Digital Commons Network^™

Recombination Suppression Drives Expansion Of The Drosophila Dot Chromosome, Annabelle Laughlin, Jaquelyn Hester, Darwin Garrido, Emily K Oh, Maria Volski, Nistha Panda, Mia Mo, Ethan Cordes, Martin Dalling, Kacie Kershaw, Malcolm Arnott, Stephen Daly, Silvia Garcia Valenzuela, Paige Thompson, Kayla L Hastert, Destiny Sabb, Kathryn Karpinski, Meher Naaz Arora, Nicholas Rius, Larissa Lobello, Sebastian Jaramillo, Omkar Sonavane, Alice Herrmann, Laura K Reed, Sarah C R Elgin, Cindy Arrigo, Christopher E Ellison

Faculty, Staff and Student Publications

Genome size varies widely, even among closely related species, yet much less is known about chromosome size variation. Here we use the fourth chromosome of Drosophila, also known as the "Muller F element" or "dot chromosome", as a model to investigate chromosome-specific size expansion. The F element of most Drosophila species is small (∼1.3 Mb) and almost entirely heterochromatic, yet harbors approximately 80 protein-coding genes. Here, we study D. kikkawai, D. takahashii, D. ananassae, and D. bipectinata, whose F elements are 2- to 15-fold larger in size compared to D. melanogaster. Through manual gene curation and comparative genomic analysis, we …

Mecp2 Interacts With The Super Elongation Complex To Regulate Transcription, Yuki Aoi, Yan Li, Guantong Qi, Luke Parkitny, Janice L Brissette, Lorin Weiner, Juan Botas, Ismael Al-Ramahi, Ali Shilatifard, Huda Y Zoghbi

Faculty, Staff and Students Publications

Loss-of-function mutations in methyl-CpG binding protein 2 (MECP2) cause Rett syndrome. While we know that MeCP2 binds to methylated cytosines on DNA, the full breadth of the molecular mechanisms by which MeCP2 regulates gene expression remains incompletely understood. Here, using a genetic modifier screen, we identify the super elongation complex, a P-TEFb–containing elongation factor that releases promoter-proximally paused RNA polymerase II, as a genetic interactor of MECP2. MeCP2 physically interacts with SEC subunits and directly binds AFF4, the scaffold of the SEC, via the transcriptional repression domain. Furthermore, MeCP2 facilitates the binding of AFF4 on a subset …

Risk Exposure And Stakeholder Oversight In College Sports: Lessons From A Lightning Incident, John J. Miller Dr., Jason W. Lee Dr., Elizabeth A. Gregg, Jeffrey F. Levine

The COSMA Journal

The management of collegiate athletic events increasingly demands systematic approaches to risk identification, assessment, and mitigation, yet risk management education within athletics remains inconsistent. As a result, athletic directors, coaches, and facility managers frequently lack the formal preparation necessary to design and implement effective risk management policies, thereby exposing institutions to operational disruption and legal liability. Severe weather events, particularly lightning storms, underscore the importance of integrating legal principles such as duty of care, premises liability, and foreseeability into institutional planning. This case study, based on a real-life incident, shows that athletic administrators, often with limited formal training in risk …

A Forensic Logging Framework For Llms, Giannis Tziakouris, Elio Biasiotto

Defensive Publications Series

Large language models (LLMs) are increasingly embedded in enterprise, operational, and security-sensitive workflows. These include automated coding assistants, knowledge management systems, and multi-agent orchestration platforms where LLMs act as intermediaries between users and external tools. While significant research has been directed toward preventive safeguards such as input filtering, refusal mechanisms, and adversarial robustness, far less attention has been paid to forensic readiness. When incidents occur, ranging from malicious prompt injections to unauthorized tool usage or exfiltration of sensitive data, existing LLM implementations fail to provide investigators with reliable records for reconstruction, containment, or attribution.

To address this deficiency, a comprehensive …

The Great Divide – A New Leader, A New Identity? Examining A Mascot Controversy And The Role Of The New Coach In School Rebranding, Jason W. Lee, Elizabeth A. Gregg, John J. Miller

The COSMA Journal

Divisive school imagery can significantly impact academic branding while raising ethical concerns. In the presented case study, issues such as those encountered by Marty Lundy, a newly hired head football coach, are addressed as he faces divisive imagery at his new school. As Marty is aware of the divisive nature of his school's imagery, he must navigate the challenge of balancing the school's tradition and community heritage with the need to promote a welcoming environment and address the potential impact on the school's reputation. Consequently, this case study encourages examining various brand communication and ethical strategies necessary for addressing such …

Evaluating Large Language Models For Automated Cv Ranking: A Hybrid Embedding Approach For Enhanced Recruitment, Sarah Mohamed Alhindaassi

Thesis/ Dissertation Defenses

Increasing numbers of applications have revealed limitations in legacy keyword-filtering-based Applicant Tracking Systems (ATS), which commonly overlook candidate potential and ignore contextual or transferable skills. Advances in Natural Language Processing (NLP) and Large Language Models (LLMs) offer an exhilarating alternative, supporting context-sensitive and human-crafted reasoning in candidate evaluation. This thesis systematically evaluates four classes of approaches, lexical models, embedding-based methods, Large Language Models (LLMs), and hybrid ensembles, for automation of Curriculum Vitae (CV) to Job Description (JD) matching without exploiting prior annotations or annotations at match time. Using a combination of publicly available datasets and real-world sample data covering three …

Tax Trends, Harry Z. Garian

Tax Adviser

No abstract provided.

Tax Trends, Harry Z. Garian

Tax Adviser

No abstract provided.

Tax Clinic, William T. Diss

Tax Adviser

No abstract provided.

Parallel Nanophotonic Inverse Design With Early Stopping, Zi Jian Wee, Hock Soon Lim, Sabrine Hachmioune, Nidhi Chaudhary, Heonjung Kim

Defensive Publications Series

Nanophotonic inverse design uses gradient-based optimization to design the topologies of devices such as waveguides and lenses. Since the optimization process is sensitive to initial conditions yet computationally expensive, it is advantageous to balance the exploration-exploitation tradeoff by allocating optimization resources only to promising designs. Inspired by hyperparameter tuning in machine learning, this disclosure proposes Asynchronous Topology Optimization with Early Stopping (ATOES), where nanophotonic devices are optimized in parallel and resources are allocated to more promising designs via an early stopping algorithm.

The Master Engineering Compliance Atlas: A Unified Architecture For Automating Global Regulatory Governance, Ai Safety, And Cyber Risk, Ramkumar Bharathan

Defensive Publications Series

This technical disclosure presents the "Master Engineering Compliance Atlas," a comprehensive framework designed to bridge the gap between complex global regulations and modern software engineering practices. As regulatory landscapes fragment across jurisdictions, this document provides a unified methodology for harmonizing requirements from major frameworks, including Sarbanes-Oxley (SOX), GDPR, the EU Digital Markets Act (DMA), the Digital Services Act (DSA), the EU AI Act, NIST SP 800-53, and ISO 27001.

Unlike traditional legal summaries, this framework focuses on technical implementation, offering specific architectural patterns, "L7" control designs, and automation strategies to achieve "Compliance as Code." It introduces a "Mega-Matrix" that maps …

Exploring Communication Strategies With Esports Fans: Signaling Physical Location And Popularity, Gavin Nolin, Ismail Karabas, Skylar King

Faculty & Staff Research and Creative Activity

Purpose

Using signaling theory as a theoretical foundation, this study aims to investigate how consumers respond to message framing emphasizing physical location and popularity of an esports team. Additionally, this research looks at how power distance belief, need for uniqueness, sense of power and pride in community are associated with consumer intentions (e.g. support likelihood, watch likelihood, follow on social media likelihood) as a function of physical location versus popularity-signaling in team communication with prospective fans. Design/methodology/approach

This research uses an experiment to test the effects of physical location and popularity-signaling on consumer intentions toward an esports team, as well …

“I Missed My Other Oncologist”: Established Relationships As Barriers And Facilitators To Accessing Car-T And Autologous Transplantation, Zachary A. K. Frosch, Clark Meshack, Caitlin Meeker, Asya Varshavsky-Yanovsky, Rashmi Khanal, Michael Bromberg, Ashwin Chandar, Emmanuel Quien, Jordan Carter, Shazia K. Nakhoda, Marcus Messmer, Charissa Montgomery, Jason A. Incorvati, Nadia D. Ali, Michael J. Styler, Carolyn Y. Fang

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND: Autologous stem cell transplantation (ASCT) and chimeric antigen receptor T-cell therapy (CAR-T) can provide significant clinical benefit, but are not equally available to all patients. Oncologist continuity and trust are important to patients, and may act as barriers to receipt of therapy. However, detailed data are lacking on the mechanism by which these might affect receipt of therapy, or how this barrier may be overcome.

METHODS: We conducted a qualitative interview study with patients with non-Hodgkin lymphoma (NHL), classic Hodgkin lymphoma (cHL) or multiple myeloma (MM) eligible for or treated with ASCT/CAR-T. Participants were recruited from a multi-site academic …

Sign Patterns Of Certain Infinite Products, Zeyu Huang, Timothy J. Huber, James Mclaughlin, Pengjun Wang, Yan Xu, Dongxi Ye

School of Mathematical & Statistical Sciences Faculty Publications

The signs of Fourier coefficients of certain eta quotients are determined by dissecting expansions for theta functions and by applying a general dissection formula for certain classes of quintuple products. A characterization is given for the coefficient sign patterns for

(qi;qi)∞(qp;qp)∞

for integers i>1 and primes p>3. The sign analysis for this quotient addresses and extends a conjecture of Bringmann et al. for the coefficients of (q2;q2)∞(q5;q5)−1∞. The sign distribution for additional classes of eta quotients is considered. This addresses multiple conjectures posed by Bringmann et al.

The Mediating Role Of Self-Efficacy And Symptom Distress In Cancer Patients, Kailei Yan, Hsiao-Lan Wang, Brent Small, Victoria Marshall, Amanda Elliott, Danielle Tometich, Theresa M. Beckie, Susan C. Mcmillan

Biennial Convention (CONV)

Cancer symptoms significantly impact the quality of life (QOL) among cancer patients (Almståhl et al., 2019; Bashir et al., 2020; Nayak et al., 2019). Self-efficacy plays a key role in managing symptoms and improving QOL (Cox-Martin et al., 2020; Erickson et al., 2021; Frensham et al., 2020; Thieser et al., 2021; Wu et al., 2019). Symptom distress, defined as the suffering from symptom occurrence, predicts QOL in cancer patients with symptoms (Badana et al., 2019). However, it is not clear whether self-efficacy and/or symptom distress mediate the effects of symptoms on QOL. This study seeks to explore if and how …

Mucosal Melanoma: Mechanisms Of Its Etiology, Progression, Resistance And Therapy, Sofie-Yasmin Hassan, Thomas W. Flanagan, Sarah-Lilly Hassan, Sybille Facca, Youssef Haikel, Mohamed Hassan

School of Graduate Studies Faculty Publications

Mucosal melanoma (MM) is a rare, aggressive cancer whose incidence has increased continuously over the years. This subtype of melanoma arises from melanocytes on hairless surfaces, typically in the respiratory tract, gastrointestinal (GI) tract, and urogenital tract. The most common sites of occurrence include the head and neck, the anorectal region, and the vulvovaginal region, while the rare sites of MM are the urinary tract and the upper and lower GI tract, including the esophagus, duodenum and the gallbladder. MM arises in melanocytes of the ectodermal mucosa that originate from neural crest cells and migrate through embryonic mesenchyme to their …

Digital Neuropsychology And Social Anxiety: The Effect Of Observer Presence And Personality On Stress And Cognition, Ava M. Dixon

Master's Theses

This study examined how observer presence and social anxiety influence stress and cognitive performance during neuropsychological assessments, focusing on the potential benefits of unsupervised digital testing environments. Eighty university students were randomly assigned to observed or unobserved digital neuropsychological conditions and completed assessments of social cognition and executive functioning and questionnaires of social anxiety and personality. Participants also completed measures of state anxiety and heart rate variability at baseline and after cognitive tests. The findings indicated that observation led to higher subjective anxiety, but it did not produce significant interactions with social anxiety on stress or cognitive performance. Post-hoc analyses …

Using Mixed Reality-Driven Virtual Coach Technology In Promoting Mobility Among Older Adults, Michael Joseph S. Dino, Ma. Kristina Malacas, Rommel Hernandez

Biennial Convention (CONV)

Objective. Physical inactivity among older adults remains a global burden, leading to a variety of health challenges and even mortality. This study evaluated the impact of a novel virtual humanoid coach-driven physical exercise program among older adults.

Method. A non-randomized (quasi) experimental research was conducted in two community senior centers. The recruited participants (n = 130) were primarily female older adults with a mean age of 66.40 and agreed to be purposively assigned to either experimental or control groups. Trained healthcare providers performed health assessments at three time points using valid and reliable tools. Descriptive statistics, t-tests, and RM-ANOVA were …

Exploring Variations In Emotional Intelligence And Burnout Among Nursing Students, Carrie Ann Bailey, Lynn Beeler, James Lewis

Biennial Convention (CONV)

The purpose of this research is to further validate a clinician language centric self-assessment of emotional intelligence and burnout to determine if there is a difference in the subscales that measure Emotional Intelligence between the accelerated baccalaureate student nurses (ABSN) and the traditional baccalaureate student nurses (BSN). Junior level traditional BSN students and first semester ABSN students were recruited and surveyed using the Maslach Burnout Inventory and the Scale of Emotional Functioning in Medicine. Demographic data was also compared between the two groups. Data was analyzed using Independent-Samples Mann-Whitney U Test. Results: The two groups of students were significantly different …

Clinical And Demographic Profiles Of Pediatric Burn Patients: A Descriptive Retrospective Analysis, Gifty Osei Berchie, Susanna Aba Abraham, Christiana Okantey, Benjamin Kofi Anumel

Biennial Convention (CONV)

Introduction: Burn injuries are a leading cause of preventable mortality and disability among children, with approximately 96,000 pediatric cases globally each year (Asefa et al., 2024). In low- and middle-income countries, particularly in Africa, children account for nearly 90% of burn cases, with those under five being most vulnerable due to developmental factors, lack of supervision, and domestic hazards. Socioeconomic challenges such as overcrowded living conditions and inadequate safety measures exacerbate the risk (Mok et al., 2023). Burns are primarily caused by scalds from hot liquids, contact burns, and flame injuries linked to unsafe cooking practices and improper storage of …

Perceived Parental Relationship Quality And Adolescent Conscious Bias: Important Links Between Affect, Agency, Gender, And Race/Ethnicity, Amanda Terrall, Michael J. Merten, Thulitha Wickrama

General Human Environmental Sciences Faculty Publications and Presentations

Introduction Guided by attachment, social cognitive, and ecological systems theories, this study examined the direct and indirect effects of perceived parent-adolescent relationship quality on youths' conscious bias toward individuals facing socioeconomic or minority-related challenges.Methods Data were collected from 702 U.S. 18-year-olds via Qualtrics online panels. Measures included parent relationship quality, negative affect, human agency, and conscious bias (disregard for minority experiences and blaming attitudes).Results The findings revealed that strong parent-teen bonds indirectly influenced conscious bias through psychosocial wellbeing. However, while negative emotions were universally influential, the impact of human agency varied depending on gender and race/ethnicity.Discussion Study findings underscore the …

How Human Personality Will Change With The Use Of Artificial Intelligence, John Mayer

UNH Personality Lab

INTRODUCTION: Human personality changes in response to new habits, situations, and maturation, among other causes. As people interact with artificial intelligence (AI), their personalities are likely to change, from their emotional responses to their self-concept.

METHODOLOGY: This theoretical account draws together empirical studies of how personality changed in response to past technological innovations, changes in personal interactions observed in people’s AI usage, changes that arise from the use and disuse of cognitive skills, and works on the self-concept. Research reports in the review were selected according to their relevance and quality.

THEORETICAL STATEMENT: While AI becomes increasingly human-like, humans increasingly …

Menopause And Motherhood: Shaping Women’S Lived Experiences, Michelle M. Ness

Biennial Convention (CONV)

Motherhood is a multifaceted role influenced by various transitions during midlife, including changing relationship dynamics with children and significant others and the onset of menopause. Mothers often shift from hands-on caregiving to an advisory role with their adult children during this time. This shift coincides with hormonal changes associated with menopause, exacerbating physical and psychological symptoms, including hot flashes, mood swings, and sleep disturbances. The hormonal changes associated with menopause profoundly impact women's emotional well-being and interpersonal relationships, potentially increasing susceptibility to mood disorders such as depression and anxiety. Additionally, the increased demand for balance between family responsibilities and professional …

Red Midge Larvae Are An Invertebrate Alternative Diet To Beef Liver For Planarian Husbandry, Jonah Pacis , '25, Danielle Ireland, Evangeline Coffinas, Jerome Sheehan, Kate Sun , '27, Eva-Maria S. Collins

Biology Faculty Works

Freshwater planarians are an emerging model for toxicology and neuroscience because of their amenability to rapid behavioral screening and remarkable ability to regenerate a cephalized nervous system. As invertebrates, planarians can help reduce the use of vertebrates in research; however, laboratories typically maintain planarians on diets of homogenized organic beef or chicken liver, raising ethical concerns with feeding a vertebrate diet. Organic liver is difficult to obtain, and preparation methods vary, introducing intra- and interlaboratory variability. Here, we show that Dugesia japonica planarians can be maintained for over a year on commercially available red midge larvae (RML), a natural prey …

Adolescent Sexting: An Exploration Of Teacher’S Perspectives Of The Relationship And Sex Education (Rse) Based Curriculum, Grace Byrne, Leigh-Ann Sweeney, Sinead Tobin

Irish Journal of Applied Social Studies

Sexting has emerged as a normative aspect of adolescent sexual exploration in Ireland and internationally. While much attention has been given to the risks and negative aspects of sexting, contemporary literature highlights the potential positives associated with adolescent sexting. Within this precarious context, little is known about the attention sexting commands within formal education of adolescents in Ireland. To better understand teachers’ perspectives of the positionality of sexting within Relationship and Sex Education (RSE) curriculum in Ireland, the researchers employed a qualitative interpretivist approach in interviewing eight RSE teachers actively delivering sex education in Irish secondary schools. Teacher’s narratives were …

Apocalypticism And Prognostication In Early ShiʿI Literature, Mohammad Amin Mansouri

All Faculty Scholarship for the College of Arts and Humanities

This article studies the origins of Jafr, an apocalyptic, eschatological and occult book attributed to the first Shiʿi imam, ʿAlī ibn Abī Ṭālib (d. 661). While it remains unclear whether Jafr was ever physically composed, it became associated with lettrism (ʿilm al-ḥurūf) in medieval Sunni and Shiʿi literature. Jafr gradually evolved into a crucial component of Islamic occult traditions and influenced various cosmological theories as well as the letter-magic practices of prominent Sunni and Shiʿi occultists. Despite its historical significance, confusion regarding Jafr’s roots, authorship and content in Shiʿi sources from the third to fifth centuries AH …

Developing Ehealth Interventions To Improve Diabetes Management In Emerging Adulthood: Qualitative Formative Study, Susan Eggly, Steven J Ondersma, Deborah A Ellis

Faculty, Staff and Student Publications

Background: Emerging adulthood is a high-risk period during which many with type 1 diabetes demonstrate suboptimal diabetes management and glycemic control. There is a need for effective, scalable interventions designed specifically for this population. Technology-based approaches are readily accessible to this age group. Furthermore, interventions consistent with self-determination theory-which posits that the fulfillment of psychological needs for autonomy, self-efficacy, and relatedness promotes intrinsic motivation for change-may resonate well with emerging adults' developmental needs for establishing independence and autonomy, and growing their social network.

Objective: This study aimed to enhance the potential relevance, sustainability, and efficacy of 3 self-determination theory-informed mobile …

Feasibility And Acceptability Of An Implementation Strategy To Enhance Use Of Classroom-Based Physical Activity Approaches In Elementary Schools: A Mixed Methods Study, Kempson Onadeko, Maria E Fernández

Faculty, Staff and Student Publications

Background: Classroom-based approaches are an evidence-based way to improve children's physical activity; however, they are inconsistently implemented in schools. We developed MAGIC (Movement for Academic Growth In Classrooms), a multifaceted implementation strategy that consists of leadership training, teacher training, and a monthly newsletter to improve use of classroom-based physical activity approaches. The purpose of this study is to examine the feasibility and acceptability of MAGIC among elementary school teachers and leaders.

Methods: We used an embedded, convergent mixed methods design. We provided the MAGIC implementation strategy to a partner elementary school. We then administered surveys to teachers to quantitatively examine …

Met Overexpression Is Associated With Superior Immunotherapy Benefit In Advanced Non-Small Cell Lung Cancer, Luisa M Solis Soto, Waree Rinsurongkawong, Bingnan Zhang, Haniel A Araujo, Yasir Y Elamin, Mehmet Altan, Claudio A Arrechedera, Jianling Zhou, Khaja B Khan, Wei Lu, Elliana Young, Carl M Gay, Tina Cascone, Lauren A Byers, Ferdinandos Skoulidis, George Blumenschein, Frank V Fossella, Anne Tsao, Marcelo V Negrao, Natalie Vokes, Jia Wu, Hai T Tran, Ignacio I Wistuba, J Jack Lee, Don L Gibbons, Ara A Vaporciyan, John V Heymach, Xiuning Le, Jianjun Zhang

Faculty, Staff and Student Publications

Background/objectives: MET overexpression is common in non-small cell lung cancer (NSCLC). The correlation between MET overexpression and immune checkpoint inhibitor (ICI) efficacy in NSCLC is underexplored.

Methods: In this retrospective observational cohort study, we curated a dataset of 279 stage IV NSCLC patients who received ICI treatment and had MET expression assessed by CLIA-certified immunohistochemistry (IHC) assay. MET expression was graded on a scale from 0 to 3+, with overexpression defined as 2+ or 3+. Clinicopathological features associated with MET expression were assessed using logistic regression. Overall survival (OS) and progression-free survival (PFS) were evaluated via Kaplan-Meier analysis and the …

Transdisciplinary Perspectives On Ai: The Fourth Annual Conference Of The European Culture And Technology Laboratory, Connell Vaughan, Ioana Madalina Moldovan, Silivan Moldovan, Noel Fitzpatrick

Books/Book Chapters

The fourth annual conference of the ECT Lab+ was hosted by Technical University of Cluj-Napoca over two days in October 2024 at the Cluj Innovation Park. The conference brought together experts from the Arts, Humanities, Social Sciences, Technology, and other fields to discuss and reflect on the advent of Artificial Intelligence and how the associated technologies are transforming how we live, work and study. Under the title Transdisciplinary perspectives on AI: Alternative Histories, Current Practices and Possible Futures the conference moved beyond simplistic technophila and technophobia to consider whether we can co-evolve with these new technologies which combine machine learning …