Digital Commons Network^™

Fluid Assessment Scoring Tool (Fast): Development Of A Novel Fluid Assessment Scoring Tool For Critically Ill Pediatric Patients-A Pilot Study, Mohammed Salameh, Pranali Awadhare, Jennifer Joiner, Michael Scheurer, Utpal Bhalala

Faculty, Staff and Students Publications

Introduction: Monitoring fluid balance (FB) is important yet challenging in the pediatric intensive care unit (PICU). Currently used, conventional methods of fluid assessment are either not feasible or unreliable. Also, there is a lack of composite scores or clinical algorithms that use different parameters of fluid status. We aim to develop a fluid assessment scoring tool (FAST) to clinically assess the fluid status of children in the PICU.

Methods: In this pilot study, we included critically ill patients aged 0-21 years who presented to our PICU between December 2020 and March 2021 and required invasive or non-invasive mechanical ventilation, inotropes, …

Emergency Department Utilization Among Co-Residing Family Caregivers Of Persons Living With Dementia, Pei-Chun Cha, Craig Rothenberg, Anita N Chary, Justine Seidenfeld, Ula Hwang, Terri Fried, Joan K Monin, Arjun K Venkatesh, Cameron J Gettel

Faculty, Staff and Students Publications

No abstract provided.

Intracranial Rhizomucor Pusillus Mucormycosis In An Adolescent Triggering A Stroke Alert: A Case Report And A Systematic Review Of Pediatric Cases, Rima El Atrache, Melissa Mizerik, Joaquin Francisco Ruiz Lopez, Eric Engstrom, Karla Patricia Salazar, Mikael C Guzman-Karlsson, Daniel Davila-Williams, Sonali Sen, Kristen S Fisher, Jennifer C Erklauer

Faculty, Staff and Students Publications

Mucormycosis is a rare, life-threatening opportunistic infection primarily affecting immunocompromised patients. The available literature on Rhizomucor pusillus (R pusillus) infections of the central nervous system (CNS) in children is very limited. We present the case of an immunocompromised adolescent with intracranial mucormycosis due to R pusillus manifesting with stroke-like symptoms. This case highlights this rare condition's diagnostic complexity and management challenges. We include a review of the available literature on pediatric R pusillus CNS infections to increase awareness among health care providers.

Optical Coherence Tomography Enables The Depth-Resolved Measurement Of Cilia Beat Frequency In Ex Vivo Human Fallopian Tubes, Dilara J Long, Tian Xia, Photini F Rice, Deirdre M Scully, Makayla Johnson, Ryan Mistifer, Andrea Aguirre, John M Heusinkveld, Irina V Larina, Jennifer K Barton

Faculty, Staff and Students Publications

Objectives: The movement of cilia in the fallopian tubes (FTs) facilitates important processes involved in fertility, and abnormalities in cilia function are linked with diseases including endometriosis and pelvic inflammatory disease. For the first time, we demonstrate the use of optical coherence tomography (OCT) to create depth-resolved mapping of motile cilia locations and quantify cilia beat frequency (CBF) in human FT samples ex vivo.

Methods: Segments of the FT ampulla were acquired from five patients following salpingectomy under an IRB approved protocol. The samples were longitudinally opened to expose the luminal surface for imaging. A sequence of at least 500 …

Bone Quality Response To Lifestyle Intervention In Older Adults With Obesity (Limb-Q Trial): A Randomised Controlled Trial, Giulia Gregori, Sanjay Mediwala, Michael Liebschner, Daeseung Kim, Mon S Bryant, Nina Klonis, Reina Armamento-Villareal, Clifford Qualls, Dennis T Villareal

Faculty, Staff and Students Publications

Background: Lifestyle interventions for weight loss might exacerbate age-related bone loss and osteoporosis. However, there is limited knowledge about their effects on bone quality. We examined whether lifestyle intervention can preserve or enhance bone quality, despite reductions in bone mineral density.

Methods: The Lifestyle Intervention to Improve Bone Quality (LIMB-Q) study was a randomised controlled trial conducted at Baylor College of Medicine and the Michael E DeBakey VA Medical Center (Houston, TX, USA) including older adults (aged 65-85 years) with obesity (BMI ≥30 kg/m2). Participants were randomly assigned to receive either an intensive lifestyle intervention (intensive lifestyle group, consisting of …

A Prospective, Randomized, Controlled Clinical Trial Of High-Frequency Electromagnetic Coupling Powered Permanent Peripheral Nerve Stimulator For The Treatment Of Chronic Craniofacial Pain, Salim M Hayek, Nameer Haider, Ashwin Viswanathan, Mehul Desai, Jeffrey Rosenberg, Niek E Vanquathem

Faculty, Staff and Students Publications

than one-fifth of the US population. While various medications and conservative treatment modalities are available for this condition, many patients have refractory symptoms. These patients suffer from social impairment, reduced quality of life, and increased financial burdens.

Objective: The objective of this study was to examine the clinical outcomes of patients receiving a permanent, high-frequency electromagnetic coupling (HF-EMC) powered peripheral nerve stimulator (PNS) system for the treatment of chronic craniofacial neuropathic pain.

Study design: This study was a multicenter, randomized, controlled clinical trial conducted under an investigational device exemption (IDE).

Setting: This study was conducted in 7 clinical sites in …

Experiences Of Emotional Support Among Parents Of Children And Adolescents With Type 1 Diabetes: A Qualitative Study, Sahar S Eshtehardi, Marissa N Baudino, Barbara J Anderson, Deborah I Thompson, David G Marrero, Marisa E Hilliard

Faculty, Staff and Students Publications

Objective: Parents of youth with type 1 diabetes (T1D) experience substantial disease-specific demands and distress, yet their perceptions about the emotional support they receive related to the challenges of caring for a child with diabetes have not been well described. This research aimed to characterize the types of emotional support parents of youth with T1D receive and how they experience emotional support.

Methods: As part of a larger qualitative study on diabetes health-related quality of life, 23 parents (96% mothers) of youth with T1D (M age = 10.9 ± 3.8 years; 35% female) completed semi-structured interviews about various aspects of …

Spatial Omics Enters The Microscopic Realm: Opportunities And Challenges, Yichen Si, Joo Sang Lee, Goo Jun, Hyun Min Kang, Jun Hee Lee

Faculty, Staff and Students Publications

Spatial transcriptomics (ST) enables systematic profiling of whole-transcriptome gene expression in tissues while preserving spatial context. Recent advances in sequencing- and imaging-based ST technologies have ushered in the era of microscopic-resolution ST (μST), allowing transcriptome mapping at cellular and even subcellular scales with unprecedented precision. Despite these advances, μST faces substantial challenges, including sparse transcript discovery per submicron (or micron)-sized spatial units and data fragmentation across platforms, hindering integration and analysis. There is also a growing demand for scalable, segmentation-free, and universally applicable analysis methods, as well as strategies for 3D mapping, multi-omics integration, and artificial intelligence (AI)-driven spatial analysis. …

An Association At The Crossroads: The 1970s Crisis Within Chrie, Bob Bosselman

ICHRIE Research Reports

The International Council on Hotel, Restaurant & Institutional Education (ICHRIE), founded in 1946, has a long history, although in the 1970s the future of the association was in doubt. This manuscript documents the crisis that nearly derailed the association, and details how this dilemma was resolved. Associations face many challenges throughout their history, and how they deal with each crisis often dictates their future.

Opiophobia In Postsurgical Adults With Cancer, Karen E. Alsbrook, Valerie Shelton, Bryan M. Fellman, Eduardo Bruera, Eileen D. Hacker

Sigma Foundation for Nursing Research Grant Reports

The purpose of this study is to explore the occurrence of opiophobia among postsurgical adults with cancer and hypothesized associations among opiophobia, anxiety, depression, pain intensity, pain interference, and opioid medication adherence during the first week following hospital discharge for surgical treatment of a malignancy.

Uinta Basin Snow Shadow: Impact Of Snow-Depth Variation On Winter Ozone Formation, Michael J. Davies, John R. Lawson, Trevor O’Neil, Seth N. Lyman, Karlee Zager, Tristan D. Coxson

Bingham Research Center

After heavy snowfall in the Uinta Basin, Utah, elevated surface ozone occurs if a cold-air pool persists and traps emissions from oil and gas industry operations. Sunlight and actinic flux from a high-albedo snowpack drive ozone buildup via photolysis. Snow coverage is paramount in initiating the cold pool and driving ozone generation. Its depth is critical for predicting ozone concentrations. The Basin’s location leeward of the Wasatch Mountains provides conditions for a precipitation shadow, where sinking air suppresses snowfall. We analyzed multiple years of ground-based snow depth measurements, surface ozone data, and meteorological observations; we found that ozone levels track …

The Global Phase Space Of The Three-Vortex Interaction System And Its Application To Vortex-Dipole Scattering, Atul Anurag

Dissertations

This dissertation presents a global reduction of the classical three-vortex problem that is free from coordinate singularities, enabling a comprehensive analysis of the system's dynamics across all circulation regimes.

To achieve this, a two-step symplectic reduction procedure is developed. The first step introduces Jacobi coordinates adapted to the symplectic structure of the vortex system, and the second applies a Lie-Poisson reduction to the resulting system. This formulation eliminates the non-physical singularities associated with collinear vortex configurations and facilitates a global phase space analysis, including a detailed and novel investigation of bifurcations.

Within this reduced framework, all relative fixed points are …

Robust Ai Solutions For Financial Markets Through Generative Modeling, Dynamic Graph Learning, And Reinforcement-Based Portfolio Optimization, Jingyi Gu

Dissertations

Financial markets are inherently uncertain and dynamic, driven by complex factors such as macroeconomic signals, investor sentiment, and evolving inter-asset relationships. While machine learning has advanced financial modeling, existing approaches often fall short in addressing the real-world intricacies of finance. This dissertation confronts two critical challenges, human-driven stochasticity and risk-intensive decision-making under real-world trading constraints, while seizing a pivotal opportunity, the structural dynamics of evolving financial systems. These elements are foundational to advancing robust and practical financial intelligence.

To this end, this dissertation develops a unified framework for robust financial modeling and decision-making. The framework is architected as a progressive, …

Large-Scale Graph Algorithms And Applications With An Emphasis On Fintech Data, Fuhuan Li

Dissertations

Graph algorithms are essential analytical tools with applications spanning cybersecurity, biology, social media, and increasingly, financial technology (FinTech). The complex and interconnected nature of financial data, particularly in cryptocurrency networks, presents unique opportunities for graph-based analysis in fraud detection and anomaly identification.

This dissertation presents the design and implementation of scalable graph algorithms tailored for large-scale networks, with particular emphasis on FinTech applications. The primary contributions include: (1) novel cover-edge based triangle counting algorithms that significantly reduce computational overhead through breadth-first search preprocessing, achieving substantial speedups over traditional methods and dramatic communication reduction in distributed settings, (2) optimized parallel implementations …

Bodipy-Based Photocages For The Controlled Release Of Hydrogen Sulfide And Persulfides, Yanmei Li

Dissertations

Reactive sulfur species (RSS) such as hydrogen sulfide (H2S) and hydropersulfides (RSSH) are crucial mediators in a variety of physiological and pathological processes. Their regulatory roles span from maintaining cellular redox balance to influencing signaling pathways critical for homeostasis and stress responses. This dissertation investigates H2S and RSSH as biologically important molecules and explores the development of boron-dipyrromethene (BODIPY)-based photocages for its controlled, light-triggered release. Given H2S and RSSH's critical role in redox regulation and cellular protection, achieving spatiotemporal control over its delivery is essential for both therapeutic and research applications. BODIPY scaffolds offer favorable photophysical properties, including visible-light activation …

Reduced Order Models Of Hydrodynamically Interacting Flapping Wings, Jose Pabon

Dissertations

Fish schools exhibit a collective behavior and self-organization that is mediated by hydrodynamic interactions between individual fish. However, the long-time evolution of hydrodynamically interacting collectives is challenging to investigate due to the persistent influence of long-lived vortical structures, and the high-resolution requirements of direct numerical simulation at large Reynolds numbers. Reduced-order models have therefore played an important role in theoretical investigations of collectives of swimming bodies. The main results detailed herein are several new reduced-order models of swimmers that self-propel by flapping, i.e., by executing a prescribed periodic rigid body motion. The models are extensions of a discrete-time dynamical system …

Harnessing Graphs For Knowledge Representation In Natural Language Processing, Uras Varolgunes

Dissertations

This work proposes innovative methods for integrating domain-specific knowledge into natural language processing tasks through the use of graphs, aiming to enhance the performance of models across various domains, including finance and healthcare. Several novel approaches are proposed that fuse graph structures with modern deep learning techniques, addressing the challenges of missing word embeddings, label prediction, and graph representation learning for large language models.

First, a powerful embedding method built on top of the recent advances in latent graph learning is introduced to address the critical problem of word embedding imputation. Second, a graph-enhanced label attention model designed for medical …

Optimizing Hip And Knee Assistance For Walking And Sit-To-Stand Transitions: An Intrinsic Muscle Mechanics Based Predictive Approach, Neethan Ratnakumar

Dissertations

As the global population ages, the demand for wearable assistive technologies continues to rise, driven by their potential to enhance mobility and independence in older adults. Effectively designed controllers for lower-limb exoskeletons to assist sit-to-stand (STS) and walking are crucial for delivering efficient, safe, and comfortable assistance during daily activities. Traditionally, controller optimization involves biomechanical modeling and user-specific customization. Musculoskeletal simulations play a central role in this process by providing insights into human-exoskeleton interaction dynamics, thereby informing and refining control strategies.

This work presents a simulation-driven approach for developing exoskeleton controllers for walking and STS using two distinct methods: optimal …

Development And Implementation Of Novel Mass Spectrometric Methods For Metabolism Studies In Drug Discoveries, Huifang Yao

Dissertations

The field of drug discovery has evolved significantly over the past few decades, with a growing emphasis on understanding the metabolic pathways and biotransformation processes that influence the pharmacokinetics and pharmacodynamics of drug candidates. Novel mass spectrometric methods have emerged as powerful tools in this domain, facilitating the comprehensive analysis of metabolic profiles and enabling the identification of metabolites with implications for safety, efficacy, and overall drug development. However, challenges remain in quantifying metabolic flux—an essential aspect of understanding drug action—particularly due to the limitations of traditional isotope kinetic assays, which often involve lengthy sample preparation and the use of …

Multi-Messenger Diagnostics Of The Origin And Transport Of Solar Energetic Particles, Meiqi Wang

Dissertations

Impulsive solar energetic electron events (SEEs) are a common phenomenon originating from the Sun. They are characterized by rapid onset and brief duration, and are commonly associated with solar flares. Solar radio bursts, which offer a rich variety of diagnostic tools for solar activities, exhibits a close relationship with impulsive solar energetic electron events. Such diagnostics are particularly powerful when combined with multi-wavelength remote sensing and in situ observations. The dissertation focuses on combining state-of-the-art microwave imaging spectroscopy data obtained by the Expanded Owens Valley Solar Array (EOVSA) with other multi-messenger observations to investigate the origin of impulsive solar energetic …

Characterizing Fish Communities Using Traditional And Emerging Monitoring Approaches In San Diego County Estuaries, Natalie Katherine De Wet

Theses

Fish communities are essential to estuarine health, playing key roles in food webs, nutrient cycling, and ecosystem functioning. However, the persistence of native fish populations is increasingly threatened by the cumulative impacts of coastal development, pollution, and climate change. Rapid, effective monitoring of species distributions is a priority, enabling timely conservation and management. However, the study of any ecosystem is limited by time, resources, and the consideration that research of a system can damage the ecosystem under study.

This research aimed to characterize fish species richness and evaluate the benefits and limitations of different estuary monitoring approaches. Specifically, this study …

The Inevitability Of Local Environmental Law, Keith H. Hirokawa, Cinnamon Carlarne Hirokawa, Lauren A. Vanwagoner

Fordham Environmental Law Review

The United States is entering a new era of environmental law. Within the first few months of President Trump’s second term in office, the administration issued a mass of executive orders, memoranda and policy changes that seek to peel back environmental protections, in many cases, to the point of erasure. The administration shuttered entire agencies, such as USAID, dissolved the Environmental Protection Agency’s research arm, terminated life-saving programs like the National Weather Service’s translation service, cut funding to housing and public health initiatives, and eliminated diversity, equity, and inclusion programs across the country. Given the reality of these large-scale drawbacks, …

Methodological Insights From Evaluating A Family Member's Voice Reorientation Programme: An Interpretive Descriptive Approach., Johnson U. Gideon, Towell-Barnard Amanda, Mclean Christopher, Robert Glenn, Ewens Beverley

Research outputs 2022 to 2026

Background: Delirium is a prevalent acute brain dysfunction in patients within intensive care units. Delirium is marked by a fluctuating mental state, inattention, and altered consciousness. This condition affects a substantial proportion of patients in intensive care units, and which leads to increased mortality, severe physiological and psychological consequences, and a significant economic burden on healthcare systems. Despite the evidence that supports the use of non-pharmacological interventions to prevent or minimise the impact of delirium such as orientation, sensory stimulation, early mobilisation, and family involvement, their implementation in intensive care units remains inconsistent. The involvement of family members in the …

Manjón, Llobet, And Barrios In Chile: Concerts And Reception In The Newspaper Record, Pablo Soto Hurtado

Soundboard Scholar

Based on an investigation of newspaper articles, this article presents a first look at the activities of Antonio Jiménez Manjón, Miguel Llobet, and Agustín Barrios in Chile between 1893 and 1918. Manjón’s concerts were well received, clashing with some of the discourse in the local media, which considered the guitar vulgar and expressionless. Llobet introduced the Tárrega school in Chile in 1912, which is in itself a milestone in the study of Tárrega’s pedagogical philosophy in that country. Furthermore, his technique was praised and, like Manjón’s, led to the challenging of prejudices against the guitar. The case of Agustín Barrios, …

The Association Between Irregular Sleep Patterns And Learning Outcomes: Implications For Students’ Health In Iraq, Hazhmat Ali, Dildar Haji Musa, Ary Habeeb Mohammed, Hiwa Abdulraheem, Sherzad Salahadeen, Alind Mustafa

Makara Journal of Health Research

Background: Students often exhibit irregular sleep patterns due to rigorous academic workloads, which exert a considerable negative impact on their mental health. The present study aims to investigate the influence of irregular sleep on academic performance.

Methods: This study recruited a cohort of 409 medical students of both genders. Upon their consent, participants filled out a closed-ended questionnaire on various sleep parameters, including sleep habits, duration, and environment.

Results: Students with irregular sleep patterns reported higher rates of sleep deprivation, late sleep onset, and troubled sleep. Moreover, they spent a longer duration using smart devices before bedtime …

The Association Between Pain Catastrophizing, Somatization, Psychological Distress And Low Back Pain Severity Among Academics In Malaysia, Noordiyana Izyanti Mohamad Saufi, Eva Nabiha Zamri

Makara Journal of Health Research

Background: Psychological factors may influence the severity of low back pain (LBP), especially in high-stress professions such as academia. This study aimed to identify the relationship between psychological factors and LBP severity among Malaysian public university academics.

Methods: This cross-sectional study aimed to assess the relationship between psychological factors and LBP among academics at four public universities located in the northern region of West Malaysia. A self-administered questionnaire was used to collect information on sociodemographic characteristics, work information, lifestyle factors, LBP presence and intensity, and psychological factors. Data were analyzed using ordinal logistic regression and reported in terms …

Academic Burnout And Its Association With Sleep Quality, Physical Activity, And Social Media Addiction Among University Students In Perak, Malaysia: A Cross-Sectional Study, Kai Eng Joanne Lim, Khang Jin Cheah, Farzana Athirah Abdul Latif, Fatin Izzaty Mohd Shahrin

Makara Journal of Health Research

Background: Academic burnout among Malaysian undergraduates is a rising concern, driven by academic pressure and compounded by lifestyle and behavioural factors. This study aimed to examine the associations between academic burnout, sleep quality, physical activity, and social media addiction.

Methods: A cross-sectional study involving 382 undergraduate students was conducted using an online survey to collect the data. The chi-square test was used to assess bivariate associations, and multivariable logistic regression was employed to identify independent predictors of academic burnout.

Results: The majority of respondents were aged 21 to 23 years (59.7%) and female (60.7%). Overall, 56.0% of …

Psychometric Properties Of The Turkish Version Of The Palliative Care Attitude Scale (T-Pcas-9) In Cancer Patients, Sevgi Demir Çam, Neşe İşcan Ayyildiz, Hasan Evcimen, Timüçin Çil, Berna Bozkurt Duman

Makara Journal of Health Research

Background: A reliable, validated Turkish measurement tool will allow researchers to measure the impact of attitudes towards palliative care on other health outcomes in individuals with chronic and critical illness. This study aimed to examine the Turkish psychometric properties of the Palliative Care Attitude Scale (PCAS-9) for individuals with cancer.

Methods: The Turkish adaptation of the PCAS-9 (T-PCAS-9) included 505 cancer patients, who were aged >18 years, had a diagnosis of cancer, and no mental problems. The factor structure of the T-PCAS-9 was examined using exploratory factor analysis, confirmatory factor analysis, convergent-divergent validity, and measurement invariance analysis.

Results: The three-factor …

A Study On Nutritional Status Among Regular Gym Goers In And Around Chennai, India, Ettiyappan Thirumurugan, Kalpana Devi Venkatesan, Pavithra Tamilmani, Devika Preetha, Joyce Albert Princy Mariya Selvanathan, Dhanyasree Mohandas, Ameer Basha Sathik, Santhosh Kumar Manjunathan, Ashika Kannadhas Sheeba

Makara Journal of Health Research

Background: The increasing sales of sports supplements indicate a concerning trend, as many gym-goers may misuse these products owing to misinformation and insufficient knowledge, potentially impacting their performance. This issue is further compounded by specific gym trainers who may lack comprehensive information and inadvertently influence their clients' choices. To address this concern, the present study evaluated dietary supplement practices and sports nutrition knowledge among regular gym-goers at fitness centers in Chennai, India.

Methods: A cross-sectional survey was conducted from November 2023 to May 2024 using a validated questionnaire distributed across Chennai, India. A total of 450 participants were …

Raising Provider Awareness Of Fluid Status In Women Undergoing Elective Cesarean Section Through The Use Of A Preoperative Checklist To Assess Fluid Status: A Quality Improvement Project, Marcus Miller, Michael Sorge

Doctor of Nurse Anesthesia Practice (DNAP) Manuscripts

Abstract

Maternal hypotension following neuraxial anesthesia during cesarean section is a common and potentially harmful complication. While vasopressors are often used for this issue, they carry risks to fetal well-being. Goal-directed fluid therapy (GDFT) provides an individualized approach that may improve outcomes by optimizing fluid status perioperatively. This quality improvement project aimed to increase provider awareness of fluid status through the implementation of a preoperative checklist that assessed fluid status in women undergoing cesarean section. A preoperative fluid assessment checklist was developed using evidence-based predictors of fluid status and integrated into anesthesia workflow. The project followed the Plan-Do-Study-Act cycle and …