Developing Anti-Inflammatory Mineral Trioxide Aggregate As Dental Implant Crown Cement To Reduce Peri-Implantitis Incidence, Yung-Fu Hsu, Sea-Fue Wang, Yi-Le Liao, Chih-Sheng Lin, Ssu-Chi Chen, Sheng-Yang Lee, Wei-Chun Lin

Journal of Dental Sciences

背景/目的：牙周組織周圍的牙科樹脂黏固劑殘留是植體周圍炎的原因之一。嚴重病例可能導致植體鬆動或脫落。因此，本研究旨在對礦物三氧化物聚集體（MTA）進行改性，使其成為一種抗發炎的牙科植體冠黏固劑（ICC）。

材料與方法：本研究評估了去離子水溶液（Daq）、羥基磷灰石溶液（Haq）和氯化鈣溶液（Caq）對ICC凝固時間、抗壓強度、黏結強度和生物相容性的影響。以單因子變異數分析（ANOVA）檢定各實驗組間的差異（ P < 0.05）。

結果：表面微觀結構分析表明，添加Haq和Caq有助於ICC顆粒間的結合。表面元素分析表明，添加Haq增加了Ca離子含量。凝固時間結果表明，與Daq相比，Caq和Haq分別使最終凝固時間縮短了46.5%和34.7%（ P < 0.05）。 Caq的抗壓強度分別比Daq和Haq高35.1%和13.4%（ P < 0.05）。三種ICC組的黏接強度結果表明，樹脂黏接劑的效果相同（ P > 0.05）。生物相容性和清除活性測試表明，ICC優於樹脂黏接劑。

結論： ICC與Caq合併使用可縮短凝固時間、提高抗壓強度、增強生物相容性並降低發炎發生的可能性。因此，ICC與Caq聯合使用可作為牙科樹脂黏固劑的替代方案。

Optical Properties Of Conventional And High-Translucency Zirconia Ceramics And Their Effects On Resin Cement Polymerization, Chia-Ling Li, Ping-Ju Chen, Jui-Che Lin, Shu-Fen Chuang

Journal of Dental Sciences

Background/purpose: Adequate polymerization of resin luting cements is essential for durable bonding in zirconia restorations. However, variations in zirconia microstructure and composition may influence translucency and light transmittance, thereby affecting resin cement polymerization. This study aimed to investigate the optical properties of conventional and high-translucency zirconia ceramics and their effects on resin cement polymerization.

Materials and methods: Six zirconia ceramics were evaluated: CerconBase, CerconHT, and VitaHT (3Y-TZP); VitaST (4Y-PSZ); and CerconXT and VitaXT (5Y-PSZ). Disk specimens (0.5 and 1.0 mm thick) were fabricated and sintered. Grain size and elemental compositions were analyzed using scanning electron microscopy and energy-dispersive X-ray …

Modulation Of Osteoclast Differentiation By Epigallocatechin-3-Gallate (Egcg)/Type I Collagen–Coated Titanium Implant Surface In Vitro, Her-Hsiung Huang, Yu-Ying Cheng, Chia-Fei Liu, Wei-Cheng Chen

Journal of Dental Sciences

Background/purpose: Implant osseointegration depends not only on osteogenesis but also on coordinated bone remodeling. Our previous study demonstrated that epigallocatechin-3-gallate (EGCG)/type I collagen–coated titanium (Ti) surfaces enhance angiogenesis and osteogenic differentiation in vitro. However, their influence on osteoclast differentiation remains unclear. This study evaluated the modulatory effects of this coating on osteoclast responses in vitro.

Materials and methods: Sandblasted and acid-etched (SLA) Ti surfaces followed by alkaline treatment (SLAA) were prepared. Type I collagen was immobilized onto SLAA surfaces using the natural crosslinker EGCG (10 or 50 μg/mL). Surface morphology, roughness, hydrophilicity, and functional groups were characterized. RAW 264.7 macrophages …

Pathogenic Oral Microbiota Abundance Is Associated With Reduced Bite Force In Patients With Periodontitis, Chih-Chieh Wen, Thu Ya Linn, Ting-Yi Renn, Hui Yin Nam, Chia-Chen Hsu, Yi-Jen Lin, Yi-Fan Wu, Wei-Jen Chang

Journal of Dental Sciences

Background/purpose: Periodontitis leads to tissue destruction and functional impairment, but the interplay between microbiota, clinical parameters, and biomechanics remains unclear. This study aimed to quantitatively correlate specific oral microbial signatures and clinical inflammatory indicators with bite force in patients with periodontitis.

Materials and methods: Fifteen patients with stage III-IV periodontitis and 15 periodontally healthy controls were recruited. Clinical parameters (Probing Depth, Clinical Attachment Loss, Bleeding on Probing, Plaque Index) and MBF (pressure-sensitive film) were recorded. Supragingival plaque was analyzed through 16S rRNA gene sequencing (PacBio SMRT) to determine microbial composition. Correlation analyses were performed.   

Results: The periodontitis …

Rigorous Validation Of Machine Learning Models For Orthodontic Extraction Prediction Using Nested Cross-Validation And Smotenc-Integrated Pipelines., Anh Thi-Ngoc Do, Hung Trong Hoang, Thuy-Trang Thi Ho, Hieu Ngoc Le

Journal of Dental Sciences

Background/purpose: Machine learning (ML) in orthodontics often suffers from optimistic bias due to data leakage and improper handling of class imbalance. This study implemented and evaluated a production-grade validation framework - nested cross-validation (CV) - for three distinct algorithm classes (logistic regression, random forest, and gradient boosting) using a consensus-labeled orthodontic dataset.

Materials and methods: A retrospective dataset of 500 patients (334 non-extraction/166 extraction) was curated with 41 processed features. Two stratified split protocols (70/30 and 80/20) were evaluated to assess model robustness. To ensure methodological rigor, a 5-fold outer/3-fold inner nested cross-validation was implemented. Crucially, SMOTENC (synthetic minority over-sampling …

Influence Of All-On-4 Implant Angles On Stability And Crestal Bone - A Finite Element Optimization Analysis,, Jing-Jie Chen, Chen-Sheng Chen

Journal of Dental Sciences

No abstract provided.

Poly-Ε-Caprolactone/Multi-Wall Carbon Nanotube Composites As Osteoinductive Scaffolds For Alveolar Bone Regeneration,, Chien-Yang Yeh, Firdiansyah Rasyid

Journal of Dental Sciences

No abstract provided.

Comparative Effects Of Plasma Activation And Monomer Infiltration On The Surface Characteristics And Wettability Of 3d-Printed Permanent Crown Resin,, Pyi Phyo Win, Szu-Yu Lai

Journal of Dental Sciences

No abstract provided.

Activities Of Dental Hygienists Registered In The Disaster Relief System Of The Japan Dental Hygienists’ Association In The 2024 Noto Peninsula Earthquake, Hitomi Suzuki, Kumiko Sugimoto

Journal of Dental Sciences

No abstract provided.

Mesenchymal Stem Cells Derived From Gingiva Normoxic Or Hypoxic-Preconditioning Allogenous Transplantation Affect Orthodontic Tooth Movement In Vivo, Alexander Patera Nugraha, Guang Hong

Journal of Dental Sciences

No abstract provided.

Strategy Of Allying General Dentistry Staffs Into Pre-Anesthetic Dental Assessment Reduces Perioperative Dental Injury Risk During General Anesthesia, Cheng Lu, Mei-Chun Chen

Journal of Dental Sciences

No abstract provided.

Oral Health-Related Quality Of Life And Diabetes Outcomes: Evidence From A Nationally Representative U.S. Sample, Hsueh-Fen Chen, Jou-Hsun Lee

Journal of Dental Sciences

No abstract provided.

Vanadium-Functionalized Methyl Methacrylate-Based Primer Enhances Self-Curing And Bonding Of Resin Cement To Polyetheretherketone Restorations, Takeru Kondo, Jun Sato

Journal of Dental Sciences

No abstract provided.

Comparative In Vivo Study Of 3d-Printed Composite Bioceramic Scaffolds Fabricated By Distinct Pre-Processing Methods, Yu-Ting Li, Ju-Hsuan Yang

Journal of Dental Sciences

No abstract provided.

Retrospective Accuracy Comparison Of Marker-Based And Marker-Free Registrations Using Dynamic Implant Navigation, Zhiyi Zhu, Shikai Zhao

Journal of Dental Sciences

No abstract provided.

Postoperative Conductive Hearing Loss After Full-Arch-Implantation Surgery Under General Anesthesia In An Oral Submucous Fibrosis Patient: A Case Report, Hao-Chen Wang, Fu-Chuan Tsai, Chia-Che Wu, Chih-Yuan Fang

Journal of Dental Sciences

No abstract provided.

Factors Influencing Dental Career Decision-Making Among High-Achieving Students In Taiwan, Chien-Hong Yu, Mei-Huei Li, Feng-Chou Cheng, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Effects Of Cleaning Protocols On The Material Properties Of Clear Aligners And Retainers: A Systematic Review, Yao-Chang Chiang, Tu Manh Nguyen, Thuy-Trang Thi Ho, Loc Minh Lu, Yang-Che Wu, Tong-Hsien Chow, Chiang-Wen Lee, Fang-Yu Fan, Li-Nai Chen, I-Ta Lee

Journal of Dental Sciences

Clear aligners and retainers are widely used in contemporary orthodontics because of their esthetic appearance, removability, and patient-centered advantages. However, repeated exposure to dietary pigments and cleaning procedures may alter their optical, surface, mechanical, and chemical properties, potentially affecting appliance appearance, hygiene, and performance. This systematic review evaluated changes in the material properties of clear aligners and retainers following different cleaning protocols. Electronic searches were performed in PubMed, Scopus, LILACS, and the Cochrane Library from inception to February 28, 2026. Twenty studies were included, comprising 18 in vitro studies and 2 randomized clinical crossover studies. Cleaning protocols were categorized as …

Herbal Medicine For Oral Ulcer Treatment: Mechanisms, Efficacy, And Therapeutic Potential, Shinn-Zong Lin, Tsung-Hsien Chuang, Chih-Yang Huang, Tsung-Jung Ho, Yi-Pang Lee

Journal of Dental Sciences

Oral ulcers are common inflammatory lesions of the oral mucosa that significantly affect patients’ quality of life through pain, eating difficulties, and psychological stress. Their development is multifactorial, involving mechanical trauma, infection, nutritional deficiencies, immune dysregulation, and oxidative stress. Conventional treatments including antiseptics, corticosteroids, and immunomodulators, provide symptomatic relief but are often limited by side effects, recurrence, and poor patient adherence. Increasing interest has therefore focused on herbal medicines as complementary or alternative therapies. Numerous single herbs such as Aloe vera, licorice, curcumin, chamomile, berberine, neem, sage, myrrh, and guava and traditional formulations have demonstrated anti-inflammatory, antioxidant, immunomodulatory, antimicrobial, and …

The Ph-Pi3k/Akt/Mtorc1 Axis In The Survival Of Stem Cells From The Apical Papilla: A Critical Target For Rescue By Microenvironment-Engineered Hydrogels In Pulp Regeneration, Chunlei Zhang, Haisheng Cao, Jie Li, Changqing Yan, Yang Liu, Shuguo Zheng, Xiaozhe Wang

Journal of Dental Sciences

Background/purpose: The pH within infected root canals fluctuates dynamically under pathological conditions, yet its impact on stem cells from the apical papilla (SCAPs) in dental pulp regeneration remains unclear. This study investigated how potential of hydrogen (pH) variations govern SCAPs survival and the associated signaling to identify therapeutic targets for enhancing tissue regeneration.

Materials and methods: SCAPs were cultured at pH 5.4-10.4. Proliferation and apoptosis were assessed using cell counting kit-8 (CCK-8) assays, real-time live-cell analysis, and flow cytometry. RNA-sequencing (RNA-seq) identified differentially expressed genes, which were validated through reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR), Western blotting, and mechanistic …

Osteoblastogenesis Stimulation By Human Umbilical Cord Stem Cell Secretome During Maxillary Expansion, Alexander Patera Nugraha, Guang Hong, Firdaus Hariri, I Gusti Aju Wahju Ardani, Adya Pramusita, Nurul Aisyah Rizky Putranti, Nindya Rizky Anjani Marhendra, Naora Dewi Rahma Fadzila, Ananda Firman Putranto, Muhammad Luthfi, Wibi Riawan, Putri Cahaya Situmorang, Rony Abdi Syahputra, Thantrira Porntaveetus, Khairul Anuar Shariff, Nissia Ananda, Maudina Dwi Heriasti, Kotaro Tanimoto

Journal of Dental Sciences

Background/purpose: Maxillary expansion induced by mechanical force (MEMF) is a standard orthodontic approach for correcting transverse maxillary deficiency. The human umbilical cord mesenchymal stem cell secretome (HUCMSC-S) has the potential to stimulate accelerate bone remodeling. This study aimed to evaluate local HUCMSC-S application effect during MEMF on the expression bone morphogenetic protein (BMP)-2, BMP-4, BMP-7, vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), transforming growth factor-beta (TGF-β), and fibroblast growth factor-2 (FGF-2) in a Wistar rat (Rattus norvegicus).

Materials and methods: Twenty-four healthy male Wistar rats (R. norvegicus) were randomly divided into four groups: …

A Bibliometric Evolution Of Molecular Mechanisms And Emerging Research Trends Of Therapeutic Resistance In Oral Cancer, Chu-Yen Chien, Ying-Chen Chen, Jia-Rong Wu, Hsu-Hua Chu, Yi-Jen Hung, Yi-Shing Shieh

Journal of Dental Sciences

Background/purpose: Drug resistance has served as a primary determinant of treatment failure and disease recurrence in oral cancer. The present study aimed to evaluate the global research landscape of drug resistance mechanisms in oral cancer by integrating bibliometric mapping with bioinformatic validation.

Materials and methods: A comprehensive dataset of 1660 publications was retrieved from the Scopus database. Bibliometric analyses were performed using Biblioshiny and VOSviewer to evaluate publication trends, collaborative networks, and thematic evolution. To bridge research trends with biological mechanisms, 1469 genes associated with oral cancer and drug resistance were extracted from the GeneCards database and subjected to functional …

Adhesion Performance Of Conventional And High-Translucency Zirconia: Effects Of Airborne-Particle Abrasion And 10-Methacryloyloxydecyl Dihydrogen Phosphate Treatments, Chia-Ling Li, Li-Li Kang, Jui-Che Lin, Shu-Fen Chuang

Journal of Dental Sciences

Background/purpose: High-translucency zirconia exhibits different microstructure and composition, which may influence their responses to mechanical and chemical treatments, affecting resin–zirconia adhesion. This study aimed to evaluate the adhesive behaviors of conventional and high-translucency zirconia, focusing on surface modifications induced by airborne-particle abrasion (AA) and 10-methacryloyloxydecyl dihydrogen phosphate (MDP).

Materials and methods: Disk-shaped specimens were fabricated from six zirconia materials: CerconBase, CerconHT, and VitaHT (3Y-TZP); VitaST (4Y-PSZ); and CerconXT and VitaXT (5Y-PSZ). Specimens were air-abraded with alumina particles at 0.25 MPa. Micromorphology and roughness were analyzed using scanning electron microscopy (SEM), profilometry, and atomic force microscopy (AFM). Surface chemical composition …

Interaction Between Removable Partial Denture Use And Number Of Natural Teeth On Health-Related Quality Of Life In Older Adults: A Cross-Sectional Study, Pai-Shien Liao, Chia-Hsuan Chou, Ya-Xin Zheng, Jiiang-Huei Jeng, Wan-Chuen Liao, Ying-Fang Chen

Journal of Dental Sciences

Background/purpose: The compensatory benefit of removable partial dentures (RPDs) on health-related quality of life (HRQoL) depends on the number of natural teeth. This study aimed to evaluate the interaction between RPD use and number of natural teeth on HRQoL, measured by EuroQoL 5-Dimension 5-Level (EQ-5D-5L) and Visual Analogue Scale (VAS).

Materials and methods: This cross-sectional study included 410 older adults. Dental status, including the number of natural teeth and the decayed, missing and filled teeth (DMFT) index, and RPD use were assessed. Participants were categorized into three groups (0-9, 10-19, and ≥ 20 natural teeth). HRQoL was measured using the …

Routine Dental Scaling And Reduced Risk Of Serious Infections In Individuals With Moderate-To-Severe Cerebral Palsy: A Nationwide Population-Based Cohort Study, Li-Wei Ou-Yang, Yu-Tung Huang, Ya-Ting Chang, Hsin-Mao Hsu, Shih-Hao Chang, Chia-Ling Wu, Tsung-Chieh Yao

Journal of Dental Sciences

Background/ purpose: Individuals with moderate-to-severe cerebral palsy (CP) are highly susceptible to serious infections. Oral biofilms may serve as reservoirs for pathogenic microorganisms, yet the impact of professional oral healthcare on systemic infection risk in this population remains unclear. This study investigated the association between routine dental scaling and the risk of serious infections and infection-related mortality among individuals with moderate-to-severe CP.

Materials and methods: This nationwide, population-based cohort study used data from Taiwan’s National Health Insurance Research Database and National Death Registry (2009–2019). Individuals with moderate-to-severe CP were categorized into a routine dental scaling group (≥1 scaling annually for …

Artificial Intelligence Assisted Multitask Framework For Dental Detection And Root Canal Filling Assessment On Periapical Radiographs, Chia-Lin Hsu, Li Wei Ou-Yang, Chih-Hao Chang, Yuan-Jin Lin, Po-Lin Huang, Kai-Syun Chiu, Heng-Chia Chen, Tsung-Yi Chen, Jia-Ching Wang, Wei-Chen Tu, Patricia Angela R. Abu

Journal of Dental Sciences

Background/purpose: Accurate evaluation of root canal filling (RCF) quality is paramount for successful endodontic outcomes. However, conventional radiographic interpretation is often subject to subjective variability. This study developed an automated, multitask artificial intelligence (AI) framework using YOLO11 and advanced image pre-processing to identify multiple dental structures and provide quantitative assessments of RCF quality on periapical radiographs.

Materials and methods: We proposed an image enhancement pipeline, which integrate intensity normalization, white top-hat transform, and linear contrast stretching to refine dental contours for training the YOLO11 multitask model. The framework simultaneously detected primary, permanent, dental crowns, and RCFs. Quantitative metrics, including …

The Bridge To Practice: A Regulatory Analysis Of Pre-Licensure Dental Training In Taiwan, Wei-Chia Su, Hsin-Hu Chen, Ching-Yu Yen, Hsun-Yu Liu, Yuan-Der Huang, Jian-Hong Yu

Journal of Dental Sciences

Background/purpose: Pre-licensure dental clinical training in Taiwan is commonly viewed as an educational issue, yet it is also shaped by regulation. Eligibility for the dentist licensing examination still requires graduation, completion of internship, and possession of a diploma, whereas lawful practice requires separate practice registration and a practice license. This study examined whether the current training framework is aligned with the legal status and clinical responsibility assigned to dental students.

Materials and methods: A qualitative regulatory analysis was conducted using current official legal and policy documents in Taiwan, including the Physicians Act, the Medical Care Act, staged examination rules, the …

Evaluation Of Retrieval-Augmented Generation (Rag) With Gpt-4o For Maxillofacial Prosthodontics Clinical Questions, Vinsensia Launardo, Merve Koseoglu, Lucky Susanto, Michael Kase, Amanda Colebeck, Heidi Huber, Maribeth Krzesinski, Derry Wijaya, Muhammad Ruslin, Alvin Gerard Wee, Heng-Li Huang, Lih-Jyh Fuh, Cortino Sukotjo

Journal of Dental Sciences

Background/purpose: Large language models (LLMs) offer promising education and clinical decision support to help address the global shortage of maxillofacial prosthodontists. To overcome the lack of source traceability in base LLMs, this study evaluated a retrieval-augmented generation (RAG) architecture for answering complex clinical questions.

Materials and methods: An expert panel consisting of five maxillofacial prosthodontists selected 15 high-complexity clinical questions. Responses were generated using base GPT-4o and a naive RAG-GPT-4o model built with domain-specific literatures. Outputs were evaluated across five parameters using a 5-point Likert scale and analyzed via Mann-Whitney U tests.

Results: No statistically significant differences …

Biological Performance Enhancement Of Ni-Free Zr-Based Bulk Metallic Glass For Dental Implants Via Nitrogen Plasma Immersion Ion Implantation, Hsun-Miao Huang, Ying-Sui Sun, Ya-Lin Huang, Kai-Yi Lin, Thantrira Porntaveetus, Thanaphum Osathanon, Wei-Cheng Chen, Her-Hsiung Huang

Journal of Dental Sciences

Background/purpose: Improving the biocompatibility of bulk metallic glass (BMG) alloys is critical for expanding their applications in biomedical fields, particularly in dental implants. This study systematically investigated the suitability of nitrogen plasma immersion ion implantation (NPIII)-treated Zr-based BMG alloy for next-generation dental implant applications, focusing on protein adsorption, platelet responses, and cell behavior.

Materials and methods: NPIII was employed as a surface modification approach to enhance the biological performance of a Ni-free Zr₆₂.₅Cu₂₂.₅Fe₅Al₁₀ BMG alloy. The effects of NPIII treatment on surface characteristics, including crystallinity, chemical composition, layer thickness, roughness, and hydrophilicity, were comprehensively analyzed. Protein adsorption …

Fault Tolerant Adaptive Control Under Actuator Saturation For Robot Manipulators, D. J. López-Araujo, N. Alvarez-Jarquin, P. Borja, A. T. Becker

School of Engineering, Computing and Mathematics

In practice, actuators inherently have natural limitations that are often overlooked by theoretical control strategies, such as bounded output and discrepancies between calculated and actual responses. Consequently, reliable control techniques must be employed to ensure safe and dependable operation. We propose an adaptive control law for global regulation in the case of partial loss of effectiveness due to input faults. The proposed control strategy maintains the system at the desired configuration while accounting for the physical limitations of the actuators. Additionally, it is suitable for dealing with unknown parameters in the vector of gravitational forces, making it robust to these …