Digital Commons Network^™

Ad-Sge-Dkk3 Gene Therapy Overcomes Resistance To Immune Checkpoint Blockade In Pleural Mesothelioma, Sung Wook Kang, Jong Min Choi, Claire Lee, Monica Vilchis, Ji Seon Shim, Sonali Mitra, Priyanka Ranchod, Allen Kuncheria, William Hudson, Peter Jindra, Veronica Lenge De Rosen, Maheshwari Ramineni, Ernest Ramsay Camp, Farrah Kheradmand, R Taylor Ripley, Shawn S Groth, Hyun-Sung Lee, Bryan M Burt

Faculty, Staff and Students Publications

Purpose: Immune checkpoint inhibitors (ICI) have limited efficacy in pleural mesothelioma. We investigated the role of Dickkopf WNT signaling pathway inhibitor 3 (DKK3) in overcoming treatment resistance.

Patients and methods: We performed preclinical studies to elucidate DKK3's role in ICI-resistant mouse mesothelioma. Based on these findings, we conducted a single-arm, phase II clinical trial of a combination of Ad-SGE-DKK3 and nivolumab for chemotherapy-refractory epithelioid pleural mesothelioma, with the objective response rate as the primary outcome.

Results: DKK3 was significantly reduced in human epithelioid mesothelioma. Overexpression of DKK3 in cancer cells activated the p53 pathway, enhanced glycolysis, increased surface PD-L1, and …

The Indian Pharmacopoeia: Enabling Open Access And Crafting A ‘Sovereign Function Exception’ For Government Works, Aparajita Lath

National Law School Journal

Standardisation of drugs and access to such standards are important levers for effective drug regulation. The Indian Pharmacopoeia, the official book of standards for drugs in the country prescribed by the Union government under the Drugs and Cosmetics Act 1940, are legally binding and enforceable. Not only do the standards have the force of law but are also government-created. The Indian Pharmacopoeia Commission (IPC), a division of the Union Department of Health and Family Welfare, has a legal monopoly over creating and publishing this compendium. Though it is legally binding, the Indian Pharmacopoeia is neither in the public domain …

Issues That Ministers Identify As Factors Contributing To Anxiety And Depression, Heather Sawtelle

Doctor of Ministry (DMin)

Although mental health is an emerging topic within the church community, the stigmatization of mental illness within ministers’ lives can create a myriad of personal beliefs that can lead to shame and discontent in ministers’ lives. Many ministers have daily stressors that compromise their mental health, and these stressors can contribute to depression or anxiety. This study defined mental health issues and described mental illness’ influence on ministers’ lives and the factors that contribute to mental health issues. This health condition, described as mental illness, involves significant changes in thinking, emotion, behavior, distress, and problems functioning in social, work, or …

Acting Religion: Analyzing The Aids Crisis Through A Religious Lens, Anya Thaovan Nguyenkhoa

Voces Novae

No abstract provided.

From Pagan Chieftains To Christian Kings: Shaping Medieval Nordic Political Culture, Carissa Chinnery

Voces Novae

No abstract provided.

Managing International Remittance Transactions In A Closed Loop Transaction Network, Vinay Babu Chennareddy, Jaishankar Kumar Venkataraman, Anil Kumar, Richard Meszaros

Defensive Publications Series

The present disclosure provides a method and a system for managing international remittance transactions in a closed loop transaction network. The method includes receiving an initiation request for an international remittance transaction that is funded by a sender via a sender funding financial institution system. The initiation request may originate from a receiver and be transmitted to the sender for review, approval and funding. The initiation request is validated at the sender funding financial institution system and transmitted to a transaction service provider system. The validated transaction is then exclusively routed to a designated financial institution system that is pre-associated …

Teachers' Feedback And Students' Emotional Wellbeing In Writing Courses, Amar Bahadur Sherma

Journal of English Learner Education

While feedback is a corrective business in every sphere of human life, most students do not have a positive perception of teachers’ feedback. Previous studies have emphasized the relationship between students’ writing achievements and the effectiveness of teachers’ feedback. However, no substantial research on how teachers’ feedback affects students’ emotional well-being has been undertaken. This article examines the relationship between students’ understanding of their teachers’ feedback on their writing assignments and emotional wellbeing. Data was collected from (N = 63) Nepali undergraduate students through Google Forms. The Forms consisted of structured and unstructured questions. According to the data, a mismatch …

Artificial Intelligence (Ai) Literacy: A Necessity In Modern Language Education, Samarnh Pang, Engheang Nol, Kimkong Heng

Journal of English Learner Education

This article aims to discuss the importance of artificial intelligence (AI) literacy in the context of an AI-driven world and argues that it is a necessity in modern language education. The article answers a few questions, focusing on why AI literacy matters for language students and educators, what AI competencies should be promoted, and how AI literacy can be effectively integrated into the curriculum and instruction. The article also brings to the fore key considerations for implementing AI literacy in language education. These considerations include providing support to students and teachers to navigate the complexity of AI use, offering AI …

Transforming K-12 Classrooms: Ten Essential Strategies For Cultural Responsiveness, Sandra Johnson, Stephanie Johnson, Regina Reber

Journal of English Learner Education

Across the United States, in K-12 classrooms, diverse student populations continue to increase, challenging educators to meet student cultural, linguistic, and academic needs. The study examined the best practices related to culturally responsive teaching (CRT) strategies to better meet all students' needs. A qualitative approach was used to collect data from licensed K-12 educators in New Mexico and Colorado. The findings revealed three essential themes: culturally responsive pedagogy, the positive impact of CRT, and the creation of physical spaces to support inclusivity. The findings revealed the significance of building strong relational capacity, encouraging collaboration, supporting multilingualism, and creating effective physical …

Why The “Whole Language Approach” To Reading Fails Ell Students & Instructional Strategies To Employ Instead, Caitlyn E. Petrus

Journal of English Learner Education

The research presented in this article demonstrates a qualitative view of the science of reading for phonemic awareness instruction, phonics instruction, vocabulary development, and reading comprehension strategies for English Language Learners (ELLs) in PK-12 schools. The research builds upon esteemed writers Dr. Sharon Vaughn and Dr. Sylvia Linan-Thompson’s work in their book Research-Based Methods of Reading Instruction for Learners, Grades K-4 and other reading experts such as Dr. Wiley Blevins and Dr. Lisa Moats to apply to the growing population for ELLs in PK-12 schools and how to shift from a “whole language classroom” to a classroom built on the …

Monopolizing The Hobby: Legal Insights Into The Consolidation Of The Sports Card Industry, Zachary Lyons

UNH Sports Law Review

No abstract provided.

Revisiting Nba V. Motorola In The Big Data Era, Laura Daly

UNH Sports Law Review

No abstract provided.

Minor League Labor Beyond The Player, Brandon Ross

UNH Sports Law Review

No abstract provided.

"Access Granted": Analyzing The Growing Use Of Biometric Data Collection At Sports Facilities, Patrick Doll

UNH Sports Law Review

No abstract provided.

U.S. Olympic Grievance And Arbitration Rules That Affect Athlete Welfare, Benjamin Barger

UNH Sports Law Review

No abstract provided.

Sedentary Behavior Patterns After Acl Reconstruction, David M. Werner, Liubov Arbeeva, Yvonne M. Golightly, Balarinivasa R. Sajja, Michael D. Rosenthal, Matthew Tao, Elizabeth Wellsandt

International Journal of Exercise Science

International Journal of Exercise Science 18(4): 636-658, 2025. Individuals after anterior cruciate ligament reconstruction (ACLR) are less physically active than their uninjured peers, but little is known about their sedentary behavior (SB). This study aimed to identify patterns of SB in individuals six and 18 months after ACLR. Eighteen individuals after ACLR wore accelerometers for one week during six- and 18-month post-operative assessments (83.3% female, 19.7±5.6 years old, BMI 23.9±kg/m²). The percentage of awake time spent in SB was estimated. A multilevel (two time points – six and 18 months), multidimensional (13 hours) functional principal component analysis generated …

Reliability Of A Linear Position Transducer During The Bench Press Across Three Segments, Jennifer Rivera, Edward Pelka, Ryan Gant, Anthony G. Pinzone, Emily C. Tagesen, Modesto A. Lebron, Adam R. Jajtner

International Journal of Exercise Science

International Journal of Exercise Science 18(2): 622-635, 2025. The purpose of this investigation was to determine inter-set and inter-session reliability of the HUMAC360 measures for duration (DUR), peak velocity (PV) and mean velocity (MV) across three segments of the bench press. Seventeen recreationally active adults participated in this investigation. During visit one, participants completed a bench press one-repetition maximum (1RM). Visits two and three consisted of two sets of three repetitions at 30%-, 50%-, 60%-, and 70 %-1RM. Segments were defined by dividing total displacement into equal thirds at the bottom (BOT), middle (MID) and top (TOP). Intraclass correlation coefficients …

Comparison Of Energy Efficiency And Vegetation In Different Establishment And Management Systems Of Steep Mountainous Grassland In The Aso Area, Japan, K Kabata, C Okamoto, M Shimizu, M Kikuchi

IGC Proceedings (1977-2023)

The Aso area is one of the most important areas for grass­land agriculture in Japan. In this area there exists ca. 44,000 hectares of which ca. 28,700 ha are steep mountainous lands ( a gradient of more than 15 degrees). Additionally, there is much precipitation (ca 2.600 mm/year) in the area. Consequently, there is a problem of grassland destruction due to soil erosion. Therefore, in order to promote the utilization and conser­vation of steep grasslands, the following two experimental grazing were carried out: 1) a two pasture system and 2) a coexistent pasture system with introduced and native grasses. In …

Comparison De La Dynamique De La Vegetation De Deux Ecosystemes Herbagers Mesoxerophiles Apres Deprise Agricole Dans Le Massif Vosgien, S Muller

IGC Proceedings (1977-2023)

Les orientations actuelles de !'agriculture europeenne dans le cadre de la Politique Agricole Commune de la Communaute Economique Europeenne devraient conduire a !'abandon dans les decennies a venir de plusieurs millions d'hectares de terres agricoles en France, entrainant des modifications ecologiques et paysageres considerables. Dans le Massif Vosgien la deprise agricole, consecutive a la regression des industries traditionnelles et a !'elevation du niveau de vie, a provoque !'abandon depuis les annees 1950 de nombreux herbages, autrefois entretenus surtout par des pluri­actifs. Ces milieux evoluent alors vers des friches herbacees seboisant plus ou moins rapidement de maniere spontanee.

Massif Vosgien constitue …

Le Role Des Plantes Herbageres Dans La Limitation Des Pertes Des Principaux Elements Nutritifs Par Le Drainage, S Kopec

IGC Proceedings (1977-2023)

Depuis longtemps on connait !'action anti-erosive des plan­tes herbageres qui empechent d'une fa< ;on tres efficace l'affais­sement des particules de sol, en particulier sur des surfaces en pente. Dans ces derniers temps on parle de plus en plus souvent du role des herbages dans la limitation du drainage des elements nutritifs du sol et de nombreuses recherches menees a cet effet dans plusieurs pays le confirment (Jones, 1972; Gachon et Tri­boi, 1967; Kopec, 1985). Dans cette etude on a presente les resultats des recherches lysimetriques Sur la quantite des principaux elements nutritifs draines par les eaux s'evacuant des terrains agricoles couverts d'herbages et d'autres cultures.

Degradation Models And Their Use In Determining The Condition Of Southern African Grasslands, O.J H. Bosch, K Kellner, S.H E. Scheepers

IGC Proceedings (1977-2023)

An understanding of the processes of change is an important prerequisite for the development of techniques for the monitor­ing of condition and trend, and to interpret the ecological sig­nificance of determined condition classes. The approach to develop and use degradation models for determining range condition is illustrated in this paper by means of basic ecological data from the relatively high rainfall zone in the climatic climax grasslands (Mentis and Huntley, 1982) of southern Africa.

An Experiment And Study On A Air-Seeding Astragalus Adsurgens For Soil Conservation On The Loess Plateau Of China, Yimin Liang, Daiqiong Li, Xinhai Cong

IGC Proceedings (1977-2023)

The irrational land utilization has resulted in destruction of original vegetation and serious soil erosion on the Loess Pla­teau in China. At present, 1600 million ton of sediment is disch­arged into the Yell ow River per year. In order to explore effec­tive avenues to speed reestablishing vegetation for controlling soil erosion, we made an experiment in seeding forage and shrubs by airplane for four years, from 1976 to 1979, in semi­arid region on the Loess Plateau. We selected suitable plant species for aerial seeding on semiarid region, determined fit aerial seeding time and seeding rate through manual broadcast and air-seeding. …

Role Potentiel Des Legumineuses Annuelles A Ressemis En France, P Masson, G Gintzburger

IGC Proceedings (1977-2023)

L'interet pour les legumineuses annuelles a ressemis est recent en France malgre !'importance de la zone mediterra­neenne et atlantique dont ces plantes sont originaires. Le trefle souterrain (Trifolium subterraneum) et les luzernes annuelles (Medicago sp.) apparaissent respectivement dans notre littera­ture specialisee a la suite de travaux d'amelioration pastorate en Corse (Etienne, 1977) et des travaux de plusieurs labora­toires de l'Institut National de la Recherche Agronomique a Montpellier (Gintzburger et Prosperi, 1987). Apres 4 ans d'experimentation dans diverses situations des Pyrenees Orientates dans le sud de la France en climat mediter­raneen (pluviometrie moyenne annuelle de 575 mm a …

Agroforestry In The Southeastern United States, H A. Pearson, C E. Lewis

IGC Proceedings (1977-2023)

Agroforestry has been practiced for many years in the tropics by intermixing forages under palms, fruit trees, or hardwoods. Interest has increased in temperate zones for combining trees, pastures, crops, and livestock. Agroforestry in the United States is generally limited to the combining of pines, tame pastures, and cattle. Our purpose is to summarize results of research and developments in the southeastern United States on cool-and warm-season forages under planted pines and pine regeneration in tame pasture.

The Effects Of Heavy Metals Applied In Digested Sewage Sludge To Grassland, A Desira Buttigieg, D A. Klessa, D A. Hall

IGC Proceedings (1977-2023)

The application of potentially toxic elements in sewage sludge to grassland has implications to environmental pol­lution and the health of grazing rumiµants. In Scotland, mod­erately acid grassland receives most of the sewage sludge applied to agricultural land and there is therefore a risk of heavy metal mobilisation and uptake by herbage. In addition, soil ingestion (Fleming, 1986) and intake of herbage contami­nated with sludge adhering to leaf surfaces may present an important means by which potentially toxic elements are absorbed by ruminants. In this paper, two aspects of sewage sludge use on grassland are studied, namely : 1. Factors affecting …

Increasing Flora Diversity In Grassland Swards, R J. Haggar, D Jones

IGC Proceedings (1977-2023)

Europe's farmers are being encouraged to take land out of agriculture in order to reduce surplus cereal production. There is therefore, increasing scope for creating new species-rich swards, although guidelines for this purpose are lacking. Several reasons are advanced for encouraging species diver­sity and conservation, including recreational, ethical, education and resource utilisation. As leisure time increases, so public interest in conservation matters increases. Scientifically, there is a need to preserve genetic diversity and to understand the com­plex plant and animal relationship leading to a rich and varied community. This paper describes two experiments aimed at achieving a . highly diverse …

Grass Plan Density For Adequate Conservation Reserve Program Stands, D W. Meyer, D Rugroden

IGC Proceedings (1977-2023)

The Conservation Reserve Program (CRP), a federal program with the objective to reduce surplus feed grain pro­duction in the United States by idling marginal cropland, has already idled nearly 12 million hectares with a target of 32 mil­lion hectares. Idled land must be seeded to perennial grasses to help prevent soil erosion. The required grass seeding has caused the cost of grass seed to increase several fold ; therefore, estab­lishment cost could be reduced considerably if seeding rates could be reduced from the present recommended 215 to 323 seeds/m2 (Dodds, 1981). Recommended seeding rates were developed from research on establishment …

Multiple Of The Intermountain Region, Forest Service, United States Department Of Agriculture, J S. Tixier, A H. Winward

IGC Proceedings (1977-2023)

Initial custodians of the National Forests of the United States were primarily concerned about protecting what were perceived as deteriorating timber stands and watersheds. Con­siderable progress was made in correcting these problems in the first half of this Century. As the population of the United States grew, more people became interested in management of all resources on these public lands. Forest Officers gradually became stewards managing a broad array of lands and resources for which there were often conflicting interests and uses. A primary use of National Forests in the Western United States has been livestock grazing. Here, animals are …

Phosphatic Settling Pond Clays As Potential Forage Legume Seed Production Site, D D. Baltensperger, G M. Prine, D S. Wofford

IGC Proceedings (1977-2023)

Forage legume species perform a vital role in the agriculture of the state of Florida (Baltensperger et al., 1985a, 1985b, and 1987; Taylord et al., 1985). Cool-season cultivars adapted to this climate must also perform well in the Pacific Northwest or California since these are the primary areas of commercial seed production (Baltensperger et al., 1987). Commercial seed for the wa:m��s_eason species is typically produced in Florida. A pri­mary hm1tmg factor for seed production in Florida is the low water-holding-capacity of the sandy soils which necessitates frequent irrigation, subsequently reducing seed quality. Potential seed production areas include reclaimed phosphate minelands …

Influence Of Reduced Intensity Of Grassland Management On Herbage Yield, Forage Quality, Sod Density And Botanical Composition, P Dahmen, W Kuhbauch, U Thome

IGC Proceedings (1977-2023)

In the Federal State of Northrhine Westfalia, a number of programs have been initiated to reduce intensity of land use with respect to unwanted environmental effects presumably coming from conventional agricultural systems. On grassland most of the programs require delayed first cuttings for hay and silage, reduced fertilization and/or less grazing pressure on pastures. Field experiments were established in order to evalu­ate consequences of these programs for practical farming and grassland ecology. Treatments include conventional grassland management systems with intensive fertilization and utilization as well as intermediate and low intensity systems.