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Jose Montanez V. Paula Price Oct 2025

Jose Montanez V. Paula Price

2025 Decisions

USDC for the Middle District of Pennsylvania


Correction: Magnetized Chitosan Hydrogel And Silk Fibroin, Reinforced With Pva: A Novel Nanobiocomposite For Biomedical And Hyperthermia Applications, Reza Eivazzadeh-Keihan, Zeinab Pajoum, Hooman Aghamirza Moghim Aliabadi, Adibeh Mohammadi, Amir Kashtiaray, Milad Salimi Bani, Banafshe Pishva, Ali Maleki, Majid M. Heravi, Mohammad Mahdavi, Elaheh Ziaei Ziabari Oct 2025

Correction: Magnetized Chitosan Hydrogel And Silk Fibroin, Reinforced With Pva: A Novel Nanobiocomposite For Biomedical And Hyperthermia Applications, Reza Eivazzadeh-Keihan, Zeinab Pajoum, Hooman Aghamirza Moghim Aliabadi, Adibeh Mohammadi, Amir Kashtiaray, Milad Salimi Bani, Banafshe Pishva, Ali Maleki, Majid M. Heravi, Mohammad Mahdavi, Elaheh Ziaei Ziabari

Rothman Institute Papers

The authors regret that they omitted a citation to ref. 1 in their original article. This citation should be included in Section 3 (Result and discussion) before Section 3.1 (FT-IR spectroscopy and XRD analysis). The authors wish to add the following paragraphs to the discussion section of the original article, to be read in Section 3 (Result and discussion) before Section 3.1 (FT-IR spectroscopy and XRD analysis), after the sentence “.Finally, hyperthermia application was appraised and all results were evaluated.” in order to clarify the novelty of this work over ref. 1. In the previous work, we developed a multifunctional …


Westport Ins Adversary Action Re: Coverage Oct 2025

Westport Ins Adversary Action Re: Coverage

Catholic Dioceses in Bankruptcy

No abstract provided.


Clinical Utility Of Diffusion Tensor Imaging In Sport-Related Concussion: A Systematic Review, Shiv Patil, Rithvik Kata, Serhat Aydin, Mert Karabacak, Konstantinos Margetis, Sotirios Bisdas Oct 2025

Clinical Utility Of Diffusion Tensor Imaging In Sport-Related Concussion: A Systematic Review, Shiv Patil, Rithvik Kata, Serhat Aydin, Mert Karabacak, Konstantinos Margetis, Sotirios Bisdas

Student Papers, Posters & Projects

OBJECTIVE: Sport-related concussion (SRC) is a prevalent form of traumatic brain injury that is associated with long-term neurological and psychiatric impairment, particularly among athletes with a history of repetitive concussions. The biological variability of SRC's impact on the brain, as well as a lack of objective biomarkers to diagnose and prognosticate concussion, has prompted interest in advanced neuroimaging methods such as diffusion tensor imaging (DTI). By measuring disruptions in water diffusivity due to head trauma, DTI can detect alterations in white matter integrity that are not visualized by conventional imaging methods. This systematic review aims to synthesize major trends and …


A Case Of Granuloma Annulare Mimicking Candidal Intertrigo In The Groin, Scotty Smith, Patrice Perche, Leonard Gately Oct 2025

A Case Of Granuloma Annulare Mimicking Candidal Intertrigo In The Groin, Scotty Smith, Patrice Perche, Leonard Gately

School of Medicine Faculty Publications

Granuloma annulare (GA) is a benign, non-infectious granulomatous skin condition of uncertain etiology, often presenting as annular erythematous plaques. While commonly localized to the hands and feet, GA has multiple clinical variants and can mimic other dermatologic conditions, leading to diagnostic challenges. We report a rare case of GA localized to the inguinal region in a 55-year-old female initially treated empirically for candidal intertrigo without improvement. Biopsy demonstrated interstitial histiocytic infiltrates dissecting between collagen bundles with increased dermal mucin, confirming a diagnosis of interstitial GA. The patient was subsequently treated with triamcinolone 0.1% ointment and hydroxychloroquine 200 mg twice daily …


Neighborhood Social Cohesion Associated With Chronic Liver Disease Prevalence And All-Cause Mortality, Tiange P. Zhang, Jennifer L. Dodge, Divya Ayyala-Somayajula, Norah A. Terrault Oct 2025

Neighborhood Social Cohesion Associated With Chronic Liver Disease Prevalence And All-Cause Mortality, Tiange P. Zhang, Jennifer L. Dodge, Divya Ayyala-Somayajula, Norah A. Terrault

Division of Gastroenterology and Hepatology Faculty Papers

Background and Aims: Neighborhood social cohesion (NSC)—the degree of trust and solidarity within a community—may influence health through multiple pathways including shaping healthy norms, perception of safety, and stress. Whether NSC influences chronic liver disease (CLD) prevalence and associated mortality in the United States is unknown. Methods: Using 172,047 adults from the 2013–2018 National Health Interview Survey with linkage to National Death Index mortality data, NSC was measured using questions on help availability, accountability, trustworthiness, and connectedness among neighbors, with composite scores (4–16) categorized as minimal (4–7), low (8–10), moderate (11–13), and high (14–16). Logistic and Cox regression tested the …


Lagomorph Spotlight Survey Results, Johan Du Toit, Shantell Garrett Oct 2025

Lagomorph Spotlight Survey Results, Johan Du Toit, Shantell Garrett

Browse all Datasets

Results of lagomorph spotlight surveys conducted in the foothills of the Henry Mountains, south-central Utah, over 2014-2022.


Synthetically Expressive: Evaluating Gesture And Voice For Emotion And Empathy In Vr And 2d Scenarios, Haoyang Du, Kiran Chhatre, Christopher Peters, Brian Keegan, Rachel Mcdonnell, Cathy Ennis Oct 2025

Synthetically Expressive: Evaluating Gesture And Voice For Emotion And Empathy In Vr And 2d Scenarios, Haoyang Du, Kiran Chhatre, Christopher Peters, Brian Keegan, Rachel Mcdonnell, Cathy Ennis

Research Outputs: 2025-Present

The creation of virtual humans increasingly leverages automated synthesis of speech and gestures, enabling expressive, adaptable agents that effectively engage users. However, the independent development of voice and gesture generation technologies, alongside the growing popularity of virtual reality (VR), presents significant questions about the integration of these signals and their ability to convey emotional detail in immersive environments. In this paper, we evaluate the influence of real and synthetic gestures and speech, alongside varying levels of immersion (VR vs. 2D displays) and emotional contexts (positive, neutral, negative) on user perceptions. We investigate how immersion affects the perceived match between gestures …


Apostel-R Recommendations For Reporting Retinal Optical Coherence Tomography Studies In Rodents, Frederike Cosima Oertel, Delia Cabrera Debuc, Peter A. Calabresi, Mei Chen, Christian Cordano, Michael Dietrich, Nicolas Feltgen, Oliver Gramlich, Ari J. Green, Janos Groh, Su-Chun Huang, Benjamin Knier, Thomas Korn, Letizia Leocani, Anat Loewenstein, Christian Van Oterendorp, Tunde Peto, Sven Schippling, Leopold Schmetterer, Steffen Schmitz-Valckenberg, Mathias W. Seeliger, Kenneth S. Shindler, Joel Schuman, Mustafa Sindi, Adnan Tufail, Jui-Kai Wang, Sebastian Wolf, Yuyi You, Martin Zinkernagel, Wolf Lagrèze, Philipp Albrecht Oct 2025

Apostel-R Recommendations For Reporting Retinal Optical Coherence Tomography Studies In Rodents, Frederike Cosima Oertel, Delia Cabrera Debuc, Peter A. Calabresi, Mei Chen, Christian Cordano, Michael Dietrich, Nicolas Feltgen, Oliver Gramlich, Ari J. Green, Janos Groh, Su-Chun Huang, Benjamin Knier, Thomas Korn, Letizia Leocani, Anat Loewenstein, Christian Van Oterendorp, Tunde Peto, Sven Schippling, Leopold Schmetterer, Steffen Schmitz-Valckenberg, Mathias W. Seeliger, Kenneth S. Shindler, Joel Schuman, Mustafa Sindi, Adnan Tufail, Jui-Kai Wang, Sebastian Wolf, Yuyi You, Martin Zinkernagel, Wolf Lagrèze, Philipp Albrecht

Department of Medicine Faculty Papers

BACKGROUND AND OBJECTIVES: Retinal optical coherence tomography (OCT) in rodent models has been used to longitudinally image retinal changes, to define end points for more costly or time-consuming experiments, and to better understand the pathophysiology underlying OCT findings in human diseases. No standardization of rodent OCT reporting currently exists. Here, we aim to establish consensus recommendation for reporting results from retinal OCT studies in rodents.

METHODS: Initial recommendations were developed based on the APOSTEL criteria for quantitative OCT reporting in humans by a core team. Using a modified Delphi process, an expert panel of rodent OCT researchers (N = 31) …


Comparing The Consistency Between Age Estimations Across Various Three-Dimensional Model Creation Methods In An Attempt To Find A Practical Proxy For Physical Remains, Jeanne R. Wood Oct 2025

Comparing The Consistency Between Age Estimations Across Various Three-Dimensional Model Creation Methods In An Attempt To Find A Practical Proxy For Physical Remains, Jeanne R. Wood

LSU Master's Theses

The purpose of this study is to determine whether digital three-dimensional models can serve as a viable alternative to physical human remains to allow continued research on fragile physical specimens. As digital three-dimensional models have become increasingly prevalent in anthropological and archaeological research, it is essential to assess their limitations and capabilities, particularly for subjective assessments that rely heavily on visual interpretation (Remondino & El-Hakim, 2006). While previous studies have focused on the use of digital three-dimensional models for quantitative measurements, their effectiveness for subjective analyses remains unclear (Cooper et al., 2003; Sholts et al., 2010; Stull et al., 2014; …


Introductory Chemistry Student Success: Investigating Study Strategies And Evaluating An Informative Utility Value Intervention, Pallavi Nayyar Oct 2025

Introductory Chemistry Student Success: Investigating Study Strategies And Evaluating An Informative Utility Value Intervention, Pallavi Nayyar

USF Tampa Graduate Theses and Dissertations

Improving retention in STEM (science, technology, engineering, and mathematics) programs is essential to meet the growing demand for skilled professionals in the domestic workforce. To achieve this, it is critical to understand and address the factors that influence student persistence in STEM degrees. Gateway courses such as general chemistry often serve as early barriers to STEM degree completion, with high rates of attrition that impact not only individual students but also institutions and society. Therefore, the aim of this work was to examine and influence the factors that contribute to student withdrawal from introductory chemistry courses in order to promote …


Social Determinants Of Self-Reported Health In Vulnerable Populations During A Polycrisis In Lebanon, Rindala Fayyad, Marie Elizabeth Ragi, Hala Ghattas Ph.D., Stephen J. Mccall Oct 2025

Social Determinants Of Self-Reported Health In Vulnerable Populations During A Polycrisis In Lebanon, Rindala Fayyad, Marie Elizabeth Ragi, Hala Ghattas Ph.D., Stephen J. Mccall

Faculty Publications

Importance: In the context of a polycrisis, which is characterized by multiple interconnected and mutually reinforcing crises, humanitarian and health needs increase. It is therefore crucial to identify social determinants impacting health and well-being of vulnerable populations to better inform appropriate interventions.

Objective: To assess the association between social determinants and pain frequency, self-rated health, and depression over time among vulnerable populations during a polycrisis in Lebanon.

Design, Setting, and Participants: In this population-based longitudinal cohort study, data were collected in Sin-El-Fil, a suburb of Beirut, Lebanon, in 4 waves: June 28 to October 26, 2022; September 8 to December …


Re: Butte Priority Soil Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Bres No. 177 – North Alice Culvert, Mike Mcanulty Oct 2025

Re: Butte Priority Soil Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Bres No. 177 – North Alice Culvert, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Documents From The October 8, 2025 Meeting Of The Associated Students Of The University Of Montana (Asum), Associated Students Of The University Of Montana, Kate Austin Payne Oct 2025

Documents From The October 8, 2025 Meeting Of The Associated Students Of The University Of Montana (Asum), Associated Students Of The University Of Montana, Kate Austin Payne

Senate Meeting Agendas and Minutes, 2007-Present

Agenda and meeting minutes from the October 8, 2025 meeting of the Associated Students of the University of Montana (ASUM).


Completion Rates For Ecological Momentary Assessments Of Food Intake During Pregnancy And Post Partum: Descriptive Study, Sarah Annalise Sanders, Serwaa Omowale, Andrea Casas, Alexis Kiyanda, Abigail Smith Kosbie, Yu-Hsuan Lai, Meredith Wallace, Stephen Rathbun, Tiffany Gary-Webb, Esa Davis, Lora Burke, Dara Méndez Oct 2025

Completion Rates For Ecological Momentary Assessments Of Food Intake During Pregnancy And Post Partum: Descriptive Study, Sarah Annalise Sanders, Serwaa Omowale, Andrea Casas, Alexis Kiyanda, Abigail Smith Kosbie, Yu-Hsuan Lai, Meredith Wallace, Stephen Rathbun, Tiffany Gary-Webb, Esa Davis, Lora Burke, Dara Méndez

Faculty, Staff and Student Publications

Background: The collection of dietary behavior data is crucial in childbearing populations. In addition to observed inequities in perinatal dietary intake and quality, burdensome assessment methods (eg, 24-h dietary recall) may limit research participation for some groups. Ecological momentary assessment (EMA) is associated with reduced recall bias and participant convenience, but there is a dearth of studies with diverse cohorts.

Objective: Our aim is to describe participant completion of food intake items in EMA surveys, overall and across individual characteristics (eg, prepregnancy BMI).

Methods: Using secondary EMA data from participants in a longitudinal study, we report average completion rates of …


2025-10-08 Exploring Campus Connections At The Fall Involvement Fair, Maya Deguzman Oct 2025

2025-10-08 Exploring Campus Connections At The Fall Involvement Fair, Maya Deguzman

The Spectator Online

No abstract provided.


Hydroxyapatite Microspheres Induce Durable Pleurodesis And Are Rapidly Cleared By Pleural Osteoclasts, Yusuke Tanaka, Yuki Takahashi, Yuma Shindo, Lori B. Pitstick, Steven L. Teitelbaum, Wei Zou, Xiangning Wang, Jason C. Woods, Kathryn A. Wikenheiser-Brokamp, Francis X. Mccormack Oct 2025

Hydroxyapatite Microspheres Induce Durable Pleurodesis And Are Rapidly Cleared By Pleural Osteoclasts, Yusuke Tanaka, Yuki Takahashi, Yuma Shindo, Lori B. Pitstick, Steven L. Teitelbaum, Wei Zou, Xiangning Wang, Jason C. Woods, Kathryn A. Wikenheiser-Brokamp, Francis X. Mccormack

2020-Current year OA Pubs

Talc pleurodesis is highly effective for preventing recurrence of pneumothorax and pleural effusion, but it can be complicated by dissemination, acute lung injury, lead exposure, and foreign body-induced chronic inflammation and pain. Our objective is to develop a safe, biodegradable, contaminant-free particle for pleurodesis. We used mouse models of pneumothorax and malignant pleural effusion to compare the efficacy and safety of pleurodesis with talc and hydroxyapatite microspheres (HAM). Intrapleural instillation of microspheres induced pleural adhesions, fibrosis, and symphysis as effectively as talc and resulted in more durable protection from experimental pneumothorax. HAM and talc both induced an osteoclastogenic, inflammatory, and …


Demographic And Biomechanical Factors Associated With Knee Excursion Angles Outside The Accepted Range, Karly Mendez Oct 2025

Demographic And Biomechanical Factors Associated With Knee Excursion Angles Outside The Accepted Range, Karly Mendez

Doctorate in Kinesiology

The knee is one of the most frequently injured musculoskeletal systems among long-distance runners, and these injuries may be explained by biomechanical inefficiencies and imbalances between the quadriceps and hamstrings. Common knee injuries in runners include patellofemoral pain syndrome, iliotibial band syndrome, and meniscal irritation. These injuries have the potential to interfere with training, reduce the number of races runners partake in, and affect performance in the long-term. The aim of this study was to investigate the relationship between quadriceps and hamstring strength and biomechanics of the knee involving long-distance runners experiencing knee pain or discomfort. Specifically, two-dimensional (2D) gait …


From Awareness To Integration: Leading The Change For Occupational Therapy, Shirley A. Wells Oct 2025

From Awareness To Integration: Leading The Change For Occupational Therapy, Shirley A. Wells

Occupational Therapy Faculty Publications

In her lecture for the inaugural Dr. Lela A. Llorens Award of Excellence for Diversity, Equity, and Inclusion, Dr. Shirley A. Wells acknowledges the growing importance of creating more inclusive and equitable environments across all aspects of health care, with occupational therapy being no exception. Inclusion and integration are fundamental values that should be woven into every part of the practice of occupational therapy. It is not enough to be aware of these concepts; occupational therapists must actively engage in Acts of Inclusion and Integration in their delivery of care, collaboration with clients and colleagues, and shaping of the future …


Analyzing Adversarial Strategies And Countermeasures For Cyberbullying Detection, Maddie Juarez, Eldor Abdukhamidov, Manuel Sandoval, Deborah Hall, Mujtaba Nazari, George Thiruvathukal, Tamer Abuhmed, Yasin Silva, Mohammed Abuhamad Oct 2025

Analyzing Adversarial Strategies And Countermeasures For Cyberbullying Detection, Maddie Juarez, Eldor Abdukhamidov, Manuel Sandoval, Deborah Hall, Mujtaba Nazari, George Thiruvathukal, Tamer Abuhmed, Yasin Silva, Mohammed Abuhamad

Computer Science: Faculty Publications and Other Works

Cyberbullying on social networking sites has become more prevalent. Most cyberbullying detection models often lack consideration of adversarial threads, leaving them vulnerable. This study evaluates the resilience of text-based cyberbullying detection models, constrained by limited available datasets, against word-level substitutions and character-level perturbations. We consider well-established ML techniques with real-world data and more recent LLM-based approaches to uncover model weaknesses. The results reveal that adversarial attacks can significantly reduce detection accuracy, e.g., most models are vulnerable to word- and character-level attacks with success rates up to 88% and 44%, respectively. We also find that LLM-based models such as CyberBERT are …


Western Ranch Management Institute, David Secrist Oct 2025

Western Ranch Management Institute, David Secrist

Funded Research Records

No abstract provided.


The Parthenon, October 08, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Caden Adkins, Scott Price, Lilli Ross, Wade Sullivan Oct 2025

The Parthenon, October 08, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Caden Adkins, Scott Price, Lilli Ross, Wade Sullivan

The Parthenon

No abstract provided.


Rtgs Determinant & Sub-Transaction Behavior During Covid-19 In Indonesia, Bastian Muzbar Zams, Akhmad Ginulur Pangersa, Gemala Srihati, Primitiva Febriarti, Nur Annisa Hasniawati Oct 2025

Rtgs Determinant & Sub-Transaction Behavior During Covid-19 In Indonesia, Bastian Muzbar Zams, Akhmad Ginulur Pangersa, Gemala Srihati, Primitiva Febriarti, Nur Annisa Hasniawati

Bulletin of Monetary Economics and Banking

This paper investigates external factors affecting Indonesia’s Real Time Gross Settlement (RTGS) transactions by applying machine learning regularization to identify key variables from a large dataset. A Vector AutoRegression (VAR) model analyzes dynamic links among RTGS sub-transactions, while Impulse Response Function (IRF) analysis examines system behavior during COVID-19 shocks. Using monthly data on 75 economic indicators, we show that 21 variables most accurately capture the movement of Bank Indonesia Real Time Gross Settlement System (BIRTGS) transactions. The study shows that monetary operation sub-transactions most strongly affect other BI-RTGS sub-transactions. Impulse Response Function analysis also finds that shocks in customer transfers …


Spectrum, Volume 55, Issue 5, Sacred Heart University Oct 2025

Spectrum, Volume 55, Issue 5, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: SHU Alumni’s Film “Flyway of Life” -- Debut of the School of Performing Arts -- Joining the Brotherhood -- How Students are Tackling Financial Literacy -- Stepping into the Spotlight -- Six Pioneers Swim Towards Nationals


Synthetically Expressive: Evaluating Gesture And Voice For Emotion And Empathy In Vr And 2d Scenarios, Haoyang Du, Kiran Chhatre, Christopher Peters, Brian Keegan, Rachel Mcdonnell, Cathy Ennis Oct 2025

Synthetically Expressive: Evaluating Gesture And Voice For Emotion And Empathy In Vr And 2d Scenarios, Haoyang Du, Kiran Chhatre, Christopher Peters, Brian Keegan, Rachel Mcdonnell, Cathy Ennis

Conference papers

The creation of virtual humans increasingly leverages automated synthesis of speech and gestures, enabling expressive, adaptable agents that effectively engage users. However, the independent development of voice and gesture generation technologies, alongside the growing popularity of virtual reality (VR), presents significant questions about the integration of these signals and their ability to convey emotional detail in immersive environments. In this paper, we evaluate the influence of real and synthetic gestures and speech, alongside varying levels of immersion (VR vs. 2D displays) and emotional contexts (positive, neutral, negative) on user perceptions. We investigate how immersion affects the perceived match between gestures …


From Simulation To Reality: Experimental Analysis Of A Quantum Entanglement Simulation With Slime Molds (Physarum Polycephalum) As Bioelectronic Components, Eduardo Miranda Oct 2025

From Simulation To Reality: Experimental Analysis Of A Quantum Entanglement Simulation With Slime Molds (Physarum Polycephalum) As Bioelectronic Components, Eduardo Miranda

School of Art, Design and Architecture

This study investigates whether it is possible to simulate quantum entanglement with theoretical memristor models, physical memristors (from Knowm Inc.) and slime molds Physarum polycephalum as bioelectric components. While the simulation with theoretical memristor models has been demonstrated in the literature, real-world experiments with electric and bioelectric components had not been done so far. Our analysis focused on identifying hysteresis curves in the voltage-current (I-V) relationship, a characteristic signature of memristive devices. Although the physical memristor produced I-V diagrams that resembled more or less hysteresis curves, the small parasitic capacitance introduced significant problems for the planned entanglement simulation. In case …


Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Ur- 19 – Butte, Anaconda & Pacific Railway From Montana Street To South Arizona Avenue – Montana Street Adjacent Parcel (Dated August 13, 2025), Molly Roby Oct 2025

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Ur- 19 – Butte, Anaconda & Pacific Railway From Montana Street To South Arizona Avenue – Montana Street Adjacent Parcel (Dated August 13, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Structural Variation, Selection, And Diversification Of The Npip Gene Family From The Human Pangenome., Philip C. Dishuck, Katherine M. Munson, Alexandra P. Lewis, Max L. Dougherty, Jason G. Underwood, William T. Harvey, Pinghsun Hsieh, Tomi Pastinen, Evan E. Eichler Oct 2025

Structural Variation, Selection, And Diversification Of The Npip Gene Family From The Human Pangenome., Philip C. Dishuck, Katherine M. Munson, Alexandra P. Lewis, Max L. Dougherty, Jason G. Underwood, William T. Harvey, Pinghsun Hsieh, Tomi Pastinen, Evan E. Eichler

Manuscripts, Articles, Book Chapters and Other Papers

The NPIP gene family is among the most positively selected gene families in humans/apes and drives independent duplication in primate lineages. These duplications promote genetic instability, leading to recurrent disease-associated microduplication and microdeletion syndromes. Despite its importance, little is known about its function or variation in humans, as short-read sequencing cannot distinguish high-identity duplications. Using long-read assemblies of 169 human haplotypes, we find extreme variation in the content and organization of NPIP loci. We identify fixed and polymorphic paralogs and observe ongoing positive selection. With long-read RNA sequencing (RNA-seq), we create paralog-specific gene models, the majority of which were not …


Mechanistic Study Of Pexidartinib-Induced Toxicity In Human Hepatic Cells, Si Chen, Yuxi Li, Xilin Li, Nan Mei, Xiaobo He, Matthew S Bryant, Xuan Qin, Feng Li, Lei Guo Oct 2025

Mechanistic Study Of Pexidartinib-Induced Toxicity In Human Hepatic Cells, Si Chen, Yuxi Li, Xilin Li, Nan Mei, Xiaobo He, Matthew S Bryant, Xuan Qin, Feng Li, Lei Guo

Faculty, Staff and Students Publications

Pexidartinib, a tyrosine kinase inhibitor, was approved by the U.S. Food and Drug Administration in 2019 for treating adult patients with symptomatic tenosynovial giant cell tumors. Because of its hepatotoxicity risks, pexidartinib received a boxed warning; however, mechanistic studies on this hepatotoxicity remain limited. In this study, we demonstrate that pexidartinib decreases cell viability in primary human hepatocytes and hepatic HepG2 cells. A 24-h treatment with pexidartinib led to apoptosis in HepG2 cells, as evidenced by increased caspase 3/7 activity and the induction of cleaved PARP and γ-H2A.X. Pexidartinib-induced endoplasmic reticulum (ER) stress was observed at early time points of …


Pathologist-Like Explainable Ai For Interpretable Gleason Grading In Prostate Cancer, Gesa Mittmann, Nidia Messias, Et Al. Oct 2025

Pathologist-Like Explainable Ai For Interpretable Gleason Grading In Prostate Cancer, Gesa Mittmann, Nidia Messias, Et Al.

2020-Current year OA Pubs

No abstract provided.