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Who’S In Charge Here?: Collegiate Athletics After The House Settlement, Pamela Ko Jan 2026

Who’S In Charge Here?: Collegiate Athletics After The House Settlement, Pamela Ko

Touro Law Review

The House v. NCAA settlement, which was approved in June 2025, paved the way for groundbreaking changes to the National Collegiate Athletic Association (NCAA) and the implementation of its rules and regulations related to athlete rights, including transformative levels and types of student-athlete compensation that have never been permitted in the history of college sports. These changes fundamentally altered the relationship between many Division I student-athletes, educational institutions, athletic conferences, and the NCAA. This Article will discuss both the short and long-term impacts of the House settlement while analyzing both the continuing role of the NCAA and the role of …


Fourth Amendment Rights In The Age Of Automated License Plate Recognition Cameras, Jessica L. Terkovich Jan 2026

Fourth Amendment Rights In The Age Of Automated License Plate Recognition Cameras, Jessica L. Terkovich

Touro Law Review

Law enforcement technology has evolved to the point of being ever-present, especially in the form of automated license plate recognition cameras. This Article analyzes recent Fourth Amendment challenges to automated license plate recognition camera systems and developments in the technological landscape in the wake of seminal cases discussing the changing expectations of privacy as law enforcement technology evolves. The Article concludes that, as is, automated license plate recognition camera systems are not unconstitutional dragnets and do not perform warrantless searches, though they have potential to raise constitutional issues in the future.


Bi-Level Optimization Of Peer-To-Peer Trading In A Decentralized Energy Market, Marshal Miezah Jan 2026

Bi-Level Optimization Of Peer-To-Peer Trading In A Decentralized Energy Market, Marshal Miezah

Graduate Theses, Dissertations, and Problem Reports (ETD)

Distributed power generation based on rooftop photovoltaic (PV) systems integrated with battery storage emerges as a promising pathway for reducing greenhouse gas emissions and im- proving flexibility in modern power systems. This study develops a bi-level optimization model to examine how prosumers maximize profit through peer-to-peer (P2P) energy trading with consumers and the grid, and how consumers minimize cost by leveraging P2P trading. The bi-level problem is reformulated as a single-level mixed-integer programming (MIP) model using Karush- Kuhn-Tucker (KKT) conditions to improve tractability and preserve market-clearing behavior. For the model validation and case study development, prosumer and consumer data are …


How Regulatory Focus Shapes Adjustment And Performance In The Return-To-Office Era: The Roles Of Change Appraisal, Perceived Organizational Support, And Psychological Safety, Karen Jean Morris Jan 2026

How Regulatory Focus Shapes Adjustment And Performance In The Return-To-Office Era: The Roles Of Change Appraisal, Perceived Organizational Support, And Psychological Safety, Karen Jean Morris

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

The COVID-19 pandemic has significantly transformed workplace norms and employee expectations, marking a notable shift towards remote work. As organizations increasingly encourage a return to physical offices, understanding employee adaptation during this transition has become essential. This dissertation leverages Regulatory Focus Theory to explore how employees' promotion and prevention focus influences their adjustment and performance upon re-entering traditional office settings.

A parallel mediation model is proposed, in which Change Appraisal, Perceived Organizational Support (POS), and Psychological Safety (PS) are identified as key mechanisms linking regulatory focus to employee outcomes. The findings may provide evidence that individuals who exhibit a …


Ai-Assisted Wheat Spike And Spikelet Detection And Density Mapping Using Multiscale Remote Sensing Data To Support Wheat Grain Yield Forecasting, Hillson Ghimire Jan 2026

Ai-Assisted Wheat Spike And Spikelet Detection And Density Mapping Using Multiscale Remote Sensing Data To Support Wheat Grain Yield Forecasting, Hillson Ghimire

Electronic Theses and Dissertations

Wheat grain yield is determined by the number of spikes per unit area, the number of grains per spike, and kernel weight. However, spike number and spikelets per spike are still measured predominantly through manual counting, a labor-intensive and subjective process that limits phenotyping throughput and selection intensity in modern wheat breeding programs. This thesis develops and evaluates a deep learning framework for automated, high-throughput phenotyping of wheat spike and spikelet traits across complementary imaging scales and implements the framework as a deployable platform. First, two large-scale benchmark datasets with oriented bounding box (OBB) annotations were established, comprising 48,521 spike …


A Wellness Approach To Aging, Retirement, And Suicide Risk: Gerontological Considerations, Seth T. Robinson, Derek J. Lee Jan 2026

A Wellness Approach To Aging, Retirement, And Suicide Risk: Gerontological Considerations, Seth T. Robinson, Derek J. Lee

Adultspan Journal

Suicide risk in older adulthood represents complex interactions between developmental transitions; changing social contexts; and interactions between ecological context and individual perceptions of belongingness, burdensomeness, and hope. This paper presents an integrative,developmentally appropriate framework for conceptualizing and addressing suicide risk in older adulthood, which is grounded in the Indivisible Self model of wellness. Drawing on current empirical knowledge of wellness, suicidality, and older adulthood, this paper presents risk and protective factors associated with older adulthood through life transitions, changing social contexts, and other relevant factors. We present a novel integration of suicide intervention, wellness, and holistic care as a suitable …


Retirement As A Psychosocial Transition: A Social Determinants Of Mental Health Framework For Counseling Practice, Janelle L. Jones, Lauren Robins, Melanie Calhoun, Aaliyah Bond-Richardson, Latesha S. Holloman, Zoe N. Stuckey Jan 2026

Retirement As A Psychosocial Transition: A Social Determinants Of Mental Health Framework For Counseling Practice, Janelle L. Jones, Lauren Robins, Melanie Calhoun, Aaliyah Bond-Richardson, Latesha S. Holloman, Zoe N. Stuckey

Adultspan Journal

Retirement is commonly framed as a normative and voluntary developmental milestone; however, access to a psychologically healthy retirement is unevenly shaped by social, economic, and structural conditions. This conceptual article applies a social determinants of mental health (SDMH) framework to retirement, conceptualizing it as a complex psychosocial transition involving identity change, shifts in purpose and meaning, relational adjustment, and emotional variability. Drawing on interdisciplinary scholarship, the manuscript examines how socioeconomic status, race and ethnicity, gendered work histories, caregiving responsibilities, health status, and access to benefits influence both the ability to retire and the experience of retirement itself. Particular attention is …


Evaluating Supplementation Strategies Using Precision Livestock Technologies And Energy Based Models In Developing Beef Heifers Grazing Dormant Rangeland, Kali-Jo Bentz Jan 2026

Evaluating Supplementation Strategies Using Precision Livestock Technologies And Energy Based Models In Developing Beef Heifers Grazing Dormant Rangeland, Kali-Jo Bentz

Electronic Theses and Dissertations

Replacement beef heifer development in extensive grazing systems is challenged by variation in forage quality, supplement intake, and animal behavior, all of which influence the ability to achieve targeted growth prior to breeding. Precision livestock technologies (PLT) enable continuous monitoring of individual animal performance, while energy-based nutritional models support individualized supplementation. However, their application under extensive grazing conditions remains poorly understood. Therefore, the objectives of this thesis were to (1) evaluate heifer utilization of multiple precision livestock technologies and their relationship with animal performance and (2) evaluate the accuracy of an individualized energy-based supplementation model by comparing predicted supplement allotments …


Assessing The Scope Of Knowledge And Decision-Making Patterns Regarding Healthy Eating During Pregnancy In Pregnant Female Adults In Southern California, Raegan Soffel Jan 2026

Assessing The Scope Of Knowledge And Decision-Making Patterns Regarding Healthy Eating During Pregnancy In Pregnant Female Adults In Southern California, Raegan Soffel

Loma Linda University Research Reports

While recognizing the link between prenatal nutrition and maternal-fetal health, this investigator-initiated study seeks to identify pregnant women's understanding of prenatal nutrition guidelines and the influences on their dietary choices. Thirty-eight eligible women completed an online, anonymous surveying assessing the scope of knowledge and decision-making patterns of healthy eating during pregnancy. The average knowledge score among the participants was 6.05/14. There was no significant difference in the knowledge scores among pregnancy periods or among total number of pregnancies. Perceptions of nutrition guidance in prenatal care, factors influencing eating behaviors, and primary sources of nutrition information were explored. The findings may …


Comparing Perceived Ideal Protein Intake In Plant-Based Versus Meat-Based Diet Consumers, Gysel Avendano, Saya Iwanaga Jan 2026

Comparing Perceived Ideal Protein Intake In Plant-Based Versus Meat-Based Diet Consumers, Gysel Avendano, Saya Iwanaga

Loma Linda University Research Reports

High-protein diets have gained significant popularity in both social media and public discussion and more recently, a significant rise in protein consumption has been observed. Existing research has reported differences in actual protein intake across dietary patterns, with animal-based diets generally associated with higher total protein intake compared to plant-based diets. This growing focus on protein raises important questions about perceived ideal protein intake and the factors that shape it.

The primary objective is to compare perceived ideal protein intake among Southern California adults consuming meat-based versus plant-based diets. Additionally, we explored the influence of protein-related knowledge, beliefs, values, information …


Concerted Proton Transfer In Homogeneous And Heterogeneous Cyclic Hydrogen-Bonded Clusters Of H2o, Hf, And Hcl, Max R. Tucker, Yuan Xue, Nathan R. Speake, Eden Nickolson, Jeremy M. Carr, Gregory S. Tschumper Jan 2026

Concerted Proton Transfer In Homogeneous And Heterogeneous Cyclic Hydrogen-Bonded Clusters Of H2o, Hf, And Hcl, Max R. Tucker, Yuan Xue, Nathan R. Speake, Eden Nickolson, Jeremy M. Carr, Gregory S. Tschumper

Chemistry Faculty Research & Creative Works

This work examines various homogeneous and heterogeneous clusters of hydrogen-bonded (HF)x(H2O)y(HCl)z complexes, where x + y + z = 3 or 4. For each unique cyclic structure associated with the xyz permutations, the geometries of the reactant, product, and transition state (TS) for concerted proton transfer (CPT) were fully optimized using second-order Møller-Plesset perturbation theory (MP2) with a mixed basis set consisting of cc-pVTZ for H atoms and aug-cc-pVTZ for O, Cl, and F atoms (denoted haTZ). Harmonic vibrational frequencies were also computed at the same level of theory to verify the nature of the stationary points. Intrinsic …


Smart Cities Beyond Methodological Cityism: Foregrounding Developmentalism, Scalar Flexing And The Rebranding Of The 'Urban', Prerona Das, Orlando Woods, Lily Kong Jan 2026

Smart Cities Beyond Methodological Cityism: Foregrounding Developmentalism, Scalar Flexing And The Rebranding Of The 'Urban', Prerona Das, Orlando Woods, Lily Kong

Research Collection College of Integrative Studies

In this paper we show that in Southeast Asia, smart city development has become a type of digital urban transformation that is not targeted towards any particular territorial formation or settlement. Instead, development-oriented states in the region leverage the smart city rhetoric as a nationwide branding strategy to leapfrog development stages. Such smart city policies are infused with a scalar logic – which we call ‘scalar flexing’ – that captures the enmeshing of local and national scales, causing local scale smart city initiatives to be stretched across wide-ranging, national-scale urban transformation agendas. We examine the nationwide 100 smart cities policies …


How Do You Fix Knowledge In Place? Digital Nomads And Infrastructural Stickiness, Emma Grimley, Prerona Das, Orlando Woods, Lily Kong Jan 2026

How Do You Fix Knowledge In Place? Digital Nomads And Infrastructural Stickiness, Emma Grimley, Prerona Das, Orlando Woods, Lily Kong

Research Collection College of Integrative Studies

Remote work has become increasingly accessible due to the growing acceptance of remote work arrangements following the COVID-19 pandemic. Some state actors, especially in countries which face a shortage of digital talent and have reputations as leisure-tourism destinations, have begun considering the opportunities for digital transformation or workforce upskilling that highly skilled remote workers may offer. This paper develops the case of remote workers in Thailand to argue that infrastructural stickiness is a critical determinant for effective knowledge transfer to occur. By infrastructural stickiness we refer to the regulatory and socio-material infrastructures that both attract and retain international remote workers …


Multidimensional Analysis Of Human Outdoor Comfort: Integrating Just-In-Time Adaptive Interventions (Jitais) In Urban Digital Twins, Binyu Lei, Pengyuan Liu, Kunihiko Fujiwara, Mario Frei, Clayton Miller, Xuan Yun Chua, Filip Biljecki Jan 2026

Multidimensional Analysis Of Human Outdoor Comfort: Integrating Just-In-Time Adaptive Interventions (Jitais) In Urban Digital Twins, Binyu Lei, Pengyuan Liu, Kunihiko Fujiwara, Mario Frei, Clayton Miller, Xuan Yun Chua, Filip Biljecki

Research Collection College of Integrative Studies

How can bidirectional information exchange be enhanced in urban digital twins, and support human-centric data and processes? Their key characteristic is the nearly real-time exchange of information, allowing adjustments to physical environments based on simulations and analytics within virtual models. Yet, achieving such interaction remains challenging, particularly regarding device deployment and infrastructure development. Embracing the concept of humans as sensors, this work develops a two-way framework based on the emerging concept of just-in-time adaptive interventions (JITAIs), exploring how urban digital twins can play a role in understanding and enhancing human comfort outdoors. Human comfort outdoors is inherently spatio-temporal and personalised, …


An Ex-Post Analysis Framework For Assessing The Effectiveness And Driving Factors Of Green Building Certification Adoption: A Case Study Of Singapore, Hao Gu, Xiaoyu Jin, Fu Xiao, Maomao Hu, Clayton Miller Jan 2026

An Ex-Post Analysis Framework For Assessing The Effectiveness And Driving Factors Of Green Building Certification Adoption: A Case Study Of Singapore, Hao Gu, Xiaoyu Jin, Fu Xiao, Maomao Hu, Clayton Miller

Research Collection College of Integrative Studies

Cities worldwide are adopting green building certification policies to meet sustainability and decarbonization targets in the building sector. However, the effectiveness of green certifications remains contested due to the difficulty of decomposing multiple influencing factors on building energy consumption. This study proposes an econometrics-based ex-post analysis framework to assess the effectiveness of green building certification policies in energy savings and identify driving factors by decomposing multiple influential factors. The proposed framework incorporates time-fixed effect models to examine factors driving the adoption of green building certifications, and causality analysis to quantify the effectiveness. Applying the framework to analyze a panel dataset …


Trust-Aware Algorithms For Stackelberg Ground Vehicle Routing, Doris Evelyn Meredith Brown Jan 2026

Trust-Aware Algorithms For Stackelberg Ground Vehicle Routing, Doris Evelyn Meredith Brown

Doctoral Dissertations

Despite decades of research focused on reducing ground vehicle traffic congestion, urban traffic networks worldwide continue to experience traffic flows that lead to increased network travel times, largely resulting from the routing decisions of individual vehicles. To address this challenge, this work leverages a Stackelberg game framework to model the interaction between a vehicle agent and a routing authority as a leader–follower game, in which the routing authority proposes routing interventions to which the agent responds. This research contributes to existing traffic mitigation literature by exploring the role of trust in route decision-making and providing trust-aware algorithms that influence vehicle …


Leveraging Artificial Intelligence In Microfinance In The Global South: Regulatory Insights Into Ai-Based Credit Underwriting, Ruth Plato-Shinar Jan 2026

Leveraging Artificial Intelligence In Microfinance In The Global South: Regulatory Insights Into Ai-Based Credit Underwriting, Ruth Plato-Shinar

Fordham International Law Journal

Microfinance has emerged as a key financial inclusion tool aimed at underserved populations, mainly in the Global South. However, it continues to face persistent structural challenges, particularly high operational costs, limited scalability, and mixed outcomes in poverty alleviation. Against this backdrop, this Article explores the integration of artificial intelligence (AI) into microfinance in the Global South, focusing on the use of machine learning for data-driven credit underwriting, which presents both a transformative opportunity and a profound regulatory challenge.

AI promises to enhance efficiency, accuracy, scalability, and financial inclusion, particularly through the use of alternative, non-financial data. At the same time, …


Due Diligence In Global Supply Chains: The Troubled Journey Of The Eu Legislation And The Global Perspective, Fabrizio Cafaggi, Federico Pistelli Jan 2026

Due Diligence In Global Supply Chains: The Troubled Journey Of The Eu Legislation And The Global Perspective, Fabrizio Cafaggi, Federico Pistelli

Fordham International Law Journal

No abstract provided.


Encryption And Globalization 15 Years Later: End-To-End Encryption And The Third Round Of The "Going Dark" Debate, Peter Swire, Kenesa Ahmad, Michael Specter Jan 2026

Encryption And Globalization 15 Years Later: End-To-End Encryption And The Third Round Of The "Going Dark" Debate, Peter Swire, Kenesa Ahmad, Michael Specter

Fordham International Law Journal

No abstract provided.


Considering Humanity: How The Martens Clause Implies A Legal Obligation To Conduct Risk Analysis In Decisions Regarding The Actual Or Threatened Use Of Nuclear Weapons, Emily Jones Jan 2026

Considering Humanity: How The Martens Clause Implies A Legal Obligation To Conduct Risk Analysis In Decisions Regarding The Actual Or Threatened Use Of Nuclear Weapons, Emily Jones

Fordham International Law Journal

No abstract provided.


Inadequate Control: International Law And Principles Applicable To Address Nuclear Weapon Security, Chloe Scaglione Radtke Jan 2026

Inadequate Control: International Law And Principles Applicable To Address Nuclear Weapon Security, Chloe Scaglione Radtke

Fordham International Law Journal

No abstract provided.


Ex Ante, Ex Post, Or A Combo Of Both? A Comparative Analysis Of Biometric Artificial Intelligence Across The Atlantic & The Self-Regulatory Solution, Ariana Tagavi Jan 2026

Ex Ante, Ex Post, Or A Combo Of Both? A Comparative Analysis Of Biometric Artificial Intelligence Across The Atlantic & The Self-Regulatory Solution, Ariana Tagavi

Fordham International Law Journal

No abstract provided.


Give The Penguins Their Freedom: The Case For Antarctic Independence, Scott L. Warner-Hudson Jan 2026

Give The Penguins Their Freedom: The Case For Antarctic Independence, Scott L. Warner-Hudson

Fordham International Law Journal

No abstract provided.


Solving High-Dimensional Differential Equations Using Recurrent And Residual Neural Network Architectures, Hind Khaled Kolaib Jan 2026

Solving High-Dimensional Differential Equations Using Recurrent And Residual Neural Network Architectures, Hind Khaled Kolaib

Knowledge Engineering and Data Science

High-dimensional Partial Differential Equations (PDEs) form the foundation of complex process modeling in various scientific and engineering applications, including finance, physics, and optimal control. However, classical numerical methods are adversely affected by the curse of dimensionality, making them inapplicable for large-scale problems. Recently, however, deep learning-based approaches have provided a new toolbox for these high-dimensional PDEs, including methods such as the Deep Backward Stochastic Differential Equation (Deep BSDE) method. Our approach draws on a more sophisticated deep learning backbone, using neural networks (in our case, a Residual Neural Network and a Long Short-Term Memory network (LSTM) integrated into the Deep …


Legal Semiotics, Political Ontology, & Merging Chronotopes Of Identity Through The Federation Of Aboriginal Nations Of The Americas, Kevin T. Inglesby Jan 2026

Legal Semiotics, Political Ontology, & Merging Chronotopes Of Identity Through The Federation Of Aboriginal Nations Of The Americas, Kevin T. Inglesby

Graduate Student Theses, Dissertations, & Professional Papers

This dissertation studies the concept of self-determination related to a confederation known as the Federation of Aboriginal Nations of the Americas. It addresses three main questions: How does FANA represent an institution of legal cooperation? In what ways does cultural capital become reproduced? And what are key principles for the Federations’ code of unity? Self-determination is a core principle of international law and may be identified through treaties and social conventions like Wunnandry. The study explores an interdisciplinary approach to American Indian selfdetermination through a focus on applied anthropology, cultural heritage, and Peircean legal semiotics to problematize some historical approaches …


Volatile Organic Compound Analysis Of Humboldt Penguin (Spheniscus Humboldti) Preen Oil: A Pilot Study, Dante E. Rojas, Mitchell M. Mccartney, Eva Borras, Michael O. Eze, Abigail Pietrow, Jennifer J. Valvo, Cristina E. Davis Jan 2026

Volatile Organic Compound Analysis Of Humboldt Penguin (Spheniscus Humboldti) Preen Oil: A Pilot Study, Dante E. Rojas, Mitchell M. Mccartney, Eva Borras, Michael O. Eze, Abigail Pietrow, Jennifer J. Valvo, Cristina E. Davis

Chemistry Faculty Research & Creative Works

Avian olfaction has gained prominence in recent decades for its roles in social communication and behavior. In penguins, the chemical characterization of preen oil remains limited. In this exploratory study, we characterized the volatile organic compound (VOC) profile of preen oil from Humboldt Penguins (Spheniscus humboldti). Preen oil from 12 captive individuals was analyzed using headspace sorptive extraction (HSSE) coupled to gas chromatography–mass spectrometry (GC–MS). Chemometric analyses examined variation in VOC profiles by sex, age class, and breeding activity. We detected 54 compounds (20 tentatively identified), including linear alcohols, methyl ketones, carboxylic acids, saturated hydrocarbons, oxygenated and nitrogen-containing organics, prenolipids, …


Soft-Chemical Scalable One-Pot Aqueous-Medium Synthesis Of Na3(Vo)2(Po4)2f-Based Cathodes: Compositional Tuning And Electrochemical Performance In Na- And Li-Ion Batteries, Prashanth Sandineni, Subal Chandra Manna, Sutapa Bhattacharya, Santhoshkumar Sundaramoorthy, Ramesh Deokate, Milad Aghayi-Anaraki, George E. Sterbinsky, Kartik Ghosh, Amitava Choudhury Jan 2026

Soft-Chemical Scalable One-Pot Aqueous-Medium Synthesis Of Na3(Vo)2(Po4)2f-Based Cathodes: Compositional Tuning And Electrochemical Performance In Na- And Li-Ion Batteries, Prashanth Sandineni, Subal Chandra Manna, Sutapa Bhattacharya, Santhoshkumar Sundaramoorthy, Ramesh Deokate, Milad Aghayi-Anaraki, George E. Sterbinsky, Kartik Ghosh, Amitava Choudhury

Chemistry Faculty Research & Creative Works

One of the most important cathode materials for Na-ion batteries, Na3(VO)2(PO4)2F, and its compositional variants have been synthesized using four different and facile one-step soft chemical routes. The as-synthesized compounds, Na2.95(VO)2(PO4)2F (I), Na2.93(VO)2(PO4)2F (II), and Na2.58(VO)2(PO4)2F (IV), crystallize in the tetragonal crystal system in the P42/mnm space group, while Na3(VO)2(PO4)2F (III) crystallizes in the orthorhombic crystal system in …


Stop-Falling A Checklist Tool For Fall Prevention In A Long-Term Care Nursing Facility, Latoya Shirley Jan 2026

Stop-Falling A Checklist Tool For Fall Prevention In A Long-Term Care Nursing Facility, Latoya Shirley

Doctor of Nursing Practice (DNP) Practice Innovation Projects

Background: Falls are common among the elderly population. Falls affect not only residents but also staff in long-term care facilities (LTCFs). Approximately one in three individuals aged 65 years or older will have a fall within a year. As the population ages, the incidence of falls continues to rise globally. Falls, overall, have a significant and widespread impact on the overall health and wellbeing of individuals, leading to increased hospitalizations, rehabilitation, reduced quality of life, and increased mortality. 
Evidence Summary: Multifactorial fall prevention programs have proven to be effective in reducing falls when implemented in various settings, such as clinics, …


Differentiation Of Cell Populations In Saliva-Skin Mixtures Using Autofluorescence Profiling, Kara Fairfax Jan 2026

Differentiation Of Cell Populations In Saliva-Skin Mixtures Using Autofluorescence Profiling, Kara Fairfax

Master of Science in Forensic Science Directed Research Projects

While DNA profiling of sexual assault evidence can identify biological contributors, determining the tissue source of recovered profiles remains a significant challenge, particularly in cases of suspected oral assault involving mixtures of epithelial cells. The initial goal of this study was to identify non-genetic signatures for differentiating two types of epithelial cells relevant to oral assaults, saliva epithelial cells and epidermal skin cells. To develop tissue-specific signatures, reference cell populations from saliva and epidermal skin surfaces were collected from 20 donors and analyzed using full spectrum flow cytometry.

Results from single-source reference samples showed that saliva-derived particle populations exhibited higher …


Impact Of Prostate Cancer Tumor Microenvironment On Alternative Splicing Landscapes In Nk Cells: An Lncap-Based In Vitro Model, Pratham N. Modi Jan 2026

Impact Of Prostate Cancer Tumor Microenvironment On Alternative Splicing Landscapes In Nk Cells: An Lncap-Based In Vitro Model, Pratham N. Modi

Honors Undergraduate Theses

NK cells play a significant role in anti-tumor activity, yet the transcriptomic mechanisms underlying NK cell dysfunction in the prostate cancer tumor microenvironment remain generally poorly characterized. While most transcriptomic studies focus on gene-level expression, alternative splicing and isoform-level analysis may reveal additional levels of regulation not identified in traditional analysis. The overall goal of this study was to characterize gene and isoform-level changes in NK cells exposed to in vitro prostate cancer conditions and to evaluate whether isoform-level analysis could provide additional depth and insights beyond gene-level analyses. NK92-MI cells were co-cultured with LNCaP prostate cancer cells using direct-contact …