Digital Commons Network^™

Pedicle Lengthening Osteotomy For Lumbar Spinal Stenosis: A Systematic Review Of Cadaveric, Computational, And Clinical Outcomes, Jonathan A Ledesma, Julio Castillo Tafur, Bradley Anderson, Lasya Rangavajjula, Mark J Lambrechts, D Greg Anderson

2020-Current year OA Pubs

Study DesignSystematic Review.ObjectiveTo review the available published literature relating to pedicle lengthening osteotomy (PLO) for lumbar spinal stenosis (LSS), and to compare this technique to existing surgical options.MethodsPubMed/MEDLINE, Embase, and Scopus were reviewed using the keywords: "pedicle lengthening", "lumbar", and "spinal stenosis." Results were reviewed for relevance and included only if they met inclusion criteria. The SYRCLE checklist was used to assess for sources of bias.ResultsInclusion criteria were biomechanical or clinical studies evaluating PLO for LSS. A total of 56 studies were identified in the Pubmed/MEDLINE database using the above-mentioned search criteria. Additionally, a total of 83 abstracts were reviewed …

Inflammatory Pain In Mice Induces Light Cycle-Dependent Effects On Sleep Architecture, Dominika J Burek, Khairunisa Mohamad Ibrahim, Andrew G Hall, Ashish Sharma, Jessica A Cucinello-Ragland, Erik S Musiek, Jose A Morón, William A Carlezon Jr

2020-Current year OA Pubs

Pain syndromes include physical, sensory, emotional, and cognitive symptoms such as disability, negative affect, feelings of stress, and fatigue. Experimental induction of long-term inflammatory pain in rodents by hindpaw injection of complete Freund's adjuvant (CFA) produces anhedonia and dysregulated naturalistic behaviors, similar to the effects of unregulated stress. We examined whether these similarities extend to changes in sleep and rhythms, such as those induced by chronic social defeat stress, using actigraphy and wireless EEG in mice. Comparisons were made between groups that received injections at the onset of the light or dark phase. We found that CFA-induced inflammatory pain alters …

Eugenics And Polygenic Embryo Screening: Public, Clinician, And Patient Perceptions Of Conditions Versus Traits, Dorit Barlevy, Rémy A Furrer, Asha Kalapatapu, Abigail Martinez, Todd Lencz, Shai Carmi, Gabriel Lázaro-Muñoz, Stacey Pereira

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Polygenic embryo screening (PES) estimates an embryo's genetic chances of developing complex conditions (eg, cancer) and traits (eg, height). Stakeholders have raised concerns that PES promotes eugenic practices and ideology.

Methods: We surveyed a nationally representative sample of the US public on approval of screening embryos for 12 conditions and 12 traits and examined the association between disapproval and concern about eugenics. We also conducted semistructured interviews with US-based reproductive endocrinology and infertility specialists and patients undergoing in vitro fertilization on their perspectives toward PES.

Results: Among the US public (n = 1423), disapproval of screening embryos for traits …

Characterization Of A Mouse Model Of Osteoarticular Infection Using Clinical Isolates Of Staphylococcus Aureus, Philip M Roper, Jessica Beetner, Jennifer L Davis, Christine Shao, Jason Zhang, Linda Cox, Nitin Kumar Pokhrel, James E Cassat, Javier Rangel-Moreno, Gowrishankar Muthukrishnan, Deborah J Veis

2020-Current year OA Pubs

Osteoarticular infection, most commonly due to

Coenzyme Q Headgroup Intermediates Can Ameliorate A Mitochondrial Encephalopathy, Guangbin Shi, Claire Miller, Sota Kuno, Alejandro G Rey Hipolito, Salsabiel El Nagar, Giulietta M Riboldi, Megan Korn, Wyatt C Tran, Zixuan Wang, Lia Ficaro, Tao Lin, Quentin Spillier, Begoña Gamallo-Lana, Drew R Jones, Matija Snuderl, Soomin C Song, Adam C Mar, Alexandra L Joyner, Roy V Sillitoe, Robert S Banh, Michael E Pacold

Duncan NRI Faculty and Staff Publications

Decreased brain levels of coenzyme Q10 (CoQ10), an endogenously synthesized lipophilic antioxidant1,2, underpin encephalopathy in primary CoQ10 deficiencies3,4 and are associated with common neurodegenerative diseases and the ageing process5,6. CoQ10 supplementation does not increase CoQ10 pools in the brain or in other tissues. The recent discovery of the mammalian CoQ10 headgroup synthesis pathway, in which 4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL) makes 4-hydroxymandelate (4-HMA) to synthesize the CoQ10 headgroup precursor 4-hydroxybenzoate (4-HB)7, offers an opportunity to pharmacologically restore CoQ10 synthesis and mechanistically treat CoQ10 deficiencies. To test whether 4-HMA …

A Consensus Guide To Preclinical Indirect Calorimetry Experiments, Alexander S Banks, David B Allison, Thierry Alquier, Ansarullah, Steven N Austad, Johan Auwerx, Julio E Ayala, Joseph A Baur, Stefania Carobbio, Gary A Churchill, Morten Dall, Rafael De Cabo, Jose Donato, Nathalia R V Dragano, Carol F Elias, Anthony W Ferrante, Brian N Finck, Jose E Galgani, Zachary Gerhart-Hines, Laurie J Goodyear, Justin L Grobe, Rana K Gupta, Kirk M Habegger, Sean M Hartig, Andrea L Hevener, Steven B Heymsfield, Corey D Holman, Martin Hrabě De Angelis, David E James, Lawrence Kazak, Jae Bum Kim, Martin Klingenspor, Xingxing Kong, Sander Kooijman, Louise Lantier, K C Kent Lloyd, James C Lo, Irfan J Lodhi, Paul S Maclean, Owen P Mcguinness, Gema Medina-Gómez, Raghavendra G Mirmira, Christopher D Morrison, Gregory J Morton, Timo D Müller, Yoshihiro Ogawa, David Pajuelo-Reguera, Matthew J Potthoff, Nathan Qi, Marc L Reitman, Patrick C N Rensen, Jan Rozman, Jennifer M Rutkowsky, Kei Sakamoto, Philipp E Scherer, Gary J Schwartz, Radislav Sedlacek, Mohammed Selloum, Saame Raza Shaikh, Shuai Chen, Gerald I Shulman, Vojtěch Škop, Alexander A Soukas, John R Speakman, Bruce M Spiegelman, Gregory R Steinberg, Katrin J Svensson, John P Thyfault, Tony Tiganis, Paul M Titchenell, Nigel Turner, Licio A Velloso, Antonio Vidal-Puig, Christopher S Ward, Ashley S Williams, Christian Wolfrum, Allison W Xu, Ying Xu, Juleen R Zierath, International Indirect Calorimetry Consensus Committee (Iiccc)

Children’s Nutrition Research Center Staff Publications

Understanding the complex factors influencing mammalian metabolism and body weight homeostasis is a long-standing challenge requiring knowledge of energy intake, absorption and expenditure. Using measurements of respiratory gas exchange, indirect calorimetry can provide non-invasive estimates of whole-body energy expenditure. However, inconsistent measurement units and flawed data normalization methods have slowed progress in this field. This guide aims to establish consensus standards to unify indirect calorimetry experiments and their analysis for more consistent, meaningful and reproducible results. By establishing community-driven standards, we hope to facilitate data comparison across research datasets. This advance will allow the creation of an in-depth, machine-readable data …

Rezafungin Versus Caspofungin For The Treatment Of Candidemia And Invasive Candidiasis: Results From The Double-Blind, Randomized, Phase 3 Restore Trial Including The China Extension Study, George R Thompson, Haihui Huang, Sizhou Feng, Yunsong Yu, Alex Soriano, Oliver A Cornely, Bart Jan Kullberg, Peter G Pappas, Marin Kollef, Jose A Vazquez, Patrick M Honore, Laura Cox, Matteo Bassetti

2020-Current year OA Pubs

BACKGROUND: Rezafungin is approved for use in adults with candidemia and/or invasive candidiasis (IC) based on data from the ReSTORE trial (NCT03667690), which demonstrated noninferior efficacy to caspofungin. For regulatory purposes, an additional cohort of patients from China was recruited to ReSTORE. Here, we compared rezafungin and caspofungin in patients with candidemia and/or IC through analysis of the ReSTORE global data plus the China extension study.

METHODS: Adults with candidemia/IC were randomized (1:1) to receive weekly rezafungin (400/200 mg) or daily caspofungin (70/50 mg) for ≤28 days. Noninferiority was concluded for primary efficacy endpoints if the upper bound of the …

Variation In Recommended Treatment Strategies Among American Surgeons For Actual Adult Traumatic Brachial Plexus Injury Cases, Michele N Christy, Christopher J Dy, R Glenn Gaston, Bryan J Loeffler, Mihir J Desai, Steve K Lee, Harvey Chim, Jeffrey B Friedrich, Sameer K Puri, Jason H Ko, Planet Study Group

2020-Current year OA Pubs

PURPOSE: The surgical management of adult traumatic brachial plexus injuries (BPI) is challenging, with no consensus on optimal strategies. This study aimed to gather preferred reconstructive strategies from BPI surgeons for actual cases from a multicenter cohort to identify areas of agreement.

METHODS: Four case files (history, physical examination, and imaging and electrodiagnostic testing results) were distributed to eight self-designated Level IV expert BPI surgeons in the United States. Each surgeon independently reviewed the cases and provided a preferred reconstructive plan via free text response.

RESULTS: For a pan-plexus case after blunt trauma (67 years old; 3 months from injury): …

Associations Of Biomarkers Of Systemic Inflammation, Angiogenesis, And Cell-To-Cell Adhesion With Tumor Budding Among Early-Onset And Later-Onset Colorectal Cancer Patients, Oda Hausmann, Adetunji T Toriola, Et Al.

2020-Current year OA Pubs

BACKGROUND: High tumor budding and elevated systemic inflammation are adverse prognostic indicators in colorectal cancer. Its underlying mechanisms remain poorly understood. It is unclear whether systemic inflammation, angiogenesis, and cell-to-cell adhesion influence tumor budding.

METHODS: We investigated n = 132 stage I-III colorectal cancer patients recruited at Huntsman Cancer Institute enrolled in the ColoCare Study. Tumor budding was evaluated using an evidence-based scoring system, and patient sera were analyzed for nine circulating biomarkers using the Meso Scale Discovery platform. We examined associations between biomarkers and tumor budding using multivariable linear regression models adjusted for age, sex, neoadjuvant treatment, stage, and …

Minimally Invasive, Bioadaptive Multimodal Sensor Probe With Safe Deployment For Real-Time Acute Compartment Syndrome Diagnosis, Seung Gi Seo, Amanda M Westman, William Moritz, Joseph Ribaudo, Mitchell A Pet, Et Al.

2020-Current year OA Pubs

Acute Compartment Syndrome (ACS) is a serious medical condition that arises from increased pressure within osteofascial compartments, leading to impaired blood flow and potential tissue damage. Early and accurate diagnosis is critical for preventing permanent damage. Current methods rely largely on qualitative assessments with limited accuracy, and those that exploit invasive pressure measurements often prove inadequate. Herein, a soft materials-based multimodal sensor probe is introduced, as well as the mechanical and thermal influences to monitor intra-compartmental pressure, tissue oxygen saturation (StO

Comparative Analysis Of Different Magnetic Anomaly Datasets Using Navigation Performance With Flight Test Data, Aaron P. Nielsen, Brandon M. Blakely, Patrick Duff

Faculty Publications

Magnetic Anomaly Navigation (MagNav) is a map-based method of navigation which relies on accurately obtaining the anomaly field to a high level of precision to achieve good navigation results. This requires utilizing high quality sensors, accurately modeling disturbance fields from the aircraft & other sources, and creating high-fidelity maps. Aeromagnetic survey data or marine track survey data must be processed into a product that can be used as a reference for a magnetic navigator and a variety of techniques can be utilized for this processing. The data collection for different survey types reflects choices typically made to study the underlying …

Uncovering Environmental Justice Disparities: Tree Canopy Inequality In Low-Income Marginalized Communities, Emmanuel Wallace

Tennessee State University Alumni Theses and Dissertations

Tree canopy inequality in low-income marginalized communities is a direct result of decades of environmental injustice within urban communities in the United States, specifically the Home Owner’s Loan Corporation. This phenomenon underscores the disproportionate distribution of tree cover, green spaces, and their myriad benefits in neighborhoods marked by poverty and social vulnerability. Rooted in a history of discriminatory urban planning practices and systemic disparities, tree canopy inequality has profound consequences on residents' health and well-being. It leads to urban heat island effects, reduced air quality, and additional socio-economic disparities. On average, urban communities of color have 33% less tree canopy …

I Am Scared Too: A Qualitative Study On The Influential Factors On The Fear Of Childbirth In Black Women, Imani Rivers

Tennessee State University Alumni Theses and Dissertations

Pregnancy and childbirth can evoke a range of emotions, including happiness, frustration, and fear. While some worry during pregnancy is expected, heightened and persistent fear can negatively impact a woman’s mental and physical health. Despite this, fear of childbirth remains underexplored, particularly in the context of Black women’s experiences. Existing literature lacks focus on the contextual and systemic factors contributing to this fear, creating a significant research gap (Reissig et al., 2021). Black women in the United States are disproportionately affected by medical mistreatment, often experiencing dismissal and silencing in clinical settings—an issue frequently rooted in implicit bias and racial …

Exploring The Cooling Effects Of Urban Forests In Summer, Xiaoyue Li

Tennessee State University Alumni Theses and Dissertations

As a nature-based solution to combat urban heat islands, urban forests can provide cooling and other co-benefits. However, little is known about the cooling benefits of urban forests in parking lots and under different land covers, especially with field observations. To address this gap, we measured air temperature (AT) and relative humidity (RH) and calculated heat index (HI) in three urban settings in Nashville, TN, in summer 2024. The research sites included: 1) Two different parking lots: parking lots with and without trees; 2) Three different distances from trees within the parking lot with trees: under trees, near trees, and …

Pd-Catalyzed Microwave Irradiated Cross-Coupling Of Carboxylic Acids And Amino Alcohols., Md Shahin Reza

Tennessee State University Alumni Theses and Dissertations

Amino esters are valuable pharmaceutical intermediates with anesthetic properties and applications as prodrugs. In this study, we have developed a new microwave-assisted method for the cross-coupling of aromatic carboxylic acids with amino alcohol using a palladium catalyst. This approach has enabled an efficient synthesis of amino esters, overcoming challenges such as side reactions and product separation.

Regioselective C-Allylation Of Indole With Potassium Allyltrifluoroborate In The Presence Of Pd-Catalyst, Milton Kumar Kundu

Tennessee State University Alumni Theses and Dissertations

Indole is a versatile heterocyclic scaffold renowned for its wide range of pharmacological activities and strong potential as a successful drug candidate. These attributes continue to inspire researchers to explore indole derivatives as promising leads in drug development. In this project, we report the development of a cross-coupling reaction of indoles and potassium allyltrifluoroborate to the corresponding 3-allylindoles in the presence of PdCl2(dtbpf) and PdCl2(dppf)CH2Cl2 catalyst under microwave heating, offering a rapid, regioselective, and high-yielding synthetic route. This methodology provides a valuable platform for generating structurally diverse indole-based compounds, which could serve as promising leads for further pharmacological evaluation and …

Effects Of Tillage On Wheat Canopy, Stephanie Adanna Anyanwu

Tennessee State University Alumni Theses and Dissertations

Abstract Wheat canopy cover and greenness are useful crop performance indicators that provide significant insight into the performance of wheat crops. Understanding the effects of no-till and conventional tillage practices on winter wheat canopy cover and greenness will help inform agronomic decision making in wheat production. Therefore, the aim of this study was to assess the effects of no-till and conventional tillage practices on wheat canopy cover and greenness using drones. Wheat canopy cover mapping was carried out using deep learning supervised classification. The normalized difference vegetation index (NDVI), green normalized difference vegetation index (GNDVI) and optimized soil adjusted vegetation …

Effects Of Straw Return On Crop Yield, Soil Organic Carbon And Greenhouse Gas Emissions, Maazeera Fatima

Tennessee State University Alumni Theses and Dissertations

Global crop residue production was substantial, at approximately 3758 × 106 mg annually. The practice of straw return, was found to enhance soil organic matter content, increase crop yield, and mitigate soil greenhouse gas emissions. However, individual studies showed inconsistent results. While meta-analyses synthesized multiple individual studies and provided overall effects of straw return, but their conclusions were varied. We evaluated meta-analyses on the effects of straw return on crop yield, soil organic carbon, and greenhouse gas emissions and proposed a grand mean response ratio to estimate an overall effect and the impacts of different properties. The result showed that …

Identification And Characterization Of Peptide Responsive Histone Modification Genes During Root Nodule Symbiosis In Medicago Truncatula, Shivani Dharam

Tennessee State University Alumni Theses and Dissertations

Nitrogen (N) is an essential but limiting macronutrient for crop growth in agroecosystems. Biological Nitrogen Fixation (BNF) is a critical biological process where atmospheric Nitrogen is converted into ammonia by Nitrogen fixing the bacteria called rhizobia, forming mutualistic relationships with legume plants. These interactions are mediated by several signaling pathways and may involve epigenetic modifications like DNA methylations, histone modifications, where gene expression is altered without any change in DNA sequence. Histones are proteins provide structural support to DNA. However, genes encoding enzymes for these post translational modifications are poorly investigated in the Leguminosae family. This project aims to answer …

Identification And Functional Verification Of Powdery Mildew Resistant Genes In Hydrangea Macrophylla, Christina Jennings

Tennessee State University Alumni Theses and Dissertations

Ornamental plant production is a continuously expanding industry in the United States and worldwide. Hydrangea species are highly valued in ornamental plant production, especially bigleaf hydrangea (Hydrangea macrophylla). Powdery mildew is of particular interest on bigleaf hydrangea as there are no resistant varieties. The causal agent of powdery mildew of bigleaf hydrangea is Golovinomyces orontii (formerly Erysiphe polygoni). The goal of this research was to provide solutions for powdery mildew disease of hydrangea through improved chemical control, development of laboratory-based research systems, and identification of genes related to powdery mildew. A detached-leaf assay was developed and evaluations correlated to whole …

Distribution And Occurrence Of Cyanohabs, Nutrients, And Water-Quality Data In The Tennessee State University Wetland, Kristi Hill

Tennessee State University Alumni Theses and Dissertations

Toxic algal blooms are an expanding issue for aquatic ecosystems because they are hazardous to human and environmental health. Algal blooms naturally occur from the combination of warm temperatures, sunlight, and abundant nutrients in water, but what triggers them to become harmful algal blooms (HABs) and begin synthesizing toxin is not well understood, and their threat to freshwater sources was not heavily researched until recently. Microcystin (MC), a freshwater algal toxin, is a HABs toxin which targets the liver and causes sickness and death in humans and animals (pets, livestock, and wildlife). Urban freshwater wetlands are among the most HAB …

Influence Of Parental Approval And Disapproval On Interracial Relationship Outcomes, Stefanie Boakye

Tennessee State University Alumni Theses and Dissertations

Interracial couples may encounter unique challenges in their relationships due to negative perceptions such as racial prejudice, discrimination, disapproval, cultural stereotypes, and opposition from society and family. These challenges can be especially difficult when the disapproval comes from their parents. This study explored how perceived parental approval influences interracial romantic relationship outcomes, specifically relationship satisfaction, commitment, and closeness. Data were collected from individuals in interracial relationships (N ≈ 80) using the Relationship Assessment Scale (RAS), the Investment Model Scale (IMS), the Relationship Closeness Inventory (RCI), and the Parent-Adult Child Relationship Questionnaire (PACQ). A multivariate analysis of variance (MANOVA) was conducted …

Mindfulness And Student Achievement In Urban Middle After-School Programs, La Shell Bonds

Tennessee State University Alumni Theses and Dissertations

This dissertation explores the influence of mindfulness-based interventions on academic achievement, disciplinary outcomes, and social-emotional learning (SEL) competencies among urban middle school students participating in after-school programs. Grounded in Vygotsky’s sociocultural theory, self-regulatory frameworks, and Dweck’s growth mindset, the study employs a quasi-experimental design with 36 participants randomly assigned to either a mindfulness intervention group or a control group that receives the standard SEL curriculum. Over two weeks, the experimental group engaged in structured mindfulness activities—including breath awareness, body scans, and peer-led circles,—while quantitative data were collected on standardized test scores (Math and English Language Arts), suspension rates, and SEL …

How The Inter-Nucleon Force Shapes Emergent Collectivity And Imparts Uncertainties In Ab Initio Nuclear Observables, Kevin Becker

LSU Doctoral Dissertations

The importance of collective motion in atomic nuclei has been well-established for many decades. Even before the advent of the nuclear shell model and its much-needed answers to surprising empirical phenomena, collectivity and surface deformation have played a vital role in broadening our knowledge. Reconciling the collective and single-particle camps into a unified description required tremendous strides in the application of group theory and advances in high-performance supercomputing, and thanks to these efforts the symmetry-adapted no-core shell model, or SA-NCSM, has developed into a reliable model for the study of deformed light and medium-mass nuclei. State-of-the-art calculations reveal remarkably simple …

Neurologists' Perspectives On Sudep Communication: A Comparative Study Across Five European Countries, Rohit Shankar

Peninsula Medical School

Objectives: The leading cause of epilepsy mortality is Sudden unexpected death in epilepsy (SUDEP). National and international guidelines recommend that people with epilepsy are counseled on SUDEP risk at the point of diagnosis or at the earliest opportunity. This study compares neurologist views from five European countries on attitudes and relevance of SUDEP communication. Methods: A cross-sectional online survey of 17 Likert questions using validated themes was circulated via different ILAE and/or equivalent organizations using a non-discriminatory exponential snowballing technique, leading to a non-probability sampling. Data were analyzed using descriptive statistics, Kruskal–Wallis, Chi-square, and Fisher's exact tests. Significance was accepted …

Early Phase Testing Of Functional Imagery Training As An Intervention For Anxiety, Jackie Andrade, D. J. Kavanagh, Carly Bowditch, Emily Mackriel, Emily Ravenshill, Amy Sime, Eleanor Trumfield, Jessica Watts, Jon May

School of Psychology

Cognitive models hypothesize a role for motivated behaviour in anxiety disorders, with safety behaviours leading to exaggerated threat appraisals and increased anticipatory anxiety. Based on the Affective Imagery Theory of Motivation, we propose that increasing motivation for engagement behaviours will reduce motivation for safety behaviours through competition for limited capacity cognitive resources supporting motivational imagery. We hypothesise that imagining successful engagement will reduce anxiety directly, and through promoting subsequent engagement. We present preliminary evidence that functional imagery training (FIT), an intervention that develops and teaches motivational imagery, reduces anxiety. FIT was delivered to undergraduates with anxiety in one session lasting …

Patient-Centered Management Of Heavy Menstrual Bleeding While On Anticoagulation: A Survey Study, Benjamin Barnett, Rushad Patell, Dana Angelini, Leben Tefera, Jordan K Schaefer, Ang Li, Alejandra Gutierrez Bernal, Shruti Chaturvedi, Anjlee Mahajan, Leslie Lake, Jori May, Anna L Parks

Faculty, Staff and Students Publications

Background: Nearly three-quarters of women experience heavy menstrual bleeding (HMB) during anticoagulation treatment for venous thromboembolism (VTE). HMB can lead to medical interventions, impact school or work and diminish quality of life (QOL). While there are several management options for HMB in patients with VTE, we lack information on how patients approach HMB treatment decisions.

Objectives: We examined patients' experience with, perceptions of, and preferences for treatment of HMB while on anticoagulation.

Methods: Clinicians and patient advocates developed a web-based survey that was distributed via patient advocacy organizations and social media between May and June 2024, targeting participants 18 years …

Flotsam And Jetsam: The Role Of Mlb Integration In The Wreckage Of The Negro Leagues, Nastasia Pollas

Dissertations, Theses, and Capstone Projects

“We are the ship, all else the sea.” Adapted from a Frederick Douglass speech, this quote by Rube Foster became the slogan of the Negro Leagues, illustrating the resolve and determination to prosper alone during a time of segregation. Setting aside long-standing rivalry and strife, Black baseball teams united under a shared vision of forming the first professional Black baseball league.

This paper examines how Giddens' structuration theory, connecting social structures with individual actions, can explain both the development and success of the league under segregation and its eventual demise during integration.

Associations Of Ambient Exposure To Benzene, Toluene, Ethylbenzene, And Xylene With Daily Mortality: A Multicountry Time-Series Study In 757 Global Locations, Lu Zhou, Ying Xiong, Francesco Sera, Ana Maria Vicedo-Cabrera, Rosana Abrutzky, Yuming Guo, Shilu Tong, Micheline De Sousa Zanotti Stagliorio Coelho, Paulo Hilario Nascimento Saldiva, Eric Lavigne, Patricia Matus Correa, Nicolás Valdés Ortega, Samuel Osorio, Dominic Roye, Jan Kyselý, Hans Orru, Marek Maasikmets, Jouni J.K. Jaakkola, Niilo Ryti, Mathilde Pascal, Veronika Huber, Susanne Breitner-Busch, Alexandra Schneider, Klea Katsouyanni, Evangelia Samoli, Alireza Entezari, Fatemeh Mayvaneh, Patrick Goodman, Ariana Zeka, Raanan Raz, Matteo Scortichini

Research Outputs: 2025-Present

BACKGROUND: The presence of benzene, toluene, ethylbenzene, and xylene isomers (BTEX) in the environment is of increasing concern due to their toxicity and ubiquity. Although the adverse health effects of BTEX exposure have been documented, robust epidemiological evidence from large-scale, multicountry studies using advanced exposure assessment methodologies remains scarce. We aimed to assess the association of short-term ambient exposure to individual BTEX components and their mixture with daily total, cardiovascular, and respiratory mortality on a global scale. METHODS: Daily data on mortality, meteorological factors, and air pollution were collected from 757 locations across 46 countries or regions. Data on individual …

Prevalence Of Oral Mucosal Lesions Among Geriatric Dental Patients In Egypt: A Cross-Sectional Study, Dalia Ghalwash, Ahmed Hamdy, Sara Abd El-Wahed

Dentistry

Background. The oral health needs of older adults must be prioritized due to the shifting demographics of the population and rising life expectancy. This study investigated the prevalence of oral mucosal lesions (OMLs) among geriatric dental patients in a sample of the Egyptian population and explored the association with age, gender, smoking habit, as well as the impact on the quality of life. Methods. This cross-sectional study screened 300 geriatric dental patients aged 65 years or older, from several dental hospitals and mobile clinics in various regions in Egypt. Demographic data and information regarding denture use, systemic diseases, and smoking …