Digital Commons Network^™

Integrated Llm-Powered Framework For Real-Time Monitoring In Machining Using Smartphone And Ai Agent Orchestration, Mustafa H. Hadi, Hussam L. Alwan, Atiya Al-Zuheri, Sang-Heon Lee, Yousef Amer

Engineering and Technology Journal

Reliable tool condition monitoring is essential for maintaining machining quality, reducing production downtime, and preventing unexpected tool failures. Conventional tool condition monitoring systems can accurately detect tool wear but typically provide limited support for automated diagnosis and maintenance decision-making. To address this limitation, this paper proposes an economical AI agent-driven maintenance framework for milling operations that integrates smartphone-based vibration sensing, one-dimensional Convolutional Neural Networks (1D-CNNs), and Large Language Model (LLM)-powered AI agents. Vibration signals acquired using a smartphone-embedded accelerometer are preprocessed and analyzed using a 1D-CNN to classify tool conditions into fresh and worn states. The classification results are then …

Occurrence And Distribution Of Polychlorinated Naphthalenes In Consumer Products And Landfill Matrices: A First Assessment In South Africa, Vhodaho Nevondo, Raissa Okwuosa, Okechukwu Jonathan Okonkwo

Engineering and Technology Journal

Polychlorinated Naphthalenes (PCNs) are persistence organic pollutants (POPs) which have been used extensively and continue to be a source of environmental and human health issues in spite of the international ban on their production. This work represents the first report of PCNs in consumer goods, landfill leachate, and sediment samples in South Africa. In this study, a total of 24 consumer goods belonging to eight categories were analyzed along with landfill leachates and sediments from the Hatherly and Goudkoppies landfills, Gauteng Province, South Africa, for some selected PCN congeners by gas chromatography mass spectrometry (GC-MS) analysis. Quality assurance procedures and …

Investigation Of Plasma-Induced Surface Modification Of Pmma Using Nd:Yag Laser-Induced Breakdown Spectroscopy, Shaimaa S. Mahdi, Asmaa J. Kadhim, Zainab Salam Khaleefah

Engineering and Technology Journal

Poly(methyl methacrylate) (PMMA) plays an important role in many applications, including biomedical, industrial, and optical applications. Due to its surface properties, which are essential to its performance. The PMMA samples were exposed to a dielectric barrier discharge (DBD) air plasma with a duration time of 300 s. In this investigation, laser-induced breakdown spectroscopy (LIBS) in combination with Fourier transform infrared spectroscopy (FTIR) was used to study the surface properties of exposed to plasma samples. The laser pulses were set to (60, 80, and 100) mJ. The resulted spectra were recorded over a wide spectral range from 200 to 1100 nm. …

Bim-Safety Integration In The Nigerian Construction Industry Using The Unified Theory Of Acceptance And Use Of Technology (Utaut) Model, Ranti T. Adebiyi, Ganiyu Amuda-Yusuf, Olubola Babalola, Nurudeen A. Bello, Aminat D. Amuda, Kaosarat A. Olowookere

Engineering and Technology Journal

Health and Safety (H&S) challenges are a significant concern in the Nigerian construction industry, largely due to the lack of a reliable national accident database and the persistence of a fatalistic safety culture. Building Information Modelling (BIM) is a transformative digital framework that enables visual hazard identification and proactive risk simulation; however, its use in site safety management remains limited and inconsistent. This study investigates the behavioural, social, and structural determinants influencing the adoption of BIM-based H&S practices among construction professionals, utilising the Unified Theory of Acceptance and Use of Technology (UTAUT). A hypothetical multi-level design was used to model …

Macro-Scale Ultra-Vacuum Containment Vaults (Uvcv) And Detached Robotic Logistics Logs For The Absolute Elimination Of Interfacial Oxidative Degradation, Christopher L. Eckes

Defensive Publications Series

This specification formalizes the macroscopic architectural layout, atmospheric seal metrics, and automated robot-to-machine routing protocols required to establish an external environmental guardrail for high-throughput Elemental Transmutation Replicator (ETR) industrial nodes. Prior art (Paper 128) details the micro-scale electro-hydrodynamic lamination of edible protective polymer skins over hyper-accelerated macro-nutrient streams. However, mechanical nozzle failures or unexpected microfluidic backpressure cascades introduce an operational vulnerability: transient exposure to ambient atmospheric oxygen (O₂) and water vapor (H₂O) can cause instant material degradation and structural collapse during high-velocity extrusion passes.

This disclosure resolves this structural vulnerability by placing the entire replication assembly inside a sealed, structural …

Dynamic Harmonic Resampling And Ternary Fluid-Canvas Operating Networks For The Elimination Of Volumetric Washout In High-Throughput System Interfaces, Christopher L. Eckes

Defensive Publications Series

This specification establishes the software-hardware architecture, fluid-canvas compilers, and low-level dynamic phase-alignment algorithms required to eliminate the downstream Acoustic Wave-Saturating Washout bottleneck within the Phase 2 Macro-Texture Structure Matrix of the Elemental Transmutation Replicator (ETR) framework. Prior art (TDC #11772, Paper 126) breaks the thermal limits of Phase 1 Synthesis, yielding a continuous, hyper-accelerated volumetric stream of unorganized liquid protein and lipid emulsions. Under static acoustic conditions, this accelerated flow rate sweeps away stationary ultrasonic nodes, preventing successful macro-texture cross-linking and fiber folding.

This disclosure resolves this fluid-dynamic constraint by deploying a Distributed Ternary Fluid-Canvas Operating Network governed by Module …

System Architecture For Ai-Synchronized Phononic Suppression Matrices And Solitonic Disruption Of The Exothermic Bonding Barrier In Atomic Layer Deposition Cores, Christopher L. Eckes

Defensive Publications Series

This specification formalizes the architectural integration, hardware layouts, and predictive real-time control algorithms required to transition the Phase 1 Ultra-Vacuum Synthesis Bed of the Elemental Transmutation Replicator (ETR) framework (Prior Art: TDC #11772) from an assembly-throttled safety regime to a hyper-accelerated, continuous-flow manufacturing matrix. Prior art (CART-CE #12157) establishes that instantaneous molecular synthesis yields extreme, localized exothermic enthalpy spikes (ΔH°f) that overwhelm the passive thermal conductivity (κ) of Silicon Carbide (SiC) dampening hulls, triggering automated laser throttling and dropping system velocity to protect structural interfaces.

This disclosure resolves this structural material bottleneck by implementing an AI-Governed Active Phononic Dampening Field. …

Method And System For Adaptive Multi-Channel Employee Performance Assessment With Dynamic Data Source Weighting And Entropy-Based Filtering, Vladimir Gorobtsov

Defensive Publications Series

The present disclosure describes a method and system for comprehensive employee performance assessment using adaptive multi-channel data integration. The system collects data from at least three independent sources (psychometric tests, physical activity monitoring, operational workload metrics, communication activity, and behavioral logs). It employs Shannon entropy-based filtering to exclude noisy sources, Tukey's interquartile range method for outlier removal, and sliding-window normalization. Dynamic weights are calculated daily based on statistical dependence between each data source and actual employee productivity. An integrated performance index is computed with seasonal adjustment. The system is scalable, computationally efficient, and reduces processing load by up to 40%. …

Technique For Solar Energy Monetization In Autonomous Electric Vehicles, James Douglass Kirk, Ruchira Ghosh, Gregory Miller

Defensive Publications Series

The present disclosure relates to an energy delivery system for an autonomous electric vehicle (EVs) designed to facilitate Vehicle-to-Grid (V2G) energy transactions. The system includes a V2G communication interface that allows the autonomous EVs to supply solar-generated energy to the electrical grid. Additionally, the system features a payment credential linkage mechanism connecting employer-provided payment credentials to the vehicle during travel. It also incorporates a solar energy collection unit for capturing solar energy and a transaction processing module that communicates with a payment network to update the financial balance associated with the linked credentials, enabling business travellers to monetize the collected …

The Everyday Monument: Architectural And Spatial Transformations Of Rome's Nasoni, 1874–Present, Sandra L. Santos

McNair Summer Research Program

Rome's nasoni are small public drinking fountains that have provided free water throughout the city since 1874. There are approximately 2,500–2,800 nasoni in Rome, actively supplying people with free drinking water. Although they are usually understood as ordinary and mundane hydraulic infrastructure, their persistence across different political periods makes them useful objects for examining the relationship between architecture, public service, and political meaning. This research asks how the forms, materials, and spatial contexts of late-nineteenth-century nasoni differed from fountains constructed or modified during the Fascist era.

Over my three weeks of fieldwork in Rome, I documented seventy-five public drinking fountains …

Promoting Safety And Confidence: Standardizing Intimate Partner Violence Screening And Improving Staff Screening Confidence In A Predominantly Latinx Community Health Center, Jordan Jiang

Master's Projects and Capstones

Objective: Intimate partner violence (IPV) is a prevalent public health problem that is screened far less consistently than comparably common conditions and disproportionately affects vulnerable groups, including low-income, Spanish-speaking, and undocumented individuals. This quality improvement project was conducted in an outpatient community health center serving a primarily Latinx, Spanish-speaking population in San Francisco, where screening across the Adult Health, Women's Health, and Teen Clinics was inconsistent, with a baseline rate of 4.1% in June 2026. Aim: The project aimed to increase overall IPV screening by 10 percentage points, from 4.1% to 14.1%, by July 31, 2026. Methods: Rogers' Diffusion of …

Urine Good Care: Catheter-Associated Urinary Tract Infection Prevention At The Bedside, Ruby Yost

Master's Projects and Capstones

Catheter-Associated Urinary Tract Infections (CAUTIs) have been associated with increased morbidity, mortality, healthcare costs, and length of stay and is one of the most common healthcare-acquired illnesses accounting for up to 40% of hospital-acquired infections (Rubi et al., 2022). Because 65-70% of CAUTIs are preventable, reducing the incidence has become a focus area for infection control and nursing quality management among hospital organizations (Tang et al. 2025). CAUTIs are urinary tract infections that occur in patients with indwelling urinary catheters and are typically associated with bacterial colonization of the urinary tract. The aim of this QI Project is to increase …

Standardizing Intimate Partner Violence Screening Among Latinx Patients In A Community Clinic Setting, Peyton O'Callaghan

Master's Projects and Capstones

Intimate partner violence (IPV) is a significant public health concern that may go unrecognized when screening practices are inconsistent. Objective: To standardize IPV screening practices and improve staff confidence across the Adult Health, Women’s Health, and Teen/Pediatric clinics of a community health center serving a predominantly Latinx, monolingual Spanish-speaking, and underserved population. Aim: To increase the overall IPV screening rate by 10% during a three-week implementation period. Methods: The project team developed and implemented a standardized four-question printed screening tool, medical assistant scripts in English and Spanish, and a staff educational in-service. These interventions addressed low screening rates, limited staff …

Nourish And Flourish: Building Confidence In Healthy Food Selection Among Older Adults In An Independent Living Facility, Emily Nguyen

Master's Projects and Capstones

The nutrition education program aims to increase confidence in selecting and maintaining healthier food choices and dietary habits for chronic conditions through weekly workshops. This quality improvement project was conducted in an independent senior living facility in Richmond, CA serving the elderly population ages 65 and up. To address the concern of low confidence levels and management of dietary patterns and chronic health conditions pertaining to nutrition, a comprehensive nutrition education program was developed with pre- and post-intervention assessment surveys to compare baseline confidence levels. The weekly workshops for this nutrition education program aims to increase confidence levels of the …

Reducing Variation, Improving Outcomes: Standardizing Gestational Diabetes Mellitus Education In A Clinical Microsystem, Thanh Le

Master's Projects and Capstones

Objective: Variations in referral, scheduling, delivery of educational information, patient materials, and documentation hampered the quality of gestational diabetes mellitus (GDM) education in the outpatient maternal-fetal medicine clinic. Purpose: The aim of the quality improvement project was to boost adherence to a standardized GDM group education framework from 0 to 50% in the course of 12 weeks and assess attendance at group visits. Methods: The microsystem analysis was conducted based on observations of group visits conducted in Spanish and English, examination of current processes and resources in use, educator pre-survey, SWOT analysis, and cause and effect analysis. The implementation of …

Standardizing Group Visits For Gestational Diabetes Education: A Quality Improvement Initiative In An Outpatient Maternal-Fetal Medicine Clinic, Nha Nguyen

Master's Projects and Capstones

Objective: At an outpatient maternal-fetal medicine clinic in Northern California, gestational diabetes mellitus (GDM) education is delivered inconsistently across nurse practitioners (NPs) and registered dietitians (RDs), with no standardized curriculum, referral criteria, or educational materials. Aim: By August 12, 2026, this project aimed to develop and implement a standardized GDM group visit framework for NPs, RDs, and scheduling staff in maternal-fetal medicine clinic, increasing compliance with standardized referral, enrollment, and educational processes from a baseline of 0% to 50%. Methods: Using baseline observations, workflow assessment, stakeholder input, and a literature review, the QI team developed standardized bilingual slide …

Face Mask Littering: Environmental Impacts, Regulatory Challenges, And Ai-Driven Waste Management Strategies For The Post-Pandemic Era, Pri̇yanka Rathee, Sari̇ta Khatkar, Renu Sehrawat, Pooja Rathee, Anurag Khatkar, Esra Küpeli̇

Turkish Journal of Medical Sciences

The widespread use of polypropylene-based face masks during the COVID-19 pandemic created a significant and persistent source of plastic pollution. This review aims to provide an integrative assessment of the environmental, toxicological, and public health implications of face mask litter and evaluate current waste management challenges and emerging technological solutions in the postpandemic context. A narrative review approach was employed, synthesizing literature published between 2020 and 2025 and indexed in major scientific databases including Web of Science, Scopus, and PubMed. Studies were selected based on their relevance to the issues of environmental contamination, microplastic generation, toxicological effects, regulatory frameworks, and …

Male Osteoporosis: Pathophysiology, Risk Assessment, And Evidence-Based Management, Seli̇n Teki̇n, Alper Gürlek

Turkish Journal of Medical Sciences

Osteoporosis in men is a common yet underrecognized condition associated with substantial fracture-related morbidity and excess mortality. Although men generally attain higher peak bone mass than women, age-related changes in bone microarchitecture, progressive cortical bone loss, declining sex steroid bioavailability, and a high prevalence of secondary causes contribute to a significant lifetime fracture risk. Importantly, a large proportion of fragility fractures in men occur at bone mineral density (BMD) values above the osteoporotic threshold, highlighting the limitations of BMD-based diagnosis alone. This review provides a comprehensive overview of the epidemiology, pathophysiology, and clinical characteristics of osteoporosis in men, with particular …

A Comparative Analysis Of Clinical Quality And Readability Of Neuropathic Pain Patient Information Leaflets: Türkiye Versus The United States, Gonul Sari, Argun Pire

Turkish Journal of Medical Sciences

Background/aim: Neuropathic pain management requires high patient adherence and complex dose-titration regimens, making the readability of patient information leaflets (PILs) a critical patient safety factor. This study aimed to compare the clinical content quality and linguistic readability of PILs for neuropathic pain medications between Türkiye (TİTCK) and the United States (DailyMed).

Materials and methods: A total of 11 pairs of innovator medications were analyzed. Clinical content was assessed using the 15-item Keystone Clinical Content Checklist (KCCC). Readability was assessed using the Ateşman index for Turkish texts and the Flesch Reading Ease Score (FRES) for English texts. Information quality and reliability …

Demographic And Clinical Characteristics Of Frequent Users Of Emergency Medical Services In Türkiye ​, Burak Bekgöz, İshak Şan

Turkish Journal of Medical Sciences

Background/aim: Overuse of emergency medical services (EMS), particularly unnecessary ambulance requests, places considerable strain on limited healthcare resources and can delay responses to urgent cases. The present study analyzes the demographic characteristics, diagnoses, urgency, and hospital transfer status of frequent users of EMS in Türkiye.

Materials and methods: Included in the study were 41,113 patients who requested EMS four or more times within a year (defined as frequent users for the purpose of the study), excluding interhospital transfers. Data were accessed from the Emergency Medical Services Automation System (ASOS) database, which contains details of patient demographics, diagnoses, triage codes, reasons …

Comparing Age Of Obesity Onset, Concerns About Weight And Body Shape, And Quality Of Life In Individuals Seeking Bariatric Surgery ​, Vi̇ldan Çakir Kardeş, Özge Saraçli, Nuray Atasoy, Levent Ati̇k, Si̇bel Kahraman Gi̇rgeç

Turkish Journal of Medical Sciences

Background/aim: This study explored the relationship between concerns about weight and body shape and quality of life in bariatric surgery candidates with morbid obesity regarding the onset of the weight problem in childhood, adolescence, or adulthood.

Materials and methods: We included 453 patients who applied to our center for preoperative bariatric surgery assessment between January 2010 and April 2019. We reviewed the sociodemographic information, psychiatric diagnoses, and results of the Body Shape Questionnaire-34, Quality of Life Scale, Beck Depression Inventory, and Beck Anxiety Inventory of all patients.

Results: Concerns about weight and body shape were increased in women (p < 0.001), unemployed patients (p = 0.001), those with a comorbid psychiatric disorder (p < 0.001), and those with childhood- or adolescent-onset of weight problems (r = –0.170; p < 0.001). Concerns about weight and body shape had a relationship with the vitality (r = –0.434), mental health (r = –0.464), social functioning (r = –0.418), pain (r = –0.307), and general health (r = –0.352) subscale scores of quality of life. Physical functioning was higher (p = 0.037) in patients with childhood- or adolescent-onset obesity compared to patients with adult-onset obesity, while mental health was higher (p = 0.001) in the latter group. Individuals with childhood- or adolescent-onset obesity inquired about bariatric surgery options at an earlier age (p < 0.001).

Conclusion: …

Comparative Analysis Of Corticosteroid Injection Alone Versus Combined Corticosteroid And Radiofrequency Ablation For Plantar Fasciitis: Short- And Medium-Term Outcomes ​, Nevci̇han Şahutoğlu Bal, Emel Başar, Hati̇ce Babaoğlan, Ülkü Sabuncu, Mustafa Cem Yilmaz, Şükri̇ye Dadali, Erkan Yavuz Akçaboy

Turkish Journal of Medical Sciences

Background/aim: Plantar fasciitis (PF) is a common cause of heel pain and may lead to functional impairment and reduced quality of life. This study aimed to compare the short- and medium-term clinical outcomes of corticosteroid injection (CSI) alone versus combined radiofrequency ablation (RFA) and CSI in patients with PF refractory to conservative treatment.

Materials and methods: This single-center retrospective comparative study included patients diagnosed with PF between 1 January 2021 and 1 January 2025. Patients who underwent either CSI alone or combined RFA and CSI after failure of conservative management were included. Pain intensity was assessed using a visual analog …

Perioperative Effects Of The Quadratus Lumborum Block In Percutaneous Biliary Drainage: A Prospective Randomized Controlled Study ​, Seyyi̇d Furkan Kina, Can Ozan Yazar, Cem Koray Çataroğlu, Erdi̇ Tangobay, Sadik Ahmet Uyanik, Savaş Altinsoy, Reyhan Polat, Jüli̇de Ergi̇l

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to evaluate the effect of the quadratus lumborum block (QLB) on intraoperative opioid consumption in patients undergoing percutaneous biliary drainage (PBD).

Materials and methods: A total of 57 patients who met the inclusion criteria were randomized into two groups: the sedation group (Group 1, n = 26) and the sedation with QLB group (Group 2, n = 26). The groups were compared in terms of intraoperative anesthetic consumption, vital parameters, postanesthesia care unit (PACU) recovery times, postoperative visual analog scale (VAS) scores, postoperative analgesic consumption, and clinician and patient satisfaction. The study was …

Evaluation Of Acne Vulgaris Patient Care In Outpatient Clinics: Guideline Adherence And Patient Education ​, Mefküre Durmuş, Betül Sena Çavdar, İbrahi̇m Etem Arica, Sena Ustaömer, Sena Güzel Karahan, Seçi̇l Çolak, Selcen Şenol

Turkish Journal of Medical Sciences

Background/aim: Acne vulgaris, affecting over 85% of adolescents, is the most prevalent chronic inflammatory skin disorder. Its management is severity-based, with specific drug selections and combinations according to guidelines. However, adherence to these guidelines and the adequacy of patient counseling remain uncertain in real-world practice. The aim in this study was to evaluate prescribing patterns in acne management, assess compliance with guidelines, and promote awareness among healthcare professionals.

Materials and methods: A prospective observational study was conducted in the dermatology outpatient clinic of a tertiary hospital in Türkiye between February and May 2025. Demographic and clinical data were collected, and …

Effect Of Vnotes Hysterectomy With Uterosacral Ligament Suspension On Overactive Bladder Symptoms In Patients With Pelvic Organ Prolapse: A Retrospective Cohort Study ​, Gonca Türker Ergün, Mahmut Kuntay Kokanali, Duygu Tuğrul Ersak, Meli̇ke Doğanay, Özlem Moraloğlu Teki̇n

Turkish Journal of Medical Sciences

Background/aim: To evaluate the anatomical and functional outcomes following vaginal natural orifice transluminal endoscopic surgery (vNOTES) hysterectomy combined with bilateral uterosacral ligament suspension in patients with apical prolapse and concomitant overactive bladder symptoms.

Materials and methods: This retrospective cohort study was conducted at a single tertiary referral center. Women with symptomatic apical prolapse (stage ≥ II) and concomitant overactive bladder symptoms were included. All patients underwent vNOTES hysterectomy with bilateral uterosacral ligament suspension. Anatomical outcomes were assessed using the Pelvic Organ Prolapse Quantification (POP-Q) system, whereas functional outcomes were evaluated using validated questionnaires, including the Pelvic Floor Distress Inventory-20 (PFDI-20), …

C-Reactive Protein–Albumin–Lymphocyte (Cally) Index As A Novel Inflammatory Marker For Sarcopenia: Evidence From A Cross-Sectional Study ​, Yasemi̇n Polat Özer, Merve Güner, Serdar Ceylan, Engi̇n Çeşmeci̇, Cafer Balci, Burcu Balam Doğu, Meltem Gülhan Hali̇l, Mustafa Cankurtaran, Mert Eşme

Turkish Journal of Medical Sciences

Background/aim: Sarcopenia is a geriatric syndrome characterized by progressive impairments in skeletal muscle mass and performance, with chronic low-grade systemic inflammation playing a pivotal role in its development. The C-reactive protein–albumin–lymphocyte (CALLY) index reflects inflammatory burden alongside immune and nutritional status; however, its association with sarcopenia in older populations has yet to be sufficiently elucidated. The present study investigates the relationship between CALLY index values and probable sarcopenia (PS) in a large cohort of geriatric outpatients.

Materials and methods: Included in this retrospective cross-sectional study were 2042 geriatric outpatients aged ≥65 years who were assessed between May 2022 and March …

Beyond Individual Willingness: Family Veto, Legal Knowledge, And The Dynamics Of Organ Donation In Türkiye ​, Hasan Gi̇ray Ankara, Hakan Değerli̇, Semi̇h Baş

Turkish Journal of Medical Sciences

Background/aim: The aim was to understand the factors underlying the dynamics of organ donation behavior by focusing on three different aspects. Three models were tested in this regard, namely (i) individual willingness for the donation of one’s own organs, (ii) willingness to approve organ donation for close relatives, and (iii) a family veto gap.

Materials and methods: A national-level adult sample from the Eurobarometer 72.3 survey (collected in 2009) conducted in Türkiye was utilized. Standard and penalized logistic regression models were employed to conduct the analyses.

Results: The results show that discussing organ donation with family members and being aware …

Nationwide Characteristics Of Infectious Disease Patients Transported By Helicopter In Türkiye, Ayşe Gülden Bekgöz, Kerem Dost Bi̇lmez, Muhammed Saltuk Deni̇z

Turkish Journal of Medical Sciences

Background/aim: To evaluate the clinical, demographic, and operational characteristics of patients with infectious diseases transported by helicopter ambulance and to examine differences in the transfer patterns, flight durations, and diagnostic categories.

Materials and methods: Registry data of patients with infectious diseases transported by helicopter ambulance were analyzed. Demographic characteristics, diagnoses, referring and receiving hospital types, intraprovincial and interprovincial transfer status, flight durations, and temporal distribution of transfers (hours, days, and months) were evaluated. Flight duration was calculated in minutes and compared between intraprovincial and interprovincial transfers.

Results: A total of 543 patients with infectious diseases were transported by helicopter ambulance. …

Vitamin D Deficiency, Depression Severity, And Suicide Risk: Evidence From Patients With Major Depressive Disorder ​, Eli̇f Küçük, Feri̇de Uysal, Seda Şenkardeş Kandemi̇r, Özgür Özkalayci, Canay Pamukçu, Ni̇hal Taşteki̇n, Meri̇h Altintaş

Turkish Journal of Medical Sciences

Background/aim: Major depressive disorder (MDD) is a common psychiatric condition characterized by depressive symptoms and suicide-related clinical features. Vitamin D status has been investigated as a potential clinical correlate of depression and suicidal ideation, but the direction and specificity of these associations remain uncertain. This cross-sectional study aimed to examine the associations among serum 25-hydroxyvitamin D [25(OH)D] levels, depressive symptom severity, suicidal ideation, and suicide-related cognitive–affective dimensions in adults diagnosed with MDD.

Materials and methods: This cross-sectional study included 97 adults aged 18–65 years who were diagnosed with MDD according to DSM-5 criteria. Depressive symptom severity and suicide-related outcomes were …

L-Theanine Attenuates Alcl3-Induced Cognitive Dysfunction And Neurotoxicity In Rats: A Behavioral And Biochemical Study, Muhammet Oğuzhan Dönmez, Azi̇ze Şener, Şeyda Karaman Ersoy, Mahdi̇ Marzi̇, Göksel Şener

Turkish Journal of Medical Sciences

Background/aim: The effects of L-theanine (LTN), a natural compound found in tea leaves, on biochemical parameters and cognitive functions were investigated in an aluminum chloride (AlCl3)-induced Alzheimer’s disease-like experimental model.

Materials and methods: A total of 32 male Wistar rats were allocated into four groups: control, AlCl3-induced AD-like group, LTN-treated AD-like group, and donepezil-treated AD-like group. Donepezil was used as a reference drug. For the induction of AlCl3- induced neurotoxicity, AlCl3 was administered by gavage at a dose of 25 mg/kg/day during the 1st week and 150 mg/kg/day for the subsequent 3 weeks. LTN was administered orally at a dose …