Digital Commons Network^™

Hyaluronic Acid Loaded With Aloe Vera-Derived Extracellular Vesicles: A New Bioactive Approach For Fibrotic Scarring, Maria Camila Ceballos Santa

Theses

Disruptions in wound healing can result in pathological outcomes ranging from chronic nonhealing wounds to excessive fibrotic scarring. Hypertrophic scars and keloids are hallmarks of this dysregulation, characterized by abnormal collagen deposition, persistent myofibroblast activation, and disorganized extracellular matrix (ECM) remodeling. Chronic inflammation and oxidative stress play central roles by increasing reactive oxygen species (ROS), which damage essential macromolecules and sustain pro-inflammatory signaling, while promoting the transdifferentiation of fibroblasts into myofibroblasts and the excessive production of ECM proteins, such as collagen and α-smooth muscle actin (α-SMA). This fibrotic cascade leads to tissue stiffness, contractility, and disfigurement, affecting the well-being of …

The Shifting Order Of Global Jurisprudence: Responses Of Intersectionality Towards Social And Economic Justice, Daniel Ketcher

Faculty and Staff Publications & Presentations

This interdisciplinary study investigates how the second Trump administration is reshaping the capacity and legitimacy of central multilateral institutions and proposes a framework for Integrative Justice Governance ( IJG ) to counteract these effects. Guided by three research questions – projecting the budgetary and normative impacts on bodies such as the WHO, the WTO, and the ICC; identifying specific mechanisms of US disengagement; and testing the conditions under which IJG-based interventions could, in theoretical terms, offset the damage through concrete examples of implementation practices – the article advances three hypotheses: the renewed US withdrawal is causing measurable or observable declines …

Large Language Models (Llms) For Clinical Note Generation: International Classification Of Disease (Icd) Code, Knowledge Graph (Kg) And Prompt Evaluation, Ivan P. Makohon

Computer Science Theses & Dissertations

In the past decade, a surge in the amount of electronic health record (EHR) data in the United States occurred, driven by a favorable policy environment created by the Health Information Technology for Economic and Clinical Health (HITECH) Act of 2009 and the 21st Century Cures Act of 2016. Clinical notes for patients’ assessments, diagnoses, and treatments are captured in these EHRs in free-form text by physicians, who spend a considerable amount of time entering them. Manually writing these notes is time-consuming, increasing patient waiting times and potentially delaying diagnoses. Large language models (LLMs), such as GPT-4o, possess the ability …

Observed Parenting, Parent-Child Aggression, And Intimate Partner Violence As Predictive Of Family Dysfunction, Paige Munshell

Psychology Theses & Dissertations

Family systems theories contextualize violence as occurring across multiple levels of the family, yet much of the existing literature focuses on a single family member’s outcome (i.e., the child) and neglects to include data collected from fathers. This study examined the associations between indicators of functioning at the dyadic-level in the family system—observed parenting, Intimate Partner Violence (IPV) perpetration, and Parent-Child Aggression (PCA) risk—and later overall family dysfunction. Participants were 180 mothers and 144 of their male partners evaluated when their child was 18 months old and re-evaluated at 4 years old. Measures of observed parenting, IPV perpetration, and PCA …

Leading With All The Feels: Exploring The Perceptions Of Middle School Administrators' Implementation Of School-Wide Social-Emotional Learning Programming, Sabrina Smith Richardson

Teaching & Learning Theses & Dissertations

Middle school administrators have multiple responsibilities that range from ensuring the safety and security of staff and students to overseeing the curriculum and instructional foci of their buildings. At the same time, middle school students are experiencing the early stages of adolescence. Because it is a complex time for students to navigate, it creates anxiety, a decline in academic achievement and motivation, and peer and academic pressures (London, 2022; Schlund, 2021). Middle school students have social-emotional needs that are not typically met in secondary schools, which means programming is not typically a part of the instructional day. This study examined …

Evaluation Of Ocean Lidar Enhancement Through Miniaturization And Gated Pmt-Based Range Extension, Chandler Austin Slater

OES Theses and Dissertations

Oceanographic lidar systems remotely characterize the vertical structure of the upper ocean by recording the light backscattered from a laser pulse as it propagates through the water column. Historically these systems have been constrained by limited detection ranges, often capturing only a portion of the illuminated water column, typically fading to noise around the 10% isolume. A primary constraint has been the limited dynamic range of digitizers, which inhibits the ability to resolve both intense near-field and faint far-field backscatter signals within a single acquisition. To address this, we developed a novel optical lidar system incorporating gated photomultiplier tubes (PMTs) …

Exploring Bonding Through Outdoor Recreation In Foster Care Utilizing Attachment Theory, Casandra L. Barnes

Communication & Theatre Arts Theses

As of 2024, there are over 328,000 children in foster care in the United States (AFCARS, 2024), many of whom experience disrupted attachments and trauma that hinder their ability to form healthy relationships. Drawing from attachment theory, this study explores how outdoor recreational activities can facilitate bonding between foster parents and their foster children. Using a mixed method approach this explorative research project consisted of two phases: a pilot study at the Virginia zoo involving foster families participating in a cooperative outdoor activity and completing post event surveys, and semi-structured interviews with foster parents to examine lived experiences of bonding …

The Presentation Of Self In Everyday Digital Life: A Study Of Self- Disclosure And Work Environments, Mackenzie Michelle Skiff

Communication & Theatre Arts Theses

The digital age impacts individuals’ lives in many ways. One impact is how and where work is completed across many careers. The work-from-home strategy enables individuals to complete work that is not within a shared space, such as an office. With the absence of this shared space, communication practices within workplaces could be changing. Specifically, self-disclosure while working from home may differ from self-disclosure within the office or hybrid (both in office and remote) work environments. This thesis investigates whether there are differences in self-disclosure practices across three different types of contemporary work environments and offers a digital update to …

The Influence Of Individual And Collective Social Capital On Teachers’ Decisions To Move Districts, Melinda Dawn Hodgkiss

Educational Leadership & Workforce Development Theses & Dissertations

Understanding what contributes to teachers’ decisions to stay or leave in a school district is complex. There is a need to further investigate factors that influence teacher retention and attrition so that policy makers and school leaders can be informed about practices that may replenish and sustain the educator workforce. In an effort to understand the essence of the lived experience of teachers who previously made a decision to move districts, this study used phenomenological methods for the purpose of discovering the role that access to individual and collective social capital played in teachers’ decision making. Semi-structured interviews were conducted …

Reflections In The Mirror: An Examination Of Racially Congruent Mentoring Of Black Teacher Candidates In A Teacher Education Program, Mary Louise Gregory

Teaching & Learning Theses & Dissertations

The high demand for Black educators in K-12 schools across the United States has caused several teacher training programs to rethink how they prepare Black teacher candidates for the teaching workforce (Andrews et al., 2019; Blazar, 2024; Milner & Howard, 2004). Improving teacher candidate training, especially for Black teacher candidates can boost K-12 Black teacher representation. Literature on Black teacher candidate’s experiences while being mentored identifies several challenges that include issues with implicit bias, microaggressions, stereotyping and other occurrences of racial discrimination (Daly et al., 2024; Hampton et al., 2008; Kardos & Johnson-Moore, 2010; Rodriguez et al., 2020). The process …

Unraveling The Links Between Substance Use And Academic Motivation In Higher Education, Melissa Lynn Goins

STEMPS Theses & Dissertations

Self-Determination Theory (SDT) posits that the quality of students’ motivation regulation (i.e., autonomous versus controlled) shapes both learning and health behavior, yet few studies have examined the relations among motivation regulation, alcohol and cannabis use, and achievement. In this study, I surveyed 459 undergraduates at a mid-sized public university in the southeastern United States. Participants completed the Academic Motivation Scale-College version 28 to assess autonomous and controlled motivation regulation, a typical-week alcohol grid, a seven-day cannabis grid, and self-reported grade point average (GPA). Results indicated that autonomous academic motivation was uniquely related to GPA; however, neither motivation variable related to …

Violence As An Ecology: Women Making Safety In Khayelitsha, Melissa J. Miller-Felton

Graduate Program in International Studies Theses & Dissertations

This dissertation asks how women in Khayelitsha make safety in a place where danger has become ordinary and where the afterlives of colonialism and apartheid still determine who waits, who walks, and who arrives home. What began as a study of risk and protection grew into an inquiry about time, dignity, and responsibility. I call the framework that emerged an ecology of violence—a way of seeing how harm gathers across generations and infrastructures, and how care, exhaustion, and survival intertwine within it.

In this ecology, violence is not a single act but a confluence of registers—slow, structural, colonial, and …

Defending Form Contract Consent, Wayne R. Barnes

Faculty Scholarship

The issue of standard form contracts has bedeviled Contracts scholars for a century. The basic problem has long been known. Contract is supposed to be a quintessentially consensual activity, whereby both parties are operating with full knowledge and comprehension of the array of terms and conditions being negotiated and agreed to. But by employing standard forms replete with boilerplate fine print, companies have created a regime whereby it is most likely irrational for consumers to bother reading the terms before consenting to the transaction. The existing “duty to read” doctrine is that consumers fully consent to all terms when they …

Local Government Standing As State Standing, Katharine Cooney, Katherine Mims Crocker

Faculty Scholarship

It is increasingly common, and controversial, for local governments to bring lawsuits as plaintiffs in federal court. Many questions about this practice raise matters that sound in policy. But some, including the issue of standing to sue, also raise issues of constitutional law. How local governments fit into standing rules should reflect how they fit into the U.S. constitutional system more broadly. As the Supreme Court put it in the famous (and infamous) 1907 case Hunter v. City of Pittsburgh, "[m]unicipal corporations are political subdivisions of the State, created as convenient agencies for exercising such of the governmental powers of …

Ai And The Fine Print Disruption Of Copyright, Nancy Kim

Penn State Law Review (2003 - Present)

No abstract provided.

R.I.P.—A Financial Incentive To Protect Your Cadaver?, William Drennan

Penn State Law Review (2003 - Present)

No abstract provided.

"That's How It Is On This Bitch Of An Earth": The Possibilities, Pitfalls, And Potential Of References To Waiting For Godot In Judicial Opinions, Ben Phillips

Penn State Law Review (2003 - Present)

No abstract provided.

Of Felons And The Mentally Ill: Range, § 922(G)(4), And The Dangerousness Solution, Colin Hitt

Penn State Law Review (2003 - Present)

No abstract provided.

The Constitution And Online Exams: A New Fourth Amendment Take On Ogletree V. Cleveland State University, Arthur Benne

Penn State Law Review (2003 - Present)

No abstract provided.

Solving The Puppy Mill Problem: Using "Carrots And Sticks" To Encourage Compliance With The Animal Welfare Act, Ashlyn Browning

Penn State Law Review (2003 - Present)

No abstract provided.

After Amgen: Examining The Supreme Court's Impact On Patents For Therapeutic Antibodies, Noah Pollio

Penn State Law Review (2003 - Present)

No abstract provided.

Part Ii Common Questions And Misconceptions About Creatine Supplementation: What Does The Scientific Evidence Really Show?, Jose Antonio, Ann F Brown, Darren G Candow, Philip D Chilibeck, Stacey J Ellery, Scott C Forbes, Bruno Gualano, Andrew R Jagim, Chad Kerksick, Richard B Kreider, Sergej M Ostojic, Eric S Rawson, Michael D Roberts, Hamilton Roschel, Abbie E Smith-Ryan, Jeffrey R Stout, Mark A Tarnopolsky, Trisha A Vandusseldorp, Darryn S Willoughby, Tim N Ziegenfuss

Faculty, Staff and Students Publications

Creatine monohydrate supplementation (CrM) is a safe and effective intervention for improving certain aspects of sport, exercise performance, and health across the lifespan. Despite its evidence-based pedigree, several questions and misconceptions about CrM remain. To initially address some of these concerns, our group published a narrative review in 2021 discussing the scientific evidence as to whether CrM leads to water retention and fat accumulation, is a steroid, causes hair loss, dehydration or muscle cramping, adversely affects renal and liver function, and if CrM is safe and/or effective for children, adolescents, biological females, and older adults. As a follow-up, the purpose …

Right Place, Right Time: Intermittent Habitats And Mosaic Structure Drive Juvenile Coho Salmon Growth In A Subarctic Alaska Watershed, Andrew Rothenberger

Fisheries

Pacific salmon (Oncorhynchus spp.) rely on diverse freshwater habitats to complete their lifecycle. Within Alaska’s short summer season, juveniles use a complex mosaic of habitats that vary in quality across space and time, but the patterns of habitat use in large complex watersheds are poorly known and difficult to document. To evaluate how habitat conditions of hydrology types influence juvenile performance, I conducted an in-situ enclosure experiment in the Fox River watershed of Kachemak Bay, Southcentral Alaska, measuring age-0 coho salmon (Oncorhynchus kisutch) growth across four hydrologic types: a glacial and snow-fed natal creek, a groundwater-fed natal creek, a non-natal …

Environmental Change In The Northeast Pacific: Climate Impacts On Phenology, Life History, And Population Dynamics In Marine And Aquatic Populations, Genoa Sullaway

Fisheries

Climate change is rapidly transforming Northeast Pacific ecosystems and fundamentally altering environmental conditions that drive species' survival, growth, and life histories. This dissertation examines relationships between environmental change and population-level processes across Northeast Pacific marine and freshwater ecosystems. This dissertation focuses on understanding the influence of environmental change on foundational zooplankton communities in the Bering Sea and Pacific salmon populations, specifically Yukon River Chum salmon and Bristol Bay Sockeye salmon. This research addresses knowledge gaps in zooplankton systems modeling, zooplankton phenology, and salmon population dynamics. First, this dissertation evaluated the performance of a systems model that utilizes climate and physical …

Patient-Centered Communication Case: Threatened Miscarriage, Anita Rohra, Daniela Ortiz, Shagun Berry, Colleen Donovan, Nicole Novotny, Stephanie Cohen, Charles Lei, Alaa Aldalati, Stephanie Stapleton, David Fernandez

Faculty, Staff and Students Publications

Audience: This communication case is intended for EM residents of all levels.

Introduction: Patient-centered communication is a necessary skill in the practice of emergency medicine. This style of communication is crucial for promoting high-quality healthcare by prioritizing patient needs, perspectives, and values. This patient-centered communication case centers on miscarriage, a diagnosis where patient-centered communication is requisite. Approximately one in six or 17.1% of patients with a final diagnosis of miscarriage, also known as early pregnancy loss, present initially to the emergency department.1 Advising a patient of the diagnosis of miscarriage requires excellent communication skills including facile rapport building, empathy, nonverbal …

Cerebellar Purkinje Cell Stripe Patterns Reveal A Differential Vulnerability And Resistance To Cell Loss During Normal Aging In Mice, Sarah G Donofrio, Cheryl Brandenburg, Amanda M Brown, Tao Lin, Hsiang-Chih Lu, Roy V Sillitoe

Faculty, Staff and Students Publications

Age-related neurodegenerative diseases involve reduced cell numbers and impaired behavioral capacity. Neurodegeneration and behavioral deficits also occur during aging, and notably in the absence of disease. The cerebellum, which modulates movement and cognition, is susceptible to cell loss in both aging and disease. Here, we demonstrate that cerebellar Purkinje cell loss in aged mice is not spatially random but rather occurs in a pattern of parasagittal stripes. We also find that aged mice exhibit impaired motor coordination and more severe tremor compared to younger mice. However, the relationship between patterned Purkinje cell loss and motor dysfunction is not straightforward. Examination …

A Novel Microfluidic Approach To Quantify Pore-Scale Mineral Dissolution In Porous Media, Rafid Musabbir Rahman, Elliott Niemur, Gianluca Blois, Farzan Kazemifar, Myeongsub Kim, Yaofa Li

Faculty Research, Scholarly, and Creative Activity

Mineral dissolution in porous media coupled with single- and/or multi-phase flows is pervasive in natural and engineering systems. Dissolution modifies the physical, hydrological, and geochemical properties of the solid matrix, resulting in a complex coupling between local dissolution rate and pore-scale flow. The work reports a microfluidic approach that includes 2D reactive porous media and advanced pore flow diagnostics for the study of pore-scale dissolution in porous media with unprecedented details. The 2D microfluidic porous media, called micromodels, were fabricated in calcite by combining photolithography and wet etching, which not only offers precise control over the structural and chemical properties, …

Insecticide-Treated Net Use And Elimination Of Malaria In Sub-Saharan African Countries: Assessing The Global Technical Strategy Using An Evolutionary Game Approach, Laxmi, Tamer Oraby, Michael G. Tyshenko, Ina Danquah, Samit Bhattacharyya

School of Mathematical & Statistical Sciences Faculty Publications

Background: Malaria continues to be a major public health challenge in Sub-Saharan Africa (SSA), where the majority of the countries have not met the World Health Assembly's endorsed Global Technical Strategy (GTS) milestones in 2020 for malaria reduction. Insecticide-treated net (ITN) usage is a well-established and effective intervention, often outperforming other measures such as indoor residual spraying (IRS). However, multiple survey studies have reported improper use of ITNs across various SSA countries. This misuse likely poses an important barrier to the intervention's success, although it remains a largely untested hypothesis.

Methods: We developed a behaviour-incidence model and statistical analysis of …

Quantization For The Mixtures Of Overlap Probability Distributions, Asha Barua, Angelina Chavera, Ivan Djordjevic, Valerie Manzano, Sergio Soto Quintero, Mrinal Kanti Roychowdhury, Hilda Tejeda

School of Mathematical & Statistical Sciences Faculty Publications

Optimal quantization for mixed distributions has emerged as a compelling area of study. In this work, we have focused on a mixed distribution formed from two uniform distributions with partially overlapping supports. For this class of distributions, we have examined the structure of optimal sets of n-means and the corresponding nth quantization errors for all positive integers n. Initially, we explicitly determined the optimal sets and quantization errors for 1 < = n < = 6. Subsequently, we established several key lemmas and propositions and proposed an algorithm that facilitates the computation of optimal n-means and quantization errors for all n >= 5. Numerical results are also presented to illustrate the application of the algorithm in deriving these quantities. The findings of this study offer valuable insight and serve as a …

Plasma Metabolomic And Proteomic Signatures Of Blood Pressure Management After Bariatric Surgery Among Adolescents, Shudi Pan, Zhenjiang Li, Juan Pablo Lewinger, Jesse A Goodrich, Hongxu Wang, Sarah Rock, Carmen Chen, Todd M Jenkins, Stephanie Sisley, Stephen R Daniels, Douglas I Walker, Max T Aung, Erika Garcia, Rob Mcconnell, Sandrah P Eckel, Michele A La Merrill, Tanya L Alderete, Zhuanghua Chen, Frank D Gilliland, Thomas H Inge, David V Conti, Justin R Ryder, Lida Chatzi

Faculty, Staff and Students Publications

Background: Emerging omics approaches, including metabolomics and proteomics, can be integrated into obesity treatment for better blood pressure management. We tested whether preoperative metabolomic and proteomic profiles predict long-term elevated blood pressure (EBP) changes better than known risk factors in adolescents undergoing bariatric surgery.

Methods: We included 108 participants from the Teen-LABS (Teen-Longitudinal Assessment of Bariatric Surgery). Plasma untargeted metabolomics (via liquid chromatography with high-resolution mass spectrometry) and Olink proteomics were assessed pre surgery. An elastic net model with stability selection was used to identify features predictive of EBP reductions 5 years post surgery. Models including identified metabolites, proteins, and …