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Applied Machine Learning In Mineral Prospectivity Mapping In The South Pass-Granite Mountains Of Wyoming, Carl D. York Jan 2026

Applied Machine Learning In Mineral Prospectivity Mapping In The South Pass-Granite Mountains Of Wyoming, Carl D. York

Graduate Theses/Dissertations

The South Pass-Granite Mountains, comprised of Archean to Tertiary rocks embedded with an Archean greenstone belt in Central Wyoming, have historically been mined for gold, iron, steel, and silver. Rare earth elements have been of increasing interest in the region and thus, several datasets have become available. Knowledge driven and data driven models are used in mineral prospectivity mapping with input data including geological mapping, geochemical data, geophysical (USGS Critical Mineral magnetic and gravity data), radiometric (U, Th, K) data and multispectral remote sensing data. Mineral prospectivity has seen a rapid improvement in recent years using advancements in machine learning …


Drone Dichotomy: Investigating The Application Of Unmanned Aerial Systems For Offensive And Defensive Chemical, Biological, Radiological, And Nuclear-Related Tasks, Evan Jacob Martinovitch Jan 2026

Drone Dichotomy: Investigating The Application Of Unmanned Aerial Systems For Offensive And Defensive Chemical, Biological, Radiological, And Nuclear-Related Tasks, Evan Jacob Martinovitch

Graduate Theses/Dissertations

This thesis investigates the application of unmanned aerial systems (UAS) for both offensive and defensive chemical, biological, radiological, and nuclear (CBRN) tasks to determine if they serve as a force multiplier on the modern battlefield. As CBRN weapons reemerge as realistic threats alongside the rapid proliferation of UAS, the intersection of these fields presents unique challenges and opportunities. Through a methodology that examines the history of the UAS-CBRN intersection, military doctrine, and the status of UAS technology, this research evaluates the capability of current and emerging UAS against specific CBRN delivery, reconnaissance and surveillance, and decontamination tasks. The analysis conducted …


Nonbinary Gender Performance And Self-Identification In Mary Shelley's Frankenstein, Lillian R. Durr Jan 2026

Nonbinary Gender Performance And Self-Identification In Mary Shelley's Frankenstein, Lillian R. Durr

Graduate Theses/Dissertations

Mary Shelley’s 1818 novel Frankenstein, a text informed by a rich Romantic era philosophical tradition, has produced an expansive contemporary body of transgender studies scholarship. Building on transgender literary studies of Frankenstein, my thesis analyzes the difference between the monster’s internalized self-perceived identity and their externally performed and perceived identity. I interpret the difference between the monster’s internal and external identity as an analogy through which to understand contemporary nonbinary experiences. The “performance” of gender that Judith Butler describes is a limited expression of an internal, inescapable, ontological experience of self-identification. The monster’s own social experience illustrates the …


The Confidence-Man Goes To The Moving Panorama: Herman Melville’S Confidence Narrator And United States Imperialism, Bradley J. Lee Jan 2026

The Confidence-Man Goes To The Moving Panorama: Herman Melville’S Confidence Narrator And United States Imperialism, Bradley J. Lee

Graduate Theses/Dissertations

This thesis argues that Herman Melville fashioned his novel The Confidence-Man; His Masquerade (1857) after the moving panorama, a popular entertainment technology contemporary with the novel. More specifically, the thesis argues that the novel recalls Banvard’s Mississippi Panorama (1846). Using Jay Leyda’s The Melville Log and John Hanners’ record of Banvard’s performances, I establish beyond reasonable doubt the possibility that Melville saw this painting, or, at the very least, was aware of it, its content, and its social position. Tracing the novel’s engagement with this panorama reveals what seems at first to be its imperialist, Manifest Destinarian undertones. The novel’s …


Small Mammal Communities Within And Land Coverage Around Southwestern Missouri Prairies, Kaitlyn J. Bebensee Jan 2026

Small Mammal Communities Within And Land Coverage Around Southwestern Missouri Prairies, Kaitlyn J. Bebensee

Graduate Theses/Dissertations

Land alterations can reduce the amount of suitable habitat necessary for persistence of an associated species. Within such constrained habitats, limited resources may elicit competition, which could cause shifts in abundance and occurrence of species. Missouri prairies have been declining in size, making it imperative to collect reference data on mammal populations within and land use types around remnants. For this study, I trapped small mammals in Southwestern Missouri prairies because they can be indicators of environmental health and can vary in abundance between prairies. I focus on the diet of two dominant small mammals, Peromyscus maniculatus and Microtus ochrogaster …


Northern Luzon In A Taiwan Flashpoint: The Philippines’ Place In U.S. Strategy, Carson Keller Jan 2026

Northern Luzon In A Taiwan Flashpoint: The Philippines’ Place In U.S. Strategy, Carson Keller

Graduate Theses/Dissertations

While the defense of Taiwan from a potential invasion by the People’s Republic of China (PRC) has long been a topic of debate and scrutiny in U.S. strategic thinking, the role of its southern neighbor, the Philippines, has received far less attention. This thesis argues that northern Luzon would constitute key terrain in a cross-strait conflict and may become an early target of People’s Liberation Army (PLA) operations. Its proximity to Taiwan and position along the Luzon Strait, particularly the Bashi Channel, places it at the center of efforts to control access to the hypothetical battlespace. Drawing on PLA and …


Flow Regime Shifts And Channel Morphological Adjustments In Response To Changing Climate Patterns: Examples From Gasconade River, Missouri, Usa, Katherine E. Brand Jan 2026

Flow Regime Shifts And Channel Morphological Adjustments In Response To Changing Climate Patterns: Examples From Gasconade River, Missouri, Usa, Katherine E. Brand

Graduate Theses/Dissertations

Recent changes in climate patterns due to anthropogenic inputs (i.e. greenhouse gases/CO₂) have caused alterations to precipitation events leading to altered flow regimes. Changes in the magnitude and frequency of flood events results in physical adjustments to river morphology, including changes in width and depth. As rivers experience more frequent and larger flood events, they accommodate by changing their morphological characteristics. The Gasconade River, a tributary of the Missouri River located in southcentral Missouri, USA, has exhibited recent patterns of acute bank erosion with limited understanding of its causes and effects on the river. This study aims to understand how …


Inherited Sins: Essays, Claire Ellerman Jan 2026

Inherited Sins: Essays, Claire Ellerman

Graduate Theses/Dissertations

Joan Didion said of her book, The Year of Magical Thinking, that, “the reason I had to write it down, is that no one had ever told me what it was like.” She was trying to make sense of her grief following the death of her husband, and in doing so, wrote a piece of creative nonfiction (CNF) that explores her own life in and around the larger ideas of mourning, connection, and moving forward. This is the ultimate aim of creative nonfiction: writing to make sense of our lives in relation to the world around us. In this …


Gene Editing And The Accessibility Of Bioterrorism: Rethinking Global Biosecurity In The Post-Covid-19 Era, Nicholas Morales Jan 2026

Gene Editing And The Accessibility Of Bioterrorism: Rethinking Global Biosecurity In The Post-Covid-19 Era, Nicholas Morales

Graduate Theses/Dissertations

COVID‑19 demonstrated how a single biological event can strain health systems, disrupt supply chains, undermine national security, and erode public trust. This shock occurred as biotechnology became dramatically more accessible: gene editing and synthetic biology tools once limited to specialized laboratories are now widely available through inexpensive equipment, open‑source data, and decentralized expertise.

This expanded access accelerates innovation but also broadens the threat landscape. The ability to reconstruct pathogens using publicly available sequences and mail‑order DNA shows that complex biological synthesis is no longer confined to state programs. These risks are amplified by opaque biotechnology activities in China, Russia, and …


When Speech Speaks Louder Than Truth: Language Variation And Credibility In The Courtroom, Melanie E. Spinnie Jan 2026

When Speech Speaks Louder Than Truth: Language Variation And Credibility In The Courtroom, Melanie E. Spinnie

Graduate Theses/Dissertations

This study aims to investigate how linguistic variation affects perceptions of credibility in courtroom settings. It focuses on how jurors, judges, and other individuals in the legal system may exhibit bias (consciously or unconsciously) based on how a defendant or witness speaks-- this could include speech disorders as well as differences in dialect, accent, and speech style. Through review of relevant literature, review of a relevant historical case, conducting a survey, and conducting a semi-structured interview, this study explores whether certain speech patterns or characteristics are disproportionately associated with negative judgments during legal proceedings, such as reduced credibility and trustworthiness. …


Spatial Patterns And Morphometric Evolution Of Sinkholes In Response To Watershed Hydrogeomorphology: Examples From A Karst Landscape In The Missouri Ozarks, Usa, Marcell Tóth Jan 2026

Spatial Patterns And Morphometric Evolution Of Sinkholes In Response To Watershed Hydrogeomorphology: Examples From A Karst Landscape In The Missouri Ozarks, Usa, Marcell Tóth

Graduate Theses/Dissertations

Sinkholes are characteristic enclosed depressions with internal drainage connecting the surface and subsurface karst hydrologic system. Their morphological evolution involves gradual subsidence of the ground surface and hazardous collapses. Therefore, understanding sinkhole morphometry and linked spatial distribution is critical for managing geohazards in karst watersheds. Sinkhole occurrence shows spatial variability based on watershed geomorphological attributes, surficial hydrological patterns, hydrogeological and geological settings. The aim of this research is to investigate morphometric properties and distribution of sinkholes in the carbonate karst-dominated lands of Mark Twain National Forest in Missouri, USA. The specific objectives were to (1) identify sinkhole clusters based on …


Confucian Thought As A Strategic Veil: How Western Strategy Should Correctly Compete With China, Owen Miller Jan 2026

Confucian Thought As A Strategic Veil: How Western Strategy Should Correctly Compete With China, Owen Miller

Graduate Theses/Dissertations

The rise of the People's Republic of China as a peer competitor to the United States constitutes the defining geopolitical challenge of the twenty-first century, but even so, Western strategic analysis has consistently failed to engage China on its own terms. The recurrent pattern of Western misinterpretation results from projecting Western assumptions onto a state whose institutional and cultural drivers operate under fundamentally different premises, where key elements of Chinese strategic culture and the Chinese Communist Party’s (CCP) instrumentalization of Confucianism as a moral veil are instruments of domestic legitimacy and external strategic narrative. The United States must recognize that …


Europe In The Indo-Pacific - Implications For The United States, Joshua G. Zinicola Jan 2026

Europe In The Indo-Pacific - Implications For The United States, Joshua G. Zinicola

Graduate Theses/Dissertations

Within the last five years the Indo-Pacific has become a region of increasing interest to European NATO members. In particular, the United Kingdom, France, and Italy have assigned strategic importance for their national security to the region, signing cooperative agreements with regional allies of the United States and deploying significant forces to the region. These agreements include commitments to jointly develop new technologies and combat systems for employment in both Europe and the Indo-Pacific, such as the Global Combat Air Programme (GCAP), and the Trilateral security partnership between Australia, the United Kingdom, and the United States (AUKUS). They also include …


A Geospatial Assessment Of Groundwater Salinization In A Multi-Aquifer System: Durango, Mexico, Juan Lopez-Sierra Jan 2026

A Geospatial Assessment Of Groundwater Salinization In A Multi-Aquifer System: Durango, Mexico, Juan Lopez-Sierra

Graduate Theses/Dissertations

Groundwater salinization poses a critical environmental concern for water resource sustainability in arid and semi-arid regions. This study evaluates spatial and temporal patterns of groundwater salinity across the state of Durango, Mexico, using total dissolved solids (TDS), sodium adsorption ratio (SAR), as salinity indicators and nitrate-nitrogen (NO₃–N) as an anthropogenic indicator. Groundwater quality data were obtained from (CONAGUA), a Mexican water agency. To assess salinity variations with respect to time, while minimizing interannual sampling bias, two multi-year sampling periods were selected: 2012-2013, and 2020-2021. Final datasets consisted of 122 wells for 2012–2013 and 131 wells for 2020–2021. The wells were …


The Room That Remembers: A Sanctuary Built From Silence, Kayla Brown Jan 2026

The Room That Remembers: A Sanctuary Built From Silence, Kayla Brown

Graduate Theses/Dissertations

This installation is a process-based paper artwork that seeks to protect, enlighten, and discover what healing can be in silence. Through the creation of immersive art objects and experiences, I seek understanding and resolutions for my lived experiences. I utilize the physicality of paper in conjunction with the fragility of topic to enhance the meaning behind my material choices. I transform the idea of a traumatic room into an activated space of healing: one that rest, time, and momentary silence exist as choice rather than by force.


Twelve Preludes, Sarah Miller-Ross Jan 2026

Twelve Preludes, Sarah Miller-Ross

Graduate Theses/Dissertations

This set of 12 Preludes for solo piano draws inspiration from Chopin’s set of 24 Preludes for the same instrument, along with ideas from other composers and various genres to create a varied set in which each piece is centered around a note of the 12-note chromatic scale. The movements are titled based on the material that inspired them, the effect they create, or the special technique or limitation they used. A brief overview of inspirational material will be discussed, then each movement will be described through the lens of their compositional processes.


31p Solution Nmr Investigation Of Abasic Dna, Clarissa R. Krimmel Jan 2026

31p Solution Nmr Investigation Of Abasic Dna, Clarissa R. Krimmel

Graduate Theses/Dissertations

Base excision repair (BER) mechanisms fix single base lesions in DNA, such as T:G mismatches. During the base excision repair mechanism, an abasic site (AP site) is formed as an intermediate. AP sites are unstable and highly mutagenic; they can stop DNA replication. This research investigates how the conformational properties of abasic sites in DNA affect the binding recognition of enzymes involved in DNA repair mechanisms, including BER. Three different abasic sequences are being analyzed for this research project. A second project looks at the effects of a naturally occurring purine derivative, hypoxanthine, on the DNA backbone. These hypoxanthine lesions …


Corpus Meum, Mea Electio, Kara L. Coonrod Jan 2026

Corpus Meum, Mea Electio, Kara L. Coonrod

Graduate Theses/Dissertations

The right to bodily autonomy and reproductive freedom is something I hold very close to my heart. Women who did not wish to embrace motherhood, or who grew beyond the walls of the hearth and home, have been far more often persecuted than praised. Over the past two years, I have created artwork borrowing the visual and material language of the Catholic church (along with personally relevant folklore) to elevate my freedom of choice and bodily autonomy in the face of religiously driven political oppression. Using a less frequently referenced organ from my reproductive system to represent my struggle against …


The United States' Nuclear Deterrent Outlook: Strategies, Challenges, And Future Prospects, Jonathon L. Beening Jan 2026

The United States' Nuclear Deterrent Outlook: Strategies, Challenges, And Future Prospects, Jonathon L. Beening

Graduate Theses/Dissertations

This study contends that the United States cannot sustain a credible nuclear deterrent through the mid-21st century without modernizing its aging nuclear arsenal and revising its nuclear doctrine to address emerging technological, geopolitical, and strategic threats posed by both near-peer adversaries and non-state actors. Through an examination of deterrence theory, historical developments, current force posture, modernization initiatives, doctrinal debates, counterarguments, and prospective geopolitical scenarios, this research assesses the adequacy of existing policies in maintaining strategic stability. The analysis concludes that credible deterrence in the coming decades will require integrated modernization, doctrinal clarity, and strategic adaptability to face any future threat …


Herp Count 2025, Camryn Gulledge Jan 2026

Herp Count 2025, Camryn Gulledge

Graduate Theses/Dissertations

Herp Count 2025 is a process-based project in which I log and document every herp (reptile or amphibian) I encounter in the wild while investigating the realities of human impact on ecosystems. During 2025, I observed 1,406 individual herps, most of which appeared not in remote wilderness but in the compromised margins of human spaces. When I observe them in a littered area, I collect nearby trash and bring it back to my studio to combine it with a detailed drawing of that specific individual. In my Contact series, I use a clean-touch printmaking process that involves a stretched plastic …


Remediation Impacts Metal Concentrations And Metal Tolerant Bacteria In Soils Of The Missouri Tri-State Mining District, Ophelia R. Pettington Jan 2026

Remediation Impacts Metal Concentrations And Metal Tolerant Bacteria In Soils Of The Missouri Tri-State Mining District, Ophelia R. Pettington

Graduate Theses/Dissertations

After over 100 years of Zn and Pb mining in the Tri-State mining district (TSMD), former mines continue to be sources of metals. Metal contaminated soils can be remediated using plant-microbe interactions. Plants manipulate their microbiome and recruit microbes to increase metal tolerance. Remediating bacteria are site-specific and identifying native microbes can accelerate remediation efforts. Studies relating microbes and metal concentrations in remediated areas in the TSMD are scarce. I collected root and bulk zone soils associated with Andropogon virginicus from remediated and non-remediated sites in Webb City, MO. I used 16S rRNA gene amplicon sequencing to evaluate the bacterial …


Heterogeneous Robots Cooperation Via Multi-Agent Reinforcement Learning, Rehab Uddin Shawon Jan 2026

Heterogeneous Robots Cooperation Via Multi-Agent Reinforcement Learning, Rehab Uddin Shawon

Graduate Theses/Dissertations

Enabling heterogeneous robots with diverse capabilities, roles, and task responsibilities to coordinate effectively in complex, dynamic environments remains a fundamental challenge in autonomous multi-robot systems. Multi-Agent Reinforcement Learning (MARL) provides a promising framework for decentralized cooperation. However, most existing MARL approaches assume homogeneous agents or fixed single-task settings and suffer significant performance degradation as the number of robot and task types increases. This thesis presents a scalable shared-policy MARL framework that allows heterogeneous robots to learn specialized behaviors for individual, sequential, and collaborative tasks involving temporal and spatial dependencies through a single neural policy. I first embed robot identity directly …


Climate Change In Gilgit-Baltistan: Satellite-Based Land Use/Land Cover Change Detection, Socio-Economic Dimensions, And Adaptation Strategies, Ali Muhammad Jan 2026

Climate Change In Gilgit-Baltistan: Satellite-Based Land Use/Land Cover Change Detection, Socio-Economic Dimensions, And Adaptation Strategies, Ali Muhammad

Graduate Theses/Dissertations

Climate change is increasingly transforming the cryosphere, hydrology, and human landscape of Gilgit-Baltistan, a highly climate-sensitive mountain region in northern Pakistan. This thesis investigates these transformations through satellite-based land use/land cover (LULC) change detection in four representative tehsils of Gilgit-Baltistan—Ali Abad, Gilgit, Nagar, and Sikander Abad—selected to span a gradient of human pressure and cryospheric exposure within the region. Using summer, cloud-free (< 10%) imagery from USGS Landsat 7 (2000) and Landsat 8 (2025), it conducts a multi-temporal comparison of environmental and socio-spatial change. After atmospheric correction and band compositing, the imagery is classified in ArcGIS Pro into six classes—Water, Barren land, Vegetation, Snow, Glacier, and Built-up—using a Support Vector Machine (SVM) classifier, with Maximum Likelihood Classification and Random Forest also tested but found less suitable for the final workflow. The analysis detects a pronounced reduction in mapped glacier-class area alongside a comparatively stable snow class, together with built-up expansion, while examining how temperature, precipitation, tourism, and population dynamics relate to observed LULC transitions. The results reveal a pattern of cryospheric decline and urban growth, with implications for water availability, ecological stability, hazard exposure, and settlement pressure. By integrating geospatial change detection with climatic and socio-economic interpretation, the thesis moves beyond mapping to explain interacting environmental and human drivers of landscape transformation and provides a reproducible remote-sensing baseline for monitoring land-surface change in heterogeneous mountainous terrain. It recommends integrated water-resource management, climate-resilient land-use planning, watershed and glacier monitoring, and sustainable tourism governance, supporting evidence-based decision-making by the Government of Gilgit-Baltistan and organizations working on climate adaptation, disaster risk reduction, and sustainable regional development.


Advancing Hate Speech Detection: Binary And Multiclass Approaches From Traditional Methods To Parameter-Efficient And Ontology-Guided Language Models, Mahmoud Abusaqer Jan 2026

Advancing Hate Speech Detection: Binary And Multiclass Approaches From Traditional Methods To Parameter-Efficient And Ontology-Guided Language Models, Mahmoud Abusaqer

Graduate Theses/Dissertations

The widespread proliferation of hate speech on social media platforms poses significant challenges for content moderation and user safety, requiring automated systems that are simultaneously accurate, efficient, and capable of fine-grained distinctions. This thesis investigates hate speech detection through five published manuscripts organized into two complementary threads: binary detection (hateful vs. non-hateful) and multiclass detection across demographic targeting categories. The binary thread progresses from a broad 38-model baseline spanning traditional machine learning, deep learning, and transformer architectures (where RoBERTa reaches 91.48% accuracy and CatBoost remains competitive at 88.60%) to parameter-efficient adaptation, in which Low-Rank Adaptation (LoRA) of large language models …


Synthesis And Characterization Of The New G3 Family Of Organoantimony(V) Cyanoximates, Thao Trang Phan Jan 2026

Synthesis And Characterization Of The New G3 Family Of Organoantimony(V) Cyanoximates, Thao Trang Phan

Graduate Theses/Dissertations

Bacterial infections pose a serious threat to humans by developing resistance, rendering antibiotics ineffective. Of the 12 antibiotics recently approved since 2017, 10 belong to an already existing class. Various resistance mechanisms, such as reduced drug uptake, active efflux, drug inactivation, and target modification, can significantly reduce the efficacy of entire classes of antibiotics. Discovering novel strategies to overcome diverse mechanisms of resistance and improve therapeutic efficacy is in high demand. Inorganic compounds with organic ligands (both complexes and organometallics) represent a new class of compounds against which antimicrobial resistance has not yet been established. Recently, we discovered two series …


Strict Scrutiny And The Viewpoint Continuum, A.G. Harmon Jan 2026

Strict Scrutiny And The Viewpoint Continuum, A.G. Harmon

Scholarly Articles

Consider the following instances: A cell phone photograph picturing a man's left kneecap. A statement that the speaker thinks, "The name Josiah is really cool." A woman who runs her bicycle over a business owner in order to gain celebrity and increase attention for her new podcast. An intentional lie told to acquire a job. A student who insists on answering his math exam questions in runic symbols.

At one point or another, American courts have considered the merits found in favor of instances similar to these and other like circumstances as amounting to "viewpoints." As such, they …


The Constitutional Significance Of The First American Pope: The Promise Of Listening In An Era Of Mutual Suspicion, Derek A. Webb Jan 2026

The Constitutional Significance Of The First American Pope: The Promise Of Listening In An Era Of Mutual Suspicion, Derek A. Webb

Scholarly Articles

Pope Leo XIV has focused a good deal of writing and speaking in the first year of his pontificate on the theme of listening, dialogue, and bridgebuilding. For Leo, listening, dialogue, and creating harmony across diverse perspectives where possible are at the heart of the Christian life. But his reflections on these themes, while rooted in theology, are aimed at a wider audience, going well beyond the church community, and addressing philosophical issues of universal human concern. Indeed, the first American pope happens to be highlighting certain ideals regarding dialogue that, while perhaps forgotten today, are central to the American …


Engineering Broiler Efficiency Through Modern Infrastructure Design And Precision Control, Chris Travers Jan 2026

Engineering Broiler Efficiency Through Modern Infrastructure Design And Precision Control, Chris Travers

Proceedings of the Arkansas Nutrition Conference

These proceedings describe a modern, innovative broiler site in South Africa constructed with the following objectives in mind: Scale, Energy Efficiency, Precision Environmental Control with AI Integration, and Off-Grid Power Autonomy.


Guide To: Conferences. Brigham-Kanner Property Rights Conference, Wolf Law Library Archives Jan 2026

Guide To: Conferences. Brigham-Kanner Property Rights Conference, Wolf Law Library Archives

Collection Guides & Finding Aids

No abstract provided.


Attenuation Of Cardiac Dysfunction In The Collagen-Induced Arthritis Mouse Model Mediated By A Reactive Aldehyde Species Inhibitor, Wenxian Zhou, Hannah J. Johnson, Michael J. Duryee, Ali Namvaran, Aradhana Thapa, Cole Blasing, Amy J. Nelson, Engle E. Sharp, Carlos D. Hunter, Bryan T. Hackfort, Bryant England, Tate M. Johnson, Daniel R. Anderson, Adam Lazorchak, Robert G. Bennett, Jill A. Poole, Keshoer R. Bidasee, Geoffrey M. Thiele, Ted R. Mikuls Jan 2026

Attenuation Of Cardiac Dysfunction In The Collagen-Induced Arthritis Mouse Model Mediated By A Reactive Aldehyde Species Inhibitor, Wenxian Zhou, Hannah J. Johnson, Michael J. Duryee, Ali Namvaran, Aradhana Thapa, Cole Blasing, Amy J. Nelson, Engle E. Sharp, Carlos D. Hunter, Bryan T. Hackfort, Bryant England, Tate M. Johnson, Daniel R. Anderson, Adam Lazorchak, Robert G. Bennett, Jill A. Poole, Keshoer R. Bidasee, Geoffrey M. Thiele, Ted R. Mikuls

Journal Articles: Cellular & Integrative Physiology

Individuals with rheumatoid arthritis (RA) experience increased risk of heart failure. Malondialdehyde-acetaldehyde (MAA) adducts are overexpressed and co-localize with citrullinated (CIT) proteins in RA myocardium. This study investigated whether reactive aldehyde species (RASP) inhibitors prevent MAA formation in vitro and attenuate cardiac dysfunction in a collagen-induced arthritis (CIA) mouse model. Among eight RASP inhibitors screened, ADX-246 demonstrated the greatest inhibition of MAA formation in vitro. Mice with early CIA (week 5) exhibited elevated levels of myocardial MAA adducts, myocardial inflammation, and reduced ejection fraction, but normal cardiac collagen deposition and diastolic function vs. control. By weeks 10-12, mice with chronic …