Digital Commons Network^™

Global Trail: Interactive Travel Memory System For Unesco Sites, Anne Sophie Beatrice Min Fa

Theses

Global Trail is an interactive mobile app designed for travellers or culture seekers to reimagine how they discover new places, engage with cultural sites and remember their travel experiences. In this digital world, photos get easily lost in phone galleries and sometimes lack an organized way to find specific memories to places visited. Through design, the app experience addresses three core objectives: Discover — users explore Unesco sites represented by badges through an interactive world map; Engage — they unlock and earn those badges when they visit those sites where they can post their memories on a community platform; and …

Multiplex Leiden Optimized Dynamic Network Microsegmentation And Flow Validation For Software Defined Networks, Rashed Husni Rashed Alnuman

Theses

Modern digital infrastructure is fundamentally built upon robust networks, which underpin seamless communication, data exchange, and the operation of critical systems. These networks facilitate everything from internet access and real-time patient vital sign transfers in healthcare to the management and control of industrial processes. As demands on networks have surged, their complexity and functionality have evolved significantly, continuously adapting to diverse sectoral needs. However, this rapid evolution has also amplified security challenges. The escalating scale and intricacy of contemporary networks have exposed vulnerabilities that traditional perimeter-based security models are often insufficient to counter. Static defenses prove inadequate in dynamic environments …

Towards A Foundational Framework For Real-World Active Learning: Theory, Algorithms, And Applications, Dayou Yu

Theses

While supervised learning has seen great success in the modern machine learning era, the challenge of obtaining high-quality labeled training data still exists. In many knowledge-rich domains, we still face the problem of letting machine learning models learn well using a limited number of labels. Active learning (AL) has been a prominent learning paradigm that deals with such problems. This thesis reviews the classical challenges of AL, summarizes how our prior work has advanced the field, and charts a course for adapting AL to realistic and challenging scenarios. We begin by discussing past work on standard scenarios for AL, including …

Retrofitting An Fdm Printer For 3d Printing With Cotton Yarn: A Novel Approach And Mechanical Property Evaluation, Muhammad Aghead Al Arnaout

Theses

The rapid rise of 3D printing in industry has intensified research into developing advanced and sustainable printing materials, as the properties of the feedstock directly influence the performance of the final product. This thesis investigates the integration of natural cotton yarn into PLA (Polylactic Acid) to enhance mechanical behavior while maintaining cost-effectiveness, using a standard 3D printer without any modifications. Experimental results across three phases demonstrated consistent improvements. In the first phase, cotton–PLA composites exhibited higher ductility (+22.27%) and toughness (+10.51%) than pure PLA, albeit with lower stress values and a slight decrease in Young’s modulus. In the second phase, …

On The Adaptation Of Latent Dynamics Models, Ryan Missel

Theses

Predicting future states of high-dimensional, partially observed dynamical systems - such as cardiac electrical propagation - is crucial for advancing fields like healthcare and physics. While univariate time-series forecasting is well-explored, high-dimensional time-series forecasting presents unresolved challenges. These challenges include the computational burden of processing high-dimensional data and the difficulty of accessing the system’s underlying dynamics directly. Classical optimization and analytical approaches become impractical as the dimensionality increases, leading to a growing interest in data-driven deep learning models, particularly those based on latent dynamics functions. Latent dynamics models provide an efficient way to map high-dimensional observations into lower-dimensional latent spaces, …

Waveform Systematics In Moderate Mass Ratio Binary Black Hole Systems, Rachel E. Mechum

Theses

Gravitational wave (GW) observations of binary black hole (BBH) mergers by advanced LIGO (aLIGO) have transformed our understanding of compact objects (COs). As detector sensitivity improves, new populations consisting of moderate to high mass ratio binaries will become increasingly accessible. Parameter estimation (PE), a process that extracts source properties such as masses and spins from GW signals, is critically dependent on accurate waveform models. However, current models may use approximations that introduce systematic errors for binaries with mass ratios between 0.05 and 0.5, affecting parameter accuracy and scientific interpretation. Using the Rapid Iterative FiTting (RIFT) algorithm, this work quantifies waveform …

Link Between Adverse Childhood Experiences And Parenting Styles Of African American Fathers, Tatianna P. Johnson

Dissertations

African American fathers may be more susceptible than fathers of other races to having a negative parenting style due to their high levels of adverse childhood experiences (ACEs). ACEs are traumatic experiences during childhood that can affect a person’s mental and physical health, income and adult parenting style. African American adults tend to have experienced multiple levels of ACEs at a higher rate than White and Asian adults (Maguire-Jack et al., 2021). ACEs can lead to adults experiencing higher levels of alcoholism, depression, health-related issues, mental illness, substance use, and academic problems. The purpose of this cross-sectional study was to …

The Impact Of Culture And Language On Internal Communication And Patient Care In Small To Medium-Sized Black Immigrant-Owned Healthcare Practices In Texas., Chisom Nwosu

Dissertations

This qualitative phenomenological study explored how cultural competency in small to medium-sized Black immigrant-owned healthcare practices in Texas affects internal communication and patient care. Through semi-structured interviews with nine clinical and administrative leaders in Dallas and Houston, five themes emerged: culturally competent leadership, intentional communication structures, language and interpretation practices, patient-centered cultural sensitivity, and the use of technology for adaptation. Findings suggest that culturally aware leadership and inclusive communication strategies foster team cohesion and improve patient trust and care. Participants reported adapting workflows to meet religious, language, and communication needs through human and technological tools. The study underscores embedding cultural …

Impact Of Hereditary Angioedema Attacks On Health-Related Quality Of Life And Work Productivity, Maeve O'Connor, Paula J Busse, Timothy J Craig, Cristine Radojicic, H James Wedner, Sherry Danese, Julie Ulloa, Vibha Desai, Tomas Andriotti, Paul K Audhya, Sandra Christiansen

2020-Current year OA Pubs

BACKGROUND: Hereditary angioedema (HAE) negatively impacts health-related quality of life (HRQoL). Few studies have characterized impairments to HRQoL, work productivity, and well-being during and following HAE attacks.

METHODS: Patients with ≥1 HAE attack in the previous 3 months were recruited by the United States (US) HAE Association (HAEA) to complete an online survey. Respondents were categorized into those who did (Treated Cohort) and did not (Untreated Cohort) manage their last attack with on-demand treatment (OD). Adapted versions of the EuroQol-Five Dimensions-Five Levels (EQ-5D-5L), EuroQol Visual Analogue Scale (EQ VAS), and Work Productivity and Activity Impairment-General Health assessments were used.

RESULTS: …

High-Density Lipoprotein-Associated Cholesterol Abnormalities In A Clinical Outcomes Study Of Dysferlin-Deficient Limb-Girdle Muscular Dystrophy Type R2, Zoe White, Alan Pestronk, Et Al.

2020-Current year OA Pubs

BACKGROUND: Limb-girdle muscular dystrophy (MD) type R2 (LGMDR2, formerly LGMD2B) is an autosomal recessive form of MD caused by variants in the dysferlin gene, DYSF. It leads to slow proximal and distal muscle weakening that generally results in loss of ambulation around early adulthood but without the lethal cardiorespiratory dysfunction observed in the more severe Duchenne MD. How loss of dysferlin causes muscle fibre death is poorly understood, but recent evidence suggests a link between muscle wasting and loss of muscle cholesterol homeostasis with circulating lipoprotein abnormalities in many forms of MD.

METHODS: Cross-sectional circulating total cholesterol (CHOL), high-density lipoprotein-associated …

Characteristics Of Responders To Interventions For Parkinson Disease: A Scoping Systematic Review, Sidney T. Baudendistel, Gammon M Earhart

2020-Current year OA Pubs

AIMS: The purpose of this review is to identify the characteristics of responders in interventions targeting motor function for individuals with Parkinson disease.

MATERIALS & METHODS: The primary search included, 'Parkinson' + 'responder.' A second, broader, search further included 'response' + 'responsiveness' + 'responsive.' Records were sorted by intervention: neuromodulation, pharmaceutical, physical, and placebo.

RESULTS: Thirteen studies were identified in the primary and 19 studies in the secondary search, culminating in 120 characteristics. For neuromodulation interventions, responders were younger at onset, more responsive to levodopa, and had more difficulties with activities of daily living. Responders to pharmaceuticals were younger at …

The Evolution Of The High Redshift Quiescent Population In Cosmos-Web, Carter B. Flayhart

Theses

Understanding the quiescent galaxy population is incredibly important in the context of galaxy evolution. These galaxies are defined as having a low star formation rate, and their evolved stellar populations makes them identifiable by their redder colors in both the observed and rest-frame. Since their rest-frame optical emission lies in the infrared (IR) regime, observations of these galaxies at high redshifts were quite difficult prior to the launch of the James Webb Space Telescope (JWST). Recent observations of this high redshift population conflict with galaxy formation and evolution models that existed prior, with quiescent galaxies being detected more frequently than …

Autophagy Regulates Müller Glial Cell Inflammatory Activation, Teresa A Doggett, Zhenqing Zhou, Sohini Rebba, Jacqueline Unsinger, Philip A Ruzycki, Thomas A Ferguson

2020-Current year OA Pubs

PURPOSE: We tested whether Müller cells utilize autophagy to support immune privilege in the eye.

METHODS: The essential autophagy gene Atg5 was deleted in retinal Müller cells. Inflammation was induced by intravitreal injection of lipopolysaccharide (LPS) that was monitored by hematoxylin and eosin (H&E) staining, immunofluorescent confocal microscopy, and flow cytometry. Single-cell RNA sequencing was performed on retinal Müller cells isolated from control and Atg5-deficient mice. Markers of Müller cell gliosis were assessed, and cytokine production in the eye was measured. Small interfering RNA knockdown techniques were used to examine LPS-induced inflammatory pathways in culture.

RESULTS: We observed increased and …

Longer Scans Boost Prediction And Cut Costs In Brain-Wide Association Studies, Leon Qi Rong Ooi, Scott Marek, Nico U F Dosenbach, Timothy O Laumann, Evan M Gordon, Et Al.

2020-Current year OA Pubs

A pervasive dilemma in brain-wide association studies

Barriers And Facilitators To Accessing Healthcare For People With Parkinson's Disease In Latin America: A Qualitative Study, Christine Jeyachandran, Catherine Spooner, Ana Margarita Rodriguez Salgado, Matthew Prina, Joel Rhee, Jorge Jesus Llibre-Guerra, Dani Kim, Juan J Llibre-Rodriguez, Mark F Harris

2020-Current year OA Pubs

AIMS: The aim of the study was to identify the barriers and facilitators to healthcare access for people with Parkinson's disease (PWP) in Spanish-speaking Latin American countries (LAC) in Central and South America, to understand their drivers and consider the implications for health systems in LAC.

METHODS: Four online semi-structured focus groups were conducted with 25 PWP who provide education and/or support to PWP. The study was designed and implemented by a person with lived experience of PD. Data were mapped to an existing model of access to healthcare that incorporates provider and consumer abilities.

FINDINGS: There were multiple provider …

Formation Control Between Leader And Migratory Follower Tissues Allows Coordinated Growth, Toru Kawanishi, Takamichi Sushida, Tony Y-C Tsai, Hiroyuki Takeda, Sean G Megason

2020-Current year OA Pubs

Coordinated growth of multiple tissues is fundamental to shaping our body, but the underlying mechanisms remain underexplored. In zebrafish embryos, midline tissues composed of the notochord, floorplate, and hypochord elongate synchronously with their lengths aligned. We show that floorplate and hypochord cells collectively migrate posteriorly along the nascent notochord extracellular matrix as it extends posteriorly, maintaining the tripartite configuration. Fibroblast growth factor-mediated migration in a spatially graded manner causes cell stretching, which triggers Yap-dependent proliferation and controls floorplate and hypochord growth. Supported by mathematical modeling, we further suggest that their growth is fine-tuned by mechanical tethering to the notochord via …

Sex-Related Measurement Bias In Autism Spectrum Disorder Symptoms In The Baby Siblings Research Consortium, Catherine A Burrows, Natasha Marrus, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Disparities exist in age of diagnosis and prevalence of autism spectrum disorder (ASD) for female compared with male children. Correcting for sources of bias is critical for improving equitable ASD identification.

OBJECTIVE: To determine whether sex differences exist in measurement of ASD symptoms using the Autism Diagnostic Observation Schedule (ADOS) among young children at high familial likelihood (HFL) and low familial likelihood (LFL) of ASD.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study collected longitudinal, prospective data from the Baby Siblings Research Consortium between January 1, 2003, and December 31, 2021. Participants included 3106 children who had an older sibling …

Disruption Of The Cerebrospinal Fluid-Plasma Protein Balance In Cognitive Impairment And Aging, Amelia Farinas, Daniel Western, Jigyasha Timsina, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

The brain barrier system, including the choroid plexus, meninges and brain vasculature, regulates substrate transport and maintains differential protein concentrations between blood and cerebrospinal fluid (CSF). Aging and neurodegeneration disrupt brain barrier function, but proteomic studies of the effects on blood-CSF protein balance are limited. Here we used SomaScan proteomics to characterize paired CSF and plasma samples from 2,171 healthy or cognitively impaired older individuals from multiple cohorts, including the Global Neurodegeneration Proteomics Consortium. We identified proteins with correlated CSF and plasma levels that are produced primarily outside the brain and are enriched for structural domains that may enable their …

Dissemination And Implementation Of A Telehealth-Enabled Program For Providing Infectious Disease Expertise In Rural Settings, Robin L P Jump, Jason P Burnham, Et Al.

2020-Current year OA Pubs

BACKGROUND: Telehealth can facilitate improving antibiotic use and related antimicrobial stewardship activities in facilities underserved by infectious diseases (IDs) expertise. We describe implementation of the Department of Veterans Affairs (VA) videoconference antimicrobial stewardship team (VAST) to connect multidisciplinary teams from rural VA medical centers (VAMCs) with geographically distant ID experts.

METHODS: We implemented VASTs at 10 rural VAMCs from September 2021 to February 2024. VASTs consisted of regular meetings between rural VAMCs and an off-site ID expert who met by videoconference to discuss clinical cases, emphasizing recommendations for antibiotic prescribing. The VA Corporate Data Warehouse was used to collect information …

The Global Neurodegeneration Proteomics Consortium: Biomarker And Drug Target Discovery For Common Neurodegenerative Diseases And Aging, Farhad Imam, Muhammad Ali, Carlos Cruchaga, Chengran Yang, Et Al.

2020-Current year OA Pubs

More than 57 million people globally suffer from neurodegenerative diseases, a figure expected to double every 20 years. Despite this growing burden, there are currently no cures, and treatment options remain limited due to disease heterogeneity, prolonged preclinical and prodromal phases, poor understanding of disease mechanisms, and diagnostic challenges. Identifying novel biomarkers is crucial for improving early detection, prognosis, staging and subtyping of these conditions. High-dimensional molecular studies in biofluids ('omics') offer promise for scalable biomarker discovery, but challenges in assembling large, diverse datasets hinder progress. To address this, the Global Neurodegeneration Proteomics Consortium (GNPC)-a public-private partnership-established one of the …

The Microrna Mir-30a Blocks Adipose Tissue Fibrosis Accumulation In Obesity, Pradip K Saha, Robert Sharp, Aaron R. Cox, Rabie Habib, Michael J. Bolt, Jessica B. Felix, Claudia E. Ramirez Bustamante, Xin Li, Sung Yun Jung, Kang Ho Kim, Kai Sun, Huaizhu Wu, Samuel Klein, Sean M. Hartig

2020-Current year OA Pubs

White adipose tissue (WAT) fibrosis occurring in obesity contributes to the inflammatory and metabolic comorbidities of insulin resistance and type 2 diabetes, yet the mechanisms involved remain poorly understood. Here, we report a role for the broadly conserved miRNA miR-30a as a regulator of WAT fibrosis and systemic glucose metabolism. Mice modified to express miR-30a at elevated levels in adipose tissues maintain insulin sensitivity coupled with reduced fatty liver disease when fed a high-fat diet. These effects were attributable to cell-autonomous functions of miR-30a that potently increase expression of adipocyte-specific genes. Proteomic screening revealed miR-30a limits profibrotic programs in subcutaneous …

Multimodal Deep Learning For Enhanced Breast Cancer Diagnosis On Sonography, Ting-Ruen Wei, Aileen Chang, Young Kang, Mahesh Patel, Yi Fang, Yuling Yan

Bioengineering

This study introduces a novel multimodal deep learning model tailored for the differentiation of benign and malignant breast masses using dual-view breast ultrasound images (radial and anti-radial views) in conjunction with corresponding radiology reports. The proposed multimodal model architecture includes specialized image and text encoders for independent feature extraction, along with a transformation layer to align the multimodal features for the subsequent classification task. The model achieved an area of the curve of 85% and outperformed unimodal models with 6% and 8% in Youden index. Additionally, our multimodal model surpassed zero-shot predictions generated by prominent foundation models such …

An Examination Of Legal Status, Law Enforcement Perception, And Crime Victimization And Reporting Among Hispanic Immigrants, Guadalupe C. Cabrera

Electronic Theses and Dissertations

This study relied on in-depth interviews with naturalized citizens and lawful permanent resident Hispanic immigrants to explore their perceptions of law enforcement and experiences with crime victimization and reporting. Past literature has explained that the absence of legal status may deter crime reporting. We added to this body of work by investigating relationships among legal status, trust, and reporting behaviors. This study finds that direct experiences with law enforcement and acquired knowledge may be a better indicator of law enforcement trust and crime reporting compared to legal status. While most participants expressed trust in law enforcement, others felt neutral due …

Empathetic Differentiated Instruction In Deaf Education: Examining Influencing Factors And Experienced Educator Practices, Laura A. Blackburn

STEMPS Master's Level Projects and Papers

This mixed-methods study investigated how experienced K–12 deaf educators implement empathetic, differentiated instruction (EDI) to support the academic and linguistic needs of deaf students who use American Sign Language (ASL) as their language of learning. Guided by Tracey and Baaki’s instructional design empathy model and grounded in constructivism, the study explored how teachers navigated the tension between standardized, English (sound-based) curriculum demands and the need to make instructional decisions aligned with signed language modalities and responsive to students’ real-time learning needs.

A custom electronic survey was distributed to a national sample of experienced educators, with 19 respondents completing Likert-scale items, …

Coastal Transition Zone Development Effects On Salt Marsh Ecology, Amanda Mei Pysher

Electronic Theses and Dissertations

The coastal transition zone (CTZ) is a regional gradient linking terrestrial and marine systems, comprising of the terrestrial upland, the marsh-upland ecotone, and estuarine salt marshes. Along all US coastlines, including the South Carolina (SC) coast from Little River to Georgetown, increases in anthropogenic development of terrestrial uplands have altered the historically established vegetation, and various physical, chemical, biological, and geological gradients. Despite the CTZ's ecological importance, the trickle-down effects of terrestrial upland development on associated high marsh habitats remain understudied. Data were collected from developed (DEV) and undeveloped (UND) shorelines across three SC estuarine inlets. Multilevel modeling (MLM) was …

Migratory Patterns Of Juvenile Shortfin Makos (Isurus Oxyrinchus): Evidence Of A Nursery In The Western North Atlantic, Julia A. Crews

Electronic Theses and Dissertations

Shortfin Makos, Isurus oxyrinchus Rafinesque, 1810, are lamnids that have a global distribution in temperate and tropical oceans. Locations of critical early life history events including birthing and nursery areas are unknown or unconfirmed for most populations. The objective of this study was to identify if a nursery area for Shortfin Makos in the northern waters of the Mid-Atlantic Bight using the criteria articulated by Heupel et al. (2007). Satellite tags were used to track the movement of juveniles (<200 cm TL, n=7) up to 5 months. Tag detections (n=882) confirmed that young makos stay in continental shelf waters of the northern Mid-Atlantic Bight off Long Island through the meteorological summer (June–August) and early meteorological fall (September–October) when sea surface temperatures are 18–23°C. There was clear migratory movement from juveniles once sea surface temperatures fell below 15°C. During late fall, some young sharks moved south towards Cape Hatteras, North Carolina, while one shark moved east up to 1,800 km into the open north Atlantic Ocean into meteorological winter. These movement data of juvenile Shortfin Makos combined with multi-year catches and sightings (2018–2024) provide strong evidence for a nursery area in the northern Mid-Atlantic Bight. By identifying a nursery area for Shortfin Makos, knowledge gaps that currently exist for this vulnerable species and support effective management can be closed.

Comparison Of Nutrient Concentrations And Primary Production Indicators Across Plume Fronts, Taylor Dishon

Electronic Theses and Dissertations

Coastal buoyant plumes carry low-salinity waters containing particulate and dissolved terrestrial materials with an abundance of nutrients into the coastal ocean, including inorganic nitrogen and phosphorous. Plume fronts act as transport barriers created from the convergence of a fresher plume with an older, saltier plume or with ambient waters, leading to potential accumulation of phytoplankton and nutrients. This accumulation creates an optimal environment for primary production. The primary goals of this study were: to investigate the distribution of and potential relationships between nutrient concentrations and chlorophyll a across plume fronts of the Winyah Bay River Plume, and examine potential relationships …

Site Fidelity, Seasonality, Movement, And Fish Associates Of Sand Tigers Carcharias Taurus In North Carolina, Ara L. Mcclanahan

Electronic Theses and Dissertations

Sand tigers Carcharias taurus are mackerel sharks with a disjunct global distribution in tropical and temperate seas. In the northwest Atlantic, sand tigers migrate along the coast of the eastern United States from the Gulf of Maine to Florida and occupy structurally complex benthic habitats. The long-term, underwater camera installation, SharkCam, at Frying Pan Tower, off Cape Fear, North Carolina, USA, sits atop an expanse of hard bottom reef frequented by sand tigers. The citizen-science platform Spot A Shark USA (SAS USA) uses images of sand tigers to identify and track individuals. This study utilized image encounters from SAS USA …

Perceptions Of First-Year College Students On Respect In The Classroom During Their High School Career, Jane Adele Bailey

Electronic Theses and Dissertations

This study examines the influence of teacher respect on classroom climate, student- teacher relationships, and academic performance. Through interviews with college students reflecting on their high school experiences, this research identifies specific teacher actions and communication that foster respect in the classroom. By identifying what respectful communication and actions are through the interviews, teachers will be able to use these in their classrooms.

Six themes were identified by the participants lived experiences. They are: teacher demeanor, social interaction, attitude, emotional support, instructional management and facilitation, and listening. The results gave specific actions and communication, in the eyes of the participants, …

Adolescent E-Cigarette Expectancies: Measure Development And Preliminary Validity Of The Electronic Nicotine Vaping Outcomes Measure For Youth, Paul T. Harrell, Kelli J. England, Tracey E. Barnett, Vani N. Simmons, Richard W. Handel, Amy C. Paulson

Department of Pediatrics Faculty Publications

BACKGROUND: Electronic nicotine delivery systems (“e-cigarettes”) are the nicotine product most commonly used by adolescents. Research, treatment, and policy could benefit from measures of adolescent e-cigarette beliefs about outcomes of use (ie, expectancies). In the current study, we developed and tested an adolescent electronic nicotine vaping expectancy measure.

METHODS: A focus group with adolescents evaluated potential e-cigarette expectancy items. A panel of national experts assisted in revision of these items. Finally, items were administered to a sample of adolescents 14-17 years old (N = 267, Mean age 15.6, SD = 1.1, 50.9% Female, 50.2% Non-Hispanic White, 22.5% Non-Hispanic Black, 14.2% …