Factors Influencing Dental Career Decision-Making Among High-Achieving Students In Taiwan, Chien-Hong Yu, Mei-Huei Li, Feng-Chou Cheng, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Effects Of Cleaning Protocols On The Material Properties Of Clear Aligners And Retainers: A Systematic Review, Yao-Chang Chiang, Tu Manh Nguyen, Thuy-Trang Thi Ho, Loc Minh Lu, Yang-Che Wu, Tong-Hsien Chow, Chiang-Wen Lee, Fang-Yu Fan, Li-Nai Chen, I-Ta Lee

Journal of Dental Sciences

Clear aligners and retainers are widely used in contemporary orthodontics because of their esthetic appearance, removability, and patient-centered advantages. However, repeated exposure to dietary pigments and cleaning procedures may alter their optical, surface, mechanical, and chemical properties, potentially affecting appliance appearance, hygiene, and performance. This systematic review evaluated changes in the material properties of clear aligners and retainers following different cleaning protocols. Electronic searches were performed in PubMed, Scopus, LILACS, and the Cochrane Library from inception to February 28, 2026. Twenty studies were included, comprising 18 in vitro studies and 2 randomized clinical crossover studies. Cleaning protocols were categorized as …

Herbal Medicine For Oral Ulcer Treatment: Mechanisms, Efficacy, And Therapeutic Potential, Shinn-Zong Lin, Tsung-Hsien Chuang, Chih-Yang Huang, Tsung-Jung Ho, Yi-Pang Lee

Journal of Dental Sciences

Oral ulcers are common inflammatory lesions of the oral mucosa that significantly affect patients’ quality of life through pain, eating difficulties, and psychological stress. Their development is multifactorial, involving mechanical trauma, infection, nutritional deficiencies, immune dysregulation, and oxidative stress. Conventional treatments including antiseptics, corticosteroids, and immunomodulators, provide symptomatic relief but are often limited by side effects, recurrence, and poor patient adherence. Increasing interest has therefore focused on herbal medicines as complementary or alternative therapies. Numerous single herbs such as Aloe vera, licorice, curcumin, chamomile, berberine, neem, sage, myrrh, and guava and traditional formulations have demonstrated anti-inflammatory, antioxidant, immunomodulatory, antimicrobial, and …

The Ph-Pi3k/Akt/Mtorc1 Axis In The Survival Of Stem Cells From The Apical Papilla: A Critical Target For Rescue By Microenvironment-Engineered Hydrogels In Pulp Regeneration, Chunlei Zhang, Haisheng Cao, Jie Li, Changqing Yan, Yang Liu, Shuguo Zheng, Xiaozhe Wang

Journal of Dental Sciences

Background/purpose: The pH within infected root canals fluctuates dynamically under pathological conditions, yet its impact on stem cells from the apical papilla (SCAPs) in dental pulp regeneration remains unclear. This study investigated how potential of hydrogen (pH) variations govern SCAPs survival and the associated signaling to identify therapeutic targets for enhancing tissue regeneration.

Materials and methods: SCAPs were cultured at pH 5.4-10.4. Proliferation and apoptosis were assessed using cell counting kit-8 (CCK-8) assays, real-time live-cell analysis, and flow cytometry. RNA-sequencing (RNA-seq) identified differentially expressed genes, which were validated through reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR), Western blotting, and mechanistic …

Osteoblastogenesis Stimulation By Human Umbilical Cord Stem Cell Secretome During Maxillary Expansion, Alexander Patera Nugraha, Guang Hong, Firdaus Hariri, I Gusti Aju Wahju Ardani, Adya Pramusita, Nurul Aisyah Rizky Putranti, Nindya Rizky Anjani Marhendra, Naora Dewi Rahma Fadzila, Ananda Firman Putranto, Muhammad Luthfi, Wibi Riawan, Putri Cahaya Situmorang, Rony Abdi Syahputra, Thantrira Porntaveetus, Khairul Anuar Shariff, Nissia Ananda, Maudina Dwi Heriasti, Kotaro Tanimoto

Journal of Dental Sciences

Background/purpose: Maxillary expansion induced by mechanical force (MEMF) is a standard orthodontic approach for correcting transverse maxillary deficiency. The human umbilical cord mesenchymal stem cell secretome (HUCMSC-S) has the potential to stimulate accelerate bone remodeling. This study aimed to evaluate local HUCMSC-S application effect during MEMF on the expression bone morphogenetic protein (BMP)-2, BMP-4, BMP-7, vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), transforming growth factor-beta (TGF-β), and fibroblast growth factor-2 (FGF-2) in a Wistar rat (Rattus norvegicus).

Materials and methods: Twenty-four healthy male Wistar rats (R. norvegicus) were randomly divided into four groups: …

A Bibliometric Evolution Of Molecular Mechanisms And Emerging Research Trends Of Therapeutic Resistance In Oral Cancer, Chu-Yen Chien, Ying-Chen Chen, Jia-Rong Wu, Hsu-Hua Chu, Yi-Jen Hung, Yi-Shing Shieh

Journal of Dental Sciences

Background/purpose: Drug resistance has served as a primary determinant of treatment failure and disease recurrence in oral cancer. The present study aimed to evaluate the global research landscape of drug resistance mechanisms in oral cancer by integrating bibliometric mapping with bioinformatic validation.

Materials and methods: A comprehensive dataset of 1660 publications was retrieved from the Scopus database. Bibliometric analyses were performed using Biblioshiny and VOSviewer to evaluate publication trends, collaborative networks, and thematic evolution. To bridge research trends with biological mechanisms, 1469 genes associated with oral cancer and drug resistance were extracted from the GeneCards database and subjected to functional …

Adhesion Performance Of Conventional And High-Translucency Zirconia: Effects Of Airborne-Particle Abrasion And 10-Methacryloyloxydecyl Dihydrogen Phosphate Treatments, Chia-Ling Li, Li-Li Kang, Jui-Che Lin, Shu-Fen Chuang

Journal of Dental Sciences

Background/purpose: High-translucency zirconia exhibits different microstructure and composition, which may influence their responses to mechanical and chemical treatments, affecting resin–zirconia adhesion. This study aimed to evaluate the adhesive behaviors of conventional and high-translucency zirconia, focusing on surface modifications induced by airborne-particle abrasion (AA) and 10-methacryloyloxydecyl dihydrogen phosphate (MDP).

Materials and methods: Disk-shaped specimens were fabricated from six zirconia materials: CerconBase, CerconHT, and VitaHT (3Y-TZP); VitaST (4Y-PSZ); and CerconXT and VitaXT (5Y-PSZ). Specimens were air-abraded with alumina particles at 0.25 MPa. Micromorphology and roughness were analyzed using scanning electron microscopy (SEM), profilometry, and atomic force microscopy (AFM). Surface chemical composition …

Interaction Between Removable Partial Denture Use And Number Of Natural Teeth On Health-Related Quality Of Life In Older Adults: A Cross-Sectional Study, Pai-Shien Liao, Chia-Hsuan Chou, Ya-Xin Zheng, Jiiang-Huei Jeng, Wan-Chuen Liao, Ying-Fang Chen

Journal of Dental Sciences

Background/purpose: The compensatory benefit of removable partial dentures (RPDs) on health-related quality of life (HRQoL) depends on the number of natural teeth. This study aimed to evaluate the interaction between RPD use and number of natural teeth on HRQoL, measured by EuroQoL 5-Dimension 5-Level (EQ-5D-5L) and Visual Analogue Scale (VAS).

Materials and methods: This cross-sectional study included 410 older adults. Dental status, including the number of natural teeth and the decayed, missing and filled teeth (DMFT) index, and RPD use were assessed. Participants were categorized into three groups (0-9, 10-19, and ≥ 20 natural teeth). HRQoL was measured using the …

Routine Dental Scaling And Reduced Risk Of Serious Infections In Individuals With Moderate-To-Severe Cerebral Palsy: A Nationwide Population-Based Cohort Study, Li-Wei Ou-Yang, Yu-Tung Huang, Ya-Ting Chang, Hsin-Mao Hsu, Shih-Hao Chang, Chia-Ling Wu, Tsung-Chieh Yao

Journal of Dental Sciences

Background/ purpose: Individuals with moderate-to-severe cerebral palsy (CP) are highly susceptible to serious infections. Oral biofilms may serve as reservoirs for pathogenic microorganisms, yet the impact of professional oral healthcare on systemic infection risk in this population remains unclear. This study investigated the association between routine dental scaling and the risk of serious infections and infection-related mortality among individuals with moderate-to-severe CP.

Materials and methods: This nationwide, population-based cohort study used data from Taiwan’s National Health Insurance Research Database and National Death Registry (2009–2019). Individuals with moderate-to-severe CP were categorized into a routine dental scaling group (≥1 scaling annually for …

Artificial Intelligence Assisted Multitask Framework For Dental Detection And Root Canal Filling Assessment On Periapical Radiographs, Chia-Lin Hsu, Li Wei Ou-Yang, Chih-Hao Chang, Yuan-Jin Lin, Po-Lin Huang, Kai-Syun Chiu, Heng-Chia Chen, Tsung-Yi Chen, Jia-Ching Wang, Wei-Chen Tu, Patricia Angela R. Abu

Journal of Dental Sciences

Background/purpose: Accurate evaluation of root canal filling (RCF) quality is paramount for successful endodontic outcomes. However, conventional radiographic interpretation is often subject to subjective variability. This study developed an automated, multitask artificial intelligence (AI) framework using YOLO11 and advanced image pre-processing to identify multiple dental structures and provide quantitative assessments of RCF quality on periapical radiographs.

Materials and methods: We proposed an image enhancement pipeline, which integrate intensity normalization, white top-hat transform, and linear contrast stretching to refine dental contours for training the YOLO11 multitask model. The framework simultaneously detected primary, permanent, dental crowns, and RCFs. Quantitative metrics, including …

The Bridge To Practice: A Regulatory Analysis Of Pre-Licensure Dental Training In Taiwan, Wei-Chia Su, Hsin-Hu Chen, Ching-Yu Yen, Hsun-Yu Liu, Yuan-Der Huang, Jian-Hong Yu

Journal of Dental Sciences

Background/purpose: Pre-licensure dental clinical training in Taiwan is commonly viewed as an educational issue, yet it is also shaped by regulation. Eligibility for the dentist licensing examination still requires graduation, completion of internship, and possession of a diploma, whereas lawful practice requires separate practice registration and a practice license. This study examined whether the current training framework is aligned with the legal status and clinical responsibility assigned to dental students.

Materials and methods: A qualitative regulatory analysis was conducted using current official legal and policy documents in Taiwan, including the Physicians Act, the Medical Care Act, staged examination rules, the …

Evaluation Of Retrieval-Augmented Generation (Rag) With Gpt-4o For Maxillofacial Prosthodontics Clinical Questions, Vinsensia Launardo, Merve Koseoglu, Lucky Susanto, Michael Kase, Amanda Colebeck, Heidi Huber, Maribeth Krzesinski, Derry Wijaya, Muhammad Ruslin, Alvin Gerard Wee, Heng-Li Huang, Lih-Jyh Fuh, Cortino Sukotjo

Journal of Dental Sciences

Background/purpose: Large language models (LLMs) offer promising education and clinical decision support to help address the global shortage of maxillofacial prosthodontists. To overcome the lack of source traceability in base LLMs, this study evaluated a retrieval-augmented generation (RAG) architecture for answering complex clinical questions.

Materials and methods: An expert panel consisting of five maxillofacial prosthodontists selected 15 high-complexity clinical questions. Responses were generated using base GPT-4o and a naive RAG-GPT-4o model built with domain-specific literatures. Outputs were evaluated across five parameters using a 5-point Likert scale and analyzed via Mann-Whitney U tests.

Results: No statistically significant differences …

Biological Performance Enhancement Of Ni-Free Zr-Based Bulk Metallic Glass For Dental Implants Via Nitrogen Plasma Immersion Ion Implantation, Hsun-Miao Huang, Ying-Sui Sun, Ya-Lin Huang, Kai-Yi Lin, Thantrira Porntaveetus, Thanaphum Osathanon, Wei-Cheng Chen, Her-Hsiung Huang

Journal of Dental Sciences

Background/purpose: Improving the biocompatibility of bulk metallic glass (BMG) alloys is critical for expanding their applications in biomedical fields, particularly in dental implants. This study systematically investigated the suitability of nitrogen plasma immersion ion implantation (NPIII)-treated Zr-based BMG alloy for next-generation dental implant applications, focusing on protein adsorption, platelet responses, and cell behavior.

Materials and methods: NPIII was employed as a surface modification approach to enhance the biological performance of a Ni-free Zr₆₂.₅Cu₂₂.₅Fe₅Al₁₀ BMG alloy. The effects of NPIII treatment on surface characteristics, including crystallinity, chemical composition, layer thickness, roughness, and hydrophilicity, were comprehensively analyzed. Protein adsorption …

Fault Tolerant Adaptive Control Under Actuator Saturation For Robot Manipulators, D. J. López-Araujo, N. Alvarez-Jarquin, P. Borja, A. T. Becker

School of Engineering, Computing and Mathematics

In practice, actuators inherently have natural limitations that are often overlooked by theoretical control strategies, such as bounded output and discrepancies between calculated and actual responses. Consequently, reliable control techniques must be employed to ensure safe and dependable operation. We propose an adaptive control law for global regulation in the case of partial loss of effectiveness due to input faults. The proposed control strategy maintains the system at the desired configuration while accounting for the physical limitations of the actuators. Additionally, it is suitable for dealing with unknown parameters in the vector of gravitational forces, making it robust to these …

Angle-Based Formation Stabilization And Maneuvers In Port-Hamiltonian Form With Bearing And Velocity Measurements, Ningbo Li, Pablo Borja, Arjan Van Der Schaft, Jacquelien M.A. Scherpen

School of Engineering, Computing and Mathematics

This paper proposes a port-Hamiltonian approach for angle-based formation stabilization and maneuvers using bearing and velocity measurements with an underlying triangulated Laman graph. The corresponding port-Hamiltonian controller is designed using virtual couplings on the errors of angle constraints in angle space. Then, the angle constraints and agent actuators are mapped by the constraint Jacobian, which can be applied to other formation constraints. In addition, to avoid unavailable distance terms in the control law, an estimator is designed based on port-Hamiltonian theory and the property that energy is coordinate-free for different sensor modalities using bearing and velocity measurements, which permits our …

Enhancing Offshore Wind Resource Assessment Through Neural Network-Based Hf Radar Data Analysis, Nikolas Martzikos, Matthew Craven, David Walker, Daniel Conley

School of Engineering, Computing and Mathematics

The increasing demand for offshore wind energy underscores the need for accurate wind speed estimation to support the design and operation of offshore wind farms. High-Frequency Radar (HFR), a widely used remote sensing technology in oceanographic research, offers promising potential for wind resource assessment, particularly in areas where conventional measurements are limited. This study explores the application of artificial neural networks (ANNs) for offshore wind speed prediction using HFR-derived data, addressing key challenges in model development and training. A key feature of this approach is the use of a decade-long dataset from the Celtic Sea, off the southwest UK coast, …

Rapid Electrochemical Biosensor With Enhanced Accuracy And Repeatability Using Pyrene Nhs Ester Modified 3d Graphene Electrodes, S. Nazir, D. Jenkins, G. Pan

School of Engineering, Computing and Mathematics

A consistent and reproducible chemical modification of the transducer interface is essential to ensure effectiveimmobilization of bioreceptors, thereby improving the sensitivity and reproducibility of biosensors. Althoughnotable progress has been made in fabricating graphene-based biosensors, the effects of surface biofunctionalization on sensing performance remain not fully understood. This study shows that combining threedimensional (3D) graphene foam electrodes with a straightforward, single-step surface biofunctionalizationmethod is key to enhancing the performance of graphene-based biosensors. Specifically, it presents a single-stepapproach to functionalize the 3D graphene foam (Gii-Sens) with 1-pyrenebutyric acid N-hydroxysuccinimideester (Pyrene-NHS ester). Electrochemical techniques, including cyclic voltammetry (CV) and differential pulsevoltammetry (DPV), confirmed …

Picturing The Past: The Role Of Photo Cue Visual Perspective On Positive Autobiographical Memory Recall In Dysphoria, Sarah Snow, Zachary Adolph Niese, Julie L Ji

School of Psychology

Positive autobiographical memory plays a key role in emotional well-being and is distorted by cognitive processing biases in dysphoria. This experiment investigated how the visual perspectives (first-person vs. third-person) of personal photographs influence recall of positive memories depending on dysphoria. Eighty-five participants (42 low dysphoria, 43 high dysphoria) submitted photos of positive events from both perspectives. Later, participants recalled these events while viewing either a first- or third-person photo before rating and describing their memory. While first-person photos promoted more recall from an own-eyes vantage point regardless of dysphoria level, dysphoria was still associated with greater observer-like recall, reduced mental …

Numerical Study Of Air Vents Influence On Wave Forces Acting On Box-Type Bridge Girders With Cavities Under Storm Surge, Khalida H. Jihad

UNF Graduate Theses and Dissertations

Along with the continuous rise of sea level, direct interaction between elevated coastal structures, such as coastal bridges, and seawater during storm surge, has been shown to potentially cause bridge failures in the past. For example, Hurricane Irma (2017) generated storm surge levels exceeding 2-3 m in portions of South Florida, causing widespread transportation disruption including roadway washouts, erosion, and bridge approach damage along US-1 in Florida Keys. Similar failures have occurred during Hurricane Ivan (2004), where uplift forces displaced spans of the Escambia Bay Bridge, and Hurricane Ian (2022), which caused partial collapse of the Sanibel Causeway when elevated …

Investigating The Effects Of Pressure On Fe And Co Intercalated 2h-Tas2 Through First-Principle Calculations, Ronald E. Putnam Jr.

UNF Graduate Theses and Dissertations

Using first-principles methods, we investigate the effects of applied isotropic pressure on the electronic and magnetic properties of intercalated Fe1/3TaS2 and Co1/3TaS2. Fe1/3TaS2 has been shown to be a ferromagnet that undergoes structural and magnetic phase transitions under applied pressure. The magnetic phase transitions are observed to be linked to the structural shift, and a mixture of magnetic phase states is present between 3 GPa and 6 GPa. Co1/3TaS2 was found to be antiferromagnetic, as confirmed by experimental work. One- and two-unit-cell systems of Co1/3TaS2 are analyzed, both showing band splitting that disappears under pressure. The application of pressure forces …

What Novice Educators Find Supportive, Robin M. Bossinger

UNF Graduate Theses and Dissertations

Teacher shortages have increased in the past two decades, creating greater emphasis on recruitment, talent development, and retention efforts for educational leaders. Novice educators feature prominently in these considerations. A teacher’s first years can be extremely challenging, and induction, the professional learning experiences specific to early career professionals, is often considered the answer. Despite the seeming ubiquity of induction, there is much variability in interpretation, enactment and outcomes. While it is generally accepted that some induction is better than no induction, new teachers deserve more intentionally designed support.

This study sought to reexamine assumptions about induction, adding to the literature …

Exploring The Undergraduate Student Perceptions Of Sense Of Belonging At Their University: A Q-Methodological Approach, Jose Acevedo

UNF Graduate Theses and Dissertations

       The transition to higher education is a significant life event requiring substantial social, academic, and psychological adjustment, during which a powerful sense of belonging is critical for student success and retention. While traditional models of student retention often prioritize support services and academic integration, they frequently overlook the intricate relational dynamics and deeply personal subjective experiences that shape belonging. This research utilized Q methodology to explore the multifaceted ways undergraduate students at the University of North Florida (UNF) understand and prioritize the determinants of institutional belonging. Guided by an integrated conceptual framework of Maslow’s Hierarchy of Needs, Self-Determination Theory, Social …

Finding Community: Addressing Doctoral Student Loneliness And Fostering Belonging In Higher Education, Sydney Hamrick

UNF Graduate Theses and Dissertations

Doctoral students often experience loneliness, isolation, marginalization, and other challenges related to belonging. While prior research has connected belonging to persistence, well-being, and academic success, little is known about doctoral students’ lived experiences of belonging and loneliness. This hermeneutic phenomenological study, grounded in Max van Manen’s Phenomenology of Practice, guided by the Sense of Community Theory and informed by a Transformative Worldview, explored how institutional, structural, relational, and personal factors shaped doctoral students’ experiences. Data were collected through semi-structured interviews and analyzed using an interpretive phenomenological approach informed by van Manen’s lifeworld existentials, including lived relation, lived space, lived …

Teacher Judgment In The Age Of Artificial Intelligence: Collaborative Inquiry Into Generative Ai For Udl-Aligned Instructional Planning In Elementary English Language Arts, Melissa G. Metz

UNF Graduate Theses and Dissertations

This action research study explores how teacher-facing generative artificial intelligence (GAI), specifically Google Gemini, can support educators in UDL-aligned instructional planning within a Title I elementary school. Although AI is often discussed in terms of student-facing applications, less is known about how GAI can assist teachers with lesson planning, differentiation, and the demands of sustaining inclusive Tier I instruction. Guided by a conceptual framework integrating Universal Design for Learning (UDL) and technology integration perspectives, the study engaged four educators in collaborative inquiry through AI Visioning Workshops, reflections, interviews, and planning artifacts.

Data were analyzed through iterative coding, analytic memoing, and …

Implementing Multi-Tiered Systems Of Support For School-Based Mental Health Services: An Explanatory Case Study Of An Elementary School, Laura Acker

UNF Graduate Theses and Dissertations

This qualitative explanatory case study examined how school-based mental health services (SBMHS) are implemented within an elementary school’s Multi-Tiered System of Supports (MTSS). Guided by the Consolidated Framework for Implementation Research (CFIR) and sensemaking theory, the study examined how educators and school-based professionals interpret and enact their roles in supporting student mental health within educational contexts. Data were collected through interviews with five MTSS team members and analyzed using a combination of deductive and inductive coding. Results showed that mental health implementation is not a fully integrated system of supports but rather a process shaped by roles and relationships influenced …

The Un-Bridged Pipeline: Leading And Preparing Women Of Color To Senior-Level Higher Education Administration, Jacqueline D. Slater

UNF Graduate Theses and Dissertations

Despite increased educational attainment among Black women, representation in senior‑level leadership positions within higher education remains limited. This qualitative study examines the experiences of Black women who serve or have served in senior‑level academic administrative roles and explores how those experiences inform guidance, preparation, and decision‑making for future Black women leaders. The study focuses on practical barriers, workplace realities, and strategies that shape leadership entry, advancement, and retention.

Using a descriptive case study design, five Black women with professional experience as presidents, provosts, vice provosts, and academic deans participated in semi‑structured interviews lasting 45 to 75 minutes. Purposeful sampling ensured …

The Composition Of Gases From A Diffusion Flame Above Longleaf Pine Needle Fuel Beds, David R. Weise, Thomas H. Fletcher, Timothy J. Johnson, Weimin Hao, Russell G. Tonkyn, Catherine A. Banach, Javier Palarea-Albaladejo, Mahsa Alizadeh, Stephen Baker

Faculty Publications

The gas and tar composition of a wildland fire diffusion flame from longleaf pine needles is currently relatively unmeasured and more data are needed to fill in the gap between pyrolysis data and smoke plume data, thus improving physical and chemical modeling of wildland smoke formation. A pilot experiment to measure light gas and tar composition of such a flame is described for three flame zones: persistent flame (flame base), intermittent flame, and smoke plume. Flame gases from 24 experimental fires were collected in canisters and analyzed for CO2, CO, H2, CH4, and C2 to C7 hydrocarbon gases. Other light …

Experimental Investigations Of Cataract-Related Visual Degradation, Intraocular Lens Optics And Dynamic Stability, Sherrie Choy

School of Health Professions Theses

Cataract commonly occurs in older adults and is associated with degraded vision, impaired mobility and increased risk of falls. Cataract surgery restores transparency of the optical media by replacing the natural lens with an artificial intraocular lens (IOL). Modern toric and aspheric IOLs can improve optical quality and refractive outcomes; yet their potential impact on dynamic balance and fall risk is not well understood. This thesis used an experimental research methodology to examine how controlled changes in visual quality, arising from simulated cataract and from differences in IOL design, toric alignment and aberration profile, influence dynamic stability and gaze behaviour, …

Adherence And Compliance With Exercise Training In Progressive Multiple Sclerosis: Rates And Correlates From The Cogex Trial, Cogex Research Team, Robert W. Motl, Andrew Argie, Roberto S. Hernandez, Brian M. Sandroff, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John Deluca, Rachel Farrell, Peter Feys, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Maria A. Rocca, Amber Salter, Anthony Feinstein

School of Health Professions

Background: There is limited understanding of adherence and compliance rates for exercise training(ET) in people with progressive multiple sclerosis(PMS).Objectives: This secondary, exploratory data analysis examined rates of adherence and compliance for continuous, moderate intensity training and high-intensity intervaltraining(HIIT) and possible correlates among people with PMS from the CogEx trial.Methods: CogEx was a multi-site, multi-arm, randomized, double-blinded, and shamcontrolled trial undertaken by 11 sites in six di8erent countries. Participants(N=311) wererandomized into one of four conditions with di8erent combinations of ET and cognitive rehabilitation, including respective sham conditions, delivered twice weekly over 12 weeks.The analysis focused on adherence and compliance rates and …

Rethinking Remimazolam: Reconciling Regulatory Positioning With Clinical Reality, Theodora Wingert, J Robert Sneyd

More Faculty of Health Research

Goyal and colleagues share a large United States health system’s experience of 9431 cases of real-world remimazolam use, offering insight into current practice patterns, recovery times, and accurate adverse event rates. The authors report rapid recovery after remimazolam, including shorter time to post-anaesthesia care unit discharge readiness and faster return to baseline on the Richmond Agitation–Sedation Scale following flumazenil administration, with a critical event rate of 0.7%. Interesting practice patterns were observed, including frequent co-administration with other anaesthetics rather than as a sole agent. Although only licensed for procedural sedation in the United States, the authors reported extensive use of …