Digital Commons Network^™

On Frand-Ly Terms: Examining The Role Of Juries In Standard-Essential Patent Disputes, Marta Krason

University of Chicago Law Review

Modern society relies on interconnected technologies, and interoperability has become crucial for meeting consumer expectations. Technology standards have emerged to ensure compatibility and interoperability across products. Once an industry selects a standard as the default for consumers and businesses, industry players begin to adapt it, often phasing out alternative—sometimes even superior— technologies. Holders of patents covering technology standards, known as standard- essential patents (SEPs), control the rights to an invention with no commercially viable alternative or that cannot be designed around while still complying with a standard. This gives SEP holders significant leverage in licensing negotiations

Standards development organizations (SDOs) …

Diffusion Mri Biomarkers For Predicting Treatment Outcomes In Infantile Epileptic Spasms Syndrome With Non-Lesional Mri, Daniel Ackom, Scott A. Beardsley, Jennifer Meylor, Kayleigh Butler, Ricardo Vega, Andrew J.D. Crow, Hema Patel, Brian D. Schmit, Pradeep Javarayee

Biomedical Engineering Faculty Research and Publications

Background

Infantile epileptic spasms syndrome (IESS) is a devastating developmental epileptic encephalopathy (DEE) and patients exhibit diffuse white matter alterations and structural remodeling. However, the correlation between these structural changes and brain network properties, or their effect on the efficacy of treatment outcomes in MRI non-lesional IESS patients is not clear.

Method

This retrospective study was conducted on IESS patients using fixel-based analysis (FBA) of diffusion MRI and graph theory analysis of structural connectivity, involving 26 non-lesional IESS patients aged 2 to 12 months and 120 age-matched controls. We further examined the differences between antiseizure medication (ASM) responders and non-responders …

Eugenics And Polygenic Embryo Screening: Public, Clinician, And Patient Perceptions Of Conditions Versus Traits, Dorit Barlevy, Rémy A Furrer, Asha Kalapatapu, Abigail Martinez, Todd Lencz, Shai Carmi, Gabriel Lázaro-Muñoz, Stacey Pereira

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Polygenic embryo screening (PES) estimates an embryo's genetic chances of developing complex conditions (eg, cancer) and traits (eg, height). Stakeholders have raised concerns that PES promotes eugenic practices and ideology.

Methods: We surveyed a nationally representative sample of the US public on approval of screening embryos for 12 conditions and 12 traits and examined the association between disapproval and concern about eugenics. We also conducted semistructured interviews with US-based reproductive endocrinology and infertility specialists and patients undergoing in vitro fertilization on their perspectives toward PES.

Results: Among the US public (n = 1423), disapproval of screening embryos for traits …

Draft Final Quarterly Operations And Maintenance Report Butte Treatment Lagoon System – Second Quarter 2025, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Indigenous Women’S Reproductive Traditions: Reclaiming Sovereignty Through 500 Years Of Colonization, Stephanie A. Sellers

Gettysburg College Faculty Books

In Indigenous Women’s Reproductive Traditions, Stephanie Sellers delves into the rich history of Indigenous women’s reproductive practices before European colonization. The book highlights traditional methods such as birth control, abortion, and child spacing, which were integral to maintaining agency over their bodies. Sellers explores how these practices were disrupted by European patriarchal structures and examines the impact of forced sterilization in the 20th century. Today, Indigenous women are reclaiming their rights through movements for reproductive justice, advocating for a return to their ancestral practices and redefining concepts of womanhood and motherhood on their own tribal terms.

From Strangers To Friends? An Ethnographic Study Of Developing Group Culture During A Short-Term Faculty-Led Study Abroad Program In Ireland, Victoria N. Seeger, Elizabeth Dimmitt, Keely Cline

Irish Journal of Academic Practice

This study examined the intersections of relationships that formed during a short-term, faculty-led study abroad programme in Ireland, and the elements of study abroad culture that allowed and fostered those relationships. We selected evidence-based ethnographic research as our approach to examine the sense of place and community in which relationships formed. We used Tuckman’s theory of group development (Tuckman & Jensen, 1977) as a theoretical framework through which to develop the ethnographic portrait of the students and explore the processes of how relationships developed over a relatively short period of time.

Pt 692.02: Independent Study - Medical Spanish, Andrew J. Kittelson

University of Montana Course Syllabi, 2021-2025

No abstract provided.

The Relationship Between Physical Activity And Health-Related Quality Of Life In College Students, Shelia Ann Fritts

Graduate Theses and Dissertations

This study explored the interaction effects of physical activity levels and race on college students' physical and mental health, focusing on Native American students. A total of 245 students participated, categorized by physical activity levels (low, moderate, and high) and race (Native American and others). Descriptive statistics outlined the sample characteristics and physical activity behaviors. At the same time, a two-way ANOVA was conducted to assess the effects of race and physical activity on health-related quality of life, measured through physical and mental composite scores (PCS and MCS). The results revealed a significant interaction effect between race and low physical …

A Theoretical Investigation Of Photo-Induced Deformations And Transitions In Nanoscale Ferroelectrics, Carmel Dansou

Graduate Theses and Dissertations

This dissertation presents a comprehensive first-principles investigation into the interaction of light with ferroelectric materials, focusing on light-induced structural responses (photostriction) and phase transitions in Ferroelectric superlattices, epitaxially strained BiFeO3 thin films, and twodimensional NbOX2 (X = Cl, Br, I) ferroelectrics. The work aims to provide microscopic insights into how light can control the lattice structure and even the crystallographic phase in these systems, with the broader goal of informing the design of light-responsive functional materials for practical technological applications. The first part explores light-induced effects in PbTiO3/SrTiO3 superlattices with different polarization orientations. Our simulations reveal that photoexcitation modifies the …

Urbanization, Climate Change, And Water Quality In Northwest Arkansas Caves, Eliezer Ugarte

Graduate Theses and Dissertations

The Ozark Cavefish is one of multiple species of conservation concern found in Cave Springs Cave and Logan Cave in Northwest Arkansas (NWA). Over the past two decades, the urbanization of NWA has negatively impacted the recharge areas of both caves, and in turn the water quality of both cave streams. The changing climate has also altered temperature and precipitation, which influence many aspects of karst groundwater. These effects are shown in the historical water quality records for both caves. However, these records are from varied sources and have never been comprehensively compiled and analyzed. This thesis approaches the issue …

Synthesis And Properties Study Of Layered Magnetic Topological Materials, Gokul Acharya

Graduate Theses and Dissertations

The discovery of topological materials (TMs) has opened up exciting opportunities for probing fundamental physics and enhancing innovative device integrations. These materials display various exotic properties, such as large magnetoresistance, high mobility, chiral anomaly, and surface Fermi arcs. The magnetic versions of ZrSiS family, LnSbTe and LnPS (Ln = lanthanide) have attracted intensive attention as these materials provide a new platform to study interplay between magnetism, topological states, and electron correlations. The vast pool of topological materials has provided exciting avenues to precisely engineer the topological states by modulating spin-orbital coupling, electronic dimensionality, and lattice constant through element substitutions. This …

A Mobility Data-Driven Approach To Analyzing And Modeling Park Accessibility Inequities And Use In U.S. Cities, Michaelmary Chukwu

Graduate Theses and Dissertations

Urban Park accessibility inequities have been a longstanding issue globally and the United States in particular. Despite the benefits that urban parks provide, use and access is not equitably distributed among the population, often favoring historically privileged populations over others (disadvantaged). Fortunately, improvements have been made in recent years to promote balanced park distribution in some cities; however, evidence still shows that most cities are behind. Interestingly, the rise in human mobility data has facilitated the study of human behavior and use of activity spaces. This thesis advances the existing studies on park accessibility and emerging human mobility to study …

Exploring The Relationship Between Grit, Burnout, And Academic Success Among First-Year Osteopathic Medical Students During Fundamentals Of Anatomic Science I Course, Heather Guzik

Graduate Theses and Dissertations

Burnout is a significant issue among healthcare professionals. Burnout refers to the mental, emotional, and physical exhaustion that can develop throughout one’s career or studies. It can affect professionalism and patient care (National Academies of Sciences, Engineering, and Medicine: National Academy of Medicine, 2019). Studies have shown that burnout begins early in an individual's medical education and can increase throughout their training (Voltmer et al., 2021). It has been suggested that students with a high level of Grit may exhibit some resistance to burnout (Jumat et al., 2020; Lee et al., 2022). This noncognitive trait measures a person’s ability to …

A Security Worth Having: The Pursuit Of Happiness Through Reading Burney, Radcliffe, And Austen, Samantha Meeks

Graduate Theses and Dissertations

This dissertation explores the works of three female authors of female protagonists in the long 18th century: Frances Burney’s Camilla and Evelina; Anne Radcliffe’s The Mysteries of Udolpho and The Italian; and Jane Austen’s Northanger Abbey, Sense and Sensibility, and Pride and Prejudice. By following the paths to security the female protagonists of these novels fashion, and identifying the elements of Stoicism and related Hellenism and the aspects of cybernetics, this dissertation delves into the choices female protagonists make along the way regarding their security and how such choices lead to agency and self-fashioning for these women. Emotional, economic, and …

Ab Initio Studies On Mechanical Properties Of Freestanding Ferroic Monolayers, John Malcolm Davis

Graduate Theses and Dissertations

This thesis explores the role of mechanical properties and elastic couplings in freestanding paradigmatic ferroic monolayers within the framework of density functional theory. This dissertation is comprised of three interconnected published studies: (i) establishing the elastic behavior across a temperature-driven phase transition in SnSe monolayers; (ii) thermally-driven phase transitions in graphene-like silicene, germanene, and stanene, examining the structural stability and band gap occlusion; and (iii) magnetoelastic coupling in an Ising-like CrSiTe3 monolayer, focused on assessing magnetic contributions to the material stiffness by establishing a proper non-magnetic reference.

Deep Learning For Land Use Classification: A Systematic Review Of Hs-Lidar Imagery, Muhammad Zia Ur Rehman, Syed Mohammed Shamsul Islam, David Blake, Anwaar Ulhaq, Naeem Janjua

Research outputs 2022 to 2026

Remote sensing (RS) technologies have significantly advanced Earth observation capabilities, enhancing the characterization and identification of surface materials through both spaceborne and airborne systems. These advancements are crucial for improving environmental monitoring and urban planning. As RS datasets have become more accessible, their increased complexity has necessitated a shift from traditional machine learning techniques to more robust deep learning approaches, particularly convolutional neural networks (CNNs) and transformer-based models known for their superior feature extraction capabilities. This systematic review focuses on the application of these deep learning techniques in land use classification, emphasizing the fusion of hyperspectral (HS) and LiDAR data. …

Society Of Vascular And Interventional Neurology (Svin) Stroke Interventional Laboratory Consensus (Silc) Criteria For Training Standards And Maintenance Of Certification In Neurointervention, Ossama Y. Mansour, Kaiz S. Asif, Roberta Novakovic-White, Boris Pabon, Santiago Ortega-Gutierrez, Atilla Ozcan Ozdemar, Alicia Castonguay, Brijesh Mehta, Dileep R. Yavagal, Ameer E. Hassan

School of Medicine Publications

The global shortage of neurointerventionalists presents a challenge to timely stroke care, particularly in low‐ and middle‐income countries. The Society of Vascular and Interventional Neurology Stroke Interventional Laboratory Consensus criteria aim to standardize training and certification in neurointervention to address these disparities. This white paper reviews existing training standards in various regions, identifies gaps, and proposes a structured framework encompassing entry requirements, program structure, and certification processes. The Stroke Interventional Laboratory Consensus criteria further outline requirements for training centers and program directors. By establishing global standards, the Stroke Interventional Laboratory Consensus criteria seek to improve patient outcomes and expand access …

Silent Damage, Early Signals: A Narrative Review Of The Evolving Role Of Cardiac Biomarkers In Oncology-Driven Cardiotoxicity, Aura Calderon, Luis Salcedo, Jose Loayza, Catherine Matos, Ivan Mogollon, Francisco Arias, Everardo Cobos

School of Medicine Publications

Advancements in cancer therapy have led to improved patient survival but have also introduced an increasing risk of cardiotoxicity, particularly with agents such as anthracyclines, trastuzumab, and various targeted treatments. Cardiotoxic effects may present as myocardial injury, systolic or diastolic dysfunction, or heart failure (HF), often developing insidiously before clinical symptoms become evident. Early detection is therefore crucial to preserve cardiovascular health in oncology patients. This narrative review examines the expanding role of cardiac biomarkers; including high-sensitivity troponins, natriuretic peptides, Galectin-3, soluble ST2, and novel molecular markers like microRNAs, in identifying and monitoring chemotherapy-induced cardiac injury. It also highlights how …

Preliminary Investigation Of The Potential Health Risks Of Non-Formfitting Body Armor With A Focus On Female Warfighters, Melissa Sutter, Catherine E. Johnson

Mining Engineering Faculty Research & Creative Works

Introduction Body armor is an important piece of protective equipment for warfighters in battlefield environments. With more women now filling military roles, body armor designs may need to be further refined to accommodate the female anatomy instead of the male-based unisex designs. Unisex designs have been found to have negative effects on female warfighter performance, resulting in discomfort, breathing difficulty, and air gaps forming between the armor and torso. This study aimed to investigate increased injury risk because of air gaps from shock wave exposure on warfighters wearing nonform-fitting armor and the influence of material properties. Based on literature, lowered …

Patient-Centered Management Of Heavy Menstrual Bleeding While On Anticoagulation: A Survey Study, Benjamin Barnett, Rushad Patell, Dana Angelini, Leben Tefera, Jordan K Schaefer, Ang Li, Alejandra Gutierrez Bernal, Shruti Chaturvedi, Anjlee Mahajan, Leslie Lake, Jori May, Anna L Parks

Faculty, Staff and Students Publications

Background: Nearly three-quarters of women experience heavy menstrual bleeding (HMB) during anticoagulation treatment for venous thromboembolism (VTE). HMB can lead to medical interventions, impact school or work and diminish quality of life (QOL). While there are several management options for HMB in patients with VTE, we lack information on how patients approach HMB treatment decisions.

Objectives: We examined patients' experience with, perceptions of, and preferences for treatment of HMB while on anticoagulation.

Methods: Clinicians and patient advocates developed a web-based survey that was distributed via patient advocacy organizations and social media between May and June 2024, targeting participants 18 years …

Eular/Acr Classification Criteria For Paediatric Chronic Nonbacterial Osteomyelitis (Cno)., Yongdong Zhao, Melissa S. Oliver, Anja Schnabel, Eveline Y. Wu, Zhaoyi Wang, Achille Marino, Cassyanne L. Aguiar, Jonathan D. Akikusa, Ummusen Kaya Akca, Beverley Almeida, Simone Appenzeller, Erin Balay-Dustrude, Ozge Basaran, Matthew L. Basiaga, Yelda Bilginer, David A. Cabral, Martina Capponi, Nathan Donaldson, Bugra Han Egeli, Emily Fox, Antonella Insalaco, Ramesh S. Iyer, Annette F. Jansson, Inna Kostik, Mikhail Kostik, Leonard K. Kovalick, Katia Tomie Kozu, Sivia K. Lapidus, Tzielan C. Lee, Aleksander Lenert, Kamran Mahmood, Edoardo Marrani, Doaa Mosad Mosa, Ian Muse, Alexander Mushkin, Katherine D. Nowicki, Farzana Nuruzzaman, Karen Onel, Manuela Pardeo, Trang Sophia Pham, Lauren Potts, Athimalaipet V. Ramanan, Angelo Ravelli, Nathan D. Rogers, Andrew W. Grim, Micol Romano, Natalie Rosenwasser, Takashi Shawn Sato, Gabriele Simonini, Jennifer B. Soep, Sara M. Stern, Timmy Strauss, Angela Taneja Kohli, Alexander C. Theos, Lori B. Tucker, Leslie F. Vogel, Shima Yasin, Stephen C. Wong, Katerina Bouchalova, Alison M. Hendry, Kevin C. Cain, Hermann J. Girschick, Fatma Dedeoglu, Christian M. Hedrich, Ronald M. Laxer, Polly J. Ferguson, Raymond Naden, Seza Ozen

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: To develop and validate classification criteria for paediatric chronic nonbacterial osteomyelitis (CNO) jointly supported by the European Alliance of Associations for Rheumatology (EULAR) and the American College of Rheumatology (ACR).

METHODS: This international initiative had 4 phases: (1) candidate items were proposed in a survey of paediatric rheumatologists, (2) criteria definition and reduction by Delphi and nominal group technique exercises, (3) criteria weighting using multicriteria decision analysis, and (4) refinement of weights and threshold score in a development cohort of 441 patients and validation in another cohort of 514 patients.

RESULTS: The new EULAR/ACR classification criteria for CNO require …

Associations Of Biomarkers Of Systemic Inflammation, Angiogenesis, And Cell-To-Cell Adhesion With Tumor Budding Among Early-Onset And Later-Onset Colorectal Cancer Patients, Oda Hausmann, Adetunji T Toriola, Et Al.

2020-Current year OA Pubs

BACKGROUND: High tumor budding and elevated systemic inflammation are adverse prognostic indicators in colorectal cancer. Its underlying mechanisms remain poorly understood. It is unclear whether systemic inflammation, angiogenesis, and cell-to-cell adhesion influence tumor budding.

METHODS: We investigated n = 132 stage I-III colorectal cancer patients recruited at Huntsman Cancer Institute enrolled in the ColoCare Study. Tumor budding was evaluated using an evidence-based scoring system, and patient sera were analyzed for nine circulating biomarkers using the Meso Scale Discovery platform. We examined associations between biomarkers and tumor budding using multivariable linear regression models adjusted for age, sex, neoadjuvant treatment, stage, and …

Minimally Invasive, Bioadaptive Multimodal Sensor Probe With Safe Deployment For Real-Time Acute Compartment Syndrome Diagnosis, Seung Gi Seo, Amanda M Westman, William Moritz, Joseph Ribaudo, Mitchell A Pet, Et Al.

2020-Current year OA Pubs

Acute Compartment Syndrome (ACS) is a serious medical condition that arises from increased pressure within osteofascial compartments, leading to impaired blood flow and potential tissue damage. Early and accurate diagnosis is critical for preventing permanent damage. Current methods rely largely on qualitative assessments with limited accuracy, and those that exploit invasive pressure measurements often prove inadequate. Herein, a soft materials-based multimodal sensor probe is introduced, as well as the mechanical and thermal influences to monitor intra-compartmental pressure, tissue oxygen saturation (StO

Characterization Of A Mouse Model Of Osteoarticular Infection Using Clinical Isolates Of Staphylococcus Aureus, Philip M Roper, Jessica Beetner, Jennifer L Davis, Christine Shao, Jason Zhang, Linda Cox, Nitin Kumar Pokhrel, James E Cassat, Javier Rangel-Moreno, Gowrishankar Muthukrishnan, Deborah J Veis

2020-Current year OA Pubs

Osteoarticular infection, most commonly due to

Variation In Recommended Treatment Strategies Among American Surgeons For Actual Adult Traumatic Brachial Plexus Injury Cases, Michele N Christy, Christopher J Dy, R Glenn Gaston, Bryan J Loeffler, Mihir J Desai, Steve K Lee, Harvey Chim, Jeffrey B Friedrich, Sameer K Puri, Jason H Ko, Planet Study Group

2020-Current year OA Pubs

PURPOSE: The surgical management of adult traumatic brachial plexus injuries (BPI) is challenging, with no consensus on optimal strategies. This study aimed to gather preferred reconstructive strategies from BPI surgeons for actual cases from a multicenter cohort to identify areas of agreement.

METHODS: Four case files (history, physical examination, and imaging and electrodiagnostic testing results) were distributed to eight self-designated Level IV expert BPI surgeons in the United States. Each surgeon independently reviewed the cases and provided a preferred reconstructive plan via free text response.

RESULTS: For a pan-plexus case after blunt trauma (67 years old; 3 months from injury): …

Walking Interventions And Cognitive Health In Older Adults: A Systematic Review Of Randomized Controlled Trials, Jongwon Lee, Delia West, Christine Pellegrini, Jingkai Wei, Sara Wilcox, Jean Neils-Strunjas, A Caroline Rudisill, Daniela B Friedman, David X Marquez, Jenna Dzwierzynski, Joyce Balls-Berry, Rachelle Gajadhar, Chih-Hsiang Yang

2020-Current year OA Pubs

ObjectiveThis systematic review summarizes the effectiveness and the dose of walking interventions on specific cognition domains in older adults, including executive function, memory, attention, processing speed, and global cognition.Data sourcePublished randomized controlled trials in PubMed, Embase, and Web of Science until 10 May 2023.Study Inclusion and Exclusion CriteriaStudies include older adults without Alzheimer's or related dementias, involving a walking intervention and performance-based neuropsychological assessments for executive function, memory, processing speed, attention, or global cognition.Data ExtractionTwo independent research assistants reviewed 8424 studies and included 17 studies.Data SynthesisParticipant demographics, intervention features (type, intensity, time, frequency, duration, format, and context), cognitive assessment tools, …

Pedicle Lengthening Osteotomy For Lumbar Spinal Stenosis: A Systematic Review Of Cadaveric, Computational, And Clinical Outcomes, Jonathan A Ledesma, Julio Castillo Tafur, Bradley Anderson, Lasya Rangavajjula, Mark J Lambrechts, D Greg Anderson

2020-Current year OA Pubs

Study DesignSystematic Review.ObjectiveTo review the available published literature relating to pedicle lengthening osteotomy (PLO) for lumbar spinal stenosis (LSS), and to compare this technique to existing surgical options.MethodsPubMed/MEDLINE, Embase, and Scopus were reviewed using the keywords: "pedicle lengthening", "lumbar", and "spinal stenosis." Results were reviewed for relevance and included only if they met inclusion criteria. The SYRCLE checklist was used to assess for sources of bias.ResultsInclusion criteria were biomechanical or clinical studies evaluating PLO for LSS. A total of 56 studies were identified in the Pubmed/MEDLINE database using the above-mentioned search criteria. Additionally, a total of 83 abstracts were reviewed …

Inflammatory Pain In Mice Induces Light Cycle-Dependent Effects On Sleep Architecture, Dominika J Burek, Khairunisa Mohamad Ibrahim, Andrew G Hall, Ashish Sharma, Jessica A Cucinello-Ragland, Erik S Musiek, Jose A Morón, William A Carlezon Jr

2020-Current year OA Pubs

Pain syndromes include physical, sensory, emotional, and cognitive symptoms such as disability, negative affect, feelings of stress, and fatigue. Experimental induction of long-term inflammatory pain in rodents by hindpaw injection of complete Freund's adjuvant (CFA) produces anhedonia and dysregulated naturalistic behaviors, similar to the effects of unregulated stress. We examined whether these similarities extend to changes in sleep and rhythms, such as those induced by chronic social defeat stress, using actigraphy and wireless EEG in mice. Comparisons were made between groups that received injections at the onset of the light or dark phase. We found that CFA-induced inflammatory pain alters …

Differences In Physician Electronic Health Record Use By Telemedicine Intensity: Evidence From 2 Academic Medical Centers, Seunghwan Kim, Robert Thombley, Elise Eiden, Sunny Lou, Julia Adler-Milstein, Thomas Kannampallil, A Jay Holmgren

2020-Current year OA Pubs

OBJECTIVE: Evaluate the association between telemedicine intensity and ambulatory physician electronic health record (EHR) use following the COVID-19 pandemic.

MATERIALS AND METHODS: This retrospective study included ambulatory physicians in 11 specialties at 2 large academic medical centers (Washington University in St Louis [WashU], University of California San Francisco [UCSF]). EHR use measures, including time-based and frequency-based, were analyzed in the post-COVID-19 period (March 1, 2021, through March 7, 2022). Multivariable regression models with 2-way fixed effects were used to assess the association between telemedicine intensity and EHR use.

RESULTS: Fully telemedicine physician-weeks were associated with higher EHR (hours per 8 …

Rezafungin Versus Caspofungin For The Treatment Of Candidemia And Invasive Candidiasis: Results From The Double-Blind, Randomized, Phase 3 Restore Trial Including The China Extension Study, George R Thompson, Haihui Huang, Sizhou Feng, Yunsong Yu, Alex Soriano, Oliver A Cornely, Bart Jan Kullberg, Peter G Pappas, Marin Kollef, Jose A Vazquez, Patrick M Honore, Laura Cox, Matteo Bassetti

2020-Current year OA Pubs

BACKGROUND: Rezafungin is approved for use in adults with candidemia and/or invasive candidiasis (IC) based on data from the ReSTORE trial (NCT03667690), which demonstrated noninferior efficacy to caspofungin. For regulatory purposes, an additional cohort of patients from China was recruited to ReSTORE. Here, we compared rezafungin and caspofungin in patients with candidemia and/or IC through analysis of the ReSTORE global data plus the China extension study.

METHODS: Adults with candidemia/IC were randomized (1:1) to receive weekly rezafungin (400/200 mg) or daily caspofungin (70/50 mg) for ≤28 days. Noninferiority was concluded for primary efficacy endpoints if the upper bound of the …