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Breath Acetone As A Biomarker For Concussion, Allyn Abadie Sep 2025

Breath Acetone As A Biomarker For Concussion, Allyn Abadie

All ETDs from UAB

Concussions represent a critical public health concern, affecting millions annually yet remain challenging to diagnose and manage. Concussions involve a range of often invisible signs and symptoms. Traditional assessments rely heavily on subjective symptom reporting, with limited objective data which may complicate return-to-play decisions. Objective physiological biomarkers are needed to complement traditional methods, detect subtle disruptions, and improve decision-making. Following concussion, the brain undergoes a neurometabolic cascade involving disrupted glucose utilization, ionic imbalances, neurotransmitter release, and reduced cerebral blood flow. This cascade creates a metabolic crisis, potentially shifting energy metabolism toward alternative substrates such as ketones. Breath acetone, a measurable …

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Calibrating A Holling-Tanner Model With Applications To S&P500 Forecasting, Jonathon Knowles Sep 2025

Calibrating A Holling-Tanner Model With Applications To S&P500 Forecasting, Jonathon Knowles

All ETDs from UAB

The primary goal of this thesis is to improve upon existing dynamical system models in economics. Existing models utilizing Lotka-Volterra dynamics display a tendency to suffer from unrealistic forecasts dominated by exponential growth and decay. Additionally, current inverse methods are only applicable in differential equation systems with linear coefficients. In this body of work, we propose novel methods for handling these challenges.

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Adult Role Transitions And Substance Use In Black And White Young Adults, Kristina Brooke Mcmahan Sep 2025

Adult Role Transitions And Substance Use In Black And White Young Adults, Kristina Brooke Mcmahan

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ADULT ROLE TRANSITIONS AND SUBSTANCE USE IN BLACK AND WHITE YOUNG ADULTS ABSTRACT Substance use, including alcohol, tobacco, and cannabis, often begins during adolescence and young adulthood, which is a developmental period marked by major life transitions such as graduating college, entering full-time employment, and parenthood. Adult role transition patterns may influence substance use and mental health outcomes; however, limited research has examined these associations in racially and socioeconomically diverse populations. The present study explored patterns of adult role transitions and their associations with substance use and mental health symptoms among young adults using data from Wave 4 of the …

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Racial Discrimination And Inflammation In Adolescence: Ethnic/Racial Processes As Moderators, Queenisha Crichlow Sep 2025

Racial Discrimination And Inflammation In Adolescence: Ethnic/Racial Processes As Moderators, Queenisha Crichlow

All ETDs from UAB

Discrimination and other psychosocial stressors contribute to chronic disease by dysregulating neuroendocrine and immune systems, which often leads to increased levels of inflammation. Given that inflammation is a key biological pathway associated with the development of chronic diseases, it has been proposed as a potential mechanism linking racial discrimination to poorer health. Most studies linking racial discrimination with inflammation have focused on adults, despite the fact that children and adolescents also experience discrimination. This dissertation explores the association between racial discrimination and inflammation, measured via salivary C-reactive protein (CRP) and proinflammatory cytokines, among Black and Hispanic adolescents. It also examines …

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Immune And Endothelial Cell Mechanisms Of Cardiovascular And Kidney Disease Risk In Obesity, Claudia Edell Sep 2025

Immune And Endothelial Cell Mechanisms Of Cardiovascular And Kidney Disease Risk In Obesity, Claudia Edell

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Obesity is a major risk factor for cardiovascular and chronic kidney disease. Both inflammation and endothelial dysfunction are hallmark signs of adverse health outcomes in obesity. Previous data from our lab has shown that a 2-week time restricted feeding (TRF) intervention reduces kidney CD3+ (T) cells and fibrosis and improves endothelial function in a mouse model of diet induced obesity (DIO). There is little known about kidney damage and T cells in obesity. We hypothesized that TRF reduces kidney damage in obese mice through mitigating T cell inflammation. We use a 20-week DIO model, with 18 weeks of ad libitum …

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Identifying The Neurobiological Substrates Of Gulf War Illness, Chloe Lisette Jones Sep 2025

Identifying The Neurobiological Substrates Of Gulf War Illness, Chloe Lisette Jones

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Gulf War Illness (GWI) affects approximately 30% of veterans who served in the 1991 Persian Gulf War and is characterized by chronic pain and fatigue, as well as cognitive, mood, gastrointestinal, and respiratory symptoms. Animal research has suggested that GWI is caused by a combination of neurotoxicants such as nerve gas, anti-nerve agent pills, and pesticides, though a definitive pathophysiological model has not been established. In this human observational study, 20 veterans with GWI and 20 healthy Gulf War veterans (HV) underwent whole-brain magnetic resonance spectroscopy (MRS) to non-invasively measure several metabolites associated with neuroinflammation. Whole blood was also collected …

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A High-Salt Diet Modulates Renal Afferent Nerve Activity; Potential Role Of The Endothelin System, Jiaxi Shen Sep 2025

A High-Salt Diet Modulates Renal Afferent Nerve Activity; Potential Role Of The Endothelin System, Jiaxi Shen

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Hypertension is a prevalent disease around the world. Increased blood pressure leads to a higher risk of stroke and coronary heart disease. Diet, lifestyle, and gene regulation are potential causative factors, and salt-sensitive hypertension is one common types of hypertension. In response to a high-salt diet, blood pressure may elevate with increasing risks of cardiovascular disease (CVD). Endothelin-1, which binds to endothelin A (ETA) and B (ETB) receptors, is strongly involved in controlling the blood vessels and sensory nerve signaling pathway between the kidney and the central nervous system during high salt dietary challenge. The function of the ETB receptor …

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Myelin Mapping In Psychosis, Victoria Lynn King Sep 2025

Myelin Mapping In Psychosis, Victoria Lynn King

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It is well established that myelin in the central nervous system is an axonal insulator which speeds the conduction velocity of action potentials. However, its role in the cortex has also been shown to support metabolic demands and aid in cortical plasticity. Myelin develops throughout childhood and adolescence from sensorimotor areas to association areas and peaks during adolescence. Importantly, this is the same time that psychosis-spectrum disorders (PSDs) begin to present clinically; thus, given the critical role of myelination in shaping the mature cortex, disruptions in this process – particularly during adolescence – are thought to partially explain the onset …

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Structural Basis For Promoter Recognition By Pseudomonas Phage Dev Virion Associated Rna Polymerase, Brittney Bird Sep 2025

Structural Basis For Promoter Recognition By Pseudomonas Phage Dev Virion Associated Rna Polymerase, Brittney Bird

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Bacteriophage DEV, a member of the Schitoviridae family, encodes a large virion-associated RNA polymerase (vRNAP) and shows significant potential for use in phage therapy. However, many aspects of DEV’s biology remain poorly understood, especially how it regulates transcription once inside the host. Recent work in our lab suggests that gene product 71 (gp71) functions as a DNA-dependent vRNAP. Analogous to the vRNAP of coliphage N4, gp71 likely initiates transcription by recognizing single-stranded DNA templates that contain early gene hairpin promoters. Based on this, my working hypothesis is that specific interactions between gp71 and the DEV early promoters PE1 and PE5 …

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Characterizing The Role Of Pneumococcal Surface Protein A And Humoral Immunity To Biofilm Antigens During Streptococcus Pneumoniae Colonization, Jessica Lane Sep 2025

Characterizing The Role Of Pneumococcal Surface Protein A And Humoral Immunity To Biofilm Antigens During Streptococcus Pneumoniae Colonization, Jessica Lane

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Streptococcus pneumoniae (Spn), or “the pneumococcus”, is a Gram-positive bacterium that colonizes the upper respiratory tract as a pathobiont. Spn is a deadly human pathogen, and one of the leading etiological agents of community-acquired pneumonia (CAP). One virulence factor of Spn is pneumococcal surface protein A (PspA), a choline-binding protein (CBP) at the surface of the bacteria that interacts with the host environment. Here, we demonstrated a novel role for PspA involving adhesion to dying host nasal epithelial cells via a multimeric complex with host lactoferrin (LF) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). We found that the PspA-GAPDH complex aggregated the bacteria …

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"Organizational Characteristics And Market Factors Associated With The Adoption Of Hospital At Home", Vincent Turner Sep 2025

"Organizational Characteristics And Market Factors Associated With The Adoption Of Hospital At Home", Vincent Turner

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ORGANIZATIONAL CHARACTERISTICS AND MARKET FACTORS ASSOCIATED WITH THE ADOPTION OF HOSPITAL AT HOME VINCENT TURNER, JR. HEALHTCARE LEADERSHIP ABSTRACT The healthcare environment has continued to be reshaped and forced to evolve over the last several decades and even more so in recent years. This evolution and reshaping have been forced by both internal and external factors withing the healthcare landscape. This has tasked hospital leaders with exploring new ways of delivering care. The COVID-19 pandemic was an external circumstance the forced hospital leaders to look at alternate ways of providing care, more specifically in the home setting. Hospitals were introduced …

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Understanding Clinical Tool Adoption In Primary Care: A Case Study Of The Cmds Care Pathway, Khushbu Khatri Park Sep 2025

Understanding Clinical Tool Adoption In Primary Care: A Case Study Of The Cmds Care Pathway, Khushbu Khatri Park

All ETDs from UAB

The rising prevalence of obesity, diabetes, and cardiovascular disease (CVD) places increasing strain on healthcare systems and primary care providers (PCPs). In response, the University of Alabama at Birmingham (UAB) adapted the Cardiometabolic Disease Staging System (CMDS), a validated clinical decision support tool, designed to stratify patient risk and guide evidence-based treatment. Embedded within the electronic health record (EHR) as a Care Pathway, the CMDS was designed for real-time use during primary care visits. This dissertation examines utilization of the CMDS in a two-phase case study, guided by the Adult Learning Theory, Group Dynamics Theory, Force Field Theory and Change …

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Controlling Properties Of Pmaa Multilayer Hydrogel Microparticles Through Network Structure, Daniel Inman Sep 2025

Controlling Properties Of Pmaa Multilayer Hydrogel Microparticles Through Network Structure, Daniel Inman

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Advancements in the fabrication of “smart” stimuli responsive hydrogel microparti-cles have been pivotal in their optimization for applications. The responsiveness of hydro-gel networks to external stimuli enhances the intrinsic properties of hydrogels to increase functionality. Through layer-by-layer assembly, the internal composition, network struc-ture, and surface chemistry of multilayer hydrogels can be directly controlled to introduce new and unique properties. Applicable to a wide variety of shapes and sizes; hydrogel mi-croparticles are versatile for biological interactions, such as, cellular internalization, tissue regeneration, biosensors, and more. Thus, this dissertation will discuss the synthesis of shaped pH-responsive hydrogel microparticles and the investigation of …

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Bridging The Gap: Exploring The Facilitators And Barriers In The Self-Management Of Diabetes And Pain In Rural Southern Communities, Kennedy Nicole Butler Sep 2025

Bridging The Gap: Exploring The Facilitators And Barriers In The Self-Management Of Diabetes And Pain In Rural Southern Communities, Kennedy Nicole Butler

All ETDs from UAB

Southern rural communities experience a higher prevalence of Type 2 diabetes (T2D) and associated comorbidities, which increases rates of premature mortality due to socio-environmental factors, pre-existing health conditions, and economic burden in comparison to their urban counterparts. Fifty percent of individuals with T2D experience pain or chronic pain (CP); however, individuals in rural communities disproportionately experience symptoms of CP. CP is a physically debilitating condition that can inhibit mobility and reduce quality of life. T2D and the co-occurrence of CP can limit an individual's ability to engage in self-managing behaviors. While diabetes self-management education and support (DSMES) programs, along with …

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Effect Of Fiber Structure Heterogeneity On The Estimation Of Material Parameters For Cardiac Scar Tissue Mechanics, Desmond Maximilian Flanagan Sep 2025

Effect Of Fiber Structure Heterogeneity On The Estimation Of Material Parameters For Cardiac Scar Tissue Mechanics, Desmond Maximilian Flanagan

All ETDs from UAB

Over one million Americans suffer from myocardial infarction (MI) per year. After MI, the heart muscle is replaced by scar, whose mechanical properties play a critical role in outcomes for surviving patients. Previously, Caggiano et al. induced MI in rats, and ex-tracted the scar tissue samples for microscopy and mechanical testing. Building on this, we investigate the effect of incorporating microscopy-derived fiber heterogeneity on the estimation of stress and material parameters. We studied the effect of fiber orientation heterogeneity on the mechanical characteriza-tion of scar tissues using finite element models (FEM) that replicated biaxial tests. We used three constitutive models—Mooney-Rivlin, …

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The Association Of Resilience Factors With Mental Health Outcomes Among Middle-Aged And Older People Living With Hiv, Jeremy Delgadillo Sep 2025

The Association Of Resilience Factors With Mental Health Outcomes Among Middle-Aged And Older People Living With Hiv, Jeremy Delgadillo

All ETDs from UAB

Research suggests that people living with HIV (PLWH), an aging chronic health population, have higher prevalence rates and severity of mental health and substance use disorders compared to people living without HIV (PLWoH). Cross-sectional and longitu-dinal studies have suggested intrapersonal resilience factors may serve a protective function in reducing the prevalence and severity of mental health and substance use outcomes among PLWH. The purpose of the current study was two-fold. The first aim was to systematically review the current state of the literature from 2000 to present that examined the associations between intrapersonal resilience factors and mental health outcomes among …

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Turn On, Tune In, Drop Shame: Exploring The Unique Therapeutic Potential Of Psychedelics For Sexual And Gender Minority Populations, Nicholas Carlisle Sep 2025

Turn On, Tune In, Drop Shame: Exploring The Unique Therapeutic Potential Of Psychedelics For Sexual And Gender Minority Populations, Nicholas Carlisle

All ETDs from UAB

Sexual and gender minority (SGM) individuals face significant disparities in mental and physical health compared to their heterosexual and cisgender counterparts, due in part to chronic exposure to distal and proximal minority stressors. Shame – a self-focused characterized by a global sense of personal deficiency or unworthiness – has emerged as a key intrapersonal mechanism linking minority stressors to adverse health outcomes. This dissertation explores the role of shame in SGM health inequities and investigates the emerging potential of psychedelics to reduce shame and improve health and wellbeing in these populations. This three-paper dissertation begins with a scoping review (Paper …

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A Short Trip: A Mixed Methods Investigation Of The Perceived Effects Of Vaporized Dmt Vs Vaporized 5-Meo-Dmt, Cynthia Estrella Ortiz Sep 2025

A Short Trip: A Mixed Methods Investigation Of The Perceived Effects Of Vaporized Dmt Vs Vaporized 5-Meo-Dmt, Cynthia Estrella Ortiz

All ETDs from UAB

The rise in psychedelic use has been accompanied by increased interest in alternative routes of administration, including vaporization. However, little is known about the characteristics and outcomes associated with vaporized forms of N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT). This mixed-methods study examined the subjective experiences and mental health correlates of individuals who reported using vaporized DMT, vaporized 5-MeO-DMT, or psilocybin mushrooms in the past six months. A total of 209 adults completed an online survey assessing demographic variables, substance use, and psychological functioning, including measures of global health (PROMIS), subjective happiness, magical ideation, spiritual connection, psychosis-like experiences (CAPE-42), and hypomanic symptoms. …

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Mcl1 And Hexokinase 2 Form A Glucose Metabolic Regulatory Axis, Robert Lee Sep 2025

Mcl1 And Hexokinase 2 Form A Glucose Metabolic Regulatory Axis, Robert Lee

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Hexokinase 2 (HK2) initiates glucose metabolism by catalyzing the conversion of glucose to glucose-6-phosphate providing the starting substrate for a vast array of metabolic pathways such as glycolysis, pentose phosphate pathway (PPP), amino acid biosynthesis and others. While HK2’s metabolic role in normal physiologic function (such as in cardiomyocytes) and cancers (through driving the Warburg Effect) are well established, there is emerging evidence that supports HK2 is also a critical mediator of protein-protein interactions that regulate cell survival. Through comprehensive review, we explore how HK2 contributes to cell survival through metabolic and protein scaffolding roles. We also investigate a novel …

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Compartmentalized Antigen Presentation By Intestinal Epithelial Cells Directs Cd4 T Cell Fate, Christopher Garrett Wilson Sep 2025

Compartmentalized Antigen Presentation By Intestinal Epithelial Cells Directs Cd4 T Cell Fate, Christopher Garrett Wilson

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The intestinal epithelium maintains a complex relationship with both commensal microbiota and enteric pathogens while orchestrating local immune responses. Although intestinal epithelial cells (IECs) can express MHC class II molecules during inflammation, their functional contribution to pathogen-specific adaptive immunity and immunological memory remains poorly defined. This dissertation investigates the hypothesis that IECs actively shape CD4+ T cell responses through antigen presentation, using Citrobacter rodentium infection as a physiologically relevant model of human attaching and effacing bacterial pathogens. The C. rodentium model offers unique advantages for dissecting epithelial-immune interactions: it naturally infects mice through oral inoculation, exhibits precise anatomical tropism for …

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Modeling The Basal Ganglia Network Using Leaky Integrate-And-Fire Neurons To Explore Its Role In Facilitating Purposive Saccades, Saarth Anjali Chitale Sep 2025

Modeling The Basal Ganglia Network Using Leaky Integrate-And-Fire Neurons To Explore Its Role In Facilitating Purposive Saccades, Saarth Anjali Chitale

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Saccadic eye movements provide a well-defined behavioral readout for investigating how the basal ganglia (BG) contribute to action selection. While saccades are controlled by multiple brain regions, including direct excitatory inputs from various cortices, the BG exerts a key inhibitory influence. Decades of experimental work using saccadic behavioral paradigms in non-human primates have yielded important insights into the activity of BG populations. These include the caudate nucleus, subthalamic nucleus, globus pallidus externus, and substantia nigra pars reticulata, as well as dopaminergic afferents from the substantia nigra pars compacta and efferent projections to the superior colliculus, which controls eye movements. Despite …

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Solitary Waves For Power Degenerate Non Linear Schro ̈Dinger Equation And Fourth Order Wave Equation., Vishnu Iyer Sep 2025

Solitary Waves For Power Degenerate Non Linear Schro ̈Dinger Equation And Fourth Order Wave Equation., Vishnu Iyer

All ETDs from UAB

In this dissertation we prove the existence and stability of solitary waves for the power degenerate non linear Schr ̈odinger equation (2.1.1) and a fourth order wave equation (3.1.1). Construction of the waves are variational in nature. For the NLS we consider a semilinear Schr ̈odinger equation, driven by the power degenerate second order differential operator ∇ · (|x|2a∇), a ∈ (0, 1). We construct the solitary waves, in the sharp range of parameters, as minimizers of the Caffarelli- Kohn-Nirenberg’s inequality. Depending on the parameter a and the nonlinearity, we establish a number of properties, such as positivity, smoothness (away …

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Bridging Fact And Fiction: Lawrence Alma-Tadema’S And Georg Ebers’ Visions Of Ancient Egypt, Elizabeth Casement Sep 2025

Bridging Fact And Fiction: Lawrence Alma-Tadema’S And Georg Ebers’ Visions Of Ancient Egypt, Elizabeth Casement

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Existing research on the methodology behind the production of ancient Egyptian-themed paintings of Lawrence Alma-Tadema (1836-1912) has centered on his use of an extensive cache of reference materials. This thesis suggests that Alma-Tadema’s sources of historical information and creative influence far exceeded his private reference library, also hinging on his vast personal network and specifically examining the collaborative friendship he maintained with German author and professor of Egyptian studies Georg Ebers (1837-1898). A thorough reading of letters from Alma-Tadema to Ebers elucidates the impact of the German author on the artist’s understanding of Egypt from the Pharaonic to the Roman …

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Standardizing Sea Urchin Husbandry: Tank Effects, Gamete Production, And Co-Culture, Raven Amber Edwards Sep 2025

Standardizing Sea Urchin Husbandry: Tank Effects, Gamete Production, And Co-Culture, Raven Amber Edwards

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This dissertation seeks to further knowledge of sea urchin husbandry in three major areas that have so far not been investigated substantially: optimal conditions for housing sea urchins in a lab-based recirculating aquaculture systems (RAS), impacts of repetitive spawning regimens on reproductive output, and co-culture utilizing juvenile oysters. All studies utilize a commercial recirculating aquaculture system that is relatively novel for culturing sea urchins. The first chapter investigated the influence of housing conditions on sea urchin growth outcomes. Under the conditions of this study, the size of the tank showed limited influence on growth; however, stocking density was found to …

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Access To Care, Structural Barriers, And Recovery Identity In Mental Health And Substance Use Disorder Treatment, Yahya Alnashri Sep 2025

Access To Care, Structural Barriers, And Recovery Identity In Mental Health And Substance Use Disorder Treatment, Yahya Alnashri

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Substance use disorders (SUDs) remain one of the most pressing public health and economic challenges in the United States, with growing recognition that recovery is a multidimensional process shaped by clinical, social, and structural factors. This dissertation explores recovery at the levels of health policy, population, and experiential levels to assess gaps in access to recovery support services, identify patterns and predictors of recovery identity, and highlight the lived experiences of individuals with opioid use disorder. First, we evaluated whether state Medicaid expansion under the ACA (2010–2019) was associated with changes in the availability of consumer-run peer support services in …

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Leveraging Computational Modelling/Simulation, Machine Learning, And Additive Manufacturing For Customized Design Of Periodontal And Bone Tissue Scaffolds, Rakesh Pemmada Sep 2025

Leveraging Computational Modelling/Simulation, Machine Learning, And Additive Manufacturing For Customized Design Of Periodontal And Bone Tissue Scaffolds, Rakesh Pemmada

All ETDs from UAB

The current dissertation presents an overarching pipeline for the development and production of custom-made scaffolds for periodontal tissue regeneration using finite element analysis (FEA), machine learning (ML), and additive manufacturing (AM).CAD anatomically realistic scaffolds were generated from CT-based maxilla and mandible models. The FEA simulation results under masticatory (100 N), parafunctional (500–550 N), and traumatic (800–850 N) loads showed region-specific distribution of stresses and strains, which guided structural reinforcement strategies. Over 1000 3D-printed PCL scaffolds were printed using various pore diameters (200–300 µm) and filament diameters. Five ML models were constructed for predicting print quality based on process factors. Classification …

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Promoting Mental Health And Social-Emotional Development In Underserved Families, Brianna Paquette Sep 2025

Promoting Mental Health And Social-Emotional Development In Underserved Families, Brianna Paquette

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The overarching goal of this dissertation was to investigate interventions that aimed to support mental health and child development in underserved families. Individuals from low-income households often experience mental health difficulties, such as higher rates of caregiver depression. Additionally, children from disadvantaged backgrounds are more likely to face difficulties with social and emotional development. This dissertation is comprised of three papers exploring interventions to facilitate child development and well-being in low-income families. The first paper is a systematic review and meta-analysis on home visiting interventions aimed at supporting the social-emotional development of children from birth to five years of age. …

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Imaging A Digital Stock Exchange, Mrigank Mrigank Sep 2025

Imaging A Digital Stock Exchange, Mrigank Mrigank

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In 2021, Rama Cont and Marvin M¨uller proposed a stochastic partial differential equation (SPDE) that models the density of orders in the limit order book at a given distance from the mid-price. In this thesis, we begin with a generalized version of the Cont–M¨uller SPDE and formulate an associated inverse problem. We present two alternative approaches to framing this inverse problem and establish, under appropriate assumptions, that it is conditionally well-posed. To solve the inverse problem, specifically, to recover the coefficients in the generalized Cont–M¨uller model, we adapt a variational approach involving the minimization of convex functionals. The recovered coefficients …

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Understanding Visual Memory Encoding And The Effects Of Endurance Exercise In Healthy Adults And People With Temporal Lobe Epilepsy, Brandon Steve Mitchell Sep 2025

Understanding Visual Memory Encoding And The Effects Of Endurance Exercise In Healthy Adults And People With Temporal Lobe Epilepsy, Brandon Steve Mitchell

All ETDs from UAB

The visual memory encoding (VME) of indoor and outdoor scenes is a complex cognitive process that primarily utilizes the bilateral hippocampi and medial temporal lobe (MTL) structures along the parahippocampal gyrus. Alpha and theta frequency band oscillations are important in the processing of visual information and memory formation, respectively. We completed hree studies investigating the cognitive process of VME in healthy adults and people with temporal lobe epilepsy (pwTLE). The first study was cross-sectional and utilized a functional magnetic resonance imaging (fMRI)-constrained magnetoencephalography (MEG) analysis in healthy adults to explore VME. The fMRI results were used as spatial priors to …

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Wellness Perspectives Of Early Career Teachers: An Exploratory Study Of School Culture And Environment, Amy Day Carr Sep 2025

Wellness Perspectives Of Early Career Teachers: An Exploratory Study Of School Culture And Environment, Amy Day Carr

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Purpose: The purpose of this grounded theory dissertation was to explore Alabama early career teachers’ perceptions of personal wellness, the wellness culture and environment of their school system, and the impact of the culture on teacher wellness and job satisfaction. Early career teachers face unique challenges that contribute to high turnover rates, yet their wellness has not been systematically studied. This study sought to answer three primary research questions with sub-questions. Teachers were asked to describe their personal wellness, the wellness culture at their schools, and the effect of the wellness culture and environment of the school on teachers in …

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