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The Food Truck: A Multi-Product Newsvendor With Expectile Risk, Sekyiwaah Nuamah Dec 2025

The Food Truck: A Multi-Product Newsvendor With Expectile Risk, Sekyiwaah Nuamah

Electronic Theses and Dissertations

The Newsvendor Problem is a fundamental model in Operation Research and Supply Chain Management used to determine the optimal order quantity under uncertain demand to minimize expected costs.
This research extends the classical Newsvendor problem to a multi--product setting, addressing the risk of asymmetric cost structures faced by a food truck. This thesis introduces expectile risk measures to quantify and manage uncertainty in demand, moving beyond traditional risk metrics. To evaluate the impact of expectile-based decision-making, we analyze three types of demand distributions--simple, symmetric, and skewed. For skewed distributions, we apply linear spline inverse interpolation to derive expectile values from …


Grokking Applied To Chaotic Iterates Of The Logistic Map, Felix Donkoh Dec 2025

Grokking Applied To Chaotic Iterates Of The Logistic Map, Felix Donkoh

Electronic Theses and Dissertations

This thesis investigates grokking, the delayed transition from memorization to generalization in neural networks trained on deterministic chaotic data. Using an integer–arithmetic discretization of the logistic map, yn+1 =( a yn(p − yn))/ p 2 , bounded aperiodic sequences were generated across control parameters α ranging from 3.0 to 4.0. Transformer-based models displayed characteristic grokking curves. In periodic and chaotic regimes, validation accuracy rose suddenly after long plateaus, while at the Feigenbaum boundary (α ≈ 3.57) generalization failed completely. Increasing data diversity restored learning in chaotic domains, and explicit α–conditioning enabled a single network to generalize across all regimes. A …


Perceptions Of Practitioners: An Examination Of Practices For Retention And Support Of Special Education Teachers, Megan L. O'Dell Dec 2025

Perceptions Of Practitioners: An Examination Of Practices For Retention And Support Of Special Education Teachers, Megan L. O'Dell

Electronic Theses and Dissertations

Teacher attrition remains a critical challenge in public education, particularly among special education teachers who face unique legal, instructional, and emotional demands. This phenomenological study explored the lived experiences of current and former K–5 special education teachers to better understand the practices and resources that influence their decision to remain in or leave the profession. The central research question investigated how leadership, professional learning, and working conditions shape teacher sustainability in special education roles. Twelve participants, including six currently employed special education teachers and six who had exited the profession, participated in semi-structured interviews. Data analysis revealed five major themes: …


"Forgive Our Living And Our Dead": Colonial Warfare In The Philippines, Mattie Fitzpatrick Dec 2025

"Forgive Our Living And Our Dead": Colonial Warfare In The Philippines, Mattie Fitzpatrick

History

In March of 1906, American troops massacred over 1,000 Filipino civilians on Bud Dajo mountain. American service members were commended for this incident. My research examines this massacre to ask why wars of insurgency are specifically subject to abuses of power, particularly during the American-Philippines War and the ensuing colonial warfare between 1898 and 1906 under the colonization of the US. My research will focus on the circumstances created to excuse US soldiers after atrocities were committed and the colonial attitudes of the time in addition to the brutal methods used by the American government in Philippines. American colonial administrators …


A Scoping Review Of Human Digital Twins In Healthcare Applications And Usage Patterns, Brant H. Tudor, Robert Burton, Joyce T. Johnson, Ryan Shargo, Geoffrey M. Gray, Jamie L. Fierstein, Frederick H. Kuo, Brandi B. Scully, Alfred Asante-Korang, Mohamed A. Rehman, Luis M. Ahumada Dec 2025

A Scoping Review Of Human Digital Twins In Healthcare Applications And Usage Patterns, Brant H. Tudor, Robert Burton, Joyce T. Johnson, Ryan Shargo, Geoffrey M. Gray, Jamie L. Fierstein, Frederick H. Kuo, Brandi B. Scully, Alfred Asante-Korang, Mohamed A. Rehman, Luis M. Ahumada

Student Publications [Scholarly]

Digital twins have become increasingly popular across various industries as dynamic virtual models of physical systems. In healthcare, Human Digital Twins (HDTs) serve as virtual counterparts to patients. According to the National Academies of Sciences, Engineering, and Medicine (NASEM), a digital twin must be personalized, dynamically updated, and have predictive capabilities to—in the context of health care—inform clinical decision-making. This scoping review aims to assess the current state of HDTs in healthcare, examining whether the literature aligns with the NASEM definition and identifying trends. A systematic literature search was conducted, covering articles published from January 2017 to July 2024. Only …


Cattlefever: An Automated Cattle Fever Estimation System, Trong Thang Pham, Ethan Coffman, Beth Kegley, Jeremy G. Powell, Jiangchao Zhao, Ngan Le Dec 2025

Cattlefever: An Automated Cattle Fever Estimation System, Trong Thang Pham, Ethan Coffman, Beth Kegley, Jeremy G. Powell, Jiangchao Zhao, Ngan Le

Electrical Engineering and Computer Science Faculty Publications and Presentations

Farmers face the critical challenge of monitoring cattle well-being for both ethical and economic success, relying on signals like body temperature and facial expressions to assess their animals' health. However, these indicators have traditionally relied on human observation with manual measurement, which is time-consuming and subjective. Despite this clear need, no automated system currently exists for monitoring cattle body temperature, and available datasets remain limited in scope. To address these challenges, we make two key contributions: (i) We introduce CattleFace-RGBT, a novel RGB-Thermal (RGB-T) Cattle Facial Landmark dataset consisting of 2,300 paired RGB and thermal images (4,600 images in total), …


The Cost Effectiveness Of A Free Summer Day Camp Voucher Program To Prevent Summer Weight Gain Among Children From Disadvantaged Households, Brian K. Chen, Michael Beets Med, Mph, Phd, Sarah Burkart, Christopher D. Pfledderer, Elizabeth Adams, Robert Glenn Weaver Med, Phd, Bridget Armstrong Ph.D., Keith Brazendale, Xuanxuan Zhu, Alexander Mclain Dec 2025

The Cost Effectiveness Of A Free Summer Day Camp Voucher Program To Prevent Summer Weight Gain Among Children From Disadvantaged Households, Brian K. Chen, Michael Beets Med, Mph, Phd, Sarah Burkart, Christopher D. Pfledderer, Elizabeth Adams, Robert Glenn Weaver Med, Phd, Bridget Armstrong Ph.D., Keith Brazendale, Xuanxuan Zhu, Alexander Mclain

Faculty Publications

Introduction

Summer day camps can mitigate summer weight gain by providing a structured daily environment that promotes healthy behaviors, but summer day camps are often cost prohibitive to families with low income. This study evaluated the cost effectiveness of providing free summer day camps to disadvantaged children to prevent summer weight gain.

Methods

A total of 422 children from a low-income school district in South Carolina were recruited and randomly assigned to receive 8–10 weeks of free summer day camps or to experience summer as usual in 2021–2023. The incremental cost-effectiveness ratio was calculated by dividing summer day camp cost …


The Sexual Objectification Experiences Of Amab Non-Binary People, Lee Rosemary Pradell Dec 2025

The Sexual Objectification Experiences Of Amab Non-Binary People, Lee Rosemary Pradell

All Graduate Theses and Dissertations, Fall 2023 to Present

The current study combines two narrative-based methods to understand how AMAB non-binary people experience sexual objectification. Sexual objectification is the process of being treated as an object instead of as a whole person while also being sexualized. Individual people can sexually objectify others (i.e., catcalling, asking “What gender are you really?”, repeatedly asking female people about when they’re giving birth); institutions and systems can also objectify people (i.e., listing sex on driver’s licenses instead of gender; providing binary bathrooms, sports teams, and schooling; labeling female reproductive care “women’s health”).

The current study employed a process chart task that guided participants …


Enabling Scalable Camera-Based Streamflow Monitoring With Serverless Cloud Computing, Sajan Neupane Dec 2025

Enabling Scalable Camera-Based Streamflow Monitoring With Serverless Cloud Computing, Sajan Neupane

All Graduate Theses and Dissertations, Fall 2023 to Present

This thesis introduces a modern and automated method for monitoring rivers and streams using cameras and cloud-based software tools. Traditional monitoring methods often rely on sensors placed directly in the water, which can be expensive, hard to install, and difficult to maintain, especially in remote or rough terrain. In contrast, this approach uses cameras to observe water flow from a distance, offering a safer and more cost-effective alternative. However, camera systems come with their own challenges, such as collecting large amounts of image data, transferring it reliably from the field, and analyzing it quickly enough to be useful. This research …


Software Developer Job Satisfaction: Interpretable Machine Learning Insights From The Stack Overflow Developer Survey, Reagan E. Hoopes Dec 2025

Software Developer Job Satisfaction: Interpretable Machine Learning Insights From The Stack Overflow Developer Survey, Reagan E. Hoopes

All Graduate Theses and Dissertations, Fall 2023 to Present

Many researchers have investigated the factors influencing software developer workplace outcomes, such as job satisfaction, due to the central role of the tech industry in the global economy and the specialized expertise of software developers. Past research has often relied on small surveys and traditional analysis methods, with limited use of modern machine learning techniques. This study introduces an efficient and scalable approach to analyzing software developer job satisfaction using interpretable machine learning.

We use data from the 2019 and 2024 Stack Overflow Developer Surveys, an annual survey of software developers worldwide that encompasses a broad range of topics, including …


From Feedback To Insight: Using Hierarchical Clustering Analysis To Identify And Analyze Feedback Dimensions In Online Courses, Reagan R. Siggard Dec 2025

From Feedback To Insight: Using Hierarchical Clustering Analysis To Identify And Analyze Feedback Dimensions In Online Courses, Reagan R. Siggard

All Graduate Theses and Dissertations, Fall 2023 to Present

The demand for online courses continues to increase, as do the critiques of their effectiveness. Studies have found that peer interactions positively impact the online course experience and that peers can offer feedback to each other at the instructor's level with proper guidance. To help understand this feedback, researchers have identified feedback dimensions. Most feedback dimensions have been created through inductive coding, not exploratory data analysis approaches. This study sought to identify those feedback dimensions that perhaps had been missed or were highly associated with those already existing in the literature, hoping to inform research and practice to improve the …


Implications Of The Attenuated Allee Effect On Population Dynamics, Dana Strong Dec 2025

Implications Of The Attenuated Allee Effect On Population Dynamics, Dana Strong

All Graduate Theses and Dissertations, Fall 2023 to Present

The Allee effect is an ecological phenomenon characterized by a per capita growth rate that increases as the population size increases in the context of low population density. The Allee effect can lead to rapid extinction events. Consequently, ecologists can attempt to control the strength of the Allee effect to help increase the population (in the case of endangered species) or decrease the population (in the case of parasites or pests).

This research aimed to study not the strength of the Allee effect, but the intensity of the Allee effect, or how rapidly cooperation between individuals causes the per capita …


Integrating Manager Perspectives Into The Evaluation Of Wetland Revegetation Strategies, Loren F. Taylor Dec 2025

Integrating Manager Perspectives Into The Evaluation Of Wetland Revegetation Strategies, Loren F. Taylor

All Graduate Theses and Dissertations, Fall 2023 to Present

Ecological restoration is the process of assisting the recovery of an ecosystem that has been degraded and is dependent on complex and context-specific decisions. The decision-making process influencing restoration is rarely examined alongside ecological processes. There is a need for research that incorporates the social, economic, institutional, and logistical considerations that shape real-world practices, as well as ecological processes. Decisions made by restoration practitioners and land managers (hereon “manager”) are challenged by the lack of information shared regarding the practical constraints (e.g., cost, labor, specialized equipment) they face. Revegetation, particularly in wetlands, poses challenges due to site conditions and degradation …


Unveiling The Interactions Between The Antibiotic Resistome And Microplastics Influenced By Trace Elements And Ppcps In Wastewater Treatment Plants, Tahira Tasneem Rahman Dec 2025

Unveiling The Interactions Between The Antibiotic Resistome And Microplastics Influenced By Trace Elements And Ppcps In Wastewater Treatment Plants, Tahira Tasneem Rahman

All Graduate Theses and Dissertations, Fall 2023 to Present

Antibiotic resistance is a growing global concern, and wastewater treatment plants play a critical role in controlling its spread. These facilities process water containing microplastics (small plastic particles), trace elements like copper and zinc, and chemicals from everyday products like pharmaceuticals and personal care products. Together, these pollutants may contribute to the survival and spread of bacteria containing antibiotic resistance genes, but their combined effects are not fully understood. This study investigated how these pollutants behave and interact in wastewater treatment plants using two approaches: direct monitoring of real treatment plants and controlled lab experiments using synthetic wastewater. Results showed …


An Evaluation Of Virtual Reality Modeling To Improve Accuracy Of Physical Education Skills In Teenage Students With Disabilities, Kristen Lee Dec 2025

An Evaluation Of Virtual Reality Modeling To Improve Accuracy Of Physical Education Skills In Teenage Students With Disabilities, Kristen Lee

All Graduate Theses and Dissertations, Fall 2023 to Present

Virtual Reality (VR) technology is becoming more common in schools, especially for teaching and training. In this study, researchers explored how VR can help teenagers with disabilities improve their physical education skills, specifically push-ups, lunges, and jumping jacks. The participants all showed an increase in their skills and reached a high level of accuracy on every skill. The results showed that adding feedback was also necessary for some participants. Additionally, participants enjoyed using the VR equipment and showed high levels of happiness throughout the study. These findings suggested that using VR technology can be an effective way to support teenagers …


Spatial Strategies For Restoring Native Biodiversity And Connectivity In Managed Landscapes Of The Upper Clutha Basin, New Zealand, Jessica Zuban Dec 2025

Spatial Strategies For Restoring Native Biodiversity And Connectivity In Managed Landscapes Of The Upper Clutha Basin, New Zealand, Jessica Zuban

All Graduate Theses and Dissertations, Fall 2023 to Present

Across New Zealand and around the world, biodiversity is declining due to the widespread loss and fragmentation of native habitat. This is especially true in agricultural landscapes, where native habitats have been replaced by intensive land use. This research focuses on the Upper Clutha Basin in Central Otago, New Zealand that has been significantly altered over time by farming, development, and other human activities. As a result, only a small amount of native vegetation remains, and the region is well below the critical threshold needed to support healthy ecological systems.

This study investigates how native vegetation can be strategically restored …


A Software Framework For Translating Onnx Models Onto The Lace-C3a Hardware, Shawn Jones Dec 2025

A Software Framework For Translating Onnx Models Onto The Lace-C3a Hardware, Shawn Jones

All Graduate Theses and Dissertations, Fall 2023 to Present

Modern computers are powerful, but they are not always efficient enough for small, low power systems like those used on satellites and scientific instruments. To solve this problem, engineers often turn to FPGAs—reconfigurable computer chips that can be customized to run specific tasks much faster and with far less energy than ordinary processors. However, finding the best possible design for an FPGA program is extremely difficult because there are millions of ways a design could be built, and only a small fraction of them actually perform well.

This thesis presents SNOW, a new framework that helps automate the search for …


Quicklime-Based Self-Healing Concrete For Bridge Deck Applications, Mehrnoosh Nazari Dec 2025

Quicklime-Based Self-Healing Concrete For Bridge Deck Applications, Mehrnoosh Nazari

All Graduate Theses and Dissertations, Fall 2023 to Present

Concrete is one of the most widely used construction materials in the world. However, over time, it can crack and deteriorate, especially on roads and bridges exposed to harsh weather and deicing salts. Inspired by the long-lasting durability of ancient Roman concrete, this study explores the self-healing capabilities of concrete incorporating quicklime (calcium oxide) aggregates to extend the service life of bridge decks. For this purpose, three concrete mixtures were developed using local materials: one without quicklime (C-Q 0%) and two with 2% (C-Q 2%) and 4% quicklime (C-Q 4%). These mixtures were tested for fresh properties, strength, durability, and …


The Effects Of Lactoferrin And Iron-Enriched Whey On Iron Status Of Collegiate Females, Connor Kemp Dec 2025

The Effects Of Lactoferrin And Iron-Enriched Whey On Iron Status Of Collegiate Females, Connor Kemp

All Graduate Theses and Dissertations, Fall 2023 to Present

Iron deficiency has remained a global issue even in developed countries despite food fortification and increased nutritional literacy, biological women of child baring age are at particular risk due to menstruation and reduced dietary intake of iron containing foods compared to men. This issue is of particular concern in athletics due to the critical role of iron in oxygen transport and energy metabolism. With nearly half of female athletes presenting low iron status iron supplementation is often necessary. With iron supplementation often resulting in gastrointestinal symptoms that could negatively impact sport performance itself there is a need to explore other …


Improvisation Of Mands Using Augmentative And Alternative Communication, Lauren Decker Dec 2025

Improvisation Of Mands Using Augmentative And Alternative Communication, Lauren Decker

All Graduate Theses and Dissertations, Fall 2023 to Present

Research shows that young children who use pictures to communicate can use colors, shapes, and functions of items to request when the specific picture of the item is not available. This problem-solving skill is called improvisation, which this study taught to a preschool aged participant with communication delays. A four-year-old preschool student was able to make these requests with basic colors, shapes, and three function pictures. They also were able to make these requests for items not taught to them in different settings. This suggests that improvisation training can be successfully implemented with preschool aged children with communication delays and …


Discourses Embedded In The Adams V. School Board Of St. Johns County Decision And The Rights Of Transgender Students In Schools, Douglas Larson Dec 2025

Discourses Embedded In The Adams V. School Board Of St. Johns County Decision And The Rights Of Transgender Students In Schools, Douglas Larson

All Graduate Theses and Dissertations, Fall 2023 to Present

This study was critical analysis of the language of the court case Adams v. School Board of St. Johns County (2022). This case was brough by a student against the School District challenging a policy that prevented him, a transgender boy, from using the boys’ restroom. The analysis was not intended to determine the merits of the case or the correctness of the legal reasoning. Rather, the analysis was performed on the text of the case—the language used by the judges—to learn about the beliefs, attitudes, and values of the judges.

The reason this analysis is important is because judges …


The Icj’S Advisory Opinion On Climate Change, Maria Antonia Tigre, Maxim Bönnemann, Antoine De Spiegeleir Dec 2025

The Icj’S Advisory Opinion On Climate Change, Maria Antonia Tigre, Maxim Bönnemann, Antoine De Spiegeleir

Sabin Center for Climate Change Law

This open-access edited volume offers the first comprehensive analysis of the International Court of Justice’s 2025 Advisory Opinion on the obligations of States in respect of climate change, one of the most consequential developments in international climate law since the adoption of the Paris Agreement. Bringing together leading scholars and practitioners from across public international law, human rights law, environmental law, and global governance, the book examines how the Court reframed climate change as a matter of binding legal obligation rather than political discretion.

The contributions explore the Opinion’s articulation of state duties under treaties, customary international law, and general …


The Disaster Management Complex: Law’S Adaptations In Times Of Climate Disaster, Michael Burger, Jeffrey Schlegelmilch, Lucia Bragg Dec 2025

The Disaster Management Complex: Law’S Adaptations In Times Of Climate Disaster, Michael Burger, Jeffrey Schlegelmilch, Lucia Bragg

Sabin Center for Climate Change Law

The Anthropocene is marked by constant climate-related disasters and defined by the urgent need to foster and implement adaptations to future climate impacts that reduce disaster risk. The intensity, frequency, and severity of extreme weather events continue to rise even as nations and corporations alike miss their emissions targets, all promising a hotter, wetter, and more extreme future. A number of federal agencies, including the Federal Emergency Management Agency (FEMA), have, at times, sought to adapt their own famously fragmented responses to these changing circumstances. However, federal disaster response is conducted against a backdrop of authorizing legislation that is designed …


Social Well-Being Moderates Behavioral Therapy Response For Generalized Anxiety Disorder., Jacob D. Armstrong, Nicole R. Baughman, Ricardo A. Wilhelm, Dalia El-Shafie, Hannah Berg, Hung-Wen Yeh, Elisabeth Akeman, Christopher Martell, Kate B. Wolitzky-Taylor, Michelle G. Craske, Martin P. Paulus, Robin Aupperle Dec 2025

Social Well-Being Moderates Behavioral Therapy Response For Generalized Anxiety Disorder., Jacob D. Armstrong, Nicole R. Baughman, Ricardo A. Wilhelm, Dalia El-Shafie, Hannah Berg, Hung-Wen Yeh, Elisabeth Akeman, Christopher Martell, Kate B. Wolitzky-Taylor, Michelle G. Craske, Martin P. Paulus, Robin Aupperle

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Identifying moderators of treatment outcome for depression and anxiety offers promise for personalizing treatment or providing novel intervention targets. Indices of social well-being have emerged as candidate moderators due to their robust impact on mental health and quality of life. Here, we examine whether measures of social support, isolation, and loneliness moderate outcomes to behavioral activation (BA) and exposure-based therapy (EXP) for individuals with GAD.

METHODS: This secondary analysis of a randomized clinical trial included 69 participants (31 EXP, 38 BA). Participants completed the GAD-7, along with NIH PROMIS (Depression; Social Isolation; and Emotional, Instrumental, and Informational Support) and …


Adenovirus Types In Us Children Hospitalized Or Seen In The Emergency Department With Acute Respiratory Illness, 2016-2019., Tess Stopczynski, Varvara Probst, Adam Gailani, Justin Z. Amarin, Olla Hamdan, Haya Hayek, Laura S. Stewart, Herdi K. Rahman, Rangaraj Selvarangan, Jennifer E. Schuster, Christopher J. Harrison, Mary E. Moffatt, Marian G. Michaels, John V. Williams, Julie A. Boom, Leila C. Sahni, Vasanthi Avadhanula, Mary Allen Staat, Elizabeth P. Schlaudecker, Christina Quigley, Geoffrey A. Weinberg, Peter G. Szilagyi, Janet A. Englund, Eileen J. Klein, Aaron T. Curns, Heidi L. Moline, Ariana P. Toepfer, James D. Chappell, Andrew J. Spieker, Natasha B. Halasa Dec 2025

Adenovirus Types In Us Children Hospitalized Or Seen In The Emergency Department With Acute Respiratory Illness, 2016-2019., Tess Stopczynski, Varvara Probst, Adam Gailani, Justin Z. Amarin, Olla Hamdan, Haya Hayek, Laura S. Stewart, Herdi K. Rahman, Rangaraj Selvarangan, Jennifer E. Schuster, Christopher J. Harrison, Mary E. Moffatt, Marian G. Michaels, John V. Williams, Julie A. Boom, Leila C. Sahni, Vasanthi Avadhanula, Mary Allen Staat, Elizabeth P. Schlaudecker, Christina Quigley, Geoffrey A. Weinberg, Peter G. Szilagyi, Janet A. Englund, Eileen J. Klein, Aaron T. Curns, Heidi L. Moline, Ariana P. Toepfer, James D. Chappell, Andrew J. Spieker, Natasha B. Halasa

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Human adenovirus (HAdV) is a common cause of pediatric acute respiratory illness (ARI), contributing to 5-13% of cases worldwide. Clinical manifestations vary by HAdV species and type; therefore, delineating type-specific disease presentations and understanding severity of specific HAdV types' disease may help develop targeted interventions.

METHODS: We conducted a multicenter, prospective study within the New Vaccine Surveillance Network to characterize HAdV types. Children < 18 years old with ARI were enrolled in the emergency department or inpatient setting at 7 US children's hospitals from 1 December 2016 to 30 November 2019. Respiratory specimens were collected and tested for HAdV and other viruses. Subsequently, typing was conducted on HAdV specimens using single-plex real-time PCR assays targeting sequences in the hexon gene. Comparisons between HAdV types were performed to determine differences in characteristics and outcomes. Generalized linear mixed effects models were used to evaluate severity.

RESULTS: Among the 1843 HAdV-positive cases, 1402 specimens (76%) were typed. The most common types detected were HAdV-C1 (n = 439), HAdV-C2 (n = 393), and HAdV-B3 (n = 221). Children with HAdV-B7 (n = 78) …


A Model For Developing Subspecialty Clinical Practice Guidelines: The Geriatric Emergency Department Guidelines 20, Lauren T Southerland, Alexander X Lo, Sangil Lee, Kirby Swan, Fabrice Mowbray, Rachel M Skains, Teresita M Hogan, Martin F Casey, Kei Ouchi, Naomi R George, Kerstin De Wit, Cameron J Gettel, Katherine Selman, Luna C Ragsdale, Anita N Chary, James D Van Oppen, Glenn Arendts, Charles L Maddow, Katherine M Hunold, Katren R Tyler, Danya Khoujah, Ula Hwang, Shan Liu Dec 2025

A Model For Developing Subspecialty Clinical Practice Guidelines: The Geriatric Emergency Department Guidelines 20, Lauren T Southerland, Alexander X Lo, Sangil Lee, Kirby Swan, Fabrice Mowbray, Rachel M Skains, Teresita M Hogan, Martin F Casey, Kei Ouchi, Naomi R George, Kerstin De Wit, Cameron J Gettel, Katherine Selman, Luna C Ragsdale, Anita N Chary, James D Van Oppen, Glenn Arendts, Charles L Maddow, Katherine M Hunold, Katren R Tyler, Danya Khoujah, Ula Hwang, Shan Liu

Faculty, Staff and Students Publications

The original consensus-based Geriatric Emergency Department (GED) Guidelines, published in 2014, established a framework of core principles for delivering high-quality, age-appropriate emergency care for older adults. In response to significant advances in geriatric emergency medicine research and evolving clinical priorities, we developed the GED Guidelines 2.0 to ensure continued relevance, clinical utility, and evidence-based rigor. This concept paper describes the systematic and iterative process undertaken to update the guidelines, including the formation of multidisciplinary working groups and the application of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. Unlike the original GED Guidelines, our approach prioritized methodological transparency, …


Part Ii Common Questions And Misconceptions About Creatine Supplementation: What Does The Scientific Evidence Really Show?, Philip D Chilibeck, Stacey J Ellery, Scott C Forbes, Bruno Gualano, Andrew R Jagim, Chad Kerksick, Richard B Kreider, Sergej M Ostojic, Eric S Rawson, Michael D Roberts, Hamilton Roschel, Abbie E Smith-Ryan, Jeffrey R Stout, Mark A Tarnopolsky, Trisha A Vandusseldorp, Darryn S Willoughby, Tim N Ziegenfuss Dec 2025

Part Ii Common Questions And Misconceptions About Creatine Supplementation: What Does The Scientific Evidence Really Show?, Philip D Chilibeck, Stacey J Ellery, Scott C Forbes, Bruno Gualano, Andrew R Jagim, Chad Kerksick, Richard B Kreider, Sergej M Ostojic, Eric S Rawson, Michael D Roberts, Hamilton Roschel, Abbie E Smith-Ryan, Jeffrey R Stout, Mark A Tarnopolsky, Trisha A Vandusseldorp, Darryn S Willoughby, Tim N Ziegenfuss

Faculty, Staff and Students Publications

Creatine monohydrate supplementation (CrM) is a safe and effective intervention for improving certain aspects of sport, exercise performance, and health across the lifespan. Despite its evidence-based pedigree, several questions and misconceptions about CrM remain. To initially address some of these concerns, our group published a narrative review in 2021 discussing the scientific evidence as to whether CrM leads to water retention and fat accumulation, is a steroid, causes hair loss, dehydration or muscle cramping, adversely affects renal and liver function, and if CrM is safe and/or effective for children, adolescents, biological females, and older adults. As a follow-up, the purpose …


Alternative Splicing Of The Snap23 Microexon Is Regulated By Mbnl, Qki, And Rbfox2 In A Tissue-Specific Manner And Is Altered In Striated Muscle Diseases, Bryan B Guzman, Rachel A Szymanski, Eunice Y Lee, Nichlas M Engels, Emma R Hinkle, Hannah J Wiedner, Aubriana N Bishop, Jonathan T Harrison, Hua Zhang, Xander H T Wehrens, Daniel Dominguez, Jimena Giudice Dec 2025

Alternative Splicing Of The Snap23 Microexon Is Regulated By Mbnl, Qki, And Rbfox2 In A Tissue-Specific Manner And Is Altered In Striated Muscle Diseases, Bryan B Guzman, Rachel A Szymanski, Eunice Y Lee, Nichlas M Engels, Emma R Hinkle, Hannah J Wiedner, Aubriana N Bishop, Jonathan T Harrison, Hua Zhang, Xander H T Wehrens, Daniel Dominguez, Jimena Giudice

Faculty, Staff and Students Publications

The reprogramming of alternative splicing networks during development is a hallmark of tissue maturation and identity. Alternative splicing of microexons (small, genomic regions ≤ 51 nucleotides) functionally regulate protein-protein interactions in the brain and is altered in several neuronal diseases. However, little is known about the regulation and function of alternatively spliced microexons in striated muscle. Here, we investigated alternative splicing of a microexon in the synaptosome-associated protein 23 (Snap23) encoded gene. We found that inclusion of this microexon is developmentally regulated and tissue-specific, as it occurs exclusively in adult heart and skeletal muscle. The alternative region is …


Halo Gravity Traction And Temporary Internal Distraction, Nicholas D. Fletcher, Anson G. Bautista, Joshua S. Murphy, K Aaron Shaw Dec 2025

Halo Gravity Traction And Temporary Internal Distraction, Nicholas D. Fletcher, Anson G. Bautista, Joshua S. Murphy, K Aaron Shaw

Manuscripts, Articles, Book Chapters and Other Papers

Severe pediatric spinal deformities may require staged correction strategies to mitigate neurologic risk and optimize cardiopulmonary outcomes. This paper reviews two adjunctive techniques—halo gravity traction (HGT) and temporary internal distraction (TID)—used in the management of rigid scoliosis. HGT enables gradual preoperative spinal elongation and coronal/sagittal realignment, improving pulmonary function and nutritional status while reducing the need for three-column osteotomies. TID offers an internal, staged distraction approach for patients contraindicated for external traction, allowing incremental correction via posterior instrumentation followed by definitive fusion. Clinical studies report Cobb angle reductions of 30–80 %, with low rates of neurologic complications when neuromonitoring and …


Decreasing Barriers To The Utilization Of Cryopreserved Sperm In Male Cancer Survivors: An Expert Review And Guide, Allyson Nevins, Luwam Ghidei, Jordan Kassab, Kevin Campbell, John Sullivan, Michael D Jochum, Laura Detti, Terri L Woodard, Larry I Lipshultz, Laurie J Mckenzie Dec 2025

Decreasing Barriers To The Utilization Of Cryopreserved Sperm In Male Cancer Survivors: An Expert Review And Guide, Allyson Nevins, Luwam Ghidei, Jordan Kassab, Kevin Campbell, John Sullivan, Michael D Jochum, Laura Detti, Terri L Woodard, Larry I Lipshultz, Laurie J Mckenzie

Faculty, Staff and Students Publications

Background: Sperm cryopreservation offers male cancer patients a critical opportunity to preserve fertility prior to gonadotoxic therapy, yet utilization of banked sperm remains modest, typically under 10%. A structured understanding of barriers across the cancer survivorship continuum is needed to support patients in utilization of cryopreserved sperm in alignment with their reproductive goals.

Materials and methods: This expert review synthesizes current evidence and clinical experience to explore the multifaceted barriers to cryopreserved sperm use and propose specific solutions. Key intervention timepoints are examined, including the post-treatment fertility return visit, long-term cryopreservation while remote from family building, readiness for family building, …