion through the rotational and standard insertion technique in terms …

Effect Of Storage And Temperature On Two Biochemical Analytes (Creatinine And Urea) In Pooled Serum Samples Stored At -20°C, Nilesha Vilas Vernekar, Vanishree Basavraj Jabannavar

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Creatinine and urea are nonprotein nitrogenous compounds which are eliminated from the body. Creatinine is a word obtained from a Greek term "Kreas" meaning flesh. An anhydrous form of creatine is creatinine. Around 0.5% of total muscle weight constitutes creatine. Muscle, brain, blood, etc., are the tissues, in which creatinine is present as high-energy compound, phosphocreatine, and creatine as free compound. Optimal storage of serum specimens in biobanks for long time for multicenter reference interval studies remains to be determined. Hence, in this context, the present study was undertaken to determine the effect of storage time and temperature on …

Formulation And Evaluation Of Gastroretentive-Floating Multiparticulate System Of Lisinopril, Manasa Moganti, H. N. Shivakumar

Indian Journal of Health Sciences and Biomedical Research KLEU

Aim and Objective:

The main objective of this research was to formulate and evaluate gastroretentive-floating multiparticulate system of lisinopril to prolong the gastric residence time.

Materials and Methods:

Gastroretentive system of lisinopril was developed by ionotropic-gelation technique using isabgol (

Plantago ovata

F.) husk mucilage (IHM) as a floating agent, sodium alginate as a mucoadhesive polymer, and sodium bicarbonate as a gas-generating agent.

Results:

The beads were evaluated for entrapment efficiency (EE),

in vitro

drug release, and

ex vivo

mucoadhesion. The beads of batch F-2 exhibited high-EE (96.04 ± 0.74%), complete drug release (95.27 ± 0.12%), and good mucoadhesion (50% …

Assessment Of Plasma Homocysteine As A Marker Of Acute Renal Injury In Patients Undergoing Extracorporeal Shock Wave Lithotripsy For Renal Stone Disease - 1-Year Cross-Sectional Study, Shruti G. Raikar, Siddalingeshwar I. Neeli, Veerendra M. Uppin, Shashi M. Uppin

Indian Journal of Health Sciences and Biomedical Research KLEU

Context:

Extracorporeal shock wave lithotripsy (ESWL) commonly used procedure for treating upper urinary tract stones may result in acute kidney injury (AKI) with release of biomarkers. Association of plasma total homocysteine (tHCy), serum high-sensitivity C-reactive protein (hs-CRP), and serum creatinine with renal dysfunction and their role as acute renal injury markers is to be assessed.

Aim:

The study aims to assess plasma tHCy as a marker of AKI in patients undergoing ESWL for renal stone disease and compare the same with other markers, i.e., serum creatinine and serum hs-CRP.

Setting and Design:

One-year cross-sectional study at a tertiary care teaching …

49, Xxxxy Syndrome An Infant Presenting With Ambiguous Genitalia, Rajendra B. Nerli, Prasad V. Magdum, Amit M. Mungarwadi, Shridhar C. Ghagane, Murigendra B. Hiremath

Indian Journal of Health Sciences and Biomedical Research KLEU

Presences of normal genes on the Y chromosome are essential for normal sex determination and sex differentiation of male genitalia. Several genes on the X chromosome and other autosomes have been shown to be anti-testes and have a detrimental effect on the development process of normal male genital system. The addition of X chromosomes to the 46, XY karyotype results in seminiferous tubules dysgenesis, hypogonadism, and malformed genitalia. We report an infant male with 49, XXXXY syndrome presenting with ambiguous genitalia and multiple extra-gonadal anomalies.

Clinical Profile Of Nasal Polyp In A Pediatric Patient An Ayurvedic Approach, Aziz Ahmed Arbar, Sweta Verma

Indian Journal of Health Sciences and Biomedical Research KLEU

Nasal polyp is a chronic inflammatory disease affecting the nasal cavity and the paranasal sinuses. It is a relatively common disease occurring in 1%–4% of the general population, but it is also seen in the pediatric population. Children present with nasal polyps are also known to have other underlying systemic diseases, mainly cystic fibrosis and bronchial asthma. Nasal polyp is common in the pediatric population especially in teenage, and is found usually bilateral. It is also commonly associated with bronchial asthma and many other systemic diseases. Beginning in preschool age, up to 50% of patients experience obstructing nasal polyp. In …

Design, Formulation, And Evaluation Of Delayed Release Oral Dosage Form Of Proton Pump Inhibitor, V. G. Jamakandi, Kiran Ashok Kubasad, Subrata Kundu, F. S. Dasankoppa

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

A proton pump inhibitor is an acid labile drug which degrades at stomach pH 1.2. Delayed release pellets were prepared to stabilize the formulation applying an enteric coat.

Objective:

the objective of the study was to design, formulation and evaluation of delayed release oral dosage form of proton pump inhibitor.

Materials and Methods:

Twelve different formulations of pellets were prepared by fluid bed technology (bottom spray technique) using different polymers for different coating processes namely seal coat (HPMC); drug coat (HPMC); barrier coat (Ethyl cellulose) and enteric coat (HPMC Phthalate). The formulated pellets were evaluated.

Results:

FTIR studies revealed …