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Full-Text Articles in Entire DC Network
Preparing Confident Elementary Mathematics Teachers: Addressing Anxiety, Building Fluency, And Strengthening Practice., Amber Diamond Pendleton
Preparing Confident Elementary Mathematics Teachers: Addressing Anxiety, Building Fluency, And Strengthening Practice., Amber Diamond Pendleton
Electronic Theses and Dissertations
This dissertation, presented in three articles, examines how elementary preservice teachers (PSTs) experience and develop as mathematics learners and future educators when methods coursework deliberately integrates mathematical reasoning with affective supports. Collectively, the studies investigate how research-informed instructional design may help address mathematics anxiety (MA), mathematics teaching anxiety (MTA), procedural fluency, and instructional practice. The first article, written for practitioners and elementary mathematics teachers, illustrates how well-established instructional routines, such as number talks and student work analysis, can be facilitated to support procedural fluency in multiplication. Using classroom vignettes, this article highlights instructional moves that make structure visible, promote strategy …
Exposure To Pm2.5 And Aging., Daniel Chris Gomes
Exposure To Pm2.5 And Aging., Daniel Chris Gomes
Electronic Theses and Dissertations
Inhalation of fine airborne particulate matter (PM2.5) is an environmental risk factor for numerous health disorders, including cardiovascular diseases (CVD). While several studies have shown that PM2.5 exposure can induce oxidative stress, DNA damage, and inflammation, the underlying mechanisms that translate these effects into systemic pathology remain poorly understood. Some recent studies have shown that PM2.5 exposure can lead to telomere shortening in leukocytes, but the generality of this outcome and contribution to endothelial dysfunction has not yet been fully explored. We hypothesized that PM2.5inhalation accelerates cellular aging and senescence in both circulating peripheral …
Controlling Selectivity In Electrocatalytic Co2 Reduction With An External Magnetic Field., Nawaraj Karki
Controlling Selectivity In Electrocatalytic Co2 Reduction With An External Magnetic Field., Nawaraj Karki
Electronic Theses and Dissertations
My dissertation describes how to alter the speciation and concentration of molecules at the electrode-electrolyte interface, and how those alterations affect reactivity and selectivity. This dissertation presents two distinct approaches to control the mass transport of neutral molecules such as carbon dioxide (CO2) at the electrode-electrolyte interface by using an external magnetic field. The first finding demonstrates that magnetic fields indirectly affect the mass transport of target analytes such as CO2 molecules by selectively interacting with charged species, such as hydroxide ions (OH-). Such interaction induces magnetohydrodynamic (MHD) effects, which generate localized hydrodynamic flow and …
Symmetry, Stability, And Robust Optimization Strategies For Nonorthogonal Multiconfiguration Self-Consistent Field Wavefunctions., Zihui Song
Electronic Theses and Dissertations
The "different orbital different configuration" (DODC) framework is a general formulation of multireference wavefunctions that allows each configuration (determinant) to possess its own set of optimized molecular orbitals, rather than sharing a common orbital basis as in conventional orthogonal configuration interaction (CI) or Complete Active Space Self-Consistent Field (CASSCF) methods. One prominent example of the DODC framework is the Nonorthogonal Configuration Interaction (NOCI) method, which relaxes the orthogonality constraint between the orbitals of different configurations. This relaxation enables a compact yet flexible description of systems exhibiting strong correlation. By employing multiple nonorthogonal reference determinants, NOCI naturally incorporates orbital relaxation and …
Characterizing Hexavalent Chromium Neurotoxicity Across Laboratory Models., Samuel Thomas Vielee
Characterizing Hexavalent Chromium Neurotoxicity Across Laboratory Models., Samuel Thomas Vielee
Electronic Theses and Dissertations
Hexavalent chromium [Cr(VI)] is a ubiquitous environmental pollutant and potent toxicant. Exposure to Cr(VI) in drinking water is primarily associated with cancers, inflammation, and hepatotoxicity; however, recent studies have identified Cr(VI) as a neurotoxicant in rodent and cell culture models. The literature suggest chromium accumulates in the brain, induces widespread neurodegeneration, and alters rodent behaviors. Despite these data, we lack a detailed and consistent assessments of Cr(VI) neurotoxicity across models, and interactions between aging and Cr(VI) neurotoxicity are not reported in the literature. In this dissertation, we characterize Cr(VI) neurotoxicity across 3 laboratory models: Sprague-Dawley rats, Caenorhabditis elegans, and …
The Ecology Of Arthropod Rain In A Tropical Forest., Andrew Robert Seiler
The Ecology Of Arthropod Rain In A Tropical Forest., Andrew Robert Seiler
Electronic Theses and Dissertations
Tropical forests are structured by complex vertical linkages and nutrient exchanges between canopy and understory habitats. These linkages include the downward flux of organisms, the movement of canopy fauna, and the recycling of nutrients through litter and organic matter deposition. This dissertation investigates arthropod rain and its role in connecting the canopy and forest floor processes in a lowland tropical forest in Panama. Chapter 2 quantifies “arthropod rain”, the fall of canopy arthropods into the understory. Using pan and pole traps, I measured the composition, abundance, and biomass of arthropods falling from the canopy and assessed environmental drivers of the …
Understanding Social And Cognitive Influences In Medical Students' Learning Processes For Step 1: An Interpretivist Case Study., Ashley Elaine Triplett
Understanding Social And Cognitive Influences In Medical Students' Learning Processes For Step 1: An Interpretivist Case Study., Ashley Elaine Triplett
Electronic Theses and Dissertations
This qualitative interpretivist case study explores, at a singular institution, medical students’ perspectives on the social and cognitive factors influencing the learning process as students prepare for the Step 1 examination. While prior research regarding medical students Step 1 preparation have focused primarily on wellness, stress, and career outcomes, limited studies have examined medical students' lived experiences to navigate what occurs during the learning process while they prepare for this critical exam. Utilizing a qualitative case study approach, this dissertation draws on fourteen student interviews, seven that passed Step 1 on their first attempt, and seven that failed. Findings reveal …
Safety Evaluation Of Epicertin, An Oral Biotherapeutic Candidate For Treating Ulcerative Colitis: A 28-Day Repeated Dose Toxicity Study., Jimmy Fernando Cifuentes Jimenez
Safety Evaluation Of Epicertin, An Oral Biotherapeutic Candidate For Treating Ulcerative Colitis: A 28-Day Repeated Dose Toxicity Study., Jimmy Fernando Cifuentes Jimenez
Electronic Theses and Dissertations
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic, relapsing inflammation of the colon and rectum with limited treatment options. Among them, immunosuppressive agents have a high rate of adverse side effects and do not cure the disease. EPICERTIN (EPT), a recombinant variant of the cholera toxin B subunit (CTB) with a C-terminal hexapeptide extension consisting of a KDEL endoplasmic reticulum (ER) retention motif, is a promising oral biotherapeutic candidate for the treatment of UC. EPT has demonstrated mucosal healing activity in mouse models of colitis and human colonic explants. EPT's mechanism of action involves binding to GM1 …
Congolese Mothers' Beliefs That Influence Health-Seeking Behaviors For Their Infants., Shawn Meiman
Congolese Mothers' Beliefs That Influence Health-Seeking Behaviors For Their Infants., Shawn Meiman
Electronic Theses and Dissertations
In 2024, approximately 100,000 refugees were admitted to the United States, with 20% coming from the DRC, while Kentucky continues to rank fourth in the country for refugee resettlement. The increasing number of Congolese refugee children in the United States and Kentucky necessitates a greater understanding of these beliefs and practices to ensure equitable, quality, and culturally informed health services. The purpose of this study was to explore Congolese refugee mothers’ culturally and socially situated beliefs, perceptions, practices, and resources related to health care that may influence their views and practices of preventive well-child health care for their infants in …
Scalable Carbon-Based Electrodes For Hole-Transport Layer-Free Perovskite Solar Cells., Sharmin Akter
Scalable Carbon-Based Electrodes For Hole-Transport Layer-Free Perovskite Solar Cells., Sharmin Akter
Electronic Theses and Dissertations
Perovskite solar cells (PSCs) have rapidly reached certified single-junction efficiencies near 26%, but deployment is still limited by operational instability, scale-up challenges, and the cost and complexity of typical device stacks. This dissertation explores a simpler, scalable approach: HTL-free PSCs using low-cost, chemically robust carbon (e.g., carbon black) counter electrodes compatible with low-temperature, solution processing. This work demonstrates how carbon-ink formulation, scalable deposition (blade vs. slot-die), and work-function-tuning additives control film quality, interfacial energetics, and device performance. Carbon inks were developed for both coating methods by systematically varying carbon-to-binder ratio, polymer chemistry, and solvent system. Among the binders screened, ethyl …
Staying Ahead Of The Pressure: A Multimodal Intensive Care Unit Hospital-Acquired Pressure Injury Quality Improvement Project At Sutter Medical Center, Sacramento, Mijung Lim, Daniela Tobler, Raquel Youkhana
Staying Ahead Of The Pressure: A Multimodal Intensive Care Unit Hospital-Acquired Pressure Injury Quality Improvement Project At Sutter Medical Center, Sacramento, Mijung Lim, Daniela Tobler, Raquel Youkhana
ELMSN E-Portfolio. A collection of Scholarly and Creative Works
Background: Hospital-acquired pressure injuries (HAPIs) are a major quality and safety concern, particularly in the intensive care units (ICUs) where critically ill and immobile patients face elevated risk. At Sutter Medical Center Sacramento (SMCS), nine confirmed HAPIs and two under investigation were reported within the medical ICU, cardiac ICU, and neurosurgical ICU by May 2025, exceeding the hospital’s target and prompting a system-wide quality improvement initiative.
Aim: The aim of this project was to: (a) reduce ICU-acquired HAPIs to fewer than four cases per quarter by December 2025 and (b) increase nursing compliance with early and ongoing prevention strategies, including …
Losing Control: Evaluative Access And The Limits Of Attributability In Angela Smith’S Theory Of Moral Responsibility, Henry Kissam
Losing Control: Evaluative Access And The Limits Of Attributability In Angela Smith’S Theory Of Moral Responsibility, Henry Kissam
Honors Theses
The unwilling addict agent archetype–who wholeheartedly resolves to abstain from taking a drug but takes it regardless–is important to moral responsibility theorists for many reasons, but two in particular stand head-and-shoulders above the rest. The first is the frequency with which the archetype must be reckoned with through our everyday practices of moral assessment. It is not an idle thought experiment, pushing nothing but the theoretical limits of a particular theory. It is a near-ubiquitous presence in real, practical moral assessment. The second reason is a consequence of the first. Because we deal with the archetype frequently, we morally assess …
By The Numbers: Numeracy, Religion, And The Quantitative Transformation Of Early Modern England (Book Review), Calvin Jongsma
By The Numbers: Numeracy, Religion, And The Quantitative Transformation Of Early Modern England (Book Review), Calvin Jongsma
Faculty Work Comprehensive List
Reviewed Title: By the Numbers: Numeracy, Religion, and the Quantitative Transformation of Early Modern England by Jessica Marie Otis. New York, NY: Oxford University Press, 2024. 264 pp. ISBN: 9780197608777.
Mechanistic Analysis Of Rare Earth Element Extraction From Coal Byproducts Using Supercritical Fluid Process: Solubility Studies Of Supercritical Carbon Dioxide With Tbp: Hno3 Complex, Zakiya Konda Nurudeen
Mechanistic Analysis Of Rare Earth Element Extraction From Coal Byproducts Using Supercritical Fluid Process: Solubility Studies Of Supercritical Carbon Dioxide With Tbp: Hno3 Complex, Zakiya Konda Nurudeen
Engineering
This thesis introduced the essence of REE application in the modern world, the primary and secondary sources of REEs. It revised the fundamentals of supercritical carbon dioxide (SC- CO2), its application in REE extraction as green technology, the complex formation of tributyl phosphate (TBP)- nitric acid (HNO3), and temperature-pressure effects in REE extraction. The methodology systematically examined the thermodynamic solubility of CO2 in TBP-nitric acid (HNO3) complexes at three molar ratios (2:1, 1:1, and 1:2), temperatures between 40-60 degrees Celsius, and at a maximum pressure of 12 MPa, respectively. Preliminary extraction experimental runs were conducted to validate solubility studies. Data …
Finite Element Analysis For The Development Of A High-Efficiency Novel Dual-Stator Electric Generator For Renewable Energy Conversion Applications, Sunday Omokhoya Joseph
Finite Element Analysis For The Development Of A High-Efficiency Novel Dual-Stator Electric Generator For Renewable Energy Conversion Applications, Sunday Omokhoya Joseph
Engineering
Renewable energy has become a persuasive solution for reducing the negative impacts of conventional energy sources and providing sustainable options to rural communities without access to the power grid. As the development of renewable energy advances, electric machines are crucial for efficiently converting and integrating these energy resources into the electrical grid. However, conventional single-stator alternating current electric machines face several challenges that hinder efficient energy conversion, such as harmonic distortion, high core and copper losses due to multiple winding groups, and structural complexity. These issues limit their performance, particularly in renewable energy applications such as wind and hydrokinetic power, …
State And Parameter Estimation Of Synchronous Generator Using Particle Filter In Classical Model Of Generator, Sauraj Poudel
State And Parameter Estimation Of Synchronous Generator Using Particle Filter In Classical Model Of Generator, Sauraj Poudel
Engineering
The accurate parameterization of machines in power systems is crucial during modeling to study the behavior of the modern power system. However, the parameters of synchronous machines are susceptible to change from the original manufacturer’s specifications due to factors like degradation of the windings and core or for rewound machines. Traditional methods to update these parameters require taking generators offline for various testing methods, which results in substantial revenue losses to the utility and sometimes blackouts in small remote microgrids. To overcome this challenge, this study proposes an approach for online parameter estimation by using available data from the generator …
Assessing Native Tallgrass Prairie Species As Main Roadside Vegetation In Arkansas, Sarah Paschal
Assessing Native Tallgrass Prairie Species As Main Roadside Vegetation In Arkansas, Sarah Paschal
Graduate Theses and Dissertations
Tallgrass prairies are among the most endangered ecosystems in North America, with Arkansas having lost over 99% of its native grasslands. This research evaluated the potential for using native tallgrass prairie species in Arkansas roadside vegetation. Two field experiments were conducted from 2022 to 2024. The first assessed seven native seed mixtures at three roadside locations (Clarksville, Huntsville, and Newport). Seed mixture composition significantly influenced establishment outcomes, with early-establishing forbs such as black-eyed Susan, partridge pea, and Illinois bundleflower performing well, though establishment varied by location. A second trial compared planting date (Autumn, Winter, Spring) and planting method (broadcast, drill …
Studies Of Trispyrazolylborate Molybdenum-Oxo Compounds And Related Reactions, Miranda Sanders
Studies Of Trispyrazolylborate Molybdenum-Oxo Compounds And Related Reactions, Miranda Sanders
Graduate Theses and Dissertations
This dissertation details the design, development, and synthesis of a molybdenum-dioxo complex bearing a trispyrazolylborate ligand. The system was tested for its efficiency as a catalyst for deoxydehydration with a small substrate scope. Deoxydehydration reactions with 1-phenyl-1,2-ethanediol, diethytartrate, and 1,2-octanediol show low yields with catalytic turnover only found for diethyltartrate. Electrochemical studies show well behaved PCET behavior with two distinct electron transfer events in the presence of a proton donor. Studies of two molybdenum-dioxo complexes bearing dianionic pincer ligands were conducted to expand further on systems that have been extensively studied in our lab. Deoxydehydration of glycerol by a molybdenum-dioxo …
Synthetic Dataset For Understanding Negation In Text-Guided Image Editing, Nhat-Tan Bui
Synthetic Dataset For Understanding Negation In Text-Guided Image Editing, Nhat-Tan Bui
Graduate Theses and Dissertations
Negation is a fundamental linguistic concept used by humans to convey information that they do not desire. Despite this, minimal research has focused on negation within text-guided image editing. This lack of research means that vision-language models (VLMs) for image editing may struggle to understand negation, implying that they struggle to provide accurate results. One barrier to achieving human-level intelligence is the lack of a standard collection by which research into negation can be evaluated. This thesis presents the first large-scale dataset, Negative Instruction (NeIn), for studying negation within instruction-based image editing. Our dataset comprises 366,957 quintuplets, i.e., source image, …
Supporting At-Risk Students Through Alternative Education: A Case Study On Reintegration, Behavior, And Stakeholder Perceptions At Sharpie Academy, Bryan O'Neal
Graduate Theses and Dissertations
This dissertation presents a mixed-methods case study examining the effectiveness of Sharpie Academy, an alternative education program within the Chalkboard Champions School District. The study investigated three central research questions: (1) How does participation in the alternative learning environment at Sharpie Academy influence students' behavior upon reintegration into the traditional education setting? (2) What are the perceptions of parents, teachers, and community members regarding the program's outcomes? (3) How do these perceptions influence stakeholder support for the academy? Data was collected from 121 participants, including 43 students and 78 adult stakeholders, using participant observation, semi-structured interviews, surveys, and document analysis. …
Bridging The Gap: Enhancing Institutional Support For Adjunct Faculty In Rural Community Colleges, Emily Joleen Mason
Bridging The Gap: Enhancing Institutional Support For Adjunct Faculty In Rural Community Colleges, Emily Joleen Mason
Graduate Theses and Dissertations
Adjunct faculty constitute approximately 70% of the academic workforce in U.S. higher education, yet they often face challenges related to professional isolation, limited institutional support, and insufficient onboarding. This qualitative study explores how institutional connectedness influences adjunct faculty retention at a rural community college in the Midwest. Using a phenomenological approach, the research investigates the lived experiences of adjunct faculty, focusing on onboarding processes, professional development opportunities, and institutional culture. Findings highlight the critical role of structured onboarding, mentorship, and continuous professional development in fostering engagement and retention among adjunct faculty. The study underscores the importance of inclusive institutional practices …
Free Radical Reactions Of Electron Rich Alkenes, David A. May Jr
Free Radical Reactions Of Electron Rich Alkenes, David A. May Jr
Graduate Theses and Dissertations
Radical reactions have known for over a century but have only been thought of as useful synthetic strategies for the last 70 years. During this period, much work has been done to develop theoretical explanations for their reactivity and modes of termination, resulting in them becoming a fundamental type of organic reaction in academia and industry. Previous studies by the McIntosh group have shown that a radical [1,3]-Rearrangement occurs when N-substituted pyridines are heated. Here, the scope of this new reaction is expanded to include polycyclic pyridines including neocuproine (2,9-dimethylphenanthroline) and 2-methylquinoline while also expanding the range of reactions available …
Increasing Soil Health In Zero-Grade, Flood-Irrigated Rice In Eastern Arkansas, Hannah Elizabeth Vickmark
Increasing Soil Health In Zero-Grade, Flood-Irrigated Rice In Eastern Arkansas, Hannah Elizabeth Vickmark
Graduate Theses and Dissertations
In an effort to build and maintain soil health and sequester soil C, many producers and researchers are turning towards regenerative management practices in agricultural systems, such as reduced tillage or no-tillage (NT), the implementation of winter cover crops (CC), and the use of organic or green manures, such as biochar. However, little research is being conducted on the long-term soil health and agronomic benefits of these practices in a flood-irrigated rice (Oryza sativa L.) production system. Three replications of seven treatment combinations were applied to 6.1 x 30.5 m rice plots. Baseline soil health properties were quantified at six …
Emotion Analysis And Neural Language Models For Classification, Andrew Mackey
Emotion Analysis And Neural Language Models For Classification, Andrew Mackey
Graduate Theses and Dissertations
Emotion analysis is a branch of artificial intelligence and natural language processing focused on recognizing emotions hidden throughout various forms of digital data, including text, images, and multi-modal representations. In this dissertation, we present four published and planned works that investigate different methodologies for natural language analysis tasks using deep learning techniques. The first published work we present considers the task of identifying fake news using various text and emotion representations. We demonstrate that emotion representations combined with word embedding techniques can improve the accuracy of fake news classification. Our second published work further investigates the fake news classification task …
Hyperspectral Indicators And Characterization Of Glyphosate-Induced Stress In Common Lambsquarters (Chenopodium Album L.), Mario Andrés Soto Valencia
Hyperspectral Indicators And Characterization Of Glyphosate-Induced Stress In Common Lambsquarters (Chenopodium Album L.), Mario Andrés Soto Valencia
Graduate Theses and Dissertations
Hyperspectral sensing enables detection of herbicide stress in weeds, but practical use requires strategies for redundancy control, rating variability management, and evaluator bias mitigation. This thesis evaluates common lambsquarters (Chenopodium album) under glyphosate exposure, aiming to identify key wavelengths, construct vegetation indices, and improve injury modeling. Greenhouse experiments used dimensionality reduction methods (principal component analysis, Relief F, Bayesian discriminant analysis) to isolate 34 unique wavelengths from about 3,200 bands. Calibration data were collected 14 days after treatment (DAT) to support wavelength selection and model development, while data from 27 DAT were used for independent validation. Class comparisons across six statistically …
Establishment Of Native Warm-Season Forages Using Organic Practices, Kolten Ray Wright
Establishment Of Native Warm-Season Forages Using Organic Practices, Kolten Ray Wright
Graduate Theses and Dissertations
Abstract Grassland agriculture is seen as a particularly sustainable form of agriculture. Many opportunities are known to use organic production methods or incorporate native warm-season grasses (NWSG) to accomplish both production goals and environmental or social outcomes. Environmental concerns have led some practitioners to question the use of organic methods to establish NWSG. As limited work has been accomplished in the northern bermudagrass belt, this project sought to compare organic establishment strategies for common NWSG species. A field trial conducted at the USDA ARS Dale Bumpers Small Farms Research Center in Booneville, AR found that NWSG establishment success in the …
Advanced Membrane Methods For Treatment Of Toxic Contaminants And Education Of Early-Career Researchers, Thomas Mckean Iii
Advanced Membrane Methods For Treatment Of Toxic Contaminants And Education Of Early-Career Researchers, Thomas Mckean Iii
Graduate Theses and Dissertations
Membrane technologies are attractive as they are linearly scalable and often require lower operating costs compared to other technologies. One area where they are particularly effective is the treatment of water contaminated with toxic substances. The simplicity of this removal mechanism provides reliable performance capable of meeting stringent removal requirements. However, membrane fouling is a major challenge that often limits their commercial viability. This research sought to investigate novel approaches to pretreatment and membrane modification to overcome fouling and high operating pressures. In addition, membrane separation processes can often be developed into simple yet educational experiments that are ideal for …
National Hero And Water Deity: The Worship Of Triệu Việt Vương In The Red River Delta, Vietnam, Huong Thi Nguyen
National Hero And Water Deity: The Worship Of Triệu Việt Vương In The Red River Delta, Vietnam, Huong Thi Nguyen
Graduate Theses and Dissertations
In my dissertation, the theory of collective memory will be deployed to address many questions regarding retaining, recovering, and re-creating the worship of King Triệu Việt Vương. He was a legendary, historical king of Vietnam who supposedly lived in the 6th century. His achievements were connected to the people living in the Red River Delta in their fight against the Liang invasion. The villagers who lived near or in this area also honored him for his spiritual power. They built a small temple/ shrine right by the riverbank to worship this King. The Vietnamese dynasties, Ly (in the 11th century), …
Effect Of Peracetic Acid Dip Frequency On The Quality And Functional Properties Of Non-Marinated And Marinated Broiler Tenderloins, Joaquin Jose Esquivel Vergara
Effect Of Peracetic Acid Dip Frequency On The Quality And Functional Properties Of Non-Marinated And Marinated Broiler Tenderloins, Joaquin Jose Esquivel Vergara
Graduate Theses and Dissertations
The poultry industry continues to balance the need for effective antimicrobial interventions with the preservation of meat quality. Among the most widely used antimicrobial agents, peracetic acid (PAA) has proven effective for reducing foodborne pathogens in poultry products. However, excessive or repeated exposure to PAA can influence meat functionality by altering protein structure, color, and water-holding capacity. Therefore, the broad objective of this study was to evaluate the effect of PAA dip frequency and post-treatment marination timing on the physicochemical and functional quality of broiler tenderloins (Pectoralis minor), in order to provide processing insights that optimize both microbial safety and …
Decorin Deficiency Promotes D-Galactose-Induced Skeletal Muscle Atrophy And Fibrosis By Regulating Itgb1/Akt/Mtor Signalling Pathway, Xiaoqin Luo, Mengxue Zhang, Lili Chen, Ruichang Wang, Jiabing Lian, Zhe Yang, Renato V. Iozzo, Jin Wang, Yan Zhang, Xiuli Bi
Decorin Deficiency Promotes D-Galactose-Induced Skeletal Muscle Atrophy And Fibrosis By Regulating Itgb1/Akt/Mtor Signalling Pathway, Xiaoqin Luo, Mengxue Zhang, Lili Chen, Ruichang Wang, Jiabing Lian, Zhe Yang, Renato V. Iozzo, Jin Wang, Yan Zhang, Xiuli Bi
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
BACKGROUND: Primary sarcopenia is an age-associated disorder with progressive and generalised loss of skeletal muscle strength and mass. Skeletal muscle fibrosis is one of the significant pathological manifestations of age-associated sarcopenia. Decorin, a small dermatan-sulfate proteoglycan, participates in extracellular matrix assembly. In numerous studies, the involvement of decorin is not restricted to matrix structural proteins, and it also affects a diverse variety of biological functions like cell growth, adhesion, migration, proliferation and differentiation. Additionally, it modulates the process of inflammation and fibrillogenesis. Based on these preclinical evidences, we hypothesised that decorin may potentially play an important role in skeletal muscles …