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Reading Between The Lines: Representations Of Dyslexia In Young Adult Literature, Carli B. Gauvin Jan 2026

Reading Between The Lines: Representations Of Dyslexia In Young Adult Literature, Carli B. Gauvin

Honors Theses and Capstones

While dyslexia affects upwards of 20% of the population, this learning disability is not commonly brought up in young adult literature. This lack of representation negatively impacts those with dyslexia, who often fail to find themselves in the books they read, and readers in general, who are given fewer opportunities to gain insight into the learning disability. Young adult books that do discuss dyslexia can be at risk of portraying the learning disability in an unfavorable light, which can make dyslexic readers feel undervalued in society and can introduce misconceptions about dyslexia to all readers. It is crucial to analyze …


Level Ii Fieldwork Students' Preparedness For Entry-Level Ot Practice Following Role-Emerging Campus-Based Education Center Placements, Julia Walkowiak, Amy Vancamp Jan 2026

Level Ii Fieldwork Students' Preparedness For Entry-Level Ot Practice Following Role-Emerging Campus-Based Education Center Placements, Julia Walkowiak, Amy Vancamp

Honors Theses and Capstones

Fieldwork is a critical component of the occupational therapy (OT) curriculum that provides students hands-on experience in various clinical settings. This allows students to practice evaluations/assessments, plan for sessions, implement interventions, write goals, and complete documentation with clients across the lifespan, integrating classroom knowledge while developing the skills needed to become entry-level practitioners. The purpose of this study was to explore occupational therapy students’ perspectives on Level II fieldwork placements in campus-based childhood centers at the University of New Hampshire and Colorado State University with a focus on their perceived preparedness for entry-level practice. Data was collected through surveys and …


Driving Monitoring Of People With Alzheimer’S Disease And Related Dementia Using Global Positioning System Technology, Julia A. Ferris Jan 2026

Driving Monitoring Of People With Alzheimer’S Disease And Related Dementia Using Global Positioning System Technology, Julia A. Ferris

Honors Theses and Capstones

No abstract provided.


Embracing Anomalous Perceptions: Sensory Anomalies, Social Stigma, And Self-Acceptance, Ty R. Hetrick Jan 2026

Embracing Anomalous Perceptions: Sensory Anomalies, Social Stigma, And Self-Acceptance, Ty R. Hetrick

Honors Theses and Capstones

Anomalous Perceptual Experiences (APEs), which include auditory and visual hallucinations, occur in the general population to varying degrees, but are often stigmatized in media and healthcare settings. However, there is an increasing focus on those who report APEs to be positive and meaningful. This study explored the lived experiences of individuals who report APEs that are interpreted meaningfully. Using a concurrent mixed methods approach, interviews and questionnaires were conducted with 3 adults who identify their APEs as meaningful. Participants described their experiences as sources of guidance, connection, and personal transformation that positively influenced their relationships, spirituality, and daily occupations. They …


Phonetics And Orthography In French: A Proposal For A New Course, Kyara A. Crespo Gutierrez Jan 2026

Phonetics And Orthography In French: A Proposal For A New Course, Kyara A. Crespo Gutierrez

Honors Theses and Capstones

No abstract provided.


Exploring The Mental Health Experiences Of Working Mothers Beyond The Postpartum Period: A Qualitative Study, Katie A. Bennett Jan 2026

Exploring The Mental Health Experiences Of Working Mothers Beyond The Postpartum Period: A Qualitative Study, Katie A. Bennett

Honors Theses and Capstones

Even as symptoms and concerns may persist or intensify with evolving parenting demands, maternal mental health beyond the postpartum period remains under-researched, especially in mothers who are employed and raising children simultaneously. This phenomenological study investigated the nuanced lived experiences of working mothers and their mental health. This study utilized convenience sampling to recruit 10 participants via Facebook groups. Each participant took part in a semi-structured interview which was audio recorded and transcribed. Transcripts were analyzed using Braun and Clarke’s thematic analysis, revealing 5 core themes: emotional strain and sensory overstimulation; stress during transitions between work and parenting roles; employment …


Inked Mobilities: Tattoos As Embodied Visual Narratives Of Youth Migration Between Italy And Australia, Giulia Marchetti Jan 2026

Inked Mobilities: Tattoos As Embodied Visual Narratives Of Youth Migration Between Italy And Australia, Giulia Marchetti

Research outputs 2022 to 2026

This article examines tattoos as embodied visual narratives within a broader study on youth transnational mobility (2019-2023). Focusing on recent Italian migration to and from Australia, 13 tattoos were documented among the 36 participants, acquired shortly before departure, during the stay in Australia, or upon return to Italy. Methodologically, the article proposes tattoo-based interviews as a participatory visual method that mobilises permanently inscribed images as sites of visual elicitation, enabling forms of reflection and storytelling. Tattoos thus operate as relational spaces of dialogue, co-interpretation, and reflexive meaning-making between researcher and participants. Epistemologically, tattoos are approached as visual narratives through which …


Mental Health Impacts Of Anti-Trans Stigma On Transgender People In Australia: A Mixed-Methods Study, Sav Zwickl, Sasha Bailey, Rin Chan, Shalem Y. Leemaqz, Joel Murray, Stevie Lane, Foster Skewis, Julian Grace, Eli Ward-Smith, Tomi Ruggles, Ada S. Cheung Jan 2026

Mental Health Impacts Of Anti-Trans Stigma On Transgender People In Australia: A Mixed-Methods Study, Sav Zwickl, Sasha Bailey, Rin Chan, Shalem Y. Leemaqz, Joel Murray, Stevie Lane, Foster Skewis, Julian Grace, Eli Ward-Smith, Tomi Ruggles, Ada S. Cheung

Research outputs 2022 to 2026

Background: Anti-trans stigma has escalated globally, yet there is limited empirical evidence examining its mental health impacts on trans populations.

Methods: In a May 2024 mixed-methods cross-sectional online survey, trans people aged ≥16 years living in Australia reported the frequency of seven anti-trans stigma experiences in the previous month, including exposure to anti-trans remarks in the news media or online; personal experience of online bullying, harassment or threats; having thought about, seen or heard about anti-trans rhetoric by Australian politicians and high-profile individuals; or anti-trans rallies; or police violence; or international anti-trans legislation and violence. Generalized linear models examined associations …


Shared Stories, Diverse Settings: A Podcast Analysis Of Stakeholder Experiences In Rural, Remote, And International Professional Experience, Marnie Harris, Narelle Lemon Jan 2026

Shared Stories, Diverse Settings: A Podcast Analysis Of Stakeholder Experiences In Rural, Remote, And International Professional Experience, Marnie Harris, Narelle Lemon

Research outputs 2022 to 2026

This study explores the experiences and perspectives of individuals involved in rural, remote, and international professional experience, with a particular focus on the support provided to pre-service teachers. Drawing on data generated through a series of in-depth podcast interviews, the research foregrounds the relational and contextual dimensions of teacher preparation across rural, remote, and international settings. Rural and remote communities face ongoing challenges in attracting and retaining teachers; therefore, this study explored the vital role that partnerships and supportive networks play in preparing pre-service teachers to succeed in these and other unfamiliar professional experience contexts. Through thematic analysis, the research …


The Influence Of Self-Compassion On The Mental Health And Well-Being Of Women Experiencing Infertility: A Systematic Review, Shwikar Othman, Mitra Javanmard, Lauren Roberts, Lisa Conlon, Mary Steen Jan 2026

The Influence Of Self-Compassion On The Mental Health And Well-Being Of Women Experiencing Infertility: A Systematic Review, Shwikar Othman, Mitra Javanmard, Lauren Roberts, Lisa Conlon, Mary Steen

Research outputs 2022 to 2026

Infertility can cause significant distress to women, increasing the risk of anxiety and depression. This systematic review examined the influence of self-compassion interventions on mental health and well-being among women experiencing infertility. The review was conducted in accordance with Joanna Briggs Institute (JBI) methodology and reported following PRISMA guideline. Databases searched included Medline, Embase, Ovid nursing database, Emcare, PsycINFO and Cochrane Library from inception to November 2024. Quality assessment was conducted using JBI critical appraisal tools. Title and abstract screening was conducted by three reviewers, and data extraction was performed independently by two reviewers. Sixteen studies met the inclusion criteria, …


When The Panic Sets In: Ai-Proofing As Pedagogical Violence In Social Work Education, Norah Hosken, Susan Bailey Jan 2026

When The Panic Sets In: Ai-Proofing As Pedagogical Violence In Social Work Education, Norah Hosken, Susan Bailey

Research outputs 2022 to 2026

Universities’ rushed responses to generative Artificial Intelligence (AI) constitute pedagogical violence against students and educators in social work programs. Drawing on Matusov and Sullivan’s pedagogical violence framework and Bourdieu’s symbolic violence, we examine how institutional mandates to ‘AI-proof’ assessments contradict core social work values while inflicting systematic harm. AI-proofing policies impose time-limited assessments disadvantaging disabled students and those with caring responsibilities, deploy surveillance technologies that discriminate against non-native English speakers, demand unsustainable workload increases from burned-out educators, and dismantle scaffolded pedagogy aligned with how social workers learn to practise. Using collaborative autoethnography, we document our experiences across Australian universities and …


Clinicians’ Experiences And Perspectives On Robot-Assisted Lower Limb And Gait Neurorehabilitation In Western Australia: Robot-Assisted Lower Limb Neurorehabilitation, Nikki Bakhtazad, Amanda Timler, Matthew K. Bagg, Rachel Buckingham, Saran Chamberlain, Barbara Singer, Patricia Martinet, Taya Hamilton, Jodie Marquez, Stuart Hodgetts, Ann Maree Vallence, Eric Gaitho, Emma Gee, Jessica Nolan Jan 2026

Clinicians’ Experiences And Perspectives On Robot-Assisted Lower Limb And Gait Neurorehabilitation In Western Australia: Robot-Assisted Lower Limb Neurorehabilitation, Nikki Bakhtazad, Amanda Timler, Matthew K. Bagg, Rachel Buckingham, Saran Chamberlain, Barbara Singer, Patricia Martinet, Taya Hamilton, Jodie Marquez, Stuart Hodgetts, Ann Maree Vallence, Eric Gaitho, Emma Gee, Jessica Nolan

Research outputs 2022 to 2026

Purpose: Robot-assisted lower limb rehabilitation (RALLR) may be an effective adjunct to conventional therapy for those with neurological conditions. Robot-assisted rehabilitation is emerging in Western Australia (WA) and local perspectives on this technology have not been explored. This study aimed to explore perspectives of WA clinicians on RALLR, to inform further implementation.

Methods: This was a cross-sectional survey of neurorehabilitation clinicians across metropolitan WA. A subset of respondents completed semi-structured interviews. Transcripts were analysed thematically.

Results: Fifty-six clinicians (across four professions) completed the survey. Eleven participated in an interview. The majority of clinicians expressed interest in upskilling in rehabilitation robotics …


Reflux Micro-Aspiration: Natural History, Pathophysiology, Clinical Presentation And Treatment, Oleksandr Khoma Jan 2026

Reflux Micro-Aspiration: Natural History, Pathophysiology, Clinical Presentation And Treatment, Oleksandr Khoma

Theses

Background

The accurate diagnosis of gastro-oesophageal reflux pulmonary micro-aspiration has only become possible recently with the introduction of a novel technique of reflux micro-aspiration scintigraphy study combined with single photon emission computed tomography (SPECT) combined with x-ray tomography (CT) in a hybrid instrument (1-3). This has allowed the accurate diagnosis of pulmonary and airway contamination with refluxate. Previously only patients with large volume symptomatic reflux aspiration were diagnosed clinically (Mendelson syndrome) or by 2-dimentional barium meal or an older plantar (2 dimensional) technique of scintigraphic aspiration studies. The concept of reflux micro-aspiration has been implicated in multiple pulmonary diseases but …


A Proposed Conceptual Framework For Assessing Quality Of Life In The United Arab Emirates: Application To Ras Al Khaimah Emirate, Aaesha Saif Al Shehhi Jan 2026

A Proposed Conceptual Framework For Assessing Quality Of Life In The United Arab Emirates: Application To Ras Al Khaimah Emirate, Aaesha Saif Al Shehhi

Dissertations

Quality of Life (QoL) has become a central concern in urban planning and sustainable development, particularly in rapidly transforming contexts such as the United Arab Emirates. This dissertation proposes and empirically validates a comprehensive framework for assessing urban QoL, with a focused application to the Emirate of Ras Al Khaimah. A mixed-methods approach integrates objective indicators and residents' subjective perceptions, aligned with national strategies including UAE Vision 2030, the National Strategy for Wellbeing 2031, and UAE Centennial 2071.

The methodology combines Geographic Information Systems (GIS), the Analytic Hierarchy Process (AHP), and statistical analyses to evaluate seven key sectors: environment, infrastructure …


Uae Traditional Folklore Through Modern Media And Its Educational Potential: The Case Of Freej, Shahad Imad Mostafa Jan 2026

Uae Traditional Folklore Through Modern Media And Its Educational Potential: The Case Of Freej, Shahad Imad Mostafa

Theses

This mixed‑methods study examined how the Emirati animated series Freej preserves traditional folklore through vernacular language, dialect, and idiomatic expressions, and evaluated its educational potential. Guided by four questions on folklore representation, dialect/idiom use, the role of the characters, and curricular applicability, the research combined content analysis of selected episodes, interviews coding and a survey of 100 Emirati participants; survey data were summarized with descriptive statistics to triangulate qualitative insights.

Findings indicated that audiences overwhelmingly perceived Freej as linguistically and culturally authentic: 95% rated the dialect as very/somewhat authentic, 94% said it reflects elders’ speech, and 89% felt the series …


Assessment Of Advanced Glazing Systems For Building Energy Efficiency In Hot-Arid Climates, Ahmad I. Elshamy, Yousef Elgefly, Yara El-Metwally, Serag Salem Jan 2026

Assessment Of Advanced Glazing Systems For Building Energy Efficiency In Hot-Arid Climates, Ahmad I. Elshamy, Yousef Elgefly, Yara El-Metwally, Serag Salem

Architectural Engineering

The built environment is considered among the most contributing factors to energy consumption. The building envelope plays a crucial role in determining the building energy consumption, regulating heat transfer and maintaining adequate indoor environmental quality. Hence, optimizing the thermal performance of the building envelope by achieving optimal glazing solutions while fulfilling the Sustainable Development Goal (SDG 7) is the main aim of this research. This study investigates the impact of various facade glazing systems on the building energy performance, focusing on the cooling energy consumption of an office building in a hot arid climate, Cairo, Egypt. The novelty of this …


Enhancing Urban Resilience In Ariha City, Syria: Integrating Active And Passive Climate Adaptation Strategies, Rania Rushdy Moussa, Ayham Ahmed Karoum Jan 2026

Enhancing Urban Resilience In Ariha City, Syria: Integrating Active And Passive Climate Adaptation Strategies, Rania Rushdy Moussa, Ayham Ahmed Karoum

Architectural Engineering

Ariha City in Syria faces urgent challenges for post-war reconstruction, including damaged infrastructure and environmental pollution resulting from the conflict. Enhancing urban resilience has become a priority to ensure sustainable recovery and mitigate the ongoing environmental impacts. This study investigates how combining traditional passive design strategies with modern active technological systems can strengthen urban resilience in this context. A two-phase methodology was employed. In the first phase, a field assessment examined existing urban conditions through site surveys, spatial analysis, and documentation of passive and active resilience strategies in both the historic center and new growth areas. In the second phase, …


Impact Of Therapeutic Design On Patients’ Satisfaction And Wellness In Healthcare Facilities., Dalia Moati Jan 2026

Impact Of Therapeutic Design On Patients’ Satisfaction And Wellness In Healthcare Facilities., Dalia Moati

Architectural Engineering

In recent years, there has been a growing recognition of the signi3icance of designing healthcare environments that extend beyond functionality. These healing hospital environments are designed to promote patient satisfaction and well-being. However, despite increased awareness of their bene3its, the global adoption of healing-centred hospital designs remains limited. While the healthcare system has long focused on treating physical ailments, there is a growing recognition that to promote overall wellness, it must shift toward a more comprehensive approach to healing, addressing not only the body but also the emotional and psychological needs of patients. This paper aims to investigate the impact …


Remote Access Restrictions To Immigration-Related Court Records, Doris H. Zhang Jan 2026

Remote Access Restrictions To Immigration-Related Court Records, Doris H. Zhang

Fordham Law Review

Journalists today often report on newsworthy federal court cases by remotely accessing the court records online. However, thanks to Federal Rule of Civil Procedure 5.2(c), remote access is not available by default in immigration-related cases. To obtain any court records in immigration cases, journalists must go to the courthouse, hire someone to go on their behalf, or ask the court to exercise its discretion to lift the Rule 5.2(c) remote access restrictions. These alternatives are burdensome, hindering the ability of the press and the public to keep track of immigration cases in federal courts. Despite the burdens on the press …


Advancing Treatment Of Pleural Infection, Estee Pui Mun Lau Jan 2026

Advancing Treatment Of Pleural Infection, Estee Pui Mun Lau

Theses: Doctorates and Masters

Introduction: Pleural infection remains a major clinical concern, with an increasing incidence worldwide. The use of intrapleural tissue plasminogen activator (tPA) with deoxyribonuclease (DNase) therapy represents a major breakthrough as it offers an effective alternative to surgery for patients who fail conventional treatment. However, the optimal dosage of tPA is yet to be established. Indwelling pleural catheter (IPC)-related infections, especially IPC-related pleural infections are a significant concern and a barrier to the uptake of IPC. The development of a long-term preventative strategy is imperative to promote uptake and improve the quality of life of patients, particularly in those who have …


Healthcare Providers’ Prescribing Practices And Emergency Management Planning For Pre-Hospital Seizure Emergencies: A Comparison Of Hungary To Norway And The United Kingdom, Rohit Shankar Jan 2026

Healthcare Providers’ Prescribing Practices And Emergency Management Planning For Pre-Hospital Seizure Emergencies: A Comparison Of Hungary To Norway And The United Kingdom, Rohit Shankar

Peninsula Medical School

Background: Seizure emergencies, include prolonged seizures and status epilepticus (SE). Benzodiazepines are recommended as first-line rescue therapy. We investigate prescribing practices, emergency planning, and clinician experiences regarding rescue medication in Hungary and compare findings with those from the United Kingdom and Norway. Methods: A cross-sectional online survey (CHERRIES-compliant) was conducted between March and October 2025 among neurologists and pediatric neurologists in Hungary. The questionnaire explored demographics, prescribing behaviours, emergency management planning, and training practices. Descriptive statistics were used for Hungarian data, and comparative analyses with the combined UK and Norwegian cohorts were performed using chi-squared, Fisher's exact, and Mann–Whitney U …


Post-Release Mortality Of European Bass (Dicentrarchus Labrax) Discarded From Small-Scale Estuarine Fishing, J. E. Stewart, T. Stamp, P. Davies, A. Hall, T. Robbins, L. Stewart, E. V. Sheehan Jan 2026

Post-Release Mortality Of European Bass (Dicentrarchus Labrax) Discarded From Small-Scale Estuarine Fishing, J. E. Stewart, T. Stamp, P. Davies, A. Hall, T. Robbins, L. Stewart, E. V. Sheehan

School of Biological and Marine Sciences

Estuaries provide essential habitats for many fish species, but their confined and accessible nature may increase fish vulnerability to capture, and few empirical studies have quantified the value of restricting net fisheries in such areas. Furthermore, management measures for some fisheries promote discarding (e.g., of European sea bass; Dicentrarchus labrax), yet the mortality of fish discarded from small-scale inshore fisheries is poorly understood. We used condition assessments, Reflex Action Mortality Predictor scores and acoustic tracking to evaluate post-release mortality of bass captured in small-scale estuarine netting and angling. Gillnet-caught bass exhibited a range of stress responses and 20%–24% mortality shortly …


Investigating Spatial And Seasonal Differences In Microgastropod Assemblages Within The Little-Studied Camamu Bay, Brazil: A Potential Bioindicator For Remote Tropical Areas?, Francisco Kelmo, Sol De Maria Cesar Ferreira, Eduardo Henrique Galvão, Martin J. Attrill Jan 2026

Investigating Spatial And Seasonal Differences In Microgastropod Assemblages Within The Little-Studied Camamu Bay, Brazil: A Potential Bioindicator For Remote Tropical Areas?, Francisco Kelmo, Sol De Maria Cesar Ferreira, Eduardo Henrique Galvão, Martin J. Attrill

School of Biological and Marine Sciences

This study investigates spatial and seasonal variation in the assemblages of benthic microgastropods (snails < 5–10 mm in length) within a poorly studied tropical bay. As these organisms are abundant, diverse and relatively easy to sample, with well-established taxonomy, they may prove a highly suitable group for ecological studies in such areas. Sediment samples were collected from three river basins in Camamu Bay, Brazil, during the wet and dry seasons. A total of 132 microgastropod species was recorded, demonstrating high diversity. The most abundant species were Eulithidium affine, Bittiolum varium, Cerithium atratum, Vitta virginea and Schwartziella bryerea. The least abundant species were Tenaturris gemma, Turbinella laevigata, Petaloconchus erectus, Parviturboides interruptus and Vitrinella cupidinensis. Statistical analysis revealed significant seasonal and spatial differences in diversity and assemblage composition, which correlated with environmental gradients. The results suggest that microgastropods are a suitable component of the biota for ecological and applied studies in marine sediments, particularly in remote tropical locations where full macrofaunal analysis may be challenging. Whilst further testing across impact gradients is needed, this approach offers a practical solution for ecological investigations in remote regions with limited taxonomic expertise and highlights microgastropods as a useful indicator taxon for impact biomonitoring in tropical marine sediments.


Case Report: Management Of A Challenging Case Presenting With Dysphagia After Thyroidectomy Requiring Administration Of Liquid 131i Via Mic-Key Low-Profile Tube—A Multidisciplinary Approach, Ahmed Ebada Salem, Sandra Ramirez, Brian R Weston, Akram Hussein, Simone Krebs Jan 2026

Case Report: Management Of A Challenging Case Presenting With Dysphagia After Thyroidectomy Requiring Administration Of Liquid 131i Via Mic-Key Low-Profile Tube—A Multidisciplinary Approach, Ahmed Ebada Salem, Sandra Ramirez, Brian R Weston, Akram Hussein, Simone Krebs

Faculty, Staff and Student Publications

Radioactive iodine (RAI) therapy with 131-iodine (131I) remains a cornerstone in the postoperative management of differentiated thyroid carcinoma (DTC). The standard route of administration is oral, typically in capsule form and less commonly as a liquid. However, in patients with severe dysphagia and compromised airway, traditional oral 131I delivery may be contraindicated due to the risk of aspiration and radioactivity contamination. These scenarios present unique clinical challenges that necessitate deviation from conventional protocols. While liquid 131I may be administered through the mouth or via nasogastric or percutaneous gastrostomy tubes, there is currently no standardized approach, and potential risks, such as …


Preliminary Examination Of Orexin Receptor Antagonism With Suvorexant In Individuals With Methamphetamine Use Disorder: A Case Series Study, Heather Webber, Jessica Badawi, Douglas Calvillo, Jin Yoon, Michael Weaver, Scott Lane, Joy Schmitz Jan 2026

Preliminary Examination Of Orexin Receptor Antagonism With Suvorexant In Individuals With Methamphetamine Use Disorder: A Case Series Study, Heather Webber, Jessica Badawi, Douglas Calvillo, Jin Yoon, Michael Weaver, Scott Lane, Joy Schmitz

Faculty, Staff and Student Publications

No abstract provided.


Contemporary Opportunities And Potential Of Auger Electron-Emitting Theranostics, Seok-Yong Lee, H Charles Manning Jan 2026

Contemporary Opportunities And Potential Of Auger Electron-Emitting Theranostics, Seok-Yong Lee, H Charles Manning

Faculty, Staff and Student Publications

Recent breakthroughs in radiopharmaceutical (RP) therapy have emerged interest in employing Auger electron (AE)-emitting radionuclides as potential agents for precise theranostics. AE provides energy with exceptional localization due to their short tissue penetration range (TPR, < 10 nm), rendering them particularly effective for targeting nuclear DNA in tumor cells. In this context, AE-emitting radionuclide therapy (AE-emitting RLT) enables the targeted destruction of tumor cells while reducing harm to adjacent healthy tissue, a significant challenge in this field. Preclinical and early clinical investigations reveal the efficacy of AE-emitting RLTs in the theranostics of diverse malignancies, such as glioblastoma, prostate cancer, and neuroendocrine tumors. Notwithstanding these developments, challenges and limitations persist regarding dosimetry, delivery efficiency, and the treatment of radiotoxicity. A new paradigm is being developed to tackle the obstacles encountered by integrating molecular target markers (e.g., PARP) that function near the nucleus to improve the intranuclear delivery efficiency of AE-emitting radionuclides. Novel radiochemical methods such as these have facilitated the more stable and efficient labeling of biomolecules with AE-emitting radionuclides. Also, recent advances in DNA-molecular targeting, nanoparticles, nucleic acid/protein engineering, click- or bioorthogonal conjugation chemistry, and artificial intelligence (AI)-based structure modeling present concrete opportunities to overcome these limitations. Moreover, the integration of diagnostic imaging companion platforms employing theranostic radioisotope pairings facilitates real-time assessment of therapeutic efficacy and biodistribution, resulting in the formulation of enhanced treatment regimens. This review summarizes the prior development, recent advancements, barriers in clinical implementation, and future perspective of AE-emitting RLTs.


Respiratory Motion Effects And Plan Robustness For Lattice Radiation Therapy, Rachael M Martin-Paulpeter, Peter A Balter, Luis A Perles, Ethan B Ludmir, Joshua S Niedzielski Jan 2026

Respiratory Motion Effects And Plan Robustness For Lattice Radiation Therapy, Rachael M Martin-Paulpeter, Peter A Balter, Luis A Perles, Ethan B Ludmir, Joshua S Niedzielski

Faculty, Staff and Student Publications

Introduction: Lattice radiation therapy (LRT), a form of spatially fractionated radiation therapy (SFRT), has shown promise in treating bulky tumors. It consists of hot and cold spots within the tumor, and the ratio between these doses is thought to be important in clinical outcomes. Respiratory motion is expected to degrade these peak-to-valley dose ratios (PVDRs) but has largely been ignored in LRT literature and clinical practice. This work aims to quantify the response of LRT dose distributions to motion to better inform motion management decisions and improve clinical outcomes.

Methods: Respiratory motion of peak-to-peak amplitudes from 0.3 to 2 cm …


Evaluation Of Organ-Specific Relative Biological Effectiveness Of Proton Therapy Using Radiation-Induced Pneumonitis As An Endpoint, Li Liao, Ting Xu, Mei Chen, Tingshi Su, Narayan Sahoo, Xiaorong Zhu, Steven J Frank, Quynh-Nhu Nguyen, Zhongxing Liao, Xiaodong Zhang Jan 2026

Evaluation Of Organ-Specific Relative Biological Effectiveness Of Proton Therapy Using Radiation-Induced Pneumonitis As An Endpoint, Li Liao, Ting Xu, Mei Chen, Tingshi Su, Narayan Sahoo, Xiaorong Zhu, Steven J Frank, Quynh-Nhu Nguyen, Zhongxing Liao, Xiaodong Zhang

Faculty, Staff and Student Publications

Background and purpose: Proton therapy has become widely used for non-small cell lung cancer (NSCLC) due to its ability to spare normal tissue. However, the commonly assumed relative biological effectiveness (RBE) of 1.1 may underestimate the therapy's true biological effects on lung, potentially leading to a higher than expected incidence of radiation-induced pneumonitis (RP). In this retrospective study, we evaluated the variability of organ-specific RBE of proton therapy using RP grade 2 or higher (RP2+) as an endpoint.

Materials and methods: Data from 270 NSCLC patients across two clinical trials were analyzed, with 134 given photon therapy and 136 given …


Trial Interviews To Explore Glycogen Storage Disease Type Ia Patient Experiences Following Gene Therapy, Diane M Turner-Bowker, Jessica Butler, Shayna Egan, David A Weinstein, David F Rodriguez-Buritica, Ayesha Ahmad, María-Luz Couce, Rebecca Riba-Wolman, John J Mitchell, Christina Theodore-Oklota Jan 2026

Trial Interviews To Explore Glycogen Storage Disease Type Ia Patient Experiences Following Gene Therapy, Diane M Turner-Bowker, Jessica Butler, Shayna Egan, David A Weinstein, David F Rodriguez-Buritica, Ayesha Ahmad, María-Luz Couce, Rebecca Riba-Wolman, John J Mitchell, Christina Theodore-Oklota

Faculty, Staff and Student Publications

Background: Glycogen storage disease type Ia (GSDIa) is a rare, inherited, autosomal recessive deficiency of glucose-6-phosphatase (G6Pase), an enzyme necessary in glycogenolysis and gluconeogenesis. To maintain normal blood glucose levels and ensure survival, individuals living with GSDIa must frequently consume complex carbohydrates (eg, uncooked cornstarch). Dietary management can result in chronic complications and significant patient burden. DTX401 (pariglasgene brecaparvovec) is an investigational adeno-associated virus serotype 8 vector (AAV8)-based gene therapy designed to restore endogenous glucose production.

Objectives: Patient experience interviews were conducted as part of an open-label, phase 1/2 dose-escalation trial (NCT03517085) evaluating the safety and efficacy of …


Digital Marine Citizenship Training Module: Toolkit For Digital Placemaking, Katharine Willis Jan 2026

Digital Marine Citizenship Training Module: Toolkit For Digital Placemaking, Katharine Willis

School of Art, Design and Architecture

As a coastal nation, the UK has long drawn inspiration from the sea - shaping our history through travel, industry, the arts, leisure and more. The coastline remains a place of identity and possibility. It also offers signifi cant benefi ts for health, wellbeing and connection, yet many local people are disconnected from nearby shores.This Training Module is an easy to use resource to reimagine community relationships with the sea and make coastal spaces more inclusive, welcoming and vibrant for all.Connected SeascapesOrigins of the Training Module The Connected Seascapes Toolkit stems from a collaborative project between Plymouth City Council, the …