Digital Commons Network^™

C-Terminal Frameshift Variants In Gpkow Are Associated With A Multisystemic X-Linked Disorder, Jung-Wan Mok, Laura Mackay, Maria Blazo, Elizabeth Mizerik, Jozef Gecz, Renee Carroll, Mathilde Nizon, Sophie Rondeau, Madeleine Joubert, Silvestre Cuinat, Wallid Deb, Fernanda Valle Sirias, Monika Weisz-Hubshman, Shamika Ketkar, Urszula Polak, Alyssa A Tran, Debra Kearney, Neil A Hanchard, Oguz Kanca, Michael F Wangler, Hugo J Bellen, Brendan H Lee, Shinya Yamamoto, Keren Machol

Duncan NRI Faculty and Staff Publications

Purpose: GPKOW, a gene on the X-chromosome, encodes a nuclear RNA-binding protein important in messenger RNA (mRNA) processing as a spliceosome subunit. This work aims to establish GPKOW as a disease-associated gene.

Methods: We describe 3 males from 2 unrelated families with hemizygous frameshift variants affecting the last exon of GPKOW p.(Arg441SerfsTer30) and p.(Ser444GlufsTer28). The effect of p.(Ser444GlufsTer28) on gene expression was evaluated in patient's fibroblasts. In vivo studies in Drosophila melanogaster targeting the sole GPKOW fly ortholog, CG10324 (Gpkow) were performed.

Results: Clinical presentations included intrauterine growth restriction, microcephaly/microencephaly, and eye, brain, skin, and skeletal abnormalities. Heterozygote females presented …

Baseline Cognition And Demographic, Lifestyle, And Cardiovascular Risk Factors In Us Pointer, Amber Thro, Tiia Ngandu, Brad Caudle, Bonnie C Sachs, Michelle Chan, Kristin R Krueger, Elizabeth R T Hartman, Athene Lee, Michele K York, Marie T Austin, Kathryn E Demos, Thomas M Holland, Xiaoyan Leng, Rema Raman, Heather M Snyder, Maria C Carrillo, Rachel A Whitmer, Mark A Espeland, Laura D Baker

Faculty, Staff and Students Publications

Introduction: Validation of the primary cognitive composite and baseline cognitive characteristics are presented for the US-Study-to-Protect-Brain-Health-Through-Lifestyle-Intervention-to-Reduce-Risk (US POINTER).

Methods: US POINTER is a multicenter, randomized clinical trial of two lifestyle interventions testing cognitive benefit in older adults without significant cognitive impairment but at-risk for decline due to well-established factors. Cognition is measured using a global cognitive composite (US POINTER modified Neuropsychological Test Battery-PmNTB).

Results: The PmNTB is a valid cognitive composite, exhibiting good psychometric properties and tracking with other established outcomes. Among the 2111 enrolled participants (mean age = 68.2 years, 69% women, 31% from race and ethnic minoritized groups), …

Under The Legal Lens: Navigating Psychological Safety And Conflict For Black Women In Legal Support Roles, Chanel M. Bradden

Electronic Theses and Dissertations

The intersectional challenges of Black women in legal support roles are an overlooked phenomenon in organizational research. Despite diversity efforts in the legal profession, Black women face challenges due to gender, race, and professional status that impact their career advancement, as well as their mental and psychological well-being. As a result of experiencing the effects of racialized workplace dynamics and destructive leadership behaviors, Black women in legal support roles find resilience through self-protection strategies while working through the effects of intersecting forms of oppression in legal workspaces. This study addressed the lack of knowledge of the lived experiences of Black …

Non-Traditional Socio-Environmental And Geospatial Determinants Of Alzheimer's Disease-Related Dementia Mortality, Skanda Moorthy, Jean-Eudes Dazard, Zhuo Chen, Ruby Charak, Shruthika Palanivel, Salil Deo, Sadeer G. Al-Kindi, Sanjay Rajagopalan

Psychological Science Faculty Publications

Importance

Design

Capability Building And Quality Management In Higher Education: An Empirical Investigation, Kanwal Nasim, Xiaowen Tian

Journal of Global Education and Research

This paper proposes a resource-capability-based framework of quality management in Higher Education (HE) and empirically tests it against the experience of HE institutes in Pakistan. The paper posits that HE institutions face intensifying global education competition in a world of accelerated globalization, fast pace of technology development, and rapidly growing knowledge. To enhance quality and performance, they need to build higher-order dynamic capabilities of knowledge creation and transfer (KCT) undergirded by orchestrating three sets of resources they own or control: Staff, students, and facilities. The paper hypothesizes how HE institutions can orchestrate the resources to build up dynamic KCT capabilities …

Causes And Effects Of Science Tutor Attrition At The Colleges Of Education In The Northern Zone Of Ghana: A Qualitative Study, Collins D. Amadu, Rose Dognia, Solomon Boachie, Taarique-Ahmad Yahaya

Journal of Global Education and Research

The study investigated the causes and effects of science tutor attrition in the colleges of education in the Northern Zone of Ghana. Three science and mathematics colleges were used for the study. The study adopted a qualitative approach with 9 participants who volunteered to take part. The interview guide was the sole instrument for data collection. The interviews were conducted through face-to-face and phone calls. The recorded conversations were transcribed and categorized into themes. The study found that the science tutor attrition rate was caused by several factors. These factors could be grouped into unmet expectations of the tutors and …

Preparing For The Inclusive Classroom: The Self-Efficacy Of Teachers Towards Implementing Inclusive Educational Practices In South Africa, Nicole C. Drude, Luzaan Schlebusch

Journal of Global Education and Research

The South African Department of Basic Education has launched a phased initiative to transform ordinary mainstream schools into full-service schools (FSS) as part of its strategy for inclusive education. To ensure the success of this initiative, it is crucial to select schools that can equitably address the diverse learning needs of all students while maintaining high standards of instruction, intervention, and support necessary for achieving success in the core curriculum. Despite this, teachers have expressed concerns about the feasibility of the initiative, particularly due to their lack of expertise in supporting students with varied educational needs. This study aimed to …

Effectiveness Of Digital Learning Materials On Students' Achievement In Science: A Meta-Analysis, Bingo L. Aligo, Maricar S. Prudente

Journal of Global Education and Research

Researchers have been examining educational resources and content to enhance and support the learning experience. As technology continues to transform the way we learn and access information, digital learning materials have become increasingly popular in modern education. This study looked at how different kinds of digital learning materials affected science students’ learning achievement. The moderator variables used were grade level (kindergarten, primary, intermediate, and secondary), subject (biological sciences, general science, and physical sciences), and length of exposure (1 to 3 weeks, 4 to 6 weeks, and 10 to 12 weeks). A total of 14 studies were considered, involving 789 students …

Afghanistan: Consolidation Of Power Under The Taliban, Challenges And Sustainability, Ali Ahmad Jalali

Journal of Strategic Security

Four years after the return of the Taliban to power in Afghanistan, the country under the clerics’ rule is peaceful but not stable. The country is internationally isolated, economically in crisis and socio-politically divided. Despite earlier pledges to share power with other Afghan parties and respect democratic rights of all Afghans,^[i] the Taliban swiftly reinstated many of their harshest policies, pushing women out of public life and allowing no dissent.

Adhering to an ideology of radical exceptionalism, the ruling Taliban maintain control over the country through a totalitarian governance while keeping ideological ties with regional and global Jihadist groups. …

The Sports-Betting Market: A Road To Sports Betting As Viable Investing, Tyler Gottlieb

Vanderbilt Journal of Entertainment & Technology Law

Since its legalization, sports betting has experienced rapid growth, both in terms of economic output and expansion into more states. The current system of sports betting in the United States requires individuals to place bets using a sportsbook. The sportsbook sets the lines on every bet. If an individual wins their bet, the sportsbook pays them money according to the listed odds. If an individual loses their bet, the sportsbook keeps the amount staked. Sportsbooks set lines in a way to ensure that on average, they make money on every bet. This system has been widely accepted, often based on …

Clinical Best Practices For Radiation Safety During An Alpha Dart Treatment, Vibha Chaswal

All Publications

Alpha DaRT is a new alpha radiation treatment for treating solid tumors and is currently being evaluated through clinical trials worldwide. Being a novel radiation treatment, it is important to discuss the safety considerations and procedures that are needed to ensure safe use of this unique approach. The objective of this article is to provide a set of recommendations-radiation safety best practices that were developed based on operational and clinical experience.

Understanding Rural Schools’ Capacity To Learn About Evidence-Based Practices That Promote Youth Mental Health: A Comparative Case Study, Savannah Hobbs, Elaine S. Belansky, Nick Cutforth, Cynthia Hazel

The Rural Educator

Amid growing student mental health concerns, numerous evidence-based practices (EBPs) exist to promote student mental health, but most rural schools do not have these practices in place. Little is known about the organizational capacity of rural schools to learn about and select youth mental health EBPs, or the role research intermediaries can play to support these processes. In this study, 11 middle school staff from three rural school districts participated in surveys and semi-structured interviews to provide information on how schools learn about and select mental health EBPs, related barriers and facilitators, and the role of intermediary support. A semi-structured …

A Comparative Case Analysis Of Rural Science Teachers’ Experiences With Professional Learning, Loraine Glidewell, Jennifer Jacobs, Anna-Ruth Allen, William Penuel, Abraham S. Lo

The Rural Educator

This article presents a comparative case analysis of three U.S. rural science teachers who participated in an online course focused on designing assessments aligned with the Framework for K–12 Science Education and the Next Generation Science Standards (NGSS). Data from surveys, designed assessments, classroom observations, and interviews were used to investigate and compare these rural teachers’ experiences before, during, and after the course. This article describes the variations among rural science teachers in their local teaching contexts, relevant prior experiences, and how they engaged in and learned from professional development. The case study teachers entered the course with differences in …

Navigating Through Difficult Roads And Terrains: Novice Teachers’ Challenges In Teaching In Remote Mountainous Settings In The Philippines, Albert C. Albina, Sarah Jean A. Salmorin, Dannyla N. Cainos, Rhea Mae C. Montano

The Rural Educator

In rural areas, the adaptation of urban-originating elementary teachers to remote mountainous school locations poses substantial challenges and necessitates innovative strategies. This study primarily explored the lived experiences of newly hired elementary teachers residing in urban areas but assigned to remote mountainous locations, specifically focusing on their adaptation processes, the challenges they encountered, and support mechanisms that influenced their teaching roles. Using a descriptive phenomenological approach and reflexive thematic analysis, this study involved in-depth interviews with nine newly hired urban-originating elementary teachers who were assigned to teach in rural schools in the Municipality of Santa Catalina, Basay, and Bayawan City, …

Understanding Grade 10 Learners’ Mathematics Learning Experiences In Rural Schools: Applying The Self-Determination Theory, Hlamulo Wiseman Mbhiza, Thabisile Nkambule

The Rural Educator

The increasing performative expectation in mathematics continuously positions rural learners in a deficit manner within the education system in post-apartheid South Africa. The often-cited low academic performance of rural learners in mathematics fosters the belief that something is wrong with their mathematical learning abilities. The problem with narrow and often decontextualized perspectives of rural learners is that their interactions with mathematical content are frequently overlooked in education research. The purpose of this study was to critically explore grade 10 rural learners’ mathematics learning experiences. We employed a qualitative descriptive approach within a case study design, using semi-structured individual interviews supported …

Scaler Rates From The Pierre Auger Observatory: A New Proxy Of Solar Activity, S. Mancuso, A. Abdul Halim, P. Abreu, M. Aglietta, I. Allekotte, K. Almeida Cheminant, B. Fick, K. Nguyen, D. Nitz, Et Al.

Michigan Tech Publications

The modulation of low-energy galactic cosmic rays reflects interplanetary magnetic field variations and can provide useful information on solar activity. An array of ground-surface detectors can reveal the secondary particles, which originate from the interaction of cosmic rays with the atmosphere. In this work, we present an investigation of the low-threshold rate (scaler) time series recorded in 16 yr of operation by the Pierre Auger Observatory surface detectors in Malargüe, Argentina. Through an advanced spectral analysis, we detected highly statistically significant variations in the time series with periods ranging from the decadal to the daily scale. We investigate their origin, …

Co-Operative Care: The Case For Worker Co-Operative Elder Care In Ireland, Gerard Doyle

Research Outputs: 2025-Present

Ireland’s population age profile is forecasted to increase over the coming decades which will have implications for the care responsibilities of families and the state. However, there is a paucity of quality elder care in Ireland. Elder care worker co-operatives could contribute to meeting this shortfall in supply. This study examines the impact of co-owned elder care provision in Ireland. A case study approach is employed with the Great Care Co-op (GCC) being the case selected. The findings emphasise that the GCC provides a quality service to its care recipients. The careworker members and family members of care recipients both …

The Methane Clumped Isotope Signatures Of The Acetoclastic And Methylotrophic Methanogenesis Pathways, Mia L. Thompson

Dartmouth College Master’s Theses

Methane is a potent greenhouse gas and critical energy source for the global economy. Atmospheric methane concentrations play a critical role in global warming, while mitigating methane emissions may provide route to short-term reduction of warming effects. In order to track rates and sources of emissions, it is first necessary to understand the sources and sinks of methane; yet, there are challenges in distinguishing abiotic (water/rock), thermogenic, and biogenic methane. Traditional approaches of using the bulk isotopes of carbon (δ¹³C) and hydrogen (δD) of methane have limitations due to overlapping signatures and sensitivity to substrate isotope composition. In …

The Ghannouchi Test: The Compatibility Of Religious Ideas And Secular Democracy, Andrew P. Sheppe

Dartmouth College Master’s Theses

Secular, democratic societies and governments evolved out of religious societies and defined themselves partially in opposition to religious authority. This historical relationship has led to a debate about the compatibility between religious ideas and modern, secular society. Ernst-Wolfgang Böckenförde posited that secular, democratic societies still depend on religious foundations. Jürgen Habermas disagrees, claiming that processes of rational dialogue can provide sufficient support.

Two prominent twentieth century theologians, Reinhold Niebuhr and Abraham Joshua Heschel demonstrate that democratic systems are enriched and protected by theistic ideas, thus supporting Böckenförde’s dictum. However, they both recognize the importance of epistemic humility and a …

Chronic Illness Education 2025: Resources To Treat Seasonal Affective Disorder, Amanda Teschner, Ayonitemi Odukoya, Brooke Waldon, Joshua Spence, Katelynn Paluch, Marilyn Li, Mercylia Untono, Nina Agemy

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Building Healthy Habits: Preventative Strategies For Childhood Obesity, Alissa Ward, Cameron Craig, Chloe Sutlick, Gabrielle Henry, Isabelle Adams, Jerimiah Gumma, Omer Abdullah, Sami Zaidi

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Improving Access To Educational Resources And Health Outcomes For Diabetes, Ami Suresh, Conner Slotnick, Danielle Santoyo, Eric Mylfurry, Karen Abdelmalek, Martin Murad, Preston Parana, Urva Mehveen

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Exercise Initiatives To Improve Child Obesity, Alice Werynski, Ashley Simbafo, Diana Kernen, Koa Williams, Linda Beqaj, Noah Krepostman, Trevor Buck

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Resources To Improve Incidence Of Atherosclerotic Cardiovascular Disease, Anthony Kavanagh, Arianna Mcclellan, Asa Smith-Villegas, Djelika Kabore, Lina Shalaby, Tara Rahmani, Vyom Grover, Zackariah Farah

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Addressing Adolescent Depression Through Community And Systems-Based Care, Anirudh Gopalam, Connor Genschaw, Don'aa Williams, Gerardo Rubio Monroy, Jennifer Nnadozie, Murray Meri, Tina Tripathi, Abdullah Mahmood

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Empowering Families With Resources To Combat Childhood Obesity, Abisola Fasakin, Alqasim Elnaggar, David Abdelnour, Mujeebah Kamal-Muili, Prit Patel, Ryan Palazzolo, Sydney Huston

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Pediatric Depression And Anxiety: Hope Through Healthcare, Andreas Mozny, Arjan Goenaga Castillo, Audrey Millar, Ebony Williams, Griffin Lotze, Haytham Al-Qasmi, Kamontip Jongnarangsin, Tricia Jain

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Improving Lifestyle Choices In Children Withtype-2 Diabetes Mellitus, David Williams, Hariharan Ramakrishnan, Luv Thakkar, Sanjana Kumar, Srikar Munukutla, Stephan Gonzalez, Taqwa Naas, Ted Hirschfield

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Resources To Improve Diabetes Mellitus In Adult Males, Abdul Naser Zamzami, David Echeverri, Isabella Costa, Musaed Al Rashidi, Pooja Menon, Xiaohan Zhan, Zain Abdun-Noor

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Improving The Understanding Of The Complexities Underlying Adult Obesity, Ethan Montoya, Maria Villalba, Morzouk Lawal, Nataliah Jwaida, Safa Razvi, Susan Lagrand, Vittal Ashwin Kandukuri, Robert Chalhoub

Patient Education Projects

No abstract provided.