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Investigating The Determinants Of Influenza Entry And Spread In Human Airway Cells Using Fluorescence Microscopy, Zijian Guo

McKelvey School of Engineering Graduate Student Theses & Dissertations

Influenza A virus (IAV) remains a significant global health challenge. IAV utilizes the receptor binding protein hemagglutinin (HA) and the receptor destroying protein neuraminidase (NA) to facilitate infection. The activities of these proteins affect multiple steps in IAV life cycle. However, it remains unclear how these IAV factors influence infection dynamics in the context of a complex cellular environment encountered in the respiratory tract. In this work, we use fluorescence microscopy and human airway epithelial cells to study influenza biology at the single-cell and single-virion level, revealing key insights into viral binding, entry, and spread. First, we focused on the …

Effective Strategies That Marketing Leaders Use To Increase Fan Base, Denise Leslie Rosa

Walden Dissertations and Doctoral Studies

Despite its growth and potential, the Women’s National Basketball Association (WNBA) consistently struggles to generate profit, remaining unprofitable in its 28th (2024) season and heading into its 29th (2025) season. The inability of women’s professional basketball marketing leaders to generate increased revenue and fan engagement has limited the sport’s growth and visibility. Grounded in McCarthy’s four Ps of marketing concept that includes product, price, place, and promotion, the purpose of the qualitative pragmatic inquiry project was to identify and explore effective and innovative marketing strategies that marketing leaders use to increase the revenue of women’s professional basketball teams and their …

Neighborhood Environment And Incident Diabetes, A Neighborhood Environment-Wide Association Study ('Ne-Was'): Results From The Hispanic Community Health Study/Study Of Latinos (Hchs/Sol)., Cara M. Smith, Elizabeth W. Spalt, Linda C. Gallo, Jordan A. Carlson, Matthew Allison, Daniela Sotres-Alvarez, Christina Cordero, Qibin Qi, Earle C. Chambers, Martha Daviglus, Amber Pirzada, Gregory A. Talavera, Robert Kaplan, Joel D. Kaufman, Stephen J. Mooney

Manuscripts, Articles, Book Chapters and Other Papers

The prevalence of type 2 diabetes is increasing among the Hispanic/Latino population. Type 2 diabetes incidence rates vary between neighborhoods, but no single aspect of the neighborhood environment is known to cause type 2 diabetes. Using data from the Hispanic Community Health Study/Study of Latinos cohort of 16,415 Hispanic/Latino adults in four major US cities, we conducted a neighborhood environment-wide association study to identify neighborhood measures or clusters of measures associated with diabetes incidence. Two-hundred and four neighborhood measures were calculated at the census tract level or within a 1-km buffer of participants' residential addresses. Independent covariate-adjusted and survey-weighted Poisson …

Rethinking The Applicability Of Section 8 Of The Canadian Charter For The Information Age And Beyond, François Tanguay-Renaud

All Papers

The Supreme Court of Canada’s interpretation of the right to be secure against unreasonable search and seizure guaranteed by section 8 of the Canadian Charter of Rights and Freedoms has remained fairly stable since the adoption of the Charter. Or at least, that is how the Court’s section 8 jurisprudence to date makes it seem. Yet, in some recent decisions dealing with digital communications and the internet—culminating in the 2024 case of R. v. Bykovets—the Court has, implicitly, brought into question the foundational principle based on which the right has historically been circumscribed. Or so I argue in …

Network Intelligence For Next-Generation Wireless Networks: Advancing Distribution And Coordination, Yonatan Melese Worku

Electrical and Computer Engineering ETDs

Next-generation wireless networks, encompassing 6G and beyond, face rigorous demands for ultra-low latency, ubiquitous connectivity, exceptionally high data rates, and robust security, necessitating innovative approaches to resource optimization and network protection. This dissertation proposes a pioneering framework that synergizes advanced methodologies—deep reinforcement learning, deep learning, blockchain, and multi-agent systems—to address these challenges. Distributed architectures, underpinned by AI-driven multi-agent systems, form the backbone of this framework, enabling seamless integration and intelligent orchestration across diverse domains. The research advances IoT-based systems leveraging machine learning for resource efficiency in healthcare applications, develops reinforcement learning-driven frameworks to optimize energy and coverage for Unmanned Aerial …

Finite Element Investigation Of Blast Load Responses In Nuclear Power Plant Containment Structures, Janak Raj Awasthi

Civil Engineering ETDs

Some significant incidents like the Chernobyl disaster (1986), the Fukushima Daiichi hydrogen explosion (2011), and some frequent military and terror threats to the nuclear Power plant structures have led to studying the capacity of power plant structures to withstand blast loadings. From this research, even one-third of the loss of the coolant is enough to damage the power plant structure. Crack starts from the wall and propagates toward the top of the dome and the foundation. The external blast shows high damage symptoms near the foundation area. Most of the steel members, including the rebars, Liner, and Tendons, showed high …

“…Stay On It…”/A Theory///“Illumination Happens”//, Lara E. Goldmann

Art & Art History ETDs

“…stay on it…”/a theory///“illumination happens”// is a critical engagement with the work of contemporary Black artists Arthur Jafa and Adam Pendleton, explored through the lens of the Black radical tradition. Bridging aesthetics, politics, and history, the dissertation investigates how their visual, sonic, and conceptual practices articulate Black life, insurgency, and imagination.

Drawing on theorists such as Fred Moten, Sylvia Wynter, Hortense Spillers, Frantz Fanon, and Cedric Robinson, the study constructs a framework that considers Blackness as an ontological, social, and aesthetic force. It examines how Jafa and Pendleton unsettle dominant epistemologies, staging acts of refusal and creation that resonate within …

Lifestyle Factors Contributing To Occupational Heat-Related Acute Kidney Injury, Jonathan Specht, Fabiano Amorim, Flavio De Castro Magalhaes, Zachary Mckenna, Zachary Schlader

Health, Exercise, and Sports Sciences ETDs

Workers worldwide are at risk for acute kidney injury due to hyperthermia and dehydration as a consequence of exertional heat stress. Limited research has explored the impact which lifestyle agents such as beverages, recreational drugs, and medications have on core temperature, hydration, and risk of acute kidney injury during physical work in the heat. To address this research gap, we explored the impact of three agents frequently used by construction workers on thermoregulation and markers of risk of acute kidney injury. First, we investigated the effect which ibuprofen ingestion has prior to one hour of running in the heat on …

Assessing The Ecological Drivers And Consequences Of Partial Migration In Hudson River Striped Bass Over Three Decades, Caitlin Egan Zimmer

Biology ETDs

Climate change and shifts in human land use have caused extensive impacts to the connectivity, structure, and resilience of aquatic populations. Partial migration (PM), where only some individuals from a population migrate while the rest remain resident, can mitigate population-level responses to environmental stressors. However, little is known of the underlying mechanisms promoting variation in migration and whether these shift over time. In the Hudson River Estuary, striped bass (Morone saxatilis) are known to exhibit anadromous PM behavior. Here, I measured carbon isotopes (δ¹³C) of essential amino acids in striped bass scales to determine variation in …

The Island Biogeography Of Mangrove-Dwelling Vertebrates: Isolation, Specialisation, And Extinction, Jian Xiong David Tan

Biology ETDs

Mangroves are highly dynamic ecosystems that are widely distributed across the coastlines of the tropics and subtropics. Despite their low plant diversity, mangroves host a disproportionately high number of terrestrial vertebrate taxa. However, mangrove specialists — taxa that only occur in mangrove habitats — exhibit a global distribution that is incongruous with the broader background distribution patterns of mangrove-associated fauna, exhibiting higher diversity in Australia and Southeast Asia. This dissertation therefore aims to assess how the diversity and distribution of mangrove specialist fauna may have been shaped by the historical biogeography of mangroves, and the effects of mangrove specialisation on …

Plant Reproductive Strategies Shift In Response To Restoration Using Beaver Dam Analogs, Laurel F. Martinez

Biology ETDs

As riparian communities become increasingly degraded, restoration treatments are being implemented in streams to recover ecosystem functions. In the Jemez Mountains, beaver dam analogs (BDAs) are used to restore degraded streams by connecting the floodplain and increasing the extent of anoxic soil conditions. These environmental disturbances are expected to alter how riparian plants recruit, particularly their allocation to seed-based and vegetative regeneration strategies. We investigated whether BDAs and associated changes in soil water filled pore space (WFPS) affected riparian plant recruitment. We investigated the number of flowering stems as a proxy for seed-based regeneration and rhizome length and mass as …

Predicting Leakage From Nuclear Material Containers At Los Alamos National Laboratory Through Drop Testing, Leak Testing, Finite Element Analysis And Digital Image Correlation, Jude M. Oka, Yu-Lin Shen, Osman Anderoglu, Pankaj Kumar, Rajendra Vaidya

Mechanical Engineering ETDs

Los Alamos National Laboratory (LANL) relies on containment vessels to safely manage special nuclear material. These containers are subject to rigorous testing—such as drop, fire, and water ingress testing—to ensure integrity under adverse conditions. While elastomer-based seals are well studied, metal-to-metal sealing mechanisms remain under investigation, particularly under dynamic loading. This research focuses on the relationship between container mating surfaces and impact loading through drop testing. Finite Element Analysis (FEA) models were developed and validated using Digital Image Correlation (DIC) to measure strain during impact. Drop tests at varying heights showed strong correlation between FEA and DIC results, confirming the …

Networked Systems: Synchronization, Decomposition And Transient Dynamics, Amirhossein Nazerian

Mechanical Engineering ETDs

This dissertation investigates synchronization, transient dynamics, control, and signal amplification in networked dynamical systems. First, it examines complete and cluster synchronization, including cases with large parametric mismatches, in both natural (e.g., brain networks, fireflies) and technological systems (e.g., power grids, robotics). Second, it studies transient dynamics in consensus processes, designing synchronization strategies that link reactivity, contraction theory, and Lyapunov exponents. Third, it addresses the computational limits of Model Predictive Control (MPC) for large networks by introducing an algebraic decomposition method that enables parallel online computation of smaller subproblems, enhancing MPC performance under hardware constraints. Finally, it analyzes the structural role …

Instability Analysis In Cylindrical Thin Film–Compliant Core Structures: Numerical Simulations And Effects Of Inelastic Deformation, Md Al Rifat Anan

Mechanical Engineering ETDs

When a thin film bonded to a thick compliant substrate is subject to in-plane compression, wrinkles can develop if the critical state for instability is reached. In various applications the film/substrate system may also take the form of cylindrical fibers, where an axial compressive loading can trigger axisymmetric wrinkles. A straightforward computational approach to simulate such wrinkling behavior is needed for material design, to either prevent wrinkling or to exploit its benefits for flexible device applications. In this work a comprehensive numerical study is undertaken by employing the finite element method. The embedded imperfection approach used previously for planar structures …

Multiscale And Multi-Model Studies Of Metal Plasticity, Luo Li

Mechanical Engineering ETDs

Plastic deformation is the process in which the material deforms permanently due to external effects. Twinning and slip are two main mechanisms of plastic deformation in metallic materials. The prominent mechanism of plastic deformation in metals that have FCC crystal structures is slip or gliding movement of dislocations, which is mainly focused on here. In the current study, frameworks for investigating plasticity phenomena of metals at different scales ranging from microscale to macroscale are demonstrated. Specifically, the macroscale modeling of plastic response of metallic materials induced by indentations are emulated by nonlinear FEA simulations. Simulation results of macroscale modeling are …

Phase Nanoscopy With Correlated Frequency Combs, Xiaobing Zhu

Optical Science and Engineering ETDs

In this dissertation a sensing method applying to any physical quantity that modifies optical phase is developed. Two pulses are produced inside a synchronously pumped Optical Parametric Oscillator, generating two identical, undistinguishable frequency combs. The physical quantity to be measured applies a small phase shift/round trip to one of the pulses, resulting in a frequency shift of the corresponding comb. The latter frequency is measured as a beat by interfering the two combs on a detector. A world record resolution, close to the quantum limit, of 0.033 nanoradian (corresponding to 0.006 fm in displacement) is achieved. A detailed analysis of …

Advancing Diamond Quantum Sensors: Isotropic Flux Concentrators And Phase Noise Mitigation, Maziar Saleh Ziabari

Optical Science and Engineering ETDs

Two methods for improving the sensitivity of nitrogen vacancy quantum sensors in diamond are explored. First, by passively concentrating the magnetic flux, three orthogonally oriented ferrite truncated cone pairs amplify the field isotropically by 19 times, allowing measurement of Earth's field without a bias field and increasing sensitivity. Through thorough analysis, modeling and tuning a novel 3-dimensional flux concentrator system, we achieve a fractional standard deviation of less than 1% anisotropy and quantify minimal deadzones and ambient temperature-limited variations below 40 nT/hour. Second, we characterize, model and calculate phase noise in NV experiments, which in NV sensors is effectively indistinguishable …

A Systematic Approach To The Characterization Of Liquid-Vapor Coexistence In Platinum, Meghan K. Lentz

Physics & Astronomy ETDs

Platinum is a material standard used in high pressure and shock compression experiments at Sandia National Laboratories. During experiments, materials are subjected to a very large range of thermodynamic conditions, during which materials regularly enter the liquid-vapor coexistence region. Despite its status as a standard, the region around the liquid-vapor critical point is poorly understood for platinum, with reported critical temperatures spanning approximately 7000 K. In this dissertation we conduct density functional theory based molecular dynamics (DFTMD) simulations for platinum for a range of temperatures and densities near liquid-vapor coexistence. The phase diagram for platinum is refined near the critical …

An Arc Of Time Through Crime: Representations Of Gypsies And Travellers In Police Killings, Coretta Phillips, Becky Taylor, Zoë James

School of Law, Humanities and Social Sciences

This paper examines newspaper stories reporting on the killings by Gypsy and Traveller offenders of PC Leslie Meehan in 1960 and PC Andrew Harper in 2019. These media representations are used as heuristic devices to explore differing media discourses about this white minority ethnic group. Sixty years apart, these stories demonstrate supportive media commentary in the earlier period and more corrosive coverage in the recent period. Making a contribution to historical criminology and its consideration of race, this paper draws from extensive archival analysis and the extant literature. It highlights the political-economic significance of home ownership, the partial inclusion of …

Understanding The Metallic And Oxide Phases In Platinum-Based Bimetallic Heterogeneous Catalysts After High-Temperature Oxidation, Stephen John Porter Jr

Nanoscience and Microsystems ETDs

Platinum (Pt) and palladium (Pd) are critical components in diesel emission control systems, enabling the conversion of harmful pollutants under demanding conditions. However, Pt’s effectiveness is hindered by sintering under high-temperature oxidizing environments. This dissertation investigates how Pt and Pd evolve under oxidizing conditions at 800°C, highlighting their distinct thermodynamic behaviors and interactions. Using TEM, EDS, EELS, XRF, XRD, and EXAFS, we show that Pd suppresses Pt sintering by reducing the volatility of PtO₂, leading to the formation of stable particles. Both Pt and Pd are present in metallic and oxide states, forming biphasic 'Janus' particles with conjoined metal and …

Using Triple Oxygen Isotopes To Investigate Water Usage In Desert Ecosystems, Cloe V. Knutson

Earth and Planetary Sciences ETDs

In arid environments, maintaining water balance can be more critical for survival than obtaining food. As droughts intensify, understanding how animals manage body water is essential. Triple oxygen isotope analysis provides a novel way to trace water sources in animals, distinguishing contributions from free water, food-derived oxygen, and atmospheric O₂. We developed an equilibration method using CO₂–H₂O oxygen exchange and measured δ^’18O and Δ^’17O values via tunable infrared laser direct spectroscopy (TILDAS). Validated against traditional fluorination methods, this technique enables streamlined analysis of whole blood and plant samples. Applied to …

Modeling Mars Chaos Terrains As Fracture Mosaics, Aidan C. Buie

Earth and Planetary Sciences ETDs

Chaos terrain exists on several planetary bodies but most notably on Mars. With 30 different named terrains and hundreds of chaotic or ”chaos-like” terrains, they are one of the most prominent and visible features on the planet. Chaos terrains have many visible similarities to each other: they all are comprised of polygonal blocks separated by fractures or channels. These blocks vary from angular to rounded and from flat plateaus to small hills, and the fractures vary from flat floored to ”v” shaped. Often, a single chaos will contain all of these morphologies. Most of the 30 named chaoses on Mars …

A Mutational Analysis Of Thatisin: How Single Point Mutations Impact The Biosynthetic Process Of A Group 16 Graspetide, John F. Boynton Jr

Chemistry and Chemical Biology ETDs

Abstract:

Graspetides are a family of Ribosomally synthesized and Post-translationally modified Peptide (RiPP) natural products named for their ATP Grasp Macrocyclases. We identified several Graspetide Biosynthetic Gene Clusters containing common double glycine cleavage motifs and attempted characterization of the mature Graspetides. One of the resulting peptides, Thatisin, has a topology with two interlocking macrolactones installed by a single ATP Grasp Ligase named ThtC. Here we use single and double point mutations to observe the impact or variation on the installation of these macrocycles. Alanine scan mutagenesis is used to assess leader peptide residues in the precursor peptide ThtA to determine …

Improving Infiltration Model Performance In Arid And Urban Regions, Samuel Stephen Coulter

Civil Engineering ETDs

Flooding in arid regions is infrequent but damaging and limited historical data makes flood modeling an important tool for flood infrastructure design. This study improves flood modeling guidance by using plot-scale tests to determine the impact of slope, compaction, gravel mulch and landscape fabric on infiltration and runoff rates in sandy soil types. This data will be used as guidance for the linear and constant model. The performance of this model was compared with the curve number model for a hypothetical 100-year design storm. Results showed that gravel mulch increased infiltration rates by 66% and reduced erosion on steep and …

Addressing Head Injuries In High School Football: An Assessment Of Best Practices And Challenges In The Area Of Concussions As Held By New Mexico Activities Association High School Varsity Football Head Coaches And Athletic Directors, Alonzo Maestas

Health, Exercise, and Sports Sciences ETDs

Youth sports participation in the United States offers children and adolescents opportunities for physical activity, skill development, social interaction, and personal achievement. However, with sports comes the risk of injury, including concussions. Concussions can have serious long-term consequences such as chronic traumatic encephalopathy (CTE). In response to the risks of concussions, New Mexico enacted a concussion law, NM Stat 22-13-31. In addition to this law, the New Mexico Activities Association (NMAA) and National Federation of High School Associations (NFHS) have also given guidance on how to manage concussions.

However, there is a gap in the literature concerning concussion education, best …

Secured Through Stone: The Power, Monuments, And Memory Of Thyra Danmarkarbót And The Jelling Dynasty, Jacquelyn Truitt

History ETDs

Sometime in the mid-tenth century on the Jutland peninsula of Denmark, the Viking Age Queen Thyra (d. ca. 958/9) passed away and the epithet Danmarkarbót—Denmark’s Adornment—was skillfully carved onto her memorial runestone. Yet Thyra’s story has been clouded by few and unreliable textual sources, by differing assessments of her familial background that have emerged from those sources, and by misrepresentations of the material culture relating to her. This thesis explores Thyra and her place within the Viking Age Jelling dynasty through textual and material evidence and considers how the construction of both medieval and modern memory work and memorialization …

Interdependence And Place In Mescalero Homelands, 1660-1865, Joseph A. Ukockis

History ETDs

This dissertation examines strategic relationships that Mescalero Apaches made among themselves and with non-Mescalero communities from 1660 to 1865. It references Mescalero place names in piecing together pertinent stories across their vast ancestral homelands, demonstrating regional continuities in social, political, and economic dynamics over two centuries. It argues that bonds of interdependence, rather than armed resistance, were critical in maintaining autonomy and the ability to move freely, conduct effective diplomacy to protect claims to homelands, access resources in times of scarcity, and form key alliances that presented possibilities for resistance to colonial domination. Central to these dynamics were Mescalero and …

College Football Or Abortion Education? An Examination Of The University Of Arizona’S 1974 Stadium Bonds Bill, Emma Masterson

History ETDs

In 1974 the University of Arizona renovated their football stadium through a bonds bill passed by the state legislature. The renovations allowed the university to increase the stadium’s capacity by 17,000 seats. While in the state house, an Arizona Congressman attached a rider to the bonds bill banning the university’s medical school from performing abortions in most circumstances, effectively barring the university from teaching the medical students how to perform the procedure as well. This thesis seeks to position the University of Arizona football stadium renovations and abortion ban within the larger histories of American higher education and Arizona. This …

Immune Regulation In Fungal Airway Inflammation And Host Defense, Ruoning Wang

Biomedical Sciences ETDs

Asthma is a chronic inflammatory disease of the lungs characterized by complex pathophysiological mechanisms and diverse endotypes, primarily categorized as T helper type 2 cell (Th2)-high and Th2-low asthma. Despite significant advances in understanding asthma pathogenesis, the mechanisms governing the pulmonary immune system’s response to external challenges have not been fully understood. To address these gaps, this comprehensive project was designed to investigate the interplay between fungal infections and specific CD4⁺ T cell populations in asthma. Our findings suggest that fungal infections can contribute to neutrophilic asthma by promoting the migration of platelet-myeloid aggregates into the lungs. We also …

Minimal Error Functions On Irregular Subsets Of The Real Line, Robert Michael Dukes

Mathematics & Statistics ETDs

Chebyshev Polynomials, those that minimize the maximal error on a compact set, are one of the most practical tools for approximating smooth functions. The classical results are on the set [-1, 1]; in this paper, we extend to more complicated subsets of the real line. We demonstrate some classical results and then take the result from [2] on regular Parreau-Widom Sets and extend it to semi-regular sets, defined as sets whose regular part is closed. We introduce the Regularity Coefficient as a series formed by evaluating the Green’s Function at irregular points. This new machinery is applied to the lower …