Digital Commons Network^™

Time-Frequency Fingerprint Analysis In Seeg Source-Space To Identify The Epileptogenic Zone, Yash Shashank Vakilna, Deniz Atilgan, Johnson Hampson, Chinmay Chinara, Takfarinas Medani, Richard M Leahy, Nuria Lacuey, Samden D Lhatoo, Sandipan Pati, John C Mosher, Jay R Gavvala

Faculty, Staff and Student Publications

This case study highlights the application of seizure fingerprint analysis in the source-space of stereo-EEG (SEEG) data to accurately localize the epileptogenic zone (EZ) in patients with complex cortical malformations. A 25-year-old female with extensive bilateral perisylvian polymicrogyria (PMG) presented with intractable focal seizures. The source-level analysis performed in Brainstorm using the sLORETA imaging algorithm subsequently showed EZ fingerprint analysis. The patient underwent MR-guided laser interstitial thermal therapy (LITT), targeting the identified EZ, resulting in postoperative seizure freedom with minimal complications. Extending the analysis from the sensor-space to the source-space could further enhance surgical planning and improve outcomes in complex …

Heightened Risk: Childhood Trauma And Anticipatory Grief Exacerbate The Impact Of Loneliness On Depressive Symptoms And Lps-Stimulated Cytokines In Dementia Caregivers, Kelly N Brice, Jensine Paoletti-Hatcher, E Lydia Wu-Chung, Vincent D Lai, Daniel L Argueta, Michelle A Chen, Itee Mahant, Bryan T Denny, Charles Green, Luis D Medina, Paul Schulz, Jennifer Stinson, Samantha K Henry, Cobi Heijnen, Christopher P Fagundes

Faculty, Staff and Student Publications

Dementia spousal caregivers are at a disproportionate risk for adverse mental and physical health outcomes. Loneliness is associated with depressive symptoms and proinflammatory cytokine production among caregivers. Additionally, childhood trauma, anticipatory grief, and poor sleep quality are all associated with enhanced stress reactivity. This study used a cross-sectional design to investigate whether loneliness is associated with proinflammatory cytokine production and depressive symptoms in caregivers, and whether these relationships are strongest among caregivers who report high levels of childhood trauma, high amounts of anticipatory grief, or poor sleep quality. A sample of 111 dementia spousal caregivers provided blood samples and completed …

Uncovering Environmental Justice Disparities: Tree Canopy Inequality In Low-Income Marginalized Communities, Emmanuel Wallace

Tennessee State University Alumni Theses and Dissertations

Tree canopy inequality in low-income marginalized communities is a direct result of decades of environmental injustice within urban communities in the United States, specifically the Home Owner’s Loan Corporation. This phenomenon underscores the disproportionate distribution of tree cover, green spaces, and their myriad benefits in neighborhoods marked by poverty and social vulnerability. Rooted in a history of discriminatory urban planning practices and systemic disparities, tree canopy inequality has profound consequences on residents' health and well-being. It leads to urban heat island effects, reduced air quality, and additional socio-economic disparities. On average, urban communities of color have 33% less tree canopy …

Mindfulness And Student Achievement In Urban Middle After-School Programs, La Shell Bonds

Tennessee State University Alumni Theses and Dissertations

This dissertation explores the influence of mindfulness-based interventions on academic achievement, disciplinary outcomes, and social-emotional learning (SEL) competencies among urban middle school students participating in after-school programs. Grounded in Vygotsky’s sociocultural theory, self-regulatory frameworks, and Dweck’s growth mindset, the study employs a quasi-experimental design with 36 participants randomly assigned to either a mindfulness intervention group or a control group that receives the standard SEL curriculum. Over two weeks, the experimental group engaged in structured mindfulness activities—including breath awareness, body scans, and peer-led circles,—while quantitative data were collected on standardized test scores (Math and English Language Arts), suspension rates, and SEL …

I Am Scared Too: A Qualitative Study On The Influential Factors On The Fear Of Childbirth In Black Women, Imani Rivers

Tennessee State University Alumni Theses and Dissertations

Pregnancy and childbirth can evoke a range of emotions, including happiness, frustration, and fear. While some worry during pregnancy is expected, heightened and persistent fear can negatively impact a woman’s mental and physical health. Despite this, fear of childbirth remains underexplored, particularly in the context of Black women’s experiences. Existing literature lacks focus on the contextual and systemic factors contributing to this fear, creating a significant research gap (Reissig et al., 2021). Black women in the United States are disproportionately affected by medical mistreatment, often experiencing dismissal and silencing in clinical settings—an issue frequently rooted in implicit bias and racial …

Exploring The Cooling Effects Of Urban Forests In Summer, Xiaoyue Li

Tennessee State University Alumni Theses and Dissertations

As a nature-based solution to combat urban heat islands, urban forests can provide cooling and other co-benefits. However, little is known about the cooling benefits of urban forests in parking lots and under different land covers, especially with field observations. To address this gap, we measured air temperature (AT) and relative humidity (RH) and calculated heat index (HI) in three urban settings in Nashville, TN, in summer 2024. The research sites included: 1) Two different parking lots: parking lots with and without trees; 2) Three different distances from trees within the parking lot with trees: under trees, near trees, and …

Dynamics And Controls Of Greenhouse Gas Emissions In Bioenergy Croplands, Lovish Kasrija

Tennessee State University Alumni Theses and Dissertations

Agriculture contributes considerably to global greenhouse gas (GHG) emissions, requiring sustainable methods for tackling climate change. This thesis includes two mega-analyses and one field experiment to investigate the impact of conservation tillage and soil amendments on crop productivity and greenhouse gas emissions. The first mega-analysis combined data from 30 meta-analyses to assess the impact of no-tillage (NT), reduced-tillage (RT), and combination NT+RT on crop yields and soil GHG emissions. NT decreased yields by 3.3% and increased N₂O emissions by 8.7%, but RT and NT+RT had no effect. The second mega-analysis found that both NT and RT considerably increased soil organic …

Regioselective C-Allylation Of Indole With Potassium Allyltrifluoroborate In The Presence Of Pd-Catalyst, Milton Kumar Kundu

Tennessee State University Alumni Theses and Dissertations

Indole is a versatile heterocyclic scaffold renowned for its wide range of pharmacological activities and strong potential as a successful drug candidate. These attributes continue to inspire researchers to explore indole derivatives as promising leads in drug development. In this project, we report the development of a cross-coupling reaction of indoles and potassium allyltrifluoroborate to the corresponding 3-allylindoles in the presence of PdCl2(dtbpf) and PdCl2(dppf)CH2Cl2 catalyst under microwave heating, offering a rapid, regioselective, and high-yielding synthetic route. This methodology provides a valuable platform for generating structurally diverse indole-based compounds, which could serve as promising leads for further pharmacological evaluation and …

Effects Of Tillage On Wheat Canopy, Stephanie Adanna Anyanwu

Tennessee State University Alumni Theses and Dissertations

Abstract Wheat canopy cover and greenness are useful crop performance indicators that provide significant insight into the performance of wheat crops. Understanding the effects of no-till and conventional tillage practices on winter wheat canopy cover and greenness will help inform agronomic decision making in wheat production. Therefore, the aim of this study was to assess the effects of no-till and conventional tillage practices on wheat canopy cover and greenness using drones. Wheat canopy cover mapping was carried out using deep learning supervised classification. The normalized difference vegetation index (NDVI), green normalized difference vegetation index (GNDVI) and optimized soil adjusted vegetation …

Pd-Catalyzed Microwave Irradiated Cross-Coupling Of Carboxylic Acids And Amino Alcohols., Md Shahin Reza

Tennessee State University Alumni Theses and Dissertations

Amino esters are valuable pharmaceutical intermediates with anesthetic properties and applications as prodrugs. In this study, we have developed a new microwave-assisted method for the cross-coupling of aromatic carboxylic acids with amino alcohol using a palladium catalyst. This approach has enabled an efficient synthesis of amino esters, overcoming challenges such as side reactions and product separation.

Effects Of Straw Return On Crop Yield, Soil Organic Carbon And Greenhouse Gas Emissions, Maazeera Fatima

Tennessee State University Alumni Theses and Dissertations

Global crop residue production was substantial, at approximately 3758 × 106 mg annually. The practice of straw return, was found to enhance soil organic matter content, increase crop yield, and mitigate soil greenhouse gas emissions. However, individual studies showed inconsistent results. While meta-analyses synthesized multiple individual studies and provided overall effects of straw return, but their conclusions were varied. We evaluated meta-analyses on the effects of straw return on crop yield, soil organic carbon, and greenhouse gas emissions and proposed a grand mean response ratio to estimate an overall effect and the impacts of different properties. The result showed that …

Identification And Characterization Of Peptide Responsive Histone Modification Genes During Root Nodule Symbiosis In Medicago Truncatula, Shivani Dharam

Tennessee State University Alumni Theses and Dissertations

Nitrogen (N) is an essential but limiting macronutrient for crop growth in agroecosystems. Biological Nitrogen Fixation (BNF) is a critical biological process where atmospheric Nitrogen is converted into ammonia by Nitrogen fixing the bacteria called rhizobia, forming mutualistic relationships with legume plants. These interactions are mediated by several signaling pathways and may involve epigenetic modifications like DNA methylations, histone modifications, where gene expression is altered without any change in DNA sequence. Histones are proteins provide structural support to DNA. However, genes encoding enzymes for these post translational modifications are poorly investigated in the Leguminosae family. This project aims to answer …

Identification And Functional Verification Of Powdery Mildew Resistant Genes In Hydrangea Macrophylla, Christina Jennings

Tennessee State University Alumni Theses and Dissertations

Ornamental plant production is a continuously expanding industry in the United States and worldwide. Hydrangea species are highly valued in ornamental plant production, especially bigleaf hydrangea (Hydrangea macrophylla). Powdery mildew is of particular interest on bigleaf hydrangea as there are no resistant varieties. The causal agent of powdery mildew of bigleaf hydrangea is Golovinomyces orontii (formerly Erysiphe polygoni). The goal of this research was to provide solutions for powdery mildew disease of hydrangea through improved chemical control, development of laboratory-based research systems, and identification of genes related to powdery mildew. A detached-leaf assay was developed and evaluations correlated to whole …

Influence Of Parental Approval And Disapproval On Interracial Relationship Outcomes, Stefanie Boakye

Tennessee State University Alumni Theses and Dissertations

Interracial couples may encounter unique challenges in their relationships due to negative perceptions such as racial prejudice, discrimination, disapproval, cultural stereotypes, and opposition from society and family. These challenges can be especially difficult when the disapproval comes from their parents. This study explored how perceived parental approval influences interracial romantic relationship outcomes, specifically relationship satisfaction, commitment, and closeness. Data were collected from individuals in interracial relationships (N ≈ 80) using the Relationship Assessment Scale (RAS), the Investment Model Scale (IMS), the Relationship Closeness Inventory (RCI), and the Parent-Adult Child Relationship Questionnaire (PACQ). A multivariate analysis of variance (MANOVA) was conducted …

Heat Stress On Germinating Tomato Pollen And The Molecular Mechanisms For Heat Response Using Single Cell Type Proteomics, Dibya Thapa Magar

Tennessee State University Alumni Theses and Dissertations

The primary objective of this study is to develop the technical workflow for collecting homogenous germinating pollen samples. Two tomato varieties, Black Vernissage (BV) and Micro Tom (MT), were grown in temperature-controlled plastic greenhouses. For the non-heated control conditions, greenhouse temperature was set at 25C/21oC (16/8 hours; day/night). For the heat-treated greenhouse, temperature was set at 32/25 oC (16/8 hours; day/night). Supplemental light was provided using plant growth LED light. Ten freshly opened flowers were collected and pollen were released into 2ml pollen germination medium (PGM) in 5-ml centrifuge tubes. After centrifugation, pollen pellets were washed three times in 2 …

Distribution And Occurrence Of Cyanohabs, Nutrients, And Water-Quality Data In The Tennessee State University Wetland, Kristi Hill

Tennessee State University Alumni Theses and Dissertations

Toxic algal blooms are an expanding issue for aquatic ecosystems because they are hazardous to human and environmental health. Algal blooms naturally occur from the combination of warm temperatures, sunlight, and abundant nutrients in water, but what triggers them to become harmful algal blooms (HABs) and begin synthesizing toxin is not well understood, and their threat to freshwater sources was not heavily researched until recently. Microcystin (MC), a freshwater algal toxin, is a HABs toxin which targets the liver and causes sickness and death in humans and animals (pets, livestock, and wildlife). Urban freshwater wetlands are among the most HAB …

Evaluating Early Successional Habitat Selection By Herpetofauna And Pygmy Rattlesnakes In Tennessee, Carlin Frost

Tennessee State University Alumni Theses and Dissertations

Coupled with climate change, global biodiversity declines are exacerbated by increasing anthropogenic pressures and ecosystem destruction. Amphibians and reptiles are particularly vulnerable due to their specific and narrow habitat requirements. In Tennessee, the Western Pygmy Rattlesnake (Sistrurus miliarius streckeri) is classified as Threatened and is primarily associated with floodplains adjacent to early successional habitats (ESH) in the western Interior Plateau ecoregion. These ESH support unique flora and fauna but have declined in recent decades, largely due to urban encroachment and disturbance suppression. Studying snakes is challenging because of their limited activity periods, small home ranges, and low detectability from cryptic …

Black And Latino Male Alumni Perceptions Of Educational Opportunity Program Impact On Campus Engagement, Social Capital, And Persistence At A Public University, Kashonda Watson

Education Doctoral

Black and Latino male students continue to graduate at lower rates than their White and female peers, particularly at PWIs in the Northeastern United States. To address these disparities, many institutions have adopted educational opportunity programs (EOPs) to provide academic, financial, and social support to students from disadvantaged backgrounds. Although EOPs have demonstrated effectiveness in supporting underrepresented students broadly, limited research has focused on the impact of EOP from the perspectives of Black and Latino male recent graduates. Using the theory of student involvement (Astin, 1984) and social capital theory (Bourdieu & Passeron, 1986; Coleman, 1988), this qualitative case study …

A Functional Perspective On Astrocyte Heterogeneity, Wookbong Kwon, Michael R Williamson, Benjamin Deneen

Faculty, Staff and Students Publications

Astrocytes are glial cells of the central nervous system (CNS) that perform an array of diverse functions that are essential for brain activity. Studies on the functional diversity of astrocytes suggest that such diversity may be derived from specialized populations. We provide an overview of the current state of research on astrocyte diversity and outline current challenges and knowledge gaps while also examining the developmental origins of these populations and how their interactions with neurons contribute to their functional heterogeneity. We highlight recent studies that provide evidence for functionally diverse astrocyte populations under homeostatic conditions and as an adaptive response …

Mindfulness And Student Achievement In Urban Middle After-School Programs, La Shell Bonds

Tennessee State University Alumni Theses and Dissertations

This dissertation explores the influence of mindfulness-based interventions on academic achievement, disciplinary outcomes, and social-emotional learning (SEL) competencies among urban middle school students participating in after-school programs. Grounded in Vygotsky’s sociocultural theory, self-regulatory frameworks, and Dweck’s growth mindset, the study employs a quasi-experimental design with 36 participants randomly assigned to either a mindfulness intervention group or a control group that receives the standard SEL curriculum. Over two weeks, the experimental group engaged in structured mindfulness activities—including breath awareness, body scans, and peer-led circles,—while quantitative data were collected on standardized test scores (Math and English Language Arts), suspension rates, and SEL …

Lipid And Cholesterol Peroxidation Leads To Α-Crystallin Membrane Aggregation And Cataract Formation, Nawal K. Khadka, Preston Hazen, Oluwaseyi Akinola, Xinzhu Pu, Laxman Mainali

Boise State University Publications and Presentations

Purpose: The significant lens chaperone protein α-crystallin (αABc), comprised of αA-crystallin (αAc) and αB-crystallin (αBc) subunits, is found to form membrane-bound aggregates with age and cataract formation. However, the molecular basis for such aggregate formation is still unclear. Our research primarily aims to elucidate the effect of lipids (phospholipids and sphingolipids) and cholesterol (Chol) peroxidation on the aggregation of αAc, αBc, and αABc to bovine lens nuclear membrane (NM).

Methods: Lipid and Chol peroxidation was induced by a photosensitized peroxidation reaction, and topographical images of NM and oxidized-NM (Ox-NM) with and without αAc, αBc, or αABc were obtained using atomic …

Physics-Based Machine Learning Framework For Predicting Structure-Property Relationships In Ded-Fabricated Low-Alloy Steels †, Atiqur Rahman, Md Hazrat Ali, Asad Waqar Malik, Muhammad Arif Mahmood, Frank Liou

Mechanical and Aerospace Engineering Faculty Research & Creative Works

The Directed Energy Deposition (DED) process has demonstrated high efficiency in manufacturing steel parts with complex geometries and superior capabilities. Understanding the complex interplays of alloy compositions, cooling rates, grain sizes, thermal histories, and mechanical properties remains a significant challenge during DED processing. Interpretable and data-driven modeling has proven effective in tackling this challenge, as machine learning (ML) algorithms continue to advance in capturing complex property structural relationships. However, accurately predicting the prime mechanical properties, including ultimate tensile strength (UTS), yield strength (YS), and hardness value (HV), remains a challenging task due to the complex and non-linear relationships among process …

Temporal Variability In The Bulk Nutritional Quality Of Estuarine Plankton, Marley Gonsalves

Master's Theses and Capstones

The temporal variability of plankton is well documented, particularly in constantly changing tidal systems such as estuaries, but the extent to which this variability applies to plankton nutritional quality is less well known. As the base of the aquatic food web, variation in phytoplankton nutritional quality stands to constrain fishery production, particularly of filter-feeders. Here, community and nutritional data was collected from Great Bay, NH, a model estuary, over seasonal, tidal, and daily time scales to identify the range and variability of nutritional quality in plankton. Bulk spectrophotometric neutral lipid and protein measurements were compared to plankton community composition data …

Differentiated Learning In An Upper-Level Undergraduate Physics Theory Course, Christina Gurney

Master's Theses and Capstones

‘One-size-fits-all’ education aims to cater to the ‘average’ student, but the ‘average’ student does not exist. Students are individuals, each with a set of needs, abilities, preferences, and interests unique to them. A variety of instructional approaches should thus be used to differentiate students’ learning. This differentiation has been studied mostly for K-12. My study extends this research into an upper-level undergraduate physics theory course. For this phenomenographic pilot study, I interviewed ten students about the differentiated homework assignments in their upper-level undergraduate classical mechanics course at the University of New Hampshire. I performed an issue-focused analysis of the data, …

A Geoacoustic Bayesian Inversion For Large Calibrated Singlebeam Echosounder And Ground Truth Datasets, Andrew Paul Niedbla

Master's Theses and Capstones

This thesis describes the development of a geoacoustic inversion technique to estimate seafloor sediment characteristics that is designed for use with existing fisheries survey single beam echosounder (SBES) datasets. The geoacoustic inversion technique consists of a forward model and inversion algorithm. The forward model is a high frequency, physics-based, near normal incidence acoustic backscatter model enhanced with a density depth gradient model and geoacoustic sediment regressions. The inversion algorithm is a parallel tempered Markov-chain Monte Carlo Bayesian inversion. The geoacoustic inversion produces posterior probability distributions for mean grain size, density, porosity, sound speed, seafloor roughness characterization, and sediment volume scattering …

Consumer Carbon Footprint Of Fashion E-Commerce: A Comparative Analysis Between Omnichannel And Pure-Player Models In Spain, David Antonio Rosas Espín, Carlos Lli Torrabadella, María Tamames Sobrino, Irene Miguel Corbacho, José Luis Olazagoitia

Artículos científicos

The rapid expansion of fashion e-commerce has raised concerns over the environmental cost of last-mile deliveries, especially in pure-player models. This preliminary study examines the estimated carbon footprint of TENDAM’s omnichannel model—based on in-store pickup and returns—compared to pure-player home delivery, using a customer-level approach across 11 Spanish cities of varying sizes. A total of 3106 face-to-face surveys were conducted in TENDAM stores, capturing data on mobility behavior, transport modes, trip chaining, and service types. Emission factors were applied using a Python-based analytical model, and results were contrasted with Monte Carlo simulations from existing literature on pure players. Our findings …

Towards Sustainable Indoor Lighting Design: Ensuring Energy Efficiency, Health And Human Wellbeing—A Review, Lara Vélez González, Alejandra Santamaría Melenchón, David Baeza Moyano, Roberto Alonso González-Lezcano

Artículos científicos

The design of lighting systems, has, in recent years, transcended the basic function of providing visibility, becoming a key com-ponent of promoting the health and well-being of occupants by integrating biological, psychological, and energy aspects. Thegrowing understanding of the effects of light on the circadian cycle has posed a fundamental challenge in luminaire design. Thetwo before-mentioned review is, to analyze how light, both artificial and natural, affects the well-being and health of occupantsin various indoor environments, such as classrooms, hospitals and offices, Indoor lighting research has advanced significantly,recognizing both visual and non-visual effects on human health. These efforts focus on …

Blockbusters Or Blind Spots? A Critical Look At Poverty, Bullets And Bandits Narratives In Latin American Cinema, Carlos Fernández-Rodríguez, Elio Quiroga Rodríguez, Luis M. Romero- Rodríguez

Artículos científicos

Historically, the cultural industries of the Global South have been relegated in the face of North American and European production predominance. In Latin America, the most internationally successful audiovisual productions, both at the cinema ticket window and festivals, usually deal with stereotypes of extreme poverty, rurality, delinquency, terrorism, and drug trafficking, which, in the collective imagination of foreign audiences, promote an exaggerated representation of the region's social problems, contributing to xenophobia, hate speech, and anti-migration discourses in countries in the Global North. This study conducts an analysis of five emblematic feature films of Latin American cinema: Cidade de Deus [ …

Use Of Perioperative Scores In Predicting Postoperative Event And Selection For Discharge After Elective Laparoscopic Cholecystectomy: A Retrospective Cohort Study, Brian Nyamweya Bundi

Master of Medicine in General Surgery

Background: While daycare laparoscopic cholecystectomy is gaining momentum in developed countries, a majority of patients in low and middle-income countries are admitted overnight. This safety precaution offers prompt access to emergency services should need arise. This precautional overnight stay has implications on cost, healthcare utilization and patient satisfaction. Daycare procedures routinely utilize scoring systems for assessing discharge readiness. We explored the utility of the modified Surgical APGAR Score (mSAS) and the White Fast Track Score (WFTS) as predictors for postoperative events and their role in identifying patients who can have a safe daycare discharge after laparoscopic cholecystectomy in this retrospective …

Medication Adherence: A Reimbursable Theory-Guided Evidence-Based Educational Intervention For Patients With Parkinson’S Disease, Amanda E. George, Melinda Hermanns, Diane B. Monsivais, Cheryl D. Parker

Nursing Faculty Publications and Presentations

Background: Parkinson’s disease is a challenging, progressive neurodegenerative process projected to affect more than 1.2 million patients by 2030, with an economic burden that will surpass $79 billion annually in the United States. Pharmacological interventions are the hallmark of treatment for symptom management for this lifelong disease. Multiple medications and a variety of dosing times have an increasingly negative effect on medication adherence. Purpose: This article will discuss medication adherence challenges, describe a theory-guided evidence-based intervention to improve medication adherence, and explore the economic implications in an outpatient clinic setting. Methods: A pilot chart review of 40 cases over 30 …